- Title
- Prospects for immunoprophylaxis against fasciola hepatica (Liver Fluke)
- Creator
- Spithill, Terry; Carmona, Carlos; Piedrafita, David; Smooker, Peter
- Date
- 2012
- Type
- Text; Book chapter
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/155153
- Identifier
- vital:11301
- Identifier
-
https://doi.org/10.1002/9783527652969.ch28
- Identifier
- ISBN:978-3-52733059-1
- Abstract
- Despite considerable research focused on the development of vaccines for Fasciola (liver fluke) infections in ruminants, there is still no commercial vaccine. Development of vaccines has been hindered both by our lack of insight into natural acquired immune mechanisms expressed by ruminants against fluke infection as well as a lack of immune correlates on hosts that are protected by experimental vaccines. In this chapter, we review the prospects and challenges we face regarding the development of experimental fluke vaccines, the nature of immune responses associated with host resistance, the potential for combination vaccines, and the criteria for commercial interest in a vaccine, including the minimal efficacy necessary to produce economic benefits in ruminants. Due to the widespread resistance of Fasciola to triclabendazole, we also discuss the potential demand for a human vaccine. © 2012 Wiley-VCH Verlag GmbH & Co. KGaA.
- Publisher
- Wiley-VCH
- Relation
- Parasitic Helminths: Targets, Screens, Drugs and Vaccines (Drug Discovery in Infectious Diseases series) Chapter 28 p. 465-484
- Rights
- Copyright © 2012 Wiley-VCH Verlag & Co.
- Rights
- This metadata is freely available under a CCO license
- Subject
- Fasciola; Fasciolosis; Immunoprophylaxis; Liver fluke; Tegument; Triclabendazole; Vaccine
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