- Title
- Telomeres, aging and exercise : Guilty by association?
- Creator
- Chilton, Warrick; O’Brien, Brendan; Charchar, Fadi
- Date
- 2017
- Type
- Text; Journal article; Review
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/164144
- Identifier
- vital:12993
- Identifier
-
https://doi.org/10.3390/ijms18122573
- Identifier
- ISBN:1661-6596
- Abstract
- Telomeres are repetitive tandem DNA sequences that cap chromosomal ends protecting genomic DNA from enzymatic degradation. Telomeres progressively shorten with cellular replication and are therefore assumed to correlate with biological and chronological age. An expanding body of evidence suggests (i) a predictable inverse association between telomere length, aging and age-related diseases and (ii) a positive association between physical activity and telomere length. Both hypotheses have garnered tremendous research attention and broad consensus; however, the evidence for each proposition is inconsistent and equivocal at best. Telomere length does not meet the basic criteria for an aging biomarker and at least 50% of key studies fail to find associations with physical activity. In this review, we address the evidence in support and refutation of the putative associations between telomere length, aging and physical activity. We finish with a brief review of plausible mechanisms and potential future research directions. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.
- Publisher
- MDPI AG
- Relation
- International Journal of Molecular Sciences Vol. 18, no. 12 (2017), p. 1-32
- Rights
- https://creativecommons.org/licenses/by/4.0
- Rights
- Copyright © 2017 by the authors. Licensee MDPI, Basel, Switzerland.
- Rights
- Open Access
- Rights
- This metadata is freely available under a CCO license
- Subject
- 0399 Other Chemical Sciences; 0604 Genetics; 0699 Other Biological Sciences; Aging; Association; Biomarker; Physical activity; Telomeres
- Full Text
- Reviewed
- Hits: 4219
- Visitors: 4335
- Downloads: 311
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Published version | 420 KB | Adobe Acrobat PDF | View Details Download |