Does padded headgear prevent head injury in rugby union football?
- Authors: McIntosh, Andrew , McCrory, Paul , Finch, Caroline , Best, John , Chalmers, David , Wolfe, Rory
- Date: 2009
- Type: Text , Journal article
- Relation: Medicine and Science in Sports and Exercise Vol. 41, no. 2 (2009), p. 306-313
- Relation: http://purl.org/au-research/grants/nhmrc/565900
- Full Text: false
- Reviewed:
- Description: BACKGROUND: Concussion is a serious problem in many contact sports, including rugby union football. The study's primary aim was to measure the efficacy of padded headgear in reducing the rates of head injury or concussion. METHODS: A cluster randomized controlled trial with three arms was conducted with rugby union football teams as the unit of randomization. Teams consisted of males participating in under 13-, 15-, 18-, and 20-yr age group competitions. The interventions were "standard" and "modified" padded headgear. Headgear wearing and injury were measured for each study team at each game over two seasons. RESULTS: Eighty-two teams participated in year 1 and 87 in year 2. A total of 1493 participants (10,040 player hours) were in the control group, 1128 participants (8170 player hours) were assigned to the standard headgear group, and 1474 participants (10,650 player hours) were assigned to the modified headgear group. The compliance rates were low in all groups, but 46% of participants wore standard headgear. An intention-to-treat analysis showed no differences in the rates of head injury or concussion between controls and headgear arms. Incidence rate ratios for standard headgear wearers referenced to controls were 0.95 and 1.02 for game and missed game injuries. Analyses of injury rates based on observed wearing patterns also showed no significant differences. Incidence rate ratios for standard headgear wearers referenced to nonwearers were 1.11 and 1.10 for game and missed game injuries. CONCLUSIONS: Padded headgear does not reduce the rate of head injury or concussion. The low compliance rates are a limitation. Although individuals may choose to wear padded headgear, the routine or mandatory use of protective headgear cannot be recommended. © 2009 by the American College of Sports Medicine.
- Description: 2003008190
Protein structure prediction based on optimal hydrophobic core formation
- Authors: Nazmul, Rumana , Chetty, Madhu , Samudrala, Ram , Chalmers, David
- Date: 2012
- Type: Text , Conference paper
- Relation: 2012 IEEEE World Congress on Computational Intelligence Intelligence, Piscataway, NJ 10th-15th June 2012 p.1856-1864
- Full Text: false
- Reviewed:
- Description: The prediction of a minimum energy protein structure from its amino acid sequence represents an important and challenging problem in computational biology. In this paper, we propose a novel heuristic approach for protein structure prediction (PSP) based on the concept of optimal hydrophobic core formation. Using 2D HP model, a well-known set of substructures analogous to the secondary structures are obtained. Some sub-conformations are appropriately classified and then incorporated as prior knowledge. Unlike most of the popular PSP approaches which are stochastic in nature, the proposed method is deterministic. The effectiveness of the proposed algorithm is evaluated by well-known benchmark as well as non-benchmark sequences commonly used with 2D HP model. Maintaining similar accuracy as other core based and population based algorithms our method is significantly faster and reduces the computation time as it avoids blind search within the hydrophobic core (H-Core).