Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c
- Zhou, Bin, Sheffer, Kate, Bennett, James, Gregg, Edward, Danaei, Goodarz, Singleton, Rosie, Shaw, Jonathan, Mishra, Anu, Lhoste, Victor, Carrillo-Larco, Rodrigo, Kengne, Andre, Phelps, Nowell, Heap, Rachel, Rayner, Archie, Stevens, Gretchen, Paciorek, Chris, Riley, Leanne, Cowan, Melanie, Savin, Stefan, Vander Hoorn, Stephen, Lu, Yuan, Pavkov, Meda, Imperatore, Giuseppina, Aguilar-Salinas, Carlos, Ahmad, Noor, Anjana, Ranjit, Davletov, Kairat, Farzadfar, Farshad, González-Villalpando, Clicerio, Charchar, Fadi
- Authors: Zhou, Bin , Sheffer, Kate , Bennett, James , Gregg, Edward , Danaei, Goodarz , Singleton, Rosie , Shaw, Jonathan , Mishra, Anu , Lhoste, Victor , Carrillo-Larco, Rodrigo , Kengne, Andre , Phelps, Nowell , Heap, Rachel , Rayner, Archie , Stevens, Gretchen , Paciorek, Chris , Riley, Leanne , Cowan, Melanie , Savin, Stefan , Vander Hoorn, Stephen , Lu, Yuan , Pavkov, Meda , Imperatore, Giuseppina , Aguilar-Salinas, Carlos , Ahmad, Noor , Anjana, Ranjit , Davletov, Kairat , Farzadfar, Farshad , González-Villalpando, Clicerio , Charchar, Fadi
- Date: 2023
- Type: Text , Journal article
- Relation: Nature Medicine Vol. 29, no. 11 (2023), p. 2885-2901
- Full Text:
- Reviewed:
- Description: Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are both used to diagnose diabetes, but these measurements can identify different people as having diabetes. We used data from 117 population-based studies and quantified, in different world regions, the prevalence of diagnosed diabetes, and whether those who were previously undiagnosed and detected as having diabetes in survey screening, had elevated FPG, HbA1c or both. We developed prediction equations for estimating the probability that a person without previously diagnosed diabetes, and at a specific level of FPG, had elevated HbA1c, and vice versa. The age-standardized proportion of diabetes that was previously undiagnosed and detected in survey screening ranged from 30% in the high-income western region to 66% in south Asia. Among those with screen-detected diabetes with either test, the age-standardized proportion who had elevated levels of both FPG and HbA1c was 29–39% across regions; the remainder had discordant elevation of FPG or HbA1c. In most low- and middle-income regions, isolated elevated HbA1c was more common than isolated elevated FPG. In these regions, the use of FPG alone may delay diabetes diagnosis and underestimate diabetes prevalence. Our prediction equations help allocate finite resources for measuring HbA1c to reduce the global shortfall in diabetes diagnosis and surveillance. © 2023, The Author(s). **Please note that there are multiple authors for this article therefore only the name of the first 30 including Federation University Australia affiliate “Fadi Charchar" is provided in this record**
- Authors: Zhou, Bin , Sheffer, Kate , Bennett, James , Gregg, Edward , Danaei, Goodarz , Singleton, Rosie , Shaw, Jonathan , Mishra, Anu , Lhoste, Victor , Carrillo-Larco, Rodrigo , Kengne, Andre , Phelps, Nowell , Heap, Rachel , Rayner, Archie , Stevens, Gretchen , Paciorek, Chris , Riley, Leanne , Cowan, Melanie , Savin, Stefan , Vander Hoorn, Stephen , Lu, Yuan , Pavkov, Meda , Imperatore, Giuseppina , Aguilar-Salinas, Carlos , Ahmad, Noor , Anjana, Ranjit , Davletov, Kairat , Farzadfar, Farshad , González-Villalpando, Clicerio , Charchar, Fadi
- Date: 2023
- Type: Text , Journal article
- Relation: Nature Medicine Vol. 29, no. 11 (2023), p. 2885-2901
- Full Text:
- Reviewed:
- Description: Fasting plasma glucose (FPG) and hemoglobin A1c (HbA1c) are both used to diagnose diabetes, but these measurements can identify different people as having diabetes. We used data from 117 population-based studies and quantified, in different world regions, the prevalence of diagnosed diabetes, and whether those who were previously undiagnosed and detected as having diabetes in survey screening, had elevated FPG, HbA1c or both. We developed prediction equations for estimating the probability that a person without previously diagnosed diabetes, and at a specific level of FPG, had elevated HbA1c, and vice versa. The age-standardized proportion of diabetes that was previously undiagnosed and detected in survey screening ranged from 30% in the high-income western region to 66% in south Asia. Among those with screen-detected diabetes with either test, the age-standardized proportion who had elevated levels of both FPG and HbA1c was 29–39% across regions; the remainder had discordant elevation of FPG or HbA1c. In most low- and middle-income regions, isolated elevated HbA1c was more common than isolated elevated FPG. In these regions, the use of FPG alone may delay diabetes diagnosis and underestimate diabetes prevalence. Our prediction equations help allocate finite resources for measuring HbA1c to reduce the global shortfall in diabetes diagnosis and surveillance. © 2023, The Author(s). **Please note that there are multiple authors for this article therefore only the name of the first 30 including Federation University Australia affiliate “Fadi Charchar" is provided in this record**
The lifestyle of our kids (LOOK) project : Outline of methods
- Telford, Richard, Bass, Shona, Budge, Marc, Byrne, Donald, Carlson, John, Coles, David, Cunningham, Ross, Daly, Robin, Dunstan, David, English, Rowena, Fitzgerald, Robert, Eser, Prisca, Gravenmaker, Karen, Haynes, Wayne, Hickman, Peter, Javaid, Ahmad, Jiang, Xiaoli, Lafferty, Tony, McGrath, Mark, Martin, Mary Kay, Naughton, Geraldine, Potter, Julia, Potter, Stacey, Prosser, Laurie, Pyne, David, Reynolds, Graham, Saunders, Philo, Seibel, Markus, Shaw, Jonathan, Southcott, Emma, Srikusalanukul, Wichat, Stuckey, Darryl, Telford, Rohan, Thomas, Kerry, Tallis, Ken, Waring, Paul
