An emerging role for immune regulatory subsets in chronic lymphocytic leukaemia
- Wallace, Morgan, Alcantara, Marice, Minoda, Yosuke, Kannourakis, George, Berzins, Stuart
- Authors: Wallace, Morgan , Alcantara, Marice , Minoda, Yosuke , Kannourakis, George , Berzins, Stuart
- Date: 2015
- Type: Text , Journal article
- Relation: International Immunopharmacology Vol. 28, no. 2 (2015), p. 897-900
- Full Text: false
- Reviewed:
- Description: The last few years has seen the burgeoning of a new category of therapeutics for cancer targeting immune regulatory pathways. Antibodies that block the PD-1/PD-L1 interaction are perhaps the most prominent of these new anti-cancer therapies, but several other inhibitory receptor ligand interactions have also shown promise as targets in clinical trials, including CTLA-4/CD80 and Lag-3/MHC class II. Related to this is a rapidly improving knowledge of 'regulatory' lymphocyte lineages, including NKT cells, MATT cells, B regulatory cells and others. These cells have potent cytokine responses that can influence the functioning of other immune cells and many researchers believe that they could be effective targets for therapies designed to enhance immune responses to cancer. This review will outline our current understanding of FOXP3 + 'Tregs', NKT cells, MAIT cells and B regulatory cells immune regulatory cell populations in cancer, with a particular focus on chronic lymphocytic leukaemia (CLL). We will discuss evidence linking CLL with immune regulatory dysfunction and the potential for new therapies targeting regulatory cells. (C) 2015 Elsevier B.V. All rights reserved.
Partitioning of metals in a degraded acid sulfate soil landscape : Influence of tidal re-inundation
- Claff, Salirian, Sullivan, Leigh, Burton, Edward, Bush, Richard, Johnston, Scott
- Authors: Claff, Salirian , Sullivan, Leigh , Burton, Edward , Bush, Richard , Johnston, Scott
- Date: 2011
- Type: Text , Journal article
- Relation: Chemosphere Vol. 85, no. 8 (2011), p. 1220-1226
- Full Text: false
- Reviewed:
- Description: The oxidation and acidification of sulfidic soil materials results in the re-partitioning of metals, generally to more mobile forms. In this study, we examine the partitioning of Fe, Cr, Cu, Mn, Ni and Zn in the acidified surface soil (0-0.1. m) and the unoxidised sub-soil materials (1.3-1.5. m) of an acid sulfate soil landscape. Metal partitioning at this acidic site was then compared to an adjacent site that was previously acidified, but has since been remediated by tidal re-inundation. Differences in metal partitioning were determined using an optimised six-step sequential extraction procedure which targets the " labile" , " acid-soluble" , " organic" , " crystalline oxide" , " pyritic" and " residual" fractions. The surficial soil materials of the acidic site had experienced considerable losses of Cr, Cu, Mn and Ni compared to the underlying parent material due to oxidation and acidification, yet only minor losses of Fe and Zn. In general, the metals most depleted from the acidified surface soil materials exhibited the greatest sequestration in the surface soil materials of the tidally remediated site. An exception to this was iron, which accumulated to highly elevated concentrations in the surficial soil materials of the tidally remediated site. The " acid-soluble" , " organic" and " pyritic" fractions displayed the greatest increase in metals following tidal remediation. This study demonstrates that prolonged tidal re-inundation of severely acidified acid sulfate soil landscapes leads to the immobilisation of trace metals through the surficial accumulation of iron oxides, organic material and pyrite. © 2011 Elsevier Ltd.
