- Title
- Patients with both langerhans cell histiocytosis and crohn’s disease highlight a common role of interleukin-23
- Creator
- Kvedaraite, Egle; Lourda, Magda; Han, Hong; Tesi, Biance; Mitchell, Jenée
- Date
- 2021
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/176147
- Identifier
- vital:15071
- Identifier
-
https://doi.org/10.1111/apa.15590
- Identifier
- ISBN:0803-5253 (ISSN)
- Abstract
- Aim: To present the first case series of patients with Langerhans cell histiocytosis (LCH) also affected by Crohn's disease (CD), both of which are granulomatous diseases, and in LCH investigate the role of interleukin (IL)-23, which is a well-described disease mediator in CD. Methods: A case series of three patients with LCH and CD were described; a cohort of LCH patients (n = 55) as well as controls (n = 55) were analysed for circulating IL-23 levels; and the relation between the percentage of LCH cells in lesions and circulating IL-23 levels was analysed in seven LCH patients. Results: Differential diagnostic challenges for these two granulomatous diseases were highlighted in the case series, and it took up to 3 years to diagnose CD. Elevated IL-23 levels were found in LCH patients. The amount of lesional LCH cells correlated with the levels of circulating IL-23. Conclusion: Both CD and LCH should be considered in patients with inflammatory gastrointestinal involvement. The IL-23 pathway is a common immunological trait between these two granulomatous diseases. ©2020 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica. ***Please note that there are multiple authors for this article therefore only the name of the first 5 including Federation University Australia affiliate “Jenée Mitchell” is provided in this record***
- Publisher
- Blackwell Publishing Ltd
- Relation
- Acta Paediatrica, International Journal of Paediatrics Vol. 110, no. 4 (2021), p. 1315-1321
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- Copyright ©2020 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
- Rights
- Open Access
- Subject
- 1114 Paediatrics and Reproductive Medicine; Crohn's disease; interleukin-23; Langerhans cell histiocytosis
- Full Text
- Reviewed
- Funder
- The study was supported by grants from the Swedish Children's Cancer Foundation (J‐IH, ML), the Stockholm County Council (ALF grant) (J‐IH), Dr Åke Olsson Foundation (ML), Robert Lundbergs Memorial Foundation (EK) and Mary Béves Foundation (EK). sens2017581
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