- Title
- Selenophene and thiophene-core estrogen receptor ligands that inhibit motility and development of parasitic stages of Haemonchus contortus
- Creator
- Preston, Sarah; Luo, Junjie; Zhang, Yuezhou; Jabbar, Abdul; Crawford, Simon; Baell, Jonathan; Hofmann, Andreas; Hu, Min; Zhou, Hai-Bing; Gasser, Robin
- Date
- 2016
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/169562
- Identifier
- vital:14034
- Identifier
-
https://doi.org/10.1186/s13071-016-1612-4
- Identifier
- ISBN:1756-3305
- Abstract
- Parasitic worms represent a substantial disease burden in animals and humans worldwide. The control of parasitic roundworms (nematodes) relies heavily on the use of anthelmintic drugs. However, widespread drug resistance in nematodes seriously compromises the effectiveness of many anthelmintics around the world. Thus, there is a need to discover new drugs, with unique modes of action, against parasites.
- Publisher
- BMC
- Relation
- Parasites & Vectors Vol. 9, no. 1 (2016), p. 346
- Rights
- http://creativecommons.org/licenses/by/4.0/
- Rights
- Copryright © 2016 The Author(s) Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Rights
- This metadata is freely available under a CCO license
- Subject
- Selective estrogen receptor modulators (SERMs); Selenophene and thiophene-core SERMs; Inhibitory activity; Haemonchus contortus; Nematode; 1108 Medical Microbiolgy
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