- Marques, Francine, Prestes, Priscilla, Lewandowski, Paul, Harrap, Stephen, Charchar, Fadi
- Authors: Marques, Francine , Prestes, Priscilla , Lewandowski, Paul , Harrap, Stephen , Charchar, Fadi
- Date: 2015
- Type: Text , Conference paper
- Relation: Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research Australasian Section Annual Scientific Meeting; Melbourne, Victoria, Australia; 13th-16th August 2016; published in Heart, Lung and Circulation. Vol. 24, p. S401-S401
- Full Text: false
- Reviewed:
- Description: Objective: The molecular processes associated with cardiac hypertrophy independent of blood pressure are still largely unknown. The hypertrophic heart rate (HHR) is normotensive and born with a reduced complement of cardiomyocytes that predisposes to cardiac hypertrophy and failure in later life. We investigated the expression of c-kit gene, a marker of cardiac stem cells and myocardial regeneration that could contribute to hypertrophy. Methods: Left ventricular c-kit mRNA expression was measured by real-time PCR in HHR and control strain in neonatal and 38-week old rats (n=7-12/group). We tested for linkage of c-kit expression with neonatal cardiac size in 197 second generation crosses (F2) of HHR and control strain. Results: c-kit mRNA was slightly up-regulated in neonatal (fold change +1.3, P=0.02) and markedly so in 38-week old HHR (+35.5, P=0.0003). Cardiac weight index was positively correlated with neonatal myocardial c-kit mRNA in the F2 population (r=0.19, P=0.007). Conclusions: In HHR hearts c-kit expression appears increased throughout life, but more so in the adult where cardiac hypertrophy is established and leading to failure. In aged hypertrophic hearts, over-expression of c-kit is likely a compensatory mechanism of the failing heart. Previous studies showed an activation of cardiac stem cells in the hypertrophic myocardium. Our study suggests that c-kit might be involved from an early age in mechanisms that lead to cardiac hypertrophy in adulthood.
Potential role for mucosal IgA in modulating Haemonchus contortus adult worm infection in sheep
- Hernández, Julia, Hernández, Alvaro, Stear, Michael, Conde-Felipe, Magnolia, Rodríguez, Eduardo, Piedrafita, David, Gonzalez, Jorge
- Authors: Hernández, Julia , Hernández, Alvaro , Stear, Michael , Conde-Felipe, Magnolia , Rodríguez, Eduardo , Piedrafita, David , Gonzalez, Jorge
- Date: 2016
- Type: Text , Journal article
- Relation: Veterinary Parasitology Vol. 223, no. (2016), p. 153-158
- Full Text: false
- Reviewed:
- Description: Haemonchus contortus (H. contortus) is a haematophagous parasite which causes important economic losses in small ruminants. On the island of Gran Canaria, two sheep breeds coexist which differ in their susceptibility to the infection with H. contortus; the resistant Canaria Hair Breed (CHB) sheep and the susceptible Canaria Sheep (CS) breed. The major target of resistance mechanisms in CHB sheep are directed to the adult parasite stage, reducing the worm burden, and decreased length and fecundity of surviving worms. Mucosal IgA (mIgA) has been shown to be an important regulator of immunity in Haemonchus and Teladorsagia infections; through correlations with larval stages where such mechanisms as antibody-dependent cell cytotoxicity and enzyme inhibition may mediate resistance. Here for the first time, we demonstrate a significant negative correlation between mIgA and adult worm length and fecundity only in the resistant CHB sheep. In contrast, and as reported in other sheep breeds, mIgA was only negatively correlated against the larval stage in the more susceptible CS breed. This study suggests mIgA may play a role in resistance to both larval and adult stages. © 2016 Elsevier B.V.
A novel motion classification based intermode selection strategy for HEVC performance improvement
- Podder, Pallab, Paul, Manoranjan, Murshed, Manzur
- Authors: Podder, Pallab , Paul, Manoranjan , Murshed, Manzur
- Date: 2015
- Type: Text , Journal article
- Relation: Neurocomputing Vol. 173, no. Part 3 (2015), p. 1211-1220
- Relation: http://purl.org/au-research/grants/arc/DP130103670
- Full Text: false
- Reviewed:
- Description: High Efficiency Video Coding (HEVC) standard adopts several new approaches to achieve higher coding efficiency (approximately 50% bit-rate reduction) compared to its predecessor H.264/AVC with same perceptual image quality. Huge computational time has also increased due to the algorithmic complexity of HEVC compared to H.264/AVC. However, it is really a demanding task to reduce the encoding time while preserving the similar quality of the video sequences. In this paper, we propose a novel efficient intermode selection technique and incorporate into HEVC framework to predict motion estimation and motion compensation modes between current and reference blocks and perform faster inter mode selection based on three dissimilar motion types in divergent video sequences. Instead of exploring and traversing all the modes exhaustively, we merely select a subset of candidate modes and the final mode from the selected subset is determined based on their lowest Lagrangian cost function. The experimental results reveal that average encoding time can be downscaled by 40% with similar rate-distortion performance compared to the exhaustive mode selection strategy in HEVC.
