Increasing chloramphenicol resistance in Streptococcus pneumoniae isolates from Papua New Guinean Children with acute bacterial meningitis

Title: Increasing chloramphenicol resistance in Streptococcus pneumoniae isolates from Papua New Guinean Children with acute bacterial meningitis
Creator: Manning, Laurens; Laman, Moses; Greenhill, Andrew; Michael, Audrey; Siba, Peter; Mueller, Ivo; Davis, Timothy
Date: 2011
Type: Text; Journal article
Identifier: http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/163757
Identifier: vital:12939
Identifier: https://doi.org/10.1128/AAC.00526-11
Identifier: ISBN:0066-4804
Abstract: In Papua New Guinean (PNG) children with acute bacterial meningitis (ABM), all Haemophilus influenzae isolates were resistant to chloramphenicol. Although Streptococcus pneumoniae isolates had a median chloramphenicol MIC of 3 μg/ml, it was ≥4 μg/ml in 42.8%, and the likelihood of an area under the 24-hour concentration-time curve/MIC ratio of >100 h at a MIC of ≥4 μg/ml was approximately 50%. All isolates were ceftriaxone sensitive. These data support ceftriaxone rather than conventional chloramphenicol for all PNG children with suspected ABM.
Relation: Antimicrobial Agents and Chemotherapy Vol. 55, no. 9 (2011), p. 4454-4456
Rights: This metadata is freely available under a CCO license
Subject: 0605 Microbiology; 1108 Medical Microbiology; 1115 Pharmacology and Pharmaceutical Sciences
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