- Title
- Repeated long-term sub-concussion impacts induce motor dysfunction in rats : a potential rodent model
- Creator
- Lavender, Andrew; Rawlings, Samuel; Warnock, Andrew; McGonigle, Terry; Hiles-Murison, Bailey; Nesbit, Michael; Lam, Virginie; Hackett, Mark; Fitzgerald, Melinda; Takechi, Ryusuke
- Date
- 2020
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/172942
- Identifier
- vital:14583
- Identifier
-
https://doi.org/10.3389/fneur.2020.00491
- Identifier
- ISBN:1664-2295 (ISSN)
- Abstract
- Whilst detrimental effects of repeated sub-concussive impacts on neurophysiological and behavioral function are increasingly reported, the underlying mechanisms are largely unknown. Here, we report that repeated sub-concussion with a light weight drop (25 g) in wild-type PVG rats for 2 weeks does not induce detectable neuromotor dysfunction assessed by beamwalk and rotarod tests. However, after 12 weeks of repeated sub-concussion, the rats exhibited moderate neuromotor dysfunction. This is the first study to demonstrate development of neuromotor dysfunction following multiple long-term sub-concussive impacts in rats. The outcomes may offer significant opportunity for future studies to understand the mechanisms of sub-concussion-induced neuropsychological changes. © Copyright © 2020 Lavender, Rawlings, Warnock, McGonigle, Hiles-Murison, Nesbit, Lam, Hackett, Fitzgerald and Takechi.
- Publisher
- Frontiers Media S.A.
- Relation
- Frontiers in Neurology Vol. 11, no. (2020), p.
- Rights
- https://creativecommons.org/licenses/by/4.0/
- Rights
- Copyright © 2020 Lavender, Rawlings, Warnock, McGonigle, Hiles-Murison, Nesbit, Lam, Hackett, Fitzgerald and Takechi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Rights
- Open Access
- Rights
- This metadata is freely available under a CCO license
- Subject
- 1103 Clinical Sciences; 1109 Neurosciences; 1701 Psychology; Beamwalk; Mild traumatic brain injury; Neuromotor function; Rotarod; Sub-concussion
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