- Title
- Effect of hydralazine on angiotensin II-induced abdominal aortic aneurysm in apolipoprotein e-deficient mice
- Creator
- Wang, Yutang; Sargisson, Owen; Nguyen, Dinh; Parker, Ketura; Pyke, Stephan; Alramahi, Ahmed; Thihlum, Liam; Fang, Yan; Wallace, Morgan; Berzins, Stuart; Oqueli, Ernesto; Magliano, Dianna; Golledge, Jonathan
- Date
- 2023
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/198930
- Identifier
- vital:19126
- Identifier
-
https://doi.org/10.3390/ijms242115955
- Identifier
- ISSN:1661-6596 (ISSN)
- Abstract
- The rupture of an abdominal aortic aneurysm (AAA) causes about 200,000 deaths worldwide each year. However, there are currently no effective drug therapies to prevent AAA formation or, when present, to decrease progression and rupture, highlighting an urgent need for more research in this field. Increased vascular inflammation and enhanced apoptosis of vascular smooth muscle cells (VSMCs) are implicated in AAA formation. Here, we investigated whether hydralazine, which has anti-inflammatory and anti-apoptotic properties, inhibited AAA formation and pathological hallmarks. In cultured VSMCs, hydralazine (100
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Relation
- International Journal of Molecular Sciences Vol. 24, no. 21 (2023), p.; https://purl.org/au-research/grants/nhmrc/1062671
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- https://creativecommons.org/licenses/by/4.0/
- Rights
- Copyright © 2023 by the authors
- Rights
- Open Access
- Subject
- 3101 Biochemistry and cell biology; 3107 Microbiology; 3404 Medicinal and biomolecular chemistry; Abdominal aortic aneurysm; Atherosclerosis; Hydralazine; Inflammation
- Full Text
- Reviewed
- Funder
- This research was funded by the National Health and Medical Research Council of Australia, grant number 1062671. Owen Sargisson was supported by a Fee-Offset Scholarship through Federation University Australia.
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