- Title
- Parasitic infection surveillance in Mississippi delta children
- Creator
- Bradbury, Richard; Arguello, Irene; Lane, Meredith; Cooley, Gretchen; Handali, Sukwan
- Date
- 2020
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/174317
- Identifier
- vital:14803
- Identifier
-
https://doi.org/10.4269/ajtmh.20-0026
- Identifier
- ISBN:0002-9637 (ISSN)
- Abstract
- Some recent studies suggest ongoing transmission of parasitic diseases in the American South; however, surveys in Mississippi children are lacking. We enrolled 166 children (median age 8 years, range 4–13 years) from the Mississippi Delta region and carried out multi-parallel real-time polymerase chain reaction (PCR) for Necator americanus, Ascaris lumbricoides, and Strongyloides stercoralis on their stool samples. Dried blood spots were obtained for multiplex serology antibody detection. Of 166 children, all reported having flushable toilets, 11% had soil exposure, and 34% had a pet dog or cat. None had prior diagnosis or treatment of parasitic disease. Multi-parallel real-time PCRs were negative on the 89 stool DNA extracts available for testing. Dried blood spot testing of all 166 children determined the seroprevalence of IgG antibodies to Toxocara spp. (3.6%), Cryptosporidium (2.4%), S. stercoralis, Fasciola hepatica, and Giardia duodenalis (all 0%). In conclusion, parasitic infections and exposure were scarce in this population. Larger studies of at-risk populations are needed. © 2020 by The American Society of Tropical Medicine and Hygiene. ***Please note that there are multiple authors for this article therefore only the name of the first 5 including Federation University Australia affiliate “Richard Bradbury ” is provided in this record***; This work was funded by the Centers for Disease Control and Prevention (RSB), the Blakeslee Fund for Genetics Research at Smith College (N. P. and S. A. W.), and the University of Mississippi Medical Center (Office of the Vice Chancellor for Research, the University of Mississippi Medical Center). R. B. reports a patent WO2019060840 “Removing Interfering Host NucleicAcids for Molecular Parasite Detection” with royalties paid to Centers for Disease Control and Prevention. This trial was observational and is exempt from registration at clinicaltrials.gov Disclaimer: The findings and conclusions of this work are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention/the Agency for Toxic Substances and Disease Registry. This work was presented at the American Society of Tropical Medicine and Hygiene Conference: Poster 522, October 28–November 1, New Orleans, LA
- Publisher
- American Society of Tropical Medicine and Hygiene
- Relation
- American Journal of Tropical Medicine and Hygiene Vol. 103, no. 3 (2020), p. 1150-1153
- Rights
- Metadata is freely available under a CCO license
- Rights
- Copyright © 2020 by The American Society of Tropical Medicine and Hygiene
- Rights
- Open Access
- Full Text
- Reviewed
- Funder
- This work was funded by the Centers for Disease Control and Prevention (RSB), the Blakeslee Fund for Genetics Research at Smith College (N. P. and S. A. W.), and the University of Mississippi Medical Center (Office of the Vice Chancellor for Research, the University of Mississippi Medical Center). R. B. reports a patent WO2019060840 “Removing Interfering Host NucleicAcids for Molecular Parasite Detection” with royalties paid to Centers for Disease Control and Prevention. This trial was observational and is exempt from registration at clinicaltrials.gov Disclaimer: The findings and conclusions of this work are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention/the Agency for Toxic Substances and Disease Registry. This work was presented at the American Society of Tropical Medicine and Hygiene Conference: Poster 522, October 28–November 1, New Orleans, LA
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