- Description: High Efficiency Video Coding (HEVC) standard adopts several new approaches to achieve higher coding efficiency (approximately 50% bit-rate reduction) compared to its predecessor H.264/AVC with same perceptual image quality. Huge computational time has also increased due to the algorithmic complexity of HEVC compared to H.264/AVC. However, it is really a demanding task to reduce the encoding time while preserving the similar quality of the video sequences. In this paper, we propose a novel efficient intermode selection technique and incorporate into HEVC framework to predict motion estimation and motion compensation modes between current and reference blocks and perform faster inter mode selection based on three dissimilar motion types in divergent video sequences. Instead of exploring and traversing all the modes exhaustively, we merely select a subset of candidate modes and the final mode from the selected subset is determined based on their lowest Lagrangian cost function. The experimental results reveal that average encoding time can be downscaled by 40% with similar rate-distortion performance compared to the exhaustive mode selection strategy in HEVC. © 2015 Elsevier B.V.
Stability of schwertmannite and jarosite in an acidic landscape : Prolonged field incubation
- Vithana, Chamindra, Sullivan, Leigh, Burton, Edward, Bush, Richard
- Authors: Vithana, Chamindra , Sullivan, Leigh , Burton, Edward , Bush, Richard
- Date: 2015
- Type: Text , Journal article
- Relation: Geoderma Vol. 239, no. (2015), p. 47-57
- Full Text: false
- Reviewed:
- Description: Schwertmannite and jarosite are two of the main secondary iron(III) minerals commonly found in acidic, iron and sulfate-rich environments such as acid mine drainage and coastal acid sulfate soils (CASS). Both minerals exert major influence on the water and soil quality in these environments. While there are many studies conducted on the stability of these two minerals under controlled laboratory conditions, the behaviour of schwertmannite and jarosite under field conditions and the factors influencing their behaviour have not been investigated directly. In the present study, we examined the net transformation of introduced schwertmannite and jarosite samples incubated in a typical acidic CASS environment. Pure (synthetic) schwertmannite and jarosite samples were exposed to two main chemical regimes: 1) aerobic-acidic water column and 2) anaerobic-neutral sediment in a CASS environment. Changes in mineralogy, micromorphology, and composition of schwertmannite and jarosite samples were monitored over a period of 12months. Schwertmannite suspended in the water column and buried in sediments transformed to goethite by the end of 12months but more quickly in anoxic, reducing sediments. However, schwertmannite incubated in the acidic water column transformed at a much faster rate than those reported for acidic and aerobic conditions in the laboratory. Jarosite incubated in both the water column and sediments was also transformed to goethite but at a much slower rate than schwertmannite. Dissimilatory microbial reduction and Fe2+-catalysed transformation likely played a major role in accelerating the transformation of both minerals to goethite in sediments. The transformation of both minerals in the water column was sensitive to the hydrological conditions and fluctuations in the water column in relation to antecedent rainfall. In comparison, the sediment's geochemistry was relatively stable and consequently the rate of transformation and dissolution of both schwertmannite and jarosite in this environment was not appreciably affected by variable hydrology. © 2014 Elsevier B.V.
