- Title
- The acute effects of aerobic exercise on Leukocyte Telomere biology
- Creator
- Chilton, Warrick
- Date
- 2018
- Type
- Text; Thesis; PhD
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/166510
- Identifier
- vital:13424
- Identifier
- https://library.federation.edu.au/record=b2752705
- Abstract
- Doctor of Philosophy; Habitual exercise is unequivocally associated with decreased all-cause mortality and morbidity. Despite the strength of the association, a large part of the decreased risk is physiologically unaccounted for. Accumulating evidence indicates that leukocyte telomere length (LTL) may be one such explanatory mechanism. Telomeres are specialized deoxyribonucleic acid (DNA) sequences located at chromosomal ends where they protect the genomic DNA from enzymatic degradation. Excessive and/or premature telomere shortening in leukocytes is associated with a host of chronic diseases and impaired immune function. Observational associations exist between LTL and habitual physical activity/exercise in multiple cohorts. However, correlation does not imply causal story and the underpinning mechanisms behind the association are unclear. The current consensus is that long-term exercise-induced reductions in oxidative stress and inflammation mediate the association. The acute dynamics of telomere biology are poorly understood; however, a growing body of evidence suggests that telomeres may be amenable to acute modulation via expression of telomereassociated genes and microRNAs. Accordingly, the overarching aim of this thesis was to characterize the acute effects of aerobic exercise on leukocyte telomere biology.
- Publisher
- Federation University Australia
- Rights
- Copyright Warrick Chilton
- Rights
- This metadata is freely available under a CCO license
- Full Text
- Thesis Supervisor
- Charchar, Fadi
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