- Authors: Telford, Richard , Bass, Shona , Budge, Marc , Byrne, Donald , Carlson, John , Coles, David , Cunningham, Ross , Daly, Robin , Dunstan, David , English, Rowena , Fitzgerald, Robert , Eser, Prisca , Gravenmaker, Karen , Haynes, Wayne , Hickman, Peter , Javaid, Ahmad , Jiang, Xiaoli , Lafferty, Tony , McGrath, Mark , Martin, Mary Kay , Naughton, Geraldine , Potter, Julia , Potter, Stacey , Prosser, Laurie , Pyne, David , Reynolds, Graham , Saunders, Philo , Seibel, Markus , Shaw, Jonathan , Southcott, Emma , Srikusalanukul, Wichat , Stuckey, Darryl , Telford, Rohan , Thomas, Kerry , Tallis, Ken , Waring, Paul
- Date: 2009
- Type: Text , Journal article
- Relation: Journal of Science and Medicine in Sport Vol. 12, no. 1 (2009), p. 156-163
- Full Text:
- Description: This methods paper outlines the overall design of a community-based multidisciplinary longitudinal study with the intent to stimulate interest and communication from scientists and practitioners studying the role of physical activity in preventive medicine. In adults, lack of regular exercise is a major risk factor in the development of chronic degenerative diseases and is a major contributor to obesity, and now we have evidence that many of our children are not sufficiently active to prevent early symptoms of chronic disease. The lifestyle of our kids (LOOK) study investigates how early physical activity contributes to health and development, utilizing a longitudinal design and a cohort of eight hundred and thirty 7-8-year-old (grade 2) school children followed to age 11-12 years (grade 6), their average family income being very close to that of Australia. We will test two hypotheses, that (a) the quantity and quality of physical activity undertaken by primary school children will influence their psychological and physical health and development; (b) compared with existing practices in primary schools, a physical education program administered by visiting specialists will enhance health and development, and lead to a more positive perception of physical activity. To test the first hypothesis we will monitor all children longitudinally over the 4 years. To test the second we will involve an intervention group of 430 children who receive two 50 min physical education classes every week from visiting specialists and a control group of 400 who continue with their usual primary school physical education with their class-room teachers. At the end of grades 2, 4, and 6 we will measure several areas of health and development including blood risk factors for chronic disease, cardiovascular structure and function, physical fitness, psychological characteristics and perceptions of physical activity, bone structure and strength, motor control, body composition, nutritional intake, influence of teachers and family, and academic performance. © 2007 Sports Medicine Australia.
- Authors: Telford, Richard , Bass, Shona , Budge, Marc , Byrne, Donald , Carlson, John , Coles, David , Cunningham, Ross , Daly, Robin , Dunstan, David , English, Rowena , Fitzgerald, Robert , Eser, Prisca , Gravenmaker, Karen , Haynes, Wayne , Hickman, Peter , Javaid, Ahmad , Jiang, Xiaoli , Lafferty, Tony , McGrath, Mark , Martin, Mary Kay , Naughton, Geraldine , Potter, Julia , Potter, Stacey , Prosser, Laurie , Pyne, David , Reynolds, Graham , Saunders, Philo , Seibel, Markus , Shaw, Jonathan , Southcott, Emma , Srikusalanukul, Wichat , Stuckey, Darryl , Telford, Rohan , Thomas, Kerry , Tallis, Ken , Waring, Paul
- Date: 2009
- Type: Text , Journal article
- Relation: Journal of Science and Medicine in Sport Vol. 12, no. 1 (2009), p. 156-163
- Full Text:
- Description: This methods paper outlines the overall design of a community-based multidisciplinary longitudinal study with the intent to stimulate interest and communication from scientists and practitioners studying the role of physical activity in preventive medicine. In adults, lack of regular exercise is a major risk factor in the development of chronic degenerative diseases and is a major contributor to obesity, and now we have evidence that many of our children are not sufficiently active to prevent early symptoms of chronic disease. The lifestyle of our kids (LOOK) study investigates how early physical activity contributes to health and development, utilizing a longitudinal design and a cohort of eight hundred and thirty 7-8-year-old (grade 2) school children followed to age 11-12 years (grade 6), their average family income being very close to that of Australia. We will test two hypotheses, that (a) the quantity and quality of physical activity undertaken by primary school children will influence their psychological and physical health and development; (b) compared with existing practices in primary schools, a physical education program administered by visiting specialists will enhance health and development, and lead to a more positive perception of physical activity. To test the first hypothesis we will monitor all children longitudinally over the 4 years. To test the second we will involve an intervention group of 430 children who receive two 50 min physical education classes every week from visiting specialists and a control group of 400 who continue with their usual primary school physical education with their class-room teachers. At the end of grades 2, 4, and 6 we will measure several areas of health and development including blood risk factors for chronic disease, cardiovascular structure and function, physical fitness, psychological characteristics and perceptions of physical activity, bone structure and strength, motor control, body composition, nutritional intake, influence of teachers and family, and academic performance. © 2007 Sports Medicine Australia.
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