Crosstalk between immune checkpoint modulators, metabolic reprogramming and cellular plasticity in triple-negative breast cancer

- Poddar, Arpita, Rao, Sushma, Prithviraj, Prithviraj, Kannourakis, George, Jayachandran, Aparna

Title
Crosstalk between immune checkpoint modulators, metabolic reprogramming and cellular plasticity in triple-negative breast cancer
Creator
Poddar, Arpita; Rao, Sushma; Prithviraj, Prithviraj; Kannourakis, George; Jayachandran, Aparna
Date
2022
Type
Text; Journal article; Review
Identifier
http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/190969
Identifier
vital:17742
Identifier
https://doi.org/10.3390/curroncol29100540
Identifier
ISSN:1718-7729 (ISSN)
Abstract
Breast cancer is one of the major causes of mortality in women worldwide. Accounting for 15–20% of all breast cancer diagnoses, the triple-negative breast cancer (TNBC) subtype presents with an aggressive clinical course, heightened metastatic potential and the poorest short-term prognosis. TNBC does not respond to hormonal therapy, only partially responds to radio- and chemotherapy, and has limited targeted therapy options, thus underlining the critical need for better therapeutic treatments. Although immunotherapy based on immune checkpoint inhibition is emerging as a promising treatment option for TNBC patients, activation of cellular plasticity programs such as metabolic reprogramming (MR) and epithelial-to-mesenchymal transition (EMT) causes immunotherapy to fail. In this report, we review the role of MR and EMT in immune checkpoint dysregulation in TNBCs and specifically shed light on development of novel combination treatment modalities for this challenging disease. We highlight the clinical relevance of crosstalk between MR, EMT, and immune checkpoints in TNBCs. © 2022 by the authors.
Publisher
MDPI
Relation
Current Oncology Vol. 29, no. 10 (2022), p. 6847-6863
Rights
All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
Rights
https://creativecommons.org/licenses/by/4.0/
Rights
Copyright © 2022 by the authors
Rights
Open Access
Subject
3211 Oncology and carcinogenesis; Breast cancers; EMT; Immune checkpoints; MET; Metabolic reprogramming; PD-L1; TNBC
Full Text
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