- Title
- Do lamins influence disease progression in cancer?
- Creator
- Hutchison, Chris
- Date
- 2014
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/170814
- Identifier
- vital:14212
- Identifier
-
https://doi.org/10.1007/978-1-4899-8032-8_27
- Identifier
- ISBN:0065-2598
- Abstract
- For nearly 60 years, diagnosis of cancer has been based on pathological tests that look for enlargement and distortion of nuclear shape. Because of their involvement in supporting nuclear architecture, it has been postulated that the basis for nuclear shape changes during cancer progression is altered expression of nuclear lamins and in particular lamins A and C. However, studies on lamin expression patterns in a range of different cancers have generated equivocal and apparently contradictory results. This might have been anticipated since cancers are diverse and complex diseases. Moreover, whilst altered epigenetic control over gene expression is a feature of many cancers, this level of control cannot be considered in isolation. Here I have reviewed those studies relating to altered expression of lamins in cancers and argue that consideration of changes in the expression of individual lamins cannot be considered in isolation but only in the context of an understanding of their functions in transformed cells. © 2014 Springer Science+Business Media New York.
- Publisher
- Springer New York LLC
- Relation
- Advances in Experimental Medicine and Biology Vol. 773, no. (2014), p. 593-604
- Rights
- This metadata is freely available under a CCO license
- Subject
- Breast cancer; Colon cancer; Lamin; Lung cancer; Nuclear lamina; Ovarian cancer; Prostate cancer; Lamin A; Lamin B; Lamin C; Ras protein; Transcription factor; Vimentin; Cancer growth; Cancer prognosis; Cell nucleus matrix; Cell transformation; Digestive system cancer; Hematologic malignancy; Human; Malignant neoplastic disease; Molecular mechanics; Nonhuman; Ovary cancer; Priority journal; Protein expression; Protein function; Protein isolation; Skin cancer; Disease Progression; Female; Humans; Lamins; Neoplasms; Prognosis; Tumor Markers, Biological; 11 Medical and Health Sciences
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