- Title
- A role for MAIT cells in colorectal cancer
- Creator
- Berzins, Stuart; Wallace, Morgan; Kannourakis, George; Kelly, Jason
- Date
- 2020
- Type
- Text; Journal article; Review
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/172892
- Identifier
- vital:14575
- Identifier
-
https://doi.org/10.3389/fimmu.2020.00949
- Identifier
- ISBN:1664-3224 (ISSN)
- Abstract
- MAIT cells are MR1-restricted T cells that are well-known for their anti-microbial properties, but they have recently been associated with different forms of cancer. Several studies have reported activated MAIT cells within the microenvironment of colorectal tumors, but there is conjecture about the nature of their response and whether they are contributing to anti-tumor immunity, or to the progression of the disease. We have reviewed the current state of knowledge about the role of MAIT cells in colorectal cancer, including their likely influence when activated and potential sources of stimulation in the tumor microenvironment. The prospects for MAIT cells being used in clinical settings as biomarkers or as targets of new immunotherapies designed to harness their function are discussed. © Copyright © 2020 Berzins, Wallace, Kannourakis and Kelly.
- Publisher
- Frontiers Media S.A.
- Relation
- Frontiers in Immunology Vol. 11, no. (2020), p.
- Rights
- https://creativecommons.org/licenses/by/4.0/
- Rights
- Copyright © 2020 Berzins, Wallace, Kannourakis and Kelly. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Rights
- Open Access
- Rights
- This metadata is freely available under a CCO license
- Subject
- 1107 Immunology; 1108 Medical Microbiology; Colorectal cancer; Human immunity; IL-13; MAIT cells; Tumor immunity
- Full Text
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