Are immigrants at risk of heart disease in Australia? A systematic review
- Dassanayake, Jayantha, Dharmage, Shyamali, Gurrin, Lyle, Sundararajan, Vijaya, Payne, Warren
- Authors: Dassanayake, Jayantha , Dharmage, Shyamali , Gurrin, Lyle , Sundararajan, Vijaya , Payne, Warren
- Date: 2009
- Type: Text , Journal article
- Relation: Australian Health Review Vol. 33, no. 3 (2009), p. 479-491
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- Description: We systematically reviewed the peer-reviewed literature to establish the prevalence of cardiovascular disease (CVD) among immigrants in Australia and whether being an immigrant is a CVD risk factor. Of 23 studies identified, 12 were included. Higher prevalence of CVD was found among Middle Eastern, South Asian and some European immigrants. Higher prevalence of CVD risk factors was found among Middle Eastern and Southern European immigrants. Higher alcohol consumption was found among immigrants from New Zealand, the United Kingdom and Ireland. Smoking and physical inactivity were highly prevalent among most immigrants.
Cardiovascular disease risk in immigrants : What is the evidence and where are the gaps?
- Dassanayake, Jayantha, Gurrin, Lyle, Payne, Warren, Sundararajan, Vijaya, Dharmage, Shyamali
- Authors: Dassanayake, Jayantha , Gurrin, Lyle , Payne, Warren , Sundararajan, Vijaya , Dharmage, Shyamali
- Date: 2011
- Type: Text , Journal article
- Relation: Asia-Pacific Journal of Public Health Vol. 23, no. 6 (2011), p. 882-895
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- Description: Objectives: This study systematically reviewed the peer-reviewed literature to establish morbidity and mortality from myocardial infarction (MI) and stroke among immigrant populations. Methods: The review considered only studies published between 1986 and 2008 that provided data on MI or stroke morbidity/mortality among first-generation immigrants. A prespecified search strategy identified 58 studies for possible inclusion. Of these, 12 met the inclusion criteria. Results: Immigrant MI mortality and morbidity varied by host country with no consistent pattern from one country or region. However, there was an overall trend for increasing risk of MI among immigrants worldwide. Chinese and African immigrants had consistently higher stroke mortality. Conclusion: MI and stroke incidence and prevalence among first-generation immigrants are related to both genetic and environmental factors, but the relative contribution of each is unclear. Prospective studies are needed to identify genetic and behavioral characteristics associated with stroke among Chinese immigrant populations. © 2011 Asia-Pacific Academic Consortium for Public Health.
Ever and cumulative occupational exposure and lung function decline in longitudinal population-based studies : a systematic review and meta-analysis
- Rabbani, Golam, Nimmi, Naima, Benke, Geza, Dharmage, Shyamali, Bui, Dinh, Sim, Malcolm, Abramson, Michael, Alif, Sheikh
- Authors: Rabbani, Golam , Nimmi, Naima , Benke, Geza , Dharmage, Shyamali , Bui, Dinh , Sim, Malcolm , Abramson, Michael , Alif, Sheikh
- Date: 2022
- Type: Text , Journal article , Review
- Relation: Occupational and Environmental Medicine Vol. 80, no. 1 (2022), p. 51-60
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- Description: Objectives Adverse occupational exposures can accelerate age-related lung function decline. Some longitudinal population-based studies have investigated this association. This study aims to examine this association using findings reported by longitudinal population-based studies. Methods Ovid Medline, PubMed, Embase, and Web of Science were searched using keywords and text words related to occupational exposures and lung function and 12 longitudinal population-based studies were identified using predefined inclusion criteria. The quality of the studies was assessed using the Newcastle-Ottawa Scale. Lung function decline was defined as annual loss of forced expiratory volume in 1 s (FEV 1), forced vital capacity (FVC) or the ratio (FEV 1 /FVC). Fixed and random-effects meta-analyses were conducted to calculate pooled estimates for ever and cumulative exposures. Heterogeneity was assessed using the I 2 test, and publication bias was evaluated using funnel plots. Results Ever exposures to gases/fumes, vapours, gases, dusts, fumes (VGDF) and aromatic solvents were significantly associated with FEV 1 decline in meta-analyses. Cumulative exposures for these three occupational agents observed a similar trend of FEV 1 decline. Ever exposures to fungicides and cumulative exposures to biological dust, fungicides and insecticides were associated with FEV 1 decline in fixed-effect models only. No statistically significant association was observed between mineral dust, herbicides and metals and FEV 1 decline in meta-analyses. Conclusion Pooled estimates from the longitudinal population-based studies have provided evidence that occupational exposures are associated with FEV 1 decline. Specific exposure control and respiratory health surveillance are required to protect the lung health of the workers. © 2023 Author(s). Published by BMJ.
