- Title
- Genetic variation within the Y chromosome is not associated with histological characteristics of the atherosclerotic carotid artery or aneurysmal wall
- Creator
- Haitjema, Saskia; van Setten, Jessica; Eales, James; van der Laan, Sander; Gandin, Ilaria; de Vries, Jean-Paul; de Borst, Gert; Pasterkamp, Gerard; Asselbergs, Folkert; Charchar, Fadi; Wilson, James; de Jager, Saskia; Tomaszewski, Maciej; den Ruijter, Hester
- Date
- 2017
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/156249
- Identifier
- vital:11392
- Identifier
-
https://doi.org/10.1016/j.atherosclerosis.2017.02.011
- Identifier
- ISSN:0021-9150
- Abstract
- Background and aims: Haplogroup I, a common European paternal lineage of the Y chromosome, is associated with increased risk of coronary artery disease in British men. It is unclear whether this haplogroup or any other haplogroup on the Y chromosome is associated with histological characteristics of the diseased vessel wall in other vascular manifestations of cardiovascular diseases showing a male preponderance. Methods: We examined Dutch men undergoing either carotid endarterectomy from the Athero-Express biobank (AE, n = 1217) or open aneurysm repair from the Aneurysm-Express biobank (AAA, n = 393). Upon resolving the Y chromosome phylogeny, each man was assigned to one of the paternal lineages based on combinations of single nucleotide polymorphisms of the male-specific region of the Y chromosome. We examined the associations between the Y chromosome and the histological characteristics of the carotid plaque and aneurysm wall, including lipid content, leukocyte infiltration and intraplaque haemorrhage, in all men. Results: A majority of men were carriers of either haplogroup I (AE: 28% AAA: 24%) or haplogroup R (AE: 59% AAA: 61%). We found no association between Y chromosomal haplogroups and histological characteristics of plaque collected from carotid arteries or tissue specimens of aneurysms. Moreover, the distribution of frequency for all Y chromosomal haplogroups in both cohorts was similar to that of a general population of Dutch men. Conclusions: Our data show that genetic variation on the Y chromosome is not associated with histological characteristics of the plaques from carotid arteries or specimens of aneurysms in men of Dutch origin. © 2017 Elsevier B.V.
- Publisher
- Elsevier Ireland Ltd
- Relation
- Atherosclerosis Vol. 259, no. (2017), p. 114-119
- Rights
- Copyright © 2017 Elsevier B.V.
- Rights
- This metadata is freely available under a CCO license
- Subject
- 1103 Clinical Sciences; 1102 Cardiorespiratory Medicine and Haematology; Aneurysm; Carotid endarterectomy; Haplogroups; Histology; Men; Plaque characteristics; Y chromosome
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