- Title
- Development and evaluation of optimization based data mining techniques analysis of brain data
- Creator
- Zarei, Mahdi
- Date
- 2015
- Type
- Text; Thesis; PhD
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/97229
- Identifier
- vital:10188
- Abstract
- Neuroscience is an interdisciplinary science which deals with the study of structure and function of the brain and nervous system. Neuroscience encompasses disciplines such as computer science, mathematics, engineering, and linguistics. The structure of the healthy brain and representation of information by neural activity are among most challenging problems in neuroscience. Neuroscience is experiencing exponentially growing volumes of data obtained by using different technologies. The investigation of such data has tremendous impact on developing new and improving existing models of both healthy and diseased brains. Various techniques have been used for collecting brain data sets for addressing neuroscience problems. These data sets can be categorized into two main groups: resting-state and state-dependent data sets. Resting-state data is based on recording the brain activity when a subject does not think about any specific concept while state-dependent data is based on recording brain activity related to specific tasks. In general, brain data sets contain a large number of features (e.g. tens of thousands) and significantly fewer samples (e.g. several hundred). Such data sets are sparse and noisy. In addition to these problems, brain data sets have a few number of subjects. Brains are very complex systems and data about any brain activity reflects very complex relationship between neurons as well as different parts of the brain. Such relationships are highly nonlinear and general purpose data mining algorithms are not always efficient for their study. The development of machine learning techniques for brain data sets is an emerging research area in neuroscience. Over the last decade, various machine learning techniques have been developed for application to brain data sets. In the meantime, some well-known algorithms such as feature selection and supervised classification have been modified for analysis of brain data sets. Support vector machines, logistic regression, and Gaussian Naive Bayes classifiers are widely used for application to brain data sets. However, Support vector machines and logistic regression algorithms are not efficient for sparse and noisy data sets and Gaussian Naive Bayes classifiers do not give high accuracy. The aim of this study is to develop new and modify the existing data mining algorithms for the analysis brain data sets. Our contribution in this thesis can be listed as follow: 1. Development of new algorithms: 1.1. Development of new voxel (feature) selection algorithms for Functional magnetic resonance imaging (fMRI) data sets, and evaluation of these algorithms on the Haxby and Science 2008 data sets. 1.2. Development of new feature selection algorithm based on the catastrophe model for regression analysis problems. 2. Development and evaluation of different versions of the adaptive neuro-fuzzy model for the analysis of the spike-discharge as a function of other neuronal parameters. 3. Development and evaluation of the modified global k-means clustering algorithm for investigation of the structure of the healthy brain. 4. Development and evaluation of region of interest (ROI) method for analysis of brain functionalconnectivity in healthy subjects and schizophrenia patients.; Doctor of Philosophy
- Publisher
- Federation University Australia
- Rights
- Copyright Mahdi Zarei
- Rights
- Open Access
- Rights
- This metadata is freely available under a CCO license
- Subject
- Optimization based data mining techniques; Brain; Data analysis; Brain data sets
- Full Text
- Thesis Supervisor
- Dzalilov, Zari
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