- Title
- The effects of transcranial direct current stimulation on corticospinal and cortico-cortical excitability and response variability : conventional versus high-definition montages
- Creator
- Pellegrini, Michael; Zoghi, Maryam; Jaberzadeh, Shapour
- Date
- 2021
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/194867
- Identifier
- vital:18435
- Identifier
-
https://doi.org/10.1016/j.neures.2020.06.002
- Identifier
- ISSN:0168-0102 (ISSN)
- Abstract
- Response variability following transcranial direct current stimulation (tDCS) highlights need for exploring different tDCS electrode montages. Corticospinal excitability (CSE), cortico-cortical excitability and intra-individual variability was compared following conventional and high-definition (HD) anodal (a-tDCS) and cathodal (c-tDCS) tDCS. Fifteen healthy males attended four sessions at-least one-week apart: conventional a-tDCS, conventional c-tDCS, HD-a-tDCS, HD-c-tDCS. TDCS was administered (1 mA, 10-minutes) over primary motor cortex (M1), via 6 × 4 cm active and 7 × 5 cm return electrodes (conventional tDCS) and 4 × 1 ring-electrodes 3.5 cm apart over M1 (HD-tDCS). For CSE, twenty-five single-pulse transcranial magnetic stimulation (TMS) peak-to-peak motor evoked potentials (MEP) were recorded at baseline, 0-minutes and 30-minutes post-tDCS. Twenty-five paired-pulse MEPs with 3-millisecond (ms) inter-pulse interval (IPI) and twenty-five at 10 ms assessed short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF). MEP standardised z-values standard deviations represented intra-individual variability. No significant changes in CSE from baseline were reported for all four interventions. No significant differences were reported in CSE between conventional and HD a-tDCS, but significant differences between conventional and HD c-tDCS 0-minutes post-tDCS. Conventional tDCS significantly reduced intra-individual variability compared to HD-tDCS for a-tDCS (0-minutes) and c-tDCS (30-minutes). No changes were reported for SICI/ICF. These novel findings of increased intra-individual variability following HD-tDCS, at the current stimulus parameters, highlight need for further nuanced research and refinement to optimise the HD-tDCS dosage-response relationship. © 2020 Elsevier B.V. and Japan Neuroscience Society
- Publisher
- Elsevier Ireland Ltd
- Relation
- Neuroscience Research Vol. 166, no. (2021), p. 12-25
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- Copyright © 2020 Elsevier B.V. and Japan Neuroscience Society
- Rights
- Open Access
- Subject
- 3101 Biochemistry and cell biology; 3209 Neurosciences; 5202 Biological psychology; Intra-individual variability; Intracortical facilitation; Short interval intracranial inhibition; Transcranial magnetic stimulation
- Full Text
- Reviewed
- Hits: 107
- Visitors: 173
- Downloads: 69
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Accepted version | 1 MB | Adobe Acrobat PDF | View Details Download |