Ecological response to hydrological variability and catchment development : Insights from a shallow oxbow lake in Lower Mississippi Valley, Arkansas
- Bhattacharya, Ruchi, Hausmann, Sonja, Hubeny, J. Bradford, Gell, Peter, Black, Jessica
- Authors: Bhattacharya, Ruchi , Hausmann, Sonja , Hubeny, J. Bradford , Gell, Peter , Black, Jessica
- Date: 2016
- Type: Text , Journal article
- Relation: Science of the Total Environment Vol. 569-570, no. (2016), p. 1087-1097
- Full Text:
- Reviewed:
- Description: The ecological response of shallow oxbow lakes to variability in hydrology and catchment development in large river floodplain ecosystems (RFE) in Arkansas remains largely unknown. Investigating these responses will advance our understanding of ecological evolution of oxbow lakes in response to the major environmental drivers, which will establish baseline conditions required to develop effective management practices for RFE. In this pilot study, we examined the potential of using a dated surface sediment core from Adams Bayou, a floodplain lake located within the Cache-Lower White River Ramsar site in SE Arkansas. Stratigraphic records of diatoms and sediment geochemistry were used to ascertain variation in Adams Bayou's ecological condition. During 1968–2008, in response to hydrological and anthropogenic changes, Adams Bayou's diatom assemblages progressed from predominantly benthic (Gomphonema parvulum and Meridion circulare) to primarily planktonic assemblage (Aulacoseira granulata and Cyclotella meneghiniana), along with a decrease in magnetic susceptibility (k) and % silt. Statistical analyses reveled that during 1968–2000, higher hydrological connectivity and catchment alterations drove Adams Bayou's ecosystem. After 2000, lower hydrological connectivity and increase in cultivation were the major drivers. The potential impact of increasing air temperature was also noted. The shift in Adams Bayou from a connected, clear, mesotrophic state to a relatively isolated, turbid and nutrient enriched state is consistent with regime shift models and highlights its sensitivity to a combination of environmental stresses prevalent in the catchment. Although fluvial systems pose challenges in establishing clear chronologies, oxbow lake sediments can be a effective paleoecological archives. Our work provides clear evidence for the change in the ecological character of this wetland of international significance and flags the need for a wider assessment of water bodies across this site under obligations to the Ramsar Convention.
- Description: The ecological response of shallow oxbow lakes to variability in hydrology and catchment development in large river floodplain ecosystems (RFE) in Arkansas remains largely unknown. Investigating these responses will advance our understanding of ecological evolution of oxbow lakes in response to the major environmental drivers, which will establish baseline conditions required to develop effective management practices for RFE. In this pilot study, we examined the potential of using a dated surface sediment core from Adams Bayou, a floodplain lake located within the Cache-Lower White River Ramsar site in SE Arkansas. Stratigraphic records of diatoms and sediment geochemistry were used to ascertain variation in Adams Bayou's ecological condition. During 1968–2008, in response to hydrological and anthropogenic changes, Adams Bayou's diatom assemblages progressed from predominantly benthic (Gomphonema parvulum and Meridion circulare) to primarily planktonic assemblage (Aulacoseira granulata and Cyclotella meneghiniana), along with a decrease in magnetic susceptibility (k) and % silt. Statistical analyses reveled that during 1968–2000, higher hydrological connectivity and catchment alterations drove Adams Bayou's ecosystem. After 2000, lower hydrological connectivity and increase in cultivation were the major drivers. The potential impact of increasing air temperature was also noted. The shift in Adams Bayou from a connected, clear, mesotrophic state to a relatively isolated, turbid and nutrient enriched state is consistent with regime shift models and highlights its sensitivity to a combination of environmental stresses prevalent in the catchment. Although fluvial systems pose challenges in establishing clear chronologies, oxbow lake sediments can be a effective paleoecological archives. Our work provides clear evidence for the change in the ecological character of this wetland of international significance and flags the need for a wider assessment of water bodies across this site under obligations to the Ramsar Convention. © 2016 Elsevier B.V.
