Inflammation and Oral Contraceptive Use in Female Athletes Before the Rio Olympic Games
- Larsen, Brianna, Cox, Amanda, Colbey, Candice, Drew, Michael, McGuire, Helen, Fazekas de St Groth, Barbara, Hughes, David, Vlahovich, Nicole, Waddington, Gordon, Burke, Louise, Lundy, Bronwen, West, Nicholas, Minahan, Clare
- Authors: Larsen, Brianna , Cox, Amanda , Colbey, Candice , Drew, Michael , McGuire, Helen , Fazekas de St Groth, Barbara , Hughes, David , Vlahovich, Nicole , Waddington, Gordon , Burke, Louise , Lundy, Bronwen , West, Nicholas , Minahan, Clare
- Date: 2020
- Type: Text , Journal article
- Relation: Frontiers in Physiology Vol. 11, no. (2020), p.
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- Description: This study investigated the association between synthetic ovarian hormone use [i.e., the oral contraceptive (OC) pill] and basal C-reactive protein (CRP), peripheral blood immune cell subsets, and circulating pro- and anti-inflammatory cytokine concentrations in elite female athletes. Elite female athletes (n = 53) selected in Rio Summer Olympic squads participated in this study; 25 were taking an OC (AthletesOC) and 28 were naturally hormonally cycling (AthletesNC). Venous blood samples were collected at rest for the determination of sex hormones, cortisol, CRP, peripheral blood mononuclear memory and naïve CD4+ T-cells, CD8+ T-cells and natural killer cells, as well as pro- and anti-inflammatory cytokine concentrations. C-reactive protein concentrations were elevated (p < 0.001) in AthletesOC (median = 2.02, IQR = 3.15) compared to AthletesNC (median = 0.57, IQR = 1.07). No differences were reported for cortisol, cytokines, or PBMC immune cell subsets, although there was a trend (p = 0.062) for higher IL-6 concentrations in AthletesNC. Female Olympians had substantially higher CRP concentrations, a marker of inflammation and tissue damage, before the Rio Olympic Games if they used an OC. Future research should examine the potential consequences for athlete performance/recovery so that, if necessary, practitioners can implement prevention programs. © Copyright © 2020 Larsen, Cox, Colbey, Drew, McGuire, Fazekas de St Groth, Hughes, Vlahovich, Waddington, Burke, Lundy, West and Minahan.
- Authors: Larsen, Brianna , Cox, Amanda , Colbey, Candice , Drew, Michael , McGuire, Helen , Fazekas de St Groth, Barbara , Hughes, David , Vlahovich, Nicole , Waddington, Gordon , Burke, Louise , Lundy, Bronwen , West, Nicholas , Minahan, Clare
- Date: 2020
- Type: Text , Journal article
- Relation: Frontiers in Physiology Vol. 11, no. (2020), p.
- Full Text:
- Reviewed:
- Description: This study investigated the association between synthetic ovarian hormone use [i.e., the oral contraceptive (OC) pill] and basal C-reactive protein (CRP), peripheral blood immune cell subsets, and circulating pro- and anti-inflammatory cytokine concentrations in elite female athletes. Elite female athletes (n = 53) selected in Rio Summer Olympic squads participated in this study; 25 were taking an OC (AthletesOC) and 28 were naturally hormonally cycling (AthletesNC). Venous blood samples were collected at rest for the determination of sex hormones, cortisol, CRP, peripheral blood mononuclear memory and naïve CD4+ T-cells, CD8+ T-cells and natural killer cells, as well as pro- and anti-inflammatory cytokine concentrations. C-reactive protein concentrations were elevated (p < 0.001) in AthletesOC (median = 2.02, IQR = 3.15) compared to AthletesNC (median = 0.57, IQR = 1.07). No differences were reported for cortisol, cytokines, or PBMC immune cell subsets, although there was a trend (p = 0.062) for higher IL-6 concentrations in AthletesNC. Female Olympians had substantially higher CRP concentrations, a marker of inflammation and tissue damage, before the Rio Olympic Games if they used an OC. Future research should examine the potential consequences for athlete performance/recovery so that, if necessary, practitioners can implement prevention programs. © Copyright © 2020 Larsen, Cox, Colbey, Drew, McGuire, Fazekas de St Groth, Hughes, Vlahovich, Waddington, Burke, Lundy, West and Minahan.
Key viral immune genes and pathways identify elite athletes with URS
- Colbey, Candice, Drew, Michael, Cox, Amanda, Vider, Jelena, Pyne, David, Vlahonich, Nicole, Hughes, David, Waddington, Gordon, Appaneal, Renee, Burke, Louise, Lundy, Bronwen, Toomey, Mary, Watts, David, Lovell, Gregory, Praet, Stephan, Halson, Shona, Welvaert, Marijke, Zhang, Ping, Cripps, Aallan, West, Nicholas
- Authors: Colbey, Candice , Drew, Michael , Cox, Amanda , Vider, Jelena , Pyne, David , Vlahonich, Nicole , Hughes, David , Waddington, Gordon , Appaneal, Renee , Burke, Louise , Lundy, Bronwen , Toomey, Mary , Watts, David , Lovell, Gregory , Praet, Stephan , Halson, Shona , Welvaert, Marijke , Zhang, Ping , Cripps, Aallan , West, Nicholas
- Date: 2020
- Type: Text , Journal article
- Relation: Exercise immunology review Vol. 26, no. (2020), p. 56-78
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- Description: PURPOSE: Habitual intense exercise may increase the incidence of upper respiratory symptoms (URS) in elite athletes. This study investigated whether immune gene expression could identify gene markers that discriminate athletes with a higher prevalence of URS. METHODS: This cross-sectional analysis of elite Australian athletes from various sports investigated whether athletes retrospectively reporting URS for two days or more in a month (n=38), had an altered immune gene expression profile compared with asymptomatic athletes (n=33). Peripheral blood samples were collected during Olympic selection events with corresponding URS data collected for the one-month period before sampling. Digital immune gene expression analysis was undertaken using the NanoString PanCancer Immune Profiling panel. RESULTS: Fifty immune genes were differentially expressed between the groups (p<0.05) and approximately 78% of these genes were more highly expressed in athletes reporting URS. Many of these genes were interferon-stimulated genes or genes involved in the Jak/Stat signalling pathway. Only interferon alpha inducible protein 27 (IFI27), an interferon stimulated gene involved in viral response, remained significantly higher in athletes reporting URS (log2 fold-difference=2.49, odds ratio 1.02 per unit increase; p<0.01) post-adjustment and discriminated athletes reporting URS from asymptomatic athletes with 78% accuracy. CONCLUSIONS: Expression of IFI27 could differentiate athletes reporting URS from asymptomatic athletes, a gene that is upregulated in the immune response to viral infection. Upregulation of viral signalling pathways provides novel information on the potential aetiology of URS in elite Olympic athletes. Copyright © 2020 International Society of Exercise and Immunology. All rights reserved.
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