- Title
- A multi-omics glimpse into the biology of arterial stiffness
- Creator
- Eales, James; Romaine, Simon; Charchar, Fadi; Tomaszewski, Maciej
- Date
- 2015
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/99302
- Identifier
- vital:10341
- Identifier
-
https://doi.org/10.1097/HJH.0000000000000783
- Identifier
- ISSN:0263-6352
- Abstract
- It has long been recognized that the structure of arteries throughout the vascular tree is not uniform. Notably, the media of large proximal (central) vessels contains relatively much greater amounts of elastin and elastic lamellae than smaller, more distal (peripheral) arteries; the converse is true of vascular smooth muscle cells. Under physiological conditions, the greater elasticity of central arteries compared with more muscular peripheral arteries allows conversion of the pulsatile nature of ventricular ejection into a relatively steady flow of blood at the distal end of the arterial system, conferring protection from pulsatile energy [1,2]. Furthermore, these differences in impedance can generate partial wave reflections, which arrive in the aorta during diastole, boosting diastolic blood pressure and augmenting coronary perfusion pressure [3].
- Publisher
- Lippincott Williams and Wilkins
- Relation
- Journal of Hypertension Vol. 34, no. 1 (2015), p. 32-35
- Rights
- Copyright Lippincott William and Wilkins
- Rights
- This metadata is freely available under a CCO license
- Subject
- Age; Arterial stiffness; Artery compliance; Elasticity; Genetic analysis; Genetic association; Genetic variability; Human; Hypertension; Pulse wave; 1103 Clinical Sciences; 1102 Cardiorespiratory Medicine and Haematology
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