- Title
- Polyclonal T-Cells Express CD1a in Langerhans Cell Histiocytosis (LCH) Lesions
- Creator
- West, Jennifer; Olsen, Sharon; Mitchell, Jenée; Priddle, Ross; Luke, Jennifer; Åkefeldt, Selma Olsson; Henter, Jan-Inge; Turville, Christopher; Kannourakis, George
- Date
- 2014
- Type
- Text; Journal article; Article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/168915
- Identifier
- vital:13938
- Identifier
- https://doi.org/10.1371/journal.pone.0109586
- Identifier
- ISBN:1932-6203
- Abstract
- Langerhans cell histiocytosis (LCH) is a complex and poorly understood disorder that has characteristics of both inflammatory and neoplastic disease. By using eight-colour flow cytometry, we have identified a previously unreported population of CD1a+/CD3+ T-cells in LCH lesions. The expression of CD1a is regarded as a hallmark of this disease; however, it has always been presumed that it was only expressed by pathogenic Langerhans cells (LCs). We have now detected CD1a expression by a range of T-cell subsets within all of the LCH lesions that were examined, establishing that CD1a expression in these lesions is no longer restricted to pathogenic LCs. The presence of CD1a+ T-cells in all of the LCH lesions that we have studied to date warrants further investigation into their biological function to determine whether these cells are important in the pathogenesis of LCH.[ABSTRACT FROM AUTHOR]
- Publisher
- Public Library of Science
- Relation
- PLoS ONE Vol. 9, no. 10 (2014), p. 1-12
- Rights
- http://creativecommons.org/licenses/by-nc-nd/4.0/
- Rights
- Copyright: © 2014 West et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Rights
- Open Access
- Subject
- LANGERHANS-cell histiocytosis; Inflammation; Neoplastic cell transformation; Cytomery; T cells; Animal cells; Antigen-presenting cells; Biochemistry; Biology and life sciences; Blood cells; Cell biology; Cellular types; Cytochemistry; Dendritic cells; Histiocytes; Immune cells; Immunocytochemistry; Immunology; Langerhans cells; Lymphocytes; Research Article; White blood cells
- Full Text
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