- Title
- Comparing the effects of multi-session anodal trans-cranial direct current stimulation of primary motor and dorsolateral prefrontal cortices on fatigue and quality of life in patients with multiple sclerosis: a double-blind, randomized, sham-controlled trial
- Creator
- Mortezanejad, Marzieh; Ehsani, Fatemeh; Masoudian, Nooshin; Zoghi, Maryam; Jaberzadeh, Shapour
- Date
- 2020
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/193063
- Identifier
- vital:18100
- Identifier
-
https://doi.org/10.1177/0269215520921506
- Identifier
- ISSN:0269-2155
- Abstract
- Objective: To compare the effects of anodal trans-cranial direct current stimulation (a-tDCS) over primary motor and dorsolateral prefrontal cortices on Fatigue Severity Scale and its lasting effect on fatigue reduction and improvement in quality of life in patients with multiple sclerosis. Design: A randomized, double-blinded, sham-controlled parallel clinical trial study. Setting: Neurological physiotherapy clinics. Subjects: Thirty-nine participants were randomly assigned to three groups: dorsolateral prefrontal cortex a-tDCS, primary motor a-tDCS (experimental groups) and sham a-tDCS. Finally, 36 participants completed the whole study (n = 12 in each group). Interventions: Participants in the experimental groups received six-session a-tDCS (1.5 mA, 20 minutes) during two weeks (three sessions per week). The sham group received six sessions of 20-minute sham stimulation. Main measures: The Fatigue Severity Scale and quality of life were assessed before, immediately and four weeks after the intervention. Results: Findings indicated a significant reduction in the Fatigue Severity Scale and a significant increase in the quality of life in both experimental groups, immediately after the intervention (P < 0.001), while Fatigue Severity Scale and quality of life changes were not significant in the sham a-tDCS group (P > 0.05). In addition, improvement of the variables remained four weeks after the intervention in dorsolateral prefrontal cortex a-tDCS (mean differences (95% confidence interval): 0.03 (−0.63 to 0.68) as compared to primary motor (−0.62 (−0.11 to −1.14) and sham a-tDCS groups (−0.47 (−1.37 to 0.43)). Conclusion: Both primary motor and dorsolateral prefrontal cortex a-tDCS as compared to sham intervention can immediately improve fatigue and quality of life. However, the effects last up to four weeks only by the dorsolateral prefrontal cortex a-tDCS.
- Publisher
- SAGE Publications
- Relation
- Clin Rehabilitation Vol. 34, no. 8 (2020), p. 1103-1111
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- © The Author(s) 2020
- Subject
- Adult; Clinical research; Clinical trials; Cortex; Double-Blind Method; Fatigue; Fatigue - etiology; Fatigue - prevention & control; Female; Humans; Intervention; Life changes; Male; Motor Cortex - physiopathology; Multiple sclerosis; Multiple Sclerosis - complications; Multiple Sclerosis - physiopathology; Multiple Sclerosis - rehabilitation; Physiotherapy; Prefrontal Cortex - physiopathology; Quality of Life; Severity; Stimulation; Transcranial Direct Current Stimulation - methods; 32 Biomedical and Clinical Sciences; 42 Health Sciences
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