- Title
- Directional reflectivity of the ellipsoid zone in dry age-related macular degeneration
- Creator
- Griffin, Shane; Jia, Yali; Johnson, Alicia; Antony, Bhavna; McDonald, H. Richard; Johnson, Robert; Lujan, Brandon
- Date
- 2021
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/197476
- Identifier
- vital:18876
- Identifier
-
https://doi.org/10.3928/23258160-20210302-05
- Identifier
- ISSN:2325-8160
- Abstract
- BACKGROUND AND OBJECTIVE: Ellipsoid zone (EZ) reflectivity on optical coherence tomography (OCT) is affected by the orientation of the scanning beam. The authors sought to determine how directional reflectivity changes in dry age-related macular degeneration (AMD). PATIENTS AND METHODS: Retrospective image analysis included 17 control and 20 dry AMD subjects. Directional OCT (D-OCT) was performed using multiple displaced pupil entrance positions. EZ pixel values and apparent incidence angles were measured. RESULTS: EZ reflectivity decreased in off-axis scans in controls ( P < .001), AMD areas between drusen ( P < .001), and AMD areas overlying drusen ( P < .001). The magnitude of decrement in EZ reflectivity was significantly higher when incidence angles exceeded 10° in controls than in AMD areas between drusen ( P = .024). CONCLUSION: EZ reflectivity in dry AMD may vary by incident angle of light less than in controls, possibly indicating alteration of photoreceptor orientation or integrity. [ Ophthalmic Surg Lasers Imaging Retina. 2021 52:145–152.]
- Publisher
- Slack Incorporated
- Relation
- Ophthalmic surgery, lasers & imaging retinq Vol. 52, no. 3 (2021), p. 145-152
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- Copyright Retina World Congress
- Subject
- Age; Age related diseases; Angle of reflection; Diabetic retinopathy; Eye diseases; Image analysis; Incidence angle; Macular degeneration; Optical Coherence Tomography; Photoreceptors; Reflectance; 3212 Ophthalmology and optometry
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