- Authors: Rabbani, Golam , Nimmi, Naima , Benke, Geza , Dharmage, Shyamali , Bui, Dinh , Sim, Malcolm , Abramson, Michael , Alif, Sheikh
- Date: 2022
- Type: Text , Journal article , Review
- Relation: Occupational and Environmental Medicine Vol. 80, no. 1 (2022), p. 51-60
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- Description: Objectives Adverse occupational exposures can accelerate age-related lung function decline. Some longitudinal population-based studies have investigated this association. This study aims to examine this association using findings reported by longitudinal population-based studies. Methods Ovid Medline, PubMed, Embase, and Web of Science were searched using keywords and text words related to occupational exposures and lung function and 12 longitudinal population-based studies were identified using predefined inclusion criteria. The quality of the studies was assessed using the Newcastle-Ottawa Scale. Lung function decline was defined as annual loss of forced expiratory volume in 1 s (FEV 1), forced vital capacity (FVC) or the ratio (FEV 1 /FVC). Fixed and random-effects meta-analyses were conducted to calculate pooled estimates for ever and cumulative exposures. Heterogeneity was assessed using the I 2 test, and publication bias was evaluated using funnel plots. Results Ever exposures to gases/fumes, vapours, gases, dusts, fumes (VGDF) and aromatic solvents were significantly associated with FEV 1 decline in meta-analyses. Cumulative exposures for these three occupational agents observed a similar trend of FEV 1 decline. Ever exposures to fungicides and cumulative exposures to biological dust, fungicides and insecticides were associated with FEV 1 decline in fixed-effect models only. No statistically significant association was observed between mineral dust, herbicides and metals and FEV 1 decline in meta-analyses. Conclusion Pooled estimates from the longitudinal population-based studies have provided evidence that occupational exposures are associated with FEV 1 decline. Specific exposure control and respiratory health surveillance are required to protect the lung health of the workers. © 2023 Author(s). Published by BMJ.
Exploration of associations between occupational exposures and current adult eczema
- Lopez, Diego, Alif, Sheikh, Dharmage, Shyamali, Lodge, Caroline, Bui, Dinh, Le Moual, Nicole, Waidyatillake, Nilakshi, Su, John, Abramson, Michael, Walters, E., Hamilton, Garun, Bowatte, Gayan, Erbas, Bircan, Benke, Geza, Perret, Jennifer, Lowe, Adrian
- Authors: Lopez, Diego , Alif, Sheikh , Dharmage, Shyamali , Lodge, Caroline , Bui, Dinh , Le Moual, Nicole , Waidyatillake, Nilakshi , Su, John , Abramson, Michael , Walters, E. , Hamilton, Garun , Bowatte, Gayan , Erbas, Bircan , Benke, Geza , Perret, Jennifer , Lowe, Adrian
- Date: 2023
- Type: Text , Journal article
- Relation: Occupational and Environmental Medicine Vol. 80, no. 10 (2023), p. 564-571
- Full Text: false
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- Description: Objectives There is a scarcity of evidence on occupational exposures that may increase eczema in adults. We aimed to investigate potential associations between occupational exposures and eczema in middle-aged adults. Methods A lifetime work history calendar was collected from the Tasmanian Longitudinal Health Study participants when they were at age 53. Their work history was collated with the occupational asthma-specific job exposure matrix to define ever-exposure and cumulative exposure unit-years since no eczema job exposure matrix is available. Eczema was determined using the report of flexural rash that was coming and going for at least 6 months in the last 12 months. Skin prick tests were used to further subgroup eczema and atopic eczema (AE) or non-AE (NAE). Logistic and multinomial regression models were used to investigate the associations. Results Eczema prevalence was 9.1%. Current occupational exposure to animals (adjusted OR, aOR=3.06 (95% CI 1.43 to 6.58)), storage mites (aOR=2.96 (95% CI 1.38 to 6.34)) and endotoxin (aOR=1.95 (95% CI 1.04 to 3.64)) were associated with increased risk of current eczema. Furthermore, increased odds of NAE were associated with current exposure to animals (aOR=5.60 (95% CI 1.45 to 21.7)) and storage mites (aOR=5.63 (95% CI 1.45 to 21.9)). Current exposures to isocyanates (aOR=5.27 (95% CI 1.17 to 23.7)) and acrylates (aOR=8.41 (95% CI 1.60 to 44.3)) were associated with AE. There was no evidence of associations between cumulative exposures and eczema prevalence. Cumulative exposure to metalworking fluids (aOR=1.10 (95% CI 1.01 to 1.22)) was associated with NAE and acrylates (aOR=1.24 (95% CI 1.04 to 1.46)) with AE. Conclusions In this exploratory assessment, multiple occupational exposures were associated with current eczema in middle-aged adults. Raising awareness and limiting these exposures during an individual's productive working life will likely have various health benefits, including reducing eczema prevalence. © Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.
