- Title
- Pneumococcal carriage, serotype distribution, and antimicrobial susceptibility in Papua New Guinean children vaccinated with PCV10 or PCV13 in a head-to-head trial
- Creator
- Orami, Tilda; Aho, Celestine; Ford, Rebecca; Pomat, William; Greenhill, Andrew; Kirkham, Lea-Ann; Masiria, Geraldine; Nivio, Birunu; Britton, Kathryn; Jacoby, Peter; Richmond, Peter; van den Biggelaar, Anita; Lehmann, Deborah
- Date
- 2023
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/197171
- Identifier
- vital:18827
- Identifier
-
https://doi.org/10.1016/j.vaccine.2023.07.026
- Identifier
- ISSN:0264-410X (ISSN)
- Abstract
- Background: Children in Papua New Guinea (PNG) are at high risk of pneumococcal infections. We investigated pneumococcal carriage rates, serotype distribution, and antimicrobial susceptibility in PNG children after vaccination with 10-valent or 13-valent pneumococcal conjugate vaccines (PCV10; PCV13). Methods: Infants (N = 262) were randomized to receive 3 doses of PCV10 or PCV13 at 1-2-3 months of age, followed by pneumococcal polysaccharide vaccination (PPV) or no PPV at 9 months of age. Nasopharyngeal swabs (NPS) collected at ages 1, 4, 9, 10, 23 and 24 months were cultured using standard bacteriological procedures. Morphologically distinct Streptococcus pneumoniae colonies were serotyped by the Quellung reaction. Antimicrobial susceptibility was determined by Kirby-Bauer disc diffusion and minimum inhibitory concentration (MIC). Results: S. pneumoniae was isolated from 883/1063 NPS collected at 1–23 months of age, including 820 serotypeable (64 different serotypes) and 144 non-serotypeable isolates. At age 23 months, 93.6% (95%CI 86.6–97.6%) of PCV10 recipients and 88.6% (95%CI 80.1–94.4%) of PCV13 recipients were pneumococcal carriers, with higher carriage of PCV10 serotypes by PCV10 recipients (19.8%, 95%CI 12.2–29.5) than PCV13 recipients (9.3%, 95%CI 4.1–17.3) (p = 0.049). There were no other statistically significant differences between PCV10 and PCV13 recipients and children receiving PPV or no PPV. Nearly half (45.6%) of carried pneumococci were non-susceptible to penicillin based on the meningitis breakpoint (MIC
- Publisher
- Elsevier Ltd
- Relation
- Vaccine Vol. 41, no. 37 (2023), p. 5392-5399
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- http://creativecommons.org/licenses/by-nc/4.0/
- Rights
- Copyright © 2023 The Authors
- Rights
- Open Access
- Subject
- 32 Biomedical and clinical sciences; 42 Health sciences; Antimicrobial resistance; Carriage; Papua New Guinea; Pneumococcal conjugate vaccine; Pneumococcus
- Full Text
- Reviewed
- Funder
- This work was supported by the Australian National Health and Medical Research Council (grant numbers APP 1087200, APP 1061428 to LAK); the Papua New Guinea Institute of Medical Research Internal Competitive Research Award Scheme; the Papua New Guinea Liquefied Natural Gas Project (a joint venture of Exxon Mobil Corporation, Oil Search, Santos, Nippon Oil, Mineral Resource Development Company and Eda Oil).
- Hits: 1842
- Visitors: 1860
- Downloads: 22
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Published version | 976 KB | Adobe Acrobat PDF | View Details Download |