- Title
- A coordination polymer for the site-specific integration of semiconducting sequences into DNA-based materials
- Creator
- Al-Mahamad, Lamia; El-Zubir, Osama; Smith, David; Horrocks, Benjamin; Houlton, Andrew
- Date
- 2017
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/187640
- Identifier
- vital:17100
- Identifier
-
https://doi.org/10.1038/s41467-017-00852-6
- Identifier
- ISSN:2041-1723
- Abstract
- Advances in bottom-up material design have been significantly progressed through DNA-based approaches. However, the routine integration of semiconducting properties, particularly long-range electrical conduction, into the basic topological motif of DNA remains challenging. Here, we demonstrate this with a coordination polymer derived from 6-thioguanosine (6-TG-H), a sulfur-containing analog of a natural nucleoside. The complexation reaction with Au(I) ions spontaneously assembles luminescent one-dimensional helical chains, characterized as {Au (μ-6-TG)} , extending many μm in length that are structurally analogous to natural DNA. Uniquely, for such a material, this gold-thiolate can be transformed into a wire-like conducting form by oxidative doping. We also show that this self-assembly reaction is compatible with a 6-TG-modified DNA duplex and provides a straightforward method by which to integrate semiconducting sequences, site-specifically, into the framework of DNA materials, transforming their properties in a fundamental and technologically useful manner.Integration of semiconducting properties into the basic topological motif of DNA remains challenging. Here, the authors show a coordination polymer derived from 6-thioguanosine that complexes with Au(I) ions to form a wire-like material that can also integrate semiconducting sequences into the framework of DNA materials.
- Publisher
- England: Nature Publishing Group
- Relation
- Nature Communications Vol. 8, no. 1 (2017), p. 720-27
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- Copyright nature
- Rights
- Open Access
- Subject
- Conduction; Coordination polymers; Deoxyribonucleic acid; DNA; Electric wire; Electrical conduction; Gene sequencing; Gene therapy; Gold; Guanosine - analogs & derivatives; Ions; Nanostructures; Nanowires; Nucleoside analogs; Nucleotide sequence; Polymers; Properties (attributes); Self assembly; Semiconductors; Sulfur; Thionucleosides; MD Multidisciplinary
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