Is being an immigrant a risk factor for CVD in Australia?
- Dassanayake, Jayantha, Gurrin, Lyle, Payne, Warren, Sundararajan, Vijaya, Dharmage, Shyamali
- Authors: Dassanayake, Jayantha , Gurrin, Lyle , Payne, Warren , Sundararajan, Vijaya , Dharmage, Shyamali
- Date: 2008
- Type: Text , Conference paper
- Relation: Circulation Vol. 118, no. 12 (Sep 2008), p. E166-E166
- Full Text: false
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- Description: Objective: To investigate whether being an immigrant is increase risk for AMI and stroke. Design and setting: A retrospective analysis of Victorian hospital admissions in 1996/97 and 2001/02 was conducted. Participants: AMI and stroke were defined using primary cases of admission of ICD-9-CM:‘P410’,ICD-10-AM:‘121’,‘122’and stroke ICD-9-CM‘P433’,’P436’,ICD- 10-AM ‘163’,‘164’diagnostic codes. Main outcome measured: Rate ratio (RR) of AMI and stroke were calculated using 1996 and 2001 Australian census data. Results: Male immigrants from three ethnic groups: USSR/Baltic (RR 3.91 95%CI 3.22,4.71), Southern Asia (RR 1.56 95%CI 1.31,1.85) and Middle East (RR 1.34 95%CI 1.10,1.63), consistently displayed higher risk for AMI (both years) than the Australian born cohort; while Southeast Asians (RR 0.51 95%CI 0.42,0.62) and Northeast Asians (RR 0.35 95%CI 0.24,0.50) were at lower risk. The findings for females were less consistent. North East Asian male and female immigrants (RR 0.57 95% CI 0.41, 0.76, RR 0.56 95%CI 0.41, 0.74), were consistently at lower risk for stroke than Australian born counterparts. Female immigrants from the Pacific Islands were consistently at higher risk (RR 1.52 95%CI 1.25, 1.84, RR 1.22 95%CI 0.98, 1.51) of stroke than Australian born women. Conclusion: A number of Non-Australian born adult males currently residing in Victoria are identified at increased risk of AMI, whereas few groups are at decreased risk, compared to Australian born males. North East Asian males and females were consistently at a lower risk for AMI and stroke than their Australian-born counterparts. However, Asia male and female immigrants are generally at a lower risk of stroke.
- Description: C1
- Dassanayake, Jayantha, Gurrin, Lyle, Payne, Warren, Sundararajan, Vijaya, Dharmage, Shyamali
- Authors: Dassanayake, Jayantha , Gurrin, Lyle , Payne, Warren , Sundararajan, Vijaya , Dharmage, Shyamali
- Date: 2011
- Type: Text , Journal article
- Relation: Asia-Pacific Journal of Public Health Vol. 23, no. 3 (2011), p. 280-287
- Full Text: false
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- Description: International mortality studies show that some subgroups of migrants have a higher risk of Cardiovascular Disease (CVD) than the native-born. To investigate whether country of birth increases the risk for acute myocardial infarction (AMI) and cerebral infarction (stroke) hospitalization in Victoria, Australia. A retrospective analysis of Victorian AMI (ICD-10-AM codes I21 and I22) and stroke (ICD-10-AM I63 and I64) discharges from routinely collected hospital data in 2001-2002 was conducted. The outcome measures were directly age standardized rate ratios (RRs) of AMI and stroke hospitalization, calculated using 2001 Australian census data, with the Australian-born as the reference group. Males from 4 ethnic groups - USSR/Baltic; Southern Asia; Middle East; and Eastern Europe, displayed higher risk for AMI hospitalization than Australian-born men, whereas males and females from Southeast Asia and Northeast Asia were at lower risk. Furthermore, males from Western Europe and females from the Pacific were also at lower risk. Females from the Middle East, Southern Asia, and Southern Europe were at higher risk of stroke hospitalization than Australian-born women; in contrast, males from Eastern Europe, NorthAsia, Southern Asia, Southern Europe, and the United Kingdom and Ireland were at lower risk. Risk for AMI and stroke hospitalization varies by country of birth in comparison with the Australian-born population. It will be import to identify the factors associated with these varying risks in order to target preventive strategies aimed at reducing risk of AMI and stroke. © 2011 APJPH.