- Authors: Bhattacharya, Ruchi , Hausmann, Sonja , Hubeny, J. Bradford , Gell, Peter , Black, Jessica
- Date: 2016
- Type: Text , Journal article
- Relation: Science of the Total Environment Vol. 569-570, no. (2016), p. 1087-1097
- Full Text:
- Reviewed:
- Description: The ecological response of shallow oxbow lakes to variability in hydrology and catchment development in large river floodplain ecosystems (RFE) in Arkansas remains largely unknown. Investigating these responses will advance our understanding of ecological evolution of oxbow lakes in response to the major environmental drivers, which will establish baseline conditions required to develop effective management practices for RFE. In this pilot study, we examined the potential of using a dated surface sediment core from Adams Bayou, a floodplain lake located within the Cache-Lower White River Ramsar site in SE Arkansas. Stratigraphic records of diatoms and sediment geochemistry were used to ascertain variation in Adams Bayou's ecological condition. During 1968–2008, in response to hydrological and anthropogenic changes, Adams Bayou's diatom assemblages progressed from predominantly benthic (Gomphonema parvulum and Meridion circulare) to primarily planktonic assemblage (Aulacoseira granulata and Cyclotella meneghiniana), along with a decrease in magnetic susceptibility (k) and % silt. Statistical analyses reveled that during 1968–2000, higher hydrological connectivity and catchment alterations drove Adams Bayou's ecosystem. After 2000, lower hydrological connectivity and increase in cultivation were the major drivers. The potential impact of increasing air temperature was also noted. The shift in Adams Bayou from a connected, clear, mesotrophic state to a relatively isolated, turbid and nutrient enriched state is consistent with regime shift models and highlights its sensitivity to a combination of environmental stresses prevalent in the catchment. Although fluvial systems pose challenges in establishing clear chronologies, oxbow lake sediments can be a effective paleoecological archives. Our work provides clear evidence for the change in the ecological character of this wetland of international significance and flags the need for a wider assessment of water bodies across this site under obligations to the Ramsar Convention.
- Description: The ecological response of shallow oxbow lakes to variability in hydrology and catchment development in large river floodplain ecosystems (RFE) in Arkansas remains largely unknown. Investigating these responses will advance our understanding of ecological evolution of oxbow lakes in response to the major environmental drivers, which will establish baseline conditions required to develop effective management practices for RFE. In this pilot study, we examined the potential of using a dated surface sediment core from Adams Bayou, a floodplain lake located within the Cache-Lower White River Ramsar site in SE Arkansas. Stratigraphic records of diatoms and sediment geochemistry were used to ascertain variation in Adams Bayou's ecological condition. During 1968–2008, in response to hydrological and anthropogenic changes, Adams Bayou's diatom assemblages progressed from predominantly benthic (Gomphonema parvulum and Meridion circulare) to primarily planktonic assemblage (Aulacoseira granulata and Cyclotella meneghiniana), along with a decrease in magnetic susceptibility (k) and % silt. Statistical analyses reveled that during 1968–2000, higher hydrological connectivity and catchment alterations drove Adams Bayou's ecosystem. After 2000, lower hydrological connectivity and increase in cultivation were the major drivers. The potential impact of increasing air temperature was also noted. The shift in Adams Bayou from a connected, clear, mesotrophic state to a relatively isolated, turbid and nutrient enriched state is consistent with regime shift models and highlights its sensitivity to a combination of environmental stresses prevalent in the catchment. Although fluvial systems pose challenges in establishing clear chronologies, oxbow lake sediments can be a effective paleoecological archives. Our work provides clear evidence for the change in the ecological character of this wetland of international significance and flags the need for a wider assessment of water bodies across this site under obligations to the Ramsar Convention. © 2016 Elsevier B.V.
Autoantibodies to iron-binding proteins in pigs infested with Sarcoptes scabiei
- Toet, Hayley, Fischer, Katja, Mounsey, Kate, Sandeman, Mark
- Authors: Toet, Hayley , Fischer, Katja , Mounsey, Kate , Sandeman, Mark
- Date: 2014
- Type: Text , Journal article
- Relation: Veterinary Parasitology Vol. 205, no. 1-2 (2014), p. 263-270
- Full Text: false
- Reviewed:
- Description: Despite the availability of effective treatments, Sarcoptes scabiei remains a major health problem in the pig industry. Unsuccessful control of the disease is often due to the lack of reliable detection methods, with current tests relying on skin scrapings and crude antigen ELISAs. A previous analysis of antigens in pig skin scrapings reported that anti-transferrin antibodies were present in S. scabiei infected animals and that this finding might be considered as a useful diagnostic tool. This paper confirms IgG autoantibodies against transferrin, including the first report of IgM autoantibodies, in both naturally and experimentally infected pigs using ELISA and dot blot assays. Autoantibodies were also detected in pigs to ferritin and to a lesser extent lactoferrin. Immunoblotting confirmed the presence of IgG and IgM autoantibodies in mange positive pigs, as well as IgM antibodies to transferrin and albumin in mange negative pigs. These findings suggest the presence of natural autoantibodies to transferrin and albumin in pigs. The development of the IgG autoimmune response may either be a host mechanism for limiting iron to the mite via antibody mediated clearance, the result of host exposure to mite iron-binding homologues or because of a mite-induced antigenic change to host transferrin. Further investigation into the formation of these autoantibodies may provide insights into the importance of iron in scabies infections and the development and perseverance of S. scabiei infections in pigs. The specificity and sensitivity of the anti-transferrin response reinforces its potential in the diagnosis of scabies in pigs. © 2014 Elsevier B.V.
