Occupational characteristics and disability-free survival after retirement age : an exploratory analysis from the ASPREE study
- Alif, Sheikh, Benke, Geza, Ronaldson, Kathlyn, Walker-Bone, Karen, Woods, Robyn, Tran, Cammie, Beilin, Lawrence, Tonkin, Andrew, Owen, Alice, McNeil, John
- Authors: Alif, Sheikh , Benke, Geza , Ronaldson, Kathlyn , Walker-Bone, Karen , Woods, Robyn , Tran, Cammie , Beilin, Lawrence , Tonkin, Andrew , Owen, Alice , McNeil, John
- Date: 2023
- Type: Text , Journal article
- Relation: Frontiers in Public Health Vol. 11, no. (2023), p.
- Full Text:
- Reviewed:
- Description: Background: Certain occupational characteristics have been linked with poor health and reduced longevity. However, the association between occupational characteristics and survival free of disability in a post-retirement age group has not been investigated. Methods: We investigated outcomes in 12,215 healthy older Australian adults in the Aspirin in Reducing Events in the Elderly (ASPREE) and ASPREE Longitudinal Study of Older Persons (ALSOP) sub-study. The ISCO-88 major occupational groups, settings, and activity levels were assigned based on free-text job descriptions. The Finnish Job Exposure Matrix was used to assign occupational characteristics to the three longest-held jobs. The primary endpoint, disability-free survival, was defined as a composite measure of death, dementia, or persistent physical disability. The endpoint of all-cause mortality was analyzed separately. Because of multiple exploratory analyses, only those associations with a two-sided value of p less than 0.005 were considered statistically significant. Cox proportional hazard models were used to calculate adjusted hazard ratios. Results: Having worked in an ‘elementary’ occupation was associated with a reduction in disability-free survival. A specific impact on disability-free survival was observed among those whose work had involved high accident risk and adverse social climate. No significant relationship was identified with those previously exposed to sedentary work, vigorous physical activity, work primarily outdoors, or a range of other occupational characteristics. All-cause mortality was not increased among any of the occupational groups. Conclusion: This exploratory study found a reduction in disability-free survival among people who worked in ‘elementary’ occupations, with specific risks associated with occupations involving high accident risks and adverse social climate. Copyright © 2023 Alif, Benke, Ronaldson, Walker-Bone, Woods, Tran, Beilin, Tonkin, Owen and McNeil.
- Authors: Alif, Sheikh , Benke, Geza , Ronaldson, Kathlyn , Walker-Bone, Karen , Woods, Robyn , Tran, Cammie , Beilin, Lawrence , Tonkin, Andrew , Owen, Alice , McNeil, John
- Date: 2023
- Type: Text , Journal article
- Relation: Frontiers in Public Health Vol. 11, no. (2023), p.
- Full Text:
- Reviewed:
- Description: Background: Certain occupational characteristics have been linked with poor health and reduced longevity. However, the association between occupational characteristics and survival free of disability in a post-retirement age group has not been investigated. Methods: We investigated outcomes in 12,215 healthy older Australian adults in the Aspirin in Reducing Events in the Elderly (ASPREE) and ASPREE Longitudinal Study of Older Persons (ALSOP) sub-study. The ISCO-88 major occupational groups, settings, and activity levels were assigned based on free-text job descriptions. The Finnish Job Exposure Matrix was used to assign occupational characteristics to the three longest-held jobs. The primary endpoint, disability-free survival, was defined as a composite measure of death, dementia, or persistent physical disability. The endpoint of all-cause mortality was analyzed separately. Because of multiple exploratory analyses, only those associations with a two-sided value of p less than 0.005 were considered statistically significant. Cox proportional hazard models were used to calculate adjusted hazard ratios. Results: Having worked in an ‘elementary’ occupation was associated with a reduction in disability-free survival. A specific impact on disability-free survival was observed among those whose work had involved high accident risk and adverse social climate. No significant relationship was identified with those previously exposed to sedentary work, vigorous physical activity, work primarily outdoors, or a range of other occupational characteristics. All-cause mortality was not increased among any of the occupational groups. Conclusion: This exploratory study found a reduction in disability-free survival among people who worked in ‘elementary’ occupations, with specific risks associated with occupations involving high accident risks and adverse social climate. Copyright © 2023 Alif, Benke, Ronaldson, Walker-Bone, Woods, Tran, Beilin, Tonkin, Owen and McNeil.
Long-term occupational exposures on disability-free survival and mortality in older adults
- Alif, Sheikh, Benke, Geza, Kromhout, Hans, Vermeulen, Roel, Tran, Cammie, Ronaldson, Kathlyn, Walker-Bone, Karen, Woods, Robyn, Beilin, Lawerence, Tonkin, Andrew, Owen, Alice, McNeil, John
- Authors: Alif, Sheikh , Benke, Geza , Kromhout, Hans , Vermeulen, Roel , Tran, Cammie , Ronaldson, Kathlyn , Walker-Bone, Karen , Woods, Robyn , Beilin, Lawerence , Tonkin, Andrew , Owen, Alice , McNeil, John
- Date: 2023
- Type: Text , Journal article
- Relation: Occupational Medicine Vol. 73, no. 8 (2023), p. 492-499
- Full Text:
- Reviewed:
- Description: Background The impact of long-term occupational exposures on health in older adults is increasingly relevant as populations age. To date, no studies have reported their impact on survival free of disability in older adults. Aims We aimed to investigate the association between long-term occupational exposure and disability-free survival (DFS), all-cause mortality and cause-specific mortality in initially healthy older adults. Methods We analysed data from 12 215 healthy participants in the ASPirin in Reducing Events in the Elderly (ASPREE) study whose mean age was 75 years. Their work history was collated with the ‘ALOHA-plus JEM’ (Job Exposure Matrix) to assign occupational exposures. The primary endpoint, DFS, was a composite measure of death, dementia or persistent physical disability. The secondary endpoint, mortality, was classified according to the underlying cause. Cox proportional hazard models were used to calculate hazard ratios and 95% confidence intervals, adjusted for confounders. Results A total of 1835 individuals reached the DFS endpoint during the median 4.7 years follow-up period. Both ever-high and cumulative exposure to all dusts and all pesticides during a person’s working years were associated with reduced DFS. Compared to no exposure, men with high exposure to dusts and pesticides had a reduced DFS. Neither of these exposures were significantly associated with all-cause mortality. Men with high occupational exposure to solvents and women exposed to dusts experienced higher all-cause and cancer-related mortality. Conclusions Long-term occupational exposure to all dusts and pesticides was associated with a reduced DFS and increased mortality in community-dwelling healthy older adults. © The Author(s) 2023. Published by Oxford University Press on behalf of the Society of Occupational Medicine.
- Authors: Alif, Sheikh , Benke, Geza , Kromhout, Hans , Vermeulen, Roel , Tran, Cammie , Ronaldson, Kathlyn , Walker-Bone, Karen , Woods, Robyn , Beilin, Lawerence , Tonkin, Andrew , Owen, Alice , McNeil, John
- Date: 2023
- Type: Text , Journal article
- Relation: Occupational Medicine Vol. 73, no. 8 (2023), p. 492-499
- Full Text:
- Reviewed:
- Description: Background The impact of long-term occupational exposures on health in older adults is increasingly relevant as populations age. To date, no studies have reported their impact on survival free of disability in older adults. Aims We aimed to investigate the association between long-term occupational exposure and disability-free survival (DFS), all-cause mortality and cause-specific mortality in initially healthy older adults. Methods We analysed data from 12 215 healthy participants in the ASPirin in Reducing Events in the Elderly (ASPREE) study whose mean age was 75 years. Their work history was collated with the ‘ALOHA-plus JEM’ (Job Exposure Matrix) to assign occupational exposures. The primary endpoint, DFS, was a composite measure of death, dementia or persistent physical disability. The secondary endpoint, mortality, was classified according to the underlying cause. Cox proportional hazard models were used to calculate hazard ratios and 95% confidence intervals, adjusted for confounders. Results A total of 1835 individuals reached the DFS endpoint during the median 4.7 years follow-up period. Both ever-high and cumulative exposure to all dusts and all pesticides during a person’s working years were associated with reduced DFS. Compared to no exposure, men with high exposure to dusts and pesticides had a reduced DFS. Neither of these exposures were significantly associated with all-cause mortality. Men with high occupational exposure to solvents and women exposed to dusts experienced higher all-cause and cancer-related mortality. Conclusions Long-term occupational exposure to all dusts and pesticides was associated with a reduced DFS and increased mortality in community-dwelling healthy older adults. © The Author(s) 2023. Published by Oxford University Press on behalf of the Society of Occupational Medicine.
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