- Bonnelykke, Klaus, Matheson, Melanie, Pers, Tune, Granell, Raquel, Strachan, David, Couto Alves, Alexessander, Linneberg, Allan, Curtin, John, Warrington, Nicole, Standl, Marie, Kerkhof, Marjan, Jonsdottir, Ingileif, Bukvic, Blazenka, Kaakinen, Marika, Sleimann, Patrick, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Schramm, Katharina, Baltic, Svetlana, Kreiner-Moller, Eskil, Simpson, Angela, Pourcain, Beate, Coin, Lachlan, Hui, Jennie, Walters, Eugene, Tiesler, Carla, Duffy, David, Jones, Graham, Marks, Guy, Danoy, Patrick, Meszaros, Desiree, Hayden, Catherine, Henders, Anjali, Chapman, Brett, Kemp, Andrew, Cheah, Faang, Southey, Melissa, Roberts, Mary, Tovey, Euan, Giles, Graham, Chung, Li, Thomas, Paul, Feather, Ian, Temple, Suzanna, Beilby, John, Morrison, Stephen, Johns, David, Mitrpant, Chalermchai, Shelton, Brad, Jenkins, Mark, Britton, Warwick, Le Souef, Peter, Hopper, John, Leeder, Stephen, Musk, Bill, Martin, Nicholas, Brown, Matthew, Ring, Susan, McArdle, Wendy, Price, Loren, Robertson, Colin, Pekkanen, Juha, Tang, Clara, Thiering, Elisabeth, Montgomery, Grant, Hartikainen, Anna-Liisa, Dharmage, Shyamali, Husemoen, Lise, Herder, Christian, Kemp, John, Elliot, Paul, James, Alan, Waldenberger, Melanie, Abramson, Michael, Fairfax, Benjamin, Knight, Julian, Gupta, Ramneek, Thompson, Philip, Holt, Patrick, Sly, Peter, Hirschhorn, Joel, Blekic, Mario, Weidinger, Stephan, Hakonarsson, Hakon, Stefansson, Kari, Heinrich, Joachim, Postma, Dirkje, Custovic, Adnan, Pennell, Craig, Jarvelin, Marjo-Riitta, Koppelman, Gerard, Timpson, Nicholas, Ferreira, Manuel, Bisgaard, Hans, Henderson, A. John
- Authors: Bonnelykke, Klaus , Matheson, Melanie , Pers, Tune , Granell, Raquel , Strachan, David , Couto Alves, Alexessander , Linneberg, Allan , Curtin, John , Warrington, Nicole , Standl, Marie , Kerkhof, Marjan , Jonsdottir, Ingileif , Bukvic, Blazenka , Kaakinen, Marika , Sleimann, Patrick , Thorleifsson, Gudmar , Thorsteinsdottir, Unnur , Schramm, Katharina , Baltic, Svetlana , Kreiner-Moller, Eskil , Simpson, Angela , Pourcain, Beate , Coin, Lachlan , Hui, Jennie , Walters, Eugene , Tiesler, Carla , Duffy, David , Jones, Graham , Marks, Guy , Danoy, Patrick , Meszaros, Desiree , Hayden, Catherine , Henders, Anjali , Chapman, Brett , Kemp, Andrew , Cheah, Faang , Southey, Melissa , Roberts, Mary , Tovey, Euan , Giles, Graham , Chung, Li , Thomas, Paul , Feather, Ian , Temple, Suzanna , Beilby, John , Morrison, Stephen , Johns, David , Mitrpant, Chalermchai , Shelton, Brad , Jenkins, Mark , Britton, Warwick , Le Souef, Peter , Hopper, John , Leeder, Stephen , Musk, Bill , Martin, Nicholas , Brown, Matthew , Ring, Susan , McArdle, Wendy , Price, Loren , Robertson, Colin , Pekkanen, Juha , Tang, Clara , Thiering, Elisabeth , Montgomery, Grant , Hartikainen, Anna-Liisa , Dharmage, Shyamali , Husemoen, Lise , Herder, Christian , Kemp, John , Elliot, Paul , James, Alan , Waldenberger, Melanie , Abramson, Michael , Fairfax, Benjamin , Knight, Julian , Gupta, Ramneek , Thompson, Philip , Holt, Patrick , Sly, Peter , Hirschhorn, Joel , Blekic, Mario , Weidinger, Stephan , Hakonarsson, Hakon , Stefansson, Kari , Heinrich, Joachim , Postma, Dirkje , Custovic, Adnan , Pennell, Craig , Jarvelin, Marjo-Riitta , Koppelman, Gerard , Timpson, Nicholas , Ferreira, Manuel , Bisgaard, Hans , Henderson, A. John
- Date: 2013
- Type: Text , Journal article
- Relation: Nature Genetics Vol. 45, no. 8 (2013), p. 902-906
- Full Text: false
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- Description: Allergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top SNPs were associated with allergic symptoms in an independent study. Risk-associated variants at these ten loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease.
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