- Title
- Foxp3+ tregs from langerhans cell histiocytosis lesions co-express CD56 and have a definitively regulatory capacity
- Creator
- Mitchell, Jenée; Kelly, Jason; Kvedaraite, E.; von Bahr Greenwood, Tatiana; Henter, Jan-Inge; Pellicci, Daniel; Berzins, Stuart; Kannourakis, George
- Date
- 2020
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/171966
- Identifier
- vital:14448
- Identifier
-
https://doi.org/10.1016/j.clim.2020.108418
- Identifier
- ISBN:1521-6616 (ISSN)
- Abstract
- Langerhans cell histiocytosis (LCH) lesions contain myeloid lineage ‘LCH’ cells. Regulatory T cells (Tregs) are also enriched within lesions, although their role in LCH pathogenesis is unknown. LCH cells are thought to produce the transforming growth factor beta (TGF-β) within lesions, however whether Tregs contribute is unestablished. Using flow cytometry, we analyzed relative frequencies of live Tregs from LCH patients and identified CD56 expression and TGF-β production by lesion Tregs. While CD56+ Tregs were enriched in lesions, overall CD56+ T cells were reduced in the blood from active LCH patients compared to non-active disease patients, and there was a negative correlation between CD8+CD56+ T cells and Tregs. We propose that inducing a Treg phenotype in T cells such as CD56+ T cells may be a mechanism by which LCH cells divert inflammatory T cell responses. Thus, Tregs within LCH lesions are likely an important component in LCH pathogenesis. © 2020
- Publisher
- Academic Press Inc.
- Relation
- Clinical Immunology Vol. 215, no. (2020), p.
- Rights
- Copyright © 2020 Published by Elsevier Inc
- Rights
- This metadata is freely available under a CCO license
- Subject
- 1107 Immunology; Cytotoxic T cells; Foxp3+ Tregs; Langerhans cell histiocytosis; LCH; TGF-β; Tregs
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