- Title
- High-intensity interval training is safe, feasible and efficacious in nonalcoholic steatohepatitis : a randomized controlled trial
- Creator
- Keating, Shelley; Croci, Ilaria; Wallen, Matthew; Cox, Emily; Thuzar, Moe; Pham, Uyen; Mielke, Gregore; Coombes, Jeff; Macdonald, Graeme; Hickman, Ingrid
- Date
- 2023
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/195845
- Identifier
- vital:18601
- Identifier
-
https://doi.org/10.1007/s10620-022-07779-z
- Identifier
- ISSN:0163-2116 (ISSN)
- Abstract
- Background: High-Intensity Interval Training (HIIT) involves bursts of high-intensity exercise interspersed with lower-intensity exercise recovery. HIIT may benefit cardiometabolic health in people with nonalcoholic steatohepatitis (NASH). Aims: We aimed to examine the safety, feasibility, and efficacy of 12-weeks of supervised HIIT compared with a sham-exercise control (CON) for improving aerobic fitness and peripheral insulin sensitivity in biopsy-proven NASH. Methods: Participants based in the community [(n = 14, 56 ± 10 years, BMI 39.2 ± 6.7 kg/m2, 64% male), NAFLD Activity Score 5 (range 3–7)] were randomized to 12-weeks of supervised HIIT (n = 8, 4 × 4 min at 85–95% maximal heart rate, interspersed with 3 min active recovery; 3 days/week) or CON (n = 6, stretching; 3 days/week). Safety (adverse events) and feasibility determined as
- Publisher
- Springer
- Relation
- Digestive Diseases and Sciences Vol. 68, no. 5 (2023), p. 2123-2139
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- http://creativecommons.org/licenses/by-nc/4.0/
- Rights
- Copyright @ 2022, The Author(s)
- Rights
- Open Access
- Subject
- 3202 Clinical sciences; Exercise; Insulin resistance; Lifestyle; Metabolic-associated fatty liver disease; NAFLD; Nonalcoholic fatty liver disease
- Full Text
- Reviewed
- Funder
- This research was supported by grants from the Diabetes Australia Research Program and Exercise and Sports Science Australia. SEK is supported by the National Health and Medical Research Council (NHMRC) of Australia via an Early Career Fellowship (1122190). The funding sources had no involvement in the study design or research processes.
- Hits: 1775
- Visitors: 1460
- Downloads: 36
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Published version | 1 MB | Adobe Acrobat PDF | View Details Download |