Women's access needs in maternity care in rural Tasmania, Australia : a mixed methods study
- Hoang, Ha, Le, Quynh, Terry, Daniel
- Authors: Hoang, Ha , Le, Quynh , Terry, Daniel
- Date: 2014
- Type: Text , Journal article
- Relation: Women and Birth Vol. 27, no. 1 (2014), p. 9-14
- Full Text:
- Reviewed:
- Description: Objectives: This study investigates (i) maternity care access issues in rural Tasmania, (ii) rural women's challenges in accessing maternity services and (iii) rural women's access needs in maternity services. Methods: A mixed-method approach using a survey and semi-structured interviews was conducted. The survey explored women's views of rural maternity services from antenatal to postnatal care, while interviews reinforced the survey results and provided insights into the access issues and needs of women in maternity care. Findings: The survey was completed by n=210 women, with a response rate of 35%, with n=22 follow-up interviews being conducted. The survey indicated the majority of rural women believed antenatal education and check-ups and postnatal check-ups should be provided locally. The majority of women surveyed also believed in the importance of having a maternity unit in the local hospital, which was further iterated and clarified within the interviews. Three main themes emerged from the interview data, namely (i) lack of access to maternity services, (ii) difficulties in accessing maternity services, and (iii) rural women's access needs. Conclusion: The study suggested that women's access needs are not fully met in some rural areas of Tasmania. Rural women face many challenges when accessing maternity services, including financial burden and risk of labouring en route. The study supports the claim that the closure of rural maternity units shifts cost and risk from the health care system to rural women and their families. © 2013 Australian College of Midwives.
- Authors: Hoang, Ha , Le, Quynh , Terry, Daniel
- Date: 2014
- Type: Text , Journal article
- Relation: Women and Birth Vol. 27, no. 1 (2014), p. 9-14
- Full Text:
- Reviewed:
- Description: Objectives: This study investigates (i) maternity care access issues in rural Tasmania, (ii) rural women's challenges in accessing maternity services and (iii) rural women's access needs in maternity services. Methods: A mixed-method approach using a survey and semi-structured interviews was conducted. The survey explored women's views of rural maternity services from antenatal to postnatal care, while interviews reinforced the survey results and provided insights into the access issues and needs of women in maternity care. Findings: The survey was completed by n=210 women, with a response rate of 35%, with n=22 follow-up interviews being conducted. The survey indicated the majority of rural women believed antenatal education and check-ups and postnatal check-ups should be provided locally. The majority of women surveyed also believed in the importance of having a maternity unit in the local hospital, which was further iterated and clarified within the interviews. Three main themes emerged from the interview data, namely (i) lack of access to maternity services, (ii) difficulties in accessing maternity services, and (iii) rural women's access needs. Conclusion: The study suggested that women's access needs are not fully met in some rural areas of Tasmania. Rural women face many challenges when accessing maternity services, including financial burden and risk of labouring en route. The study supports the claim that the closure of rural maternity units shifts cost and risk from the health care system to rural women and their families. © 2013 Australian College of Midwives.
