Ever and cumulative occupational exposure and lung function decline in longitudinal population-based studies : a systematic review and meta-analysis
- Rabbani, Golam, Nimmi, Naima, Benke, Geza, Dharmage, Shyamali, Bui, Dinh, Sim, Malcolm, Abramson, Michael, Alif, Sheikh
- Authors: Rabbani, Golam , Nimmi, Naima , Benke, Geza , Dharmage, Shyamali , Bui, Dinh , Sim, Malcolm , Abramson, Michael , Alif, Sheikh
- Date: 2022
- Type: Text , Journal article , Review
- Relation: Occupational and Environmental Medicine Vol. 80, no. 1 (2022), p. 51-60
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- Description: Objectives Adverse occupational exposures can accelerate age-related lung function decline. Some longitudinal population-based studies have investigated this association. This study aims to examine this association using findings reported by longitudinal population-based studies. Methods Ovid Medline, PubMed, Embase, and Web of Science were searched using keywords and text words related to occupational exposures and lung function and 12 longitudinal population-based studies were identified using predefined inclusion criteria. The quality of the studies was assessed using the Newcastle-Ottawa Scale. Lung function decline was defined as annual loss of forced expiratory volume in 1 s (FEV 1), forced vital capacity (FVC) or the ratio (FEV 1 /FVC). Fixed and random-effects meta-analyses were conducted to calculate pooled estimates for ever and cumulative exposures. Heterogeneity was assessed using the I 2 test, and publication bias was evaluated using funnel plots. Results Ever exposures to gases/fumes, vapours, gases, dusts, fumes (VGDF) and aromatic solvents were significantly associated with FEV 1 decline in meta-analyses. Cumulative exposures for these three occupational agents observed a similar trend of FEV 1 decline. Ever exposures to fungicides and cumulative exposures to biological dust, fungicides and insecticides were associated with FEV 1 decline in fixed-effect models only. No statistically significant association was observed between mineral dust, herbicides and metals and FEV 1 decline in meta-analyses. Conclusion Pooled estimates from the longitudinal population-based studies have provided evidence that occupational exposures are associated with FEV 1 decline. Specific exposure control and respiratory health surveillance are required to protect the lung health of the workers. © 2023 Author(s). Published by BMJ.
- Authors: Rabbani, Golam , Nimmi, Naima , Benke, Geza , Dharmage, Shyamali , Bui, Dinh , Sim, Malcolm , Abramson, Michael , Alif, Sheikh
- Date: 2022
- Type: Text , Journal article , Review
- Relation: Occupational and Environmental Medicine Vol. 80, no. 1 (2022), p. 51-60
- Full Text:
- Reviewed:
- Description: Objectives Adverse occupational exposures can accelerate age-related lung function decline. Some longitudinal population-based studies have investigated this association. This study aims to examine this association using findings reported by longitudinal population-based studies. Methods Ovid Medline, PubMed, Embase, and Web of Science were searched using keywords and text words related to occupational exposures and lung function and 12 longitudinal population-based studies were identified using predefined inclusion criteria. The quality of the studies was assessed using the Newcastle-Ottawa Scale. Lung function decline was defined as annual loss of forced expiratory volume in 1 s (FEV 1), forced vital capacity (FVC) or the ratio (FEV 1 /FVC). Fixed and random-effects meta-analyses were conducted to calculate pooled estimates for ever and cumulative exposures. Heterogeneity was assessed using the I 2 test, and publication bias was evaluated using funnel plots. Results Ever exposures to gases/fumes, vapours, gases, dusts, fumes (VGDF) and aromatic solvents were significantly associated with FEV 1 decline in meta-analyses. Cumulative exposures for these three occupational agents observed a similar trend of FEV 1 decline. Ever exposures to fungicides and cumulative exposures to biological dust, fungicides and insecticides were associated with FEV 1 decline in fixed-effect models only. No statistically significant association was observed between mineral dust, herbicides and metals and FEV 1 decline in meta-analyses. Conclusion Pooled estimates from the longitudinal population-based studies have provided evidence that occupational exposures are associated with FEV 1 decline. Specific exposure control and respiratory health surveillance are required to protect the lung health of the workers. © 2023 Author(s). Published by BMJ.
Exploration of associations between occupational exposures and current adult eczema
- Lopez, Diego, Alif, Sheikh, Dharmage, Shyamali, Lodge, Caroline, Bui, Dinh, Le Moual, Nicole, Waidyatillake, Nilakshi, Su, John, Abramson, Michael, Walters, E., Hamilton, Garun, Bowatte, Gayan, Erbas, Bircan, Benke, Geza, Perret, Jennifer, Lowe, Adrian
- Authors: Lopez, Diego , Alif, Sheikh , Dharmage, Shyamali , Lodge, Caroline , Bui, Dinh , Le Moual, Nicole , Waidyatillake, Nilakshi , Su, John , Abramson, Michael , Walters, E. , Hamilton, Garun , Bowatte, Gayan , Erbas, Bircan , Benke, Geza , Perret, Jennifer , Lowe, Adrian
- Date: 2023
- Type: Text , Journal article
- Relation: Occupational and Environmental Medicine Vol. 80, no. 10 (2023), p. 564-571
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- Description: Objectives There is a scarcity of evidence on occupational exposures that may increase eczema in adults. We aimed to investigate potential associations between occupational exposures and eczema in middle-aged adults. Methods A lifetime work history calendar was collected from the Tasmanian Longitudinal Health Study participants when they were at age 53. Their work history was collated with the occupational asthma-specific job exposure matrix to define ever-exposure and cumulative exposure unit-years since no eczema job exposure matrix is available. Eczema was determined using the report of flexural rash that was coming and going for at least 6 months in the last 12 months. Skin prick tests were used to further subgroup eczema and atopic eczema (AE) or non-AE (NAE). Logistic and multinomial regression models were used to investigate the associations. Results Eczema prevalence was 9.1%. Current occupational exposure to animals (adjusted OR, aOR=3.06 (95% CI 1.43 to 6.58)), storage mites (aOR=2.96 (95% CI 1.38 to 6.34)) and endotoxin (aOR=1.95 (95% CI 1.04 to 3.64)) were associated with increased risk of current eczema. Furthermore, increased odds of NAE were associated with current exposure to animals (aOR=5.60 (95% CI 1.45 to 21.7)) and storage mites (aOR=5.63 (95% CI 1.45 to 21.9)). Current exposures to isocyanates (aOR=5.27 (95% CI 1.17 to 23.7)) and acrylates (aOR=8.41 (95% CI 1.60 to 44.3)) were associated with AE. There was no evidence of associations between cumulative exposures and eczema prevalence. Cumulative exposure to metalworking fluids (aOR=1.10 (95% CI 1.01 to 1.22)) was associated with NAE and acrylates (aOR=1.24 (95% CI 1.04 to 1.46)) with AE. Conclusions In this exploratory assessment, multiple occupational exposures were associated with current eczema in middle-aged adults. Raising awareness and limiting these exposures during an individual's productive working life will likely have various health benefits, including reducing eczema prevalence. © Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.
- Bonnelykke, Klaus, Matheson, Melanie, Pers, Tune, Granell, Raquel, Strachan, David, Couto Alves, Alexessander, Linneberg, Allan, Curtin, John, Warrington, Nicole, Standl, Marie, Kerkhof, Marjan, Jonsdottir, Ingileif, Bukvic, Blazenka, Kaakinen, Marika, Sleimann, Patrick, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Schramm, Katharina, Baltic, Svetlana, Kreiner-Moller, Eskil, Simpson, Angela, Pourcain, Beate, Coin, Lachlan, Hui, Jennie, Walters, Eugene, Tiesler, Carla, Duffy, David, Jones, Graham, Marks, Guy, Danoy, Patrick, Meszaros, Desiree, Hayden, Catherine, Henders, Anjali, Chapman, Brett, Kemp, Andrew, Cheah, Faang, Southey, Melissa, Roberts, Mary, Tovey, Euan, Giles, Graham, Chung, Li, Thomas, Paul, Feather, Ian, Temple, Suzanna, Beilby, John, Morrison, Stephen, Johns, David, Mitrpant, Chalermchai, Shelton, Brad, Jenkins, Mark, Britton, Warwick, Le Souef, Peter, Hopper, John, Leeder, Stephen, Musk, Bill, Martin, Nicholas, Brown, Matthew, Ring, Susan, McArdle, Wendy, Price, Loren, Robertson, Colin, Pekkanen, Juha, Tang, Clara, Thiering, Elisabeth, Montgomery, Grant, Hartikainen, Anna-Liisa, Dharmage, Shyamali, Husemoen, Lise, Herder, Christian, Kemp, John, Elliot, Paul, James, Alan, Waldenberger, Melanie, Abramson, Michael, Fairfax, Benjamin, Knight, Julian, Gupta, Ramneek, Thompson, Philip, Holt, Patrick, Sly, Peter, Hirschhorn, Joel, Blekic, Mario, Weidinger, Stephan, Hakonarsson, Hakon, Stefansson, Kari, Heinrich, Joachim, Postma, Dirkje, Custovic, Adnan, Pennell, Craig, Jarvelin, Marjo-Riitta, Koppelman, Gerard, Timpson, Nicholas, Ferreira, Manuel, Bisgaard, Hans, Henderson, A. John
- Authors: Bonnelykke, Klaus , Matheson, Melanie , Pers, Tune , Granell, Raquel , Strachan, David , Couto Alves, Alexessander , Linneberg, Allan , Curtin, John , Warrington, Nicole , Standl, Marie , Kerkhof, Marjan , Jonsdottir, Ingileif , Bukvic, Blazenka , Kaakinen, Marika , Sleimann, Patrick , Thorleifsson, Gudmar , Thorsteinsdottir, Unnur , Schramm, Katharina , Baltic, Svetlana , Kreiner-Moller, Eskil , Simpson, Angela , Pourcain, Beate , Coin, Lachlan , Hui, Jennie , Walters, Eugene , Tiesler, Carla , Duffy, David , Jones, Graham , Marks, Guy , Danoy, Patrick , Meszaros, Desiree , Hayden, Catherine , Henders, Anjali , Chapman, Brett , Kemp, Andrew , Cheah, Faang , Southey, Melissa , Roberts, Mary , Tovey, Euan , Giles, Graham , Chung, Li , Thomas, Paul , Feather, Ian , Temple, Suzanna , Beilby, John , Morrison, Stephen , Johns, David , Mitrpant, Chalermchai , Shelton, Brad , Jenkins, Mark , Britton, Warwick , Le Souef, Peter , Hopper, John , Leeder, Stephen , Musk, Bill , Martin, Nicholas , Brown, Matthew , Ring, Susan , McArdle, Wendy , Price, Loren , Robertson, Colin , Pekkanen, Juha , Tang, Clara , Thiering, Elisabeth , Montgomery, Grant , Hartikainen, Anna-Liisa , Dharmage, Shyamali , Husemoen, Lise , Herder, Christian , Kemp, John , Elliot, Paul , James, Alan , Waldenberger, Melanie , Abramson, Michael , Fairfax, Benjamin , Knight, Julian , Gupta, Ramneek , Thompson, Philip , Holt, Patrick , Sly, Peter , Hirschhorn, Joel , Blekic, Mario , Weidinger, Stephan , Hakonarsson, Hakon , Stefansson, Kari , Heinrich, Joachim , Postma, Dirkje , Custovic, Adnan , Pennell, Craig , Jarvelin, Marjo-Riitta , Koppelman, Gerard , Timpson, Nicholas , Ferreira, Manuel , Bisgaard, Hans , Henderson, A. John
- Date: 2013
- Type: Text , Journal article
- Relation: Nature Genetics Vol. 45, no. 8 (2013), p. 902-906
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- Description: Allergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top SNPs were associated with allergic symptoms in an independent study. Risk-associated variants at these ten loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease.
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