- Title
- Serum antinuclear autoantibodies are associated with measures of oxidative stress and lifestyle factors : analysis of LIPIDOGRAM2015 and LIPIDOGEN2015 studies
- Creator
- Krzemień, Pawel; Kasperczyk, S; Banach, Maciej; Kasperczyk, Aleksandra; Dobrakowski, Michal; Tomasik, Tomasz; Windak, Adam; Mastej, Miroslaw; Catapano, Alberico; Ray, Kausik; Mikhailidis, Dimitri; Toth, Peter; Howard, George; Lip, Gregory; Tomaszewski, Maciej; Charchar, Fadi; Sattar, Naveed; Williams, Bryan; MacDonald, Thomas; Penson, Peter; Jóźwiak, Jacek
- Date
- 2023
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/196575
- Identifier
- vital:18726
- Identifier
-
https://doi.org/10.5114/aoms/139313
- Identifier
- ISSN:1734-1922 (ISSN)
- Abstract
- Introduction: Oxidative stress is one of many factors suspected to promote antinuclear autoantibody (ANA) formation. Reactive oxygen species can induce changes in the antigenic structure of macromolecules, causing the immune system to treat them as “neo-antigens” and start production of autoantibodies. This study was designed to evaluate the relationship between oxidative stress markers, lifestyle factors and the detection of ANA. Material and methods: We examined measures of oxidative stress indices of free-radical damage to lipids and proteins, such as total oxidant status (TOS), concentration of protein thiol groups (PSH), and malondialdehyde (MDA), activity of superoxide dismutase (SOD) in 1731 serum samples. The parameters of the non-enzymatic antioxidant system, such as total antioxidant status (TAS) and uric acid (UA) concentration, were also measured and the oxidative stress index (OSI-index) was calculated. All samples were tested for the presence of ANA using an indirect immunofluorescence assay (IIFA). Results: The presence of ANA in women was associated with lower physical activity (p = 0.036), less frequent smoking (p = 0.007) and drinking of alcohol (p = 0.024) accompanied by significant changes in SOD isoenzymes activity (p < 0.001) and a higher uric acid (UA) concentration (p < 0.001). In ANA positive males we observed lower concentrations of PSH (p = 0.046) and increased concentrations of MDA (p = 0.047). Conclusions: The results indicate that local oxidative stress may be associated with increased probability of ANA formation in a sex-specific manner. © 2021 Termedia & Banach.
- Publisher
- Termedia Publishing House Ltd.
- Relation
- Archives of Medical Science Vol. 19, no. 5 (2023), p. 1214-1227
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- http://creativecommons.org/licenses/by-nc-sa/4.0/).
- Rights
- Copyright © 2021 Termedia & Banach
- Rights
- Open Access
- Subject
- 3202 Clinical sciences; Antinuclear autoantibody; Lifestyle diseases; Oxidative stress; Reactive oxygen species
- Full Text
- Reviewed
- Funder
- The present study was an initiative of the Polish Lipid Association (PoLA) and the College of Fami- ly Physicians in Poland (CFPiP). The present study was funded by an unrestricted educational grant from Valeant (Warsaw, Poland). Valeant had no role in study design, data analysis, data interpretation, or writing of the report. The present study was also supported by the Silesian Analytical Laboratories (SLA), CHDE, BIO-RAD and Euroimmun.
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