SmartEdge : An end-to-end encryption framework for an edge-enabled smart city application
- Jan, Mian, Zhang, Wenjing, Usman, Muhammad, Tan, Zhiyuan, Khan, Fazlullah, Luo, Entao
- Authors: Jan, Mian , Zhang, Wenjing , Usman, Muhammad , Tan, Zhiyuan , Khan, Fazlullah , Luo, Entao
- Date: 2019
- Type: Text , Journal article
- Relation: Journal of Network and Computer Applications Vol. 137, no. (2019), p. 1-10
- Full Text:
- Reviewed:
- Description: The Internet of Things (IoT) has the potential to transform communities around the globe into smart cities. The massive deployment of sensor-embedded devices in the smart cities generates voluminous amounts of data that need to be stored and processed in an efficient manner. Long-haul data transmission to the remote cloud data centers leads to higher delay and bandwidth consumption. In smart cities, the delay-sensitive applications have stringent requirements in term of response time. To reduce latency and bandwidth consumption, edge computing plays a pivotal role. The resource-constrained smart devices at the network core need to offload computationally complex tasks to the edge devices located in their vicinity and have relatively higher resources. In this paper, we propose an end-to-end encryption framework, SmartEdge, for a smart city application by executing computationally complex tasks at the network edge and cloud data centers. Using a lightweight symmetric encryption technique, we establish a secure connection among the smart core devices for multimedia streaming towards the registered and verified edge devices. Upon receiving the data, the edge devices encrypts the multimedia streams, encodes them, and broadcast to the cloud data centers. Prior to the broadcasting, each edge device establishes a secured connection with a data center that relies on the combination of symmetric and asymmetric encryption techniques. In SmartEdge, the execution of a lightweight encryption technique at the resource-constrained smart devices, and relatively complex encryption techniques at the network edge and cloud data centers reduce the resource utilization of the entire network. The proposed framework reduces the response time, security overhead, computational and communication costs, and has a lower end-to-end encryption delay for participating entities. Moreover, the proposed scheme is highly resilient against various adversarial attacks.
- Authors: Jan, Mian , Zhang, Wenjing , Usman, Muhammad , Tan, Zhiyuan , Khan, Fazlullah , Luo, Entao
- Date: 2019
- Type: Text , Journal article
- Relation: Journal of Network and Computer Applications Vol. 137, no. (2019), p. 1-10
- Full Text:
- Reviewed:
- Description: The Internet of Things (IoT) has the potential to transform communities around the globe into smart cities. The massive deployment of sensor-embedded devices in the smart cities generates voluminous amounts of data that need to be stored and processed in an efficient manner. Long-haul data transmission to the remote cloud data centers leads to higher delay and bandwidth consumption. In smart cities, the delay-sensitive applications have stringent requirements in term of response time. To reduce latency and bandwidth consumption, edge computing plays a pivotal role. The resource-constrained smart devices at the network core need to offload computationally complex tasks to the edge devices located in their vicinity and have relatively higher resources. In this paper, we propose an end-to-end encryption framework, SmartEdge, for a smart city application by executing computationally complex tasks at the network edge and cloud data centers. Using a lightweight symmetric encryption technique, we establish a secure connection among the smart core devices for multimedia streaming towards the registered and verified edge devices. Upon receiving the data, the edge devices encrypts the multimedia streams, encodes them, and broadcast to the cloud data centers. Prior to the broadcasting, each edge device establishes a secured connection with a data center that relies on the combination of symmetric and asymmetric encryption techniques. In SmartEdge, the execution of a lightweight encryption technique at the resource-constrained smart devices, and relatively complex encryption techniques at the network edge and cloud data centers reduce the resource utilization of the entire network. The proposed framework reduces the response time, security overhead, computational and communication costs, and has a lower end-to-end encryption delay for participating entities. Moreover, the proposed scheme is highly resilient against various adversarial attacks.
Blockchain leveraged decentralized IoT eHealth framework
- Uddin, Ashraf, Stranieri, Andrew, Gondal, Iqbal, Balasubramanian, Venki
- Authors: Uddin, Ashraf , Stranieri, Andrew , Gondal, Iqbal , Balasubramanian, Venki
- Date: 2020
- Type: Text , Journal article
- Relation: Internet of Things Vol. 9, no. March 2020 p. 100159
- Full Text:
- Reviewed:
- Description: Blockchain technologies recently emerging for eHealth, can facilitate a secure, decentral- ized and patient-driven, record management system. However, Blockchain technologies cannot accommodate the storage of data generated from IoT devices in remote patient management (RPM) settings as this application requires a fast consensus mechanism, care- ful management of keys and enhanced protocols for privacy. In this paper, we propose a Blockchain leveraged decentralized eHealth architecture which comprises three layers: (1) The Sensing layer –Body Area Sensor Networks include medical sensors typically on or in a patient body transmitting data to a smartphone. (2) The NEAR processing layer –Edge Networks consist of devices at one hop from data sensing IoT devices. (3) The FAR pro- cessing layer –Core Networks comprise Cloud or other high computing servers). A Patient Agent (PA) software replicated on the three layers processes medical data to ensure reli- able, secure and private communication. The PA executes a lightweight Blockchain consen- sus mechanism and utilizes a Blockchain leveraged task-offloading algorithm to ensure pa- tient’s privacy while outsourcing tasks. Performance analysis of the decentralized eHealth architecture has been conducted to demonstrate the feasibility of the system in the pro- cessing and storage of RPM data.
- Authors: Uddin, Ashraf , Stranieri, Andrew , Gondal, Iqbal , Balasubramanian, Venki
- Date: 2020
- Type: Text , Journal article
- Relation: Internet of Things Vol. 9, no. March 2020 p. 100159
- Full Text:
- Reviewed:
- Description: Blockchain technologies recently emerging for eHealth, can facilitate a secure, decentral- ized and patient-driven, record management system. However, Blockchain technologies cannot accommodate the storage of data generated from IoT devices in remote patient management (RPM) settings as this application requires a fast consensus mechanism, care- ful management of keys and enhanced protocols for privacy. In this paper, we propose a Blockchain leveraged decentralized eHealth architecture which comprises three layers: (1) The Sensing layer –Body Area Sensor Networks include medical sensors typically on or in a patient body transmitting data to a smartphone. (2) The NEAR processing layer –Edge Networks consist of devices at one hop from data sensing IoT devices. (3) The FAR pro- cessing layer –Core Networks comprise Cloud or other high computing servers). A Patient Agent (PA) software replicated on the three layers processes medical data to ensure reli- able, secure and private communication. The PA executes a lightweight Blockchain consen- sus mechanism and utilizes a Blockchain leveraged task-offloading algorithm to ensure pa- tient’s privacy while outsourcing tasks. Performance analysis of the decentralized eHealth architecture has been conducted to demonstrate the feasibility of the system in the pro- cessing and storage of RPM data.
Monitoring core body temperature in infantry soldiers and airfield defence guards
- Ham, Daniel, Lee, C., Payne, Warren, Harvey, Jack
- Authors: Ham, Daniel , Lee, C. , Payne, Warren , Harvey, Jack
- Date: 2005
- Type: Text , Conference paper
- Relation: Journal of Science and Medicine in Sport Vol. 8, no. 4 Supplement (2005), p. 58
- Full Text: false
- Reviewed:
- Description: During strenuous and/or extended exercise in hot environments, considerable body heat can be produced. If the heat produced is above the body's thermoregulatory capacities, or if these capacities are impeded, a rise in core body temperature (Tc) will occur. Infantry soldiers and Airfield Defence Guards within the Australian Defence Force (ADF) are often based in areas which expose them to high levels of thermal stress. Furthermore, they must perform physically demanding training and operations, often in full camouflage, and on occasions with a range of equipment including body armour, which further increases the risk of developing a heat illness during training tasks. The ADF is addressing this issue as part of the Defence Physical Employment Standards (DPES) project, which aims at developing new employment standards using tests that reflect job requirements, and in which soldiers and airmen will be required to complete a number of strenuous and/or extended physical tasks. Two high risk tasks involve marching for either 10 or 20 km at an average velocity of 6km/hr, wearing full camouflage and carrying a 45kg pack. A third high risk task, which simulates movement in urban terrