- Title
- Circulating microRNAs and hypertension - From new insights into blood pressure regulation to biomarkers of cardiovascular risk
- Creator
- Romaine, Simon; Charchar, Fadi; Samani, Nilesh; Tomaszewski, Maciej
- Date
- 2016
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/100035
- Identifier
- vital:10465
- Identifier
-
https://doi.org/10.1016/j.coph.2015.12.002
- Identifier
- ISSN:1471-4892
- Abstract
- Hypertension is a leading cause of cardiovascular morbidity and mortality worldwide, yet the molecular mechanisms underpinning the development of high blood pressure remain incompletely understood. MicroRNAs are small, non-coding RNA molecules approximately 22 nucleotides in length that act as post-transcriptional regulators of gene expression. We highlight, through a review of recent literature, that studies on circulating microRNAs have provided novel insights into blood pressure regulation. They have also complemented tissue-based and animal-based experiments in shedding new light on our understanding of established pathways in hypertension, such as the renin-angiotensin system. Despite a number of challenges, we believe microRNAs herald particular potential in becoming effective biomarkers of target-organ damage in hypertension. © 2016 Elsevier Ltd. All rights reserved.
- Publisher
- Elsevier Ltd
- Relation
- Current Opinion in Pharmacology Vol. 27, no. (2016), p. 1-7; http://purl.org/au-research/grants/nhmrc/1009490
- Rights
- Copyright © 2016 Elsevier Ltd. All rights reserved.
- Rights
- This metadata is freely available under a CCO license
- Subject
- 1115 Pharmacology and Pharmaceutical Sciences; Angiogenesis; Blood pressure regulation; Cell communication; Cell migration; Cohort analysis; Diastolic blood pressure; Disease course; Endothelium cell; Essential hypertension; Heart failure; Heart left ventricle hypertrophy; Human cytomegalovirus; Metabolic syndrome X; Microarray analysis; Pathogenesis; Peripheral blood mononuclear cell; Polymerase chain reaction; Positive end expiratory pressure; Renin angiotensin aldosterone system; Resistant hypertension; RNA replication; Sleep disordered breathing; Systolic blood pressure; White coat hypertension
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