- Title
- Molecular structures and structural dynamics of prion proteins and prions : Mechanism underlying the resistance to prion diseases
- Creator
- Zhang, Jiapu
- Date
- 2015
- Type
- Text; Book
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/169246
- Identifier
- vital:14005
- Identifier
-
https://doi.org/10.1007/978-94-017-7318-8
- Identifier
- ISBN:978-94-017-7318-8
- Abstract
- This monograph is the first easy-to-read-and-understand book on prion proteins' molecular dynamics (MD) simulations and on prions' molecular modelling (MM) constructions. It enables researchers to see what is crucial to the conformational change from normal cellular prion protein (PrPC) to diseased infectious prions (PrPSc), using MD and MM techniques. As we all know, prion diseases, caused by the body's own proteins, are invariably fatal and highly infectious neurodegenerative diseases effecting humans and almost all animals for a major public health concern. Prion contains no nucleic acids and it is a misshapen or conformation-changed protein that acts like an infectious agent; thus prion diseases are called “protein structural conformational” diseases. PrPC is predominant in
- Publisher
- Springer Science+Business Media Dordrecht
- Relation
- Focus on Structural Biology Vol. 9
- Rights
- Copyright © Springer Science+Business Media Dordrecht 2015
- Rights
- This metadata is freely available under a CCO license
- Subject
- Molecular modeling; Molecular structures; Prion amyloid fibrils; Prion diseases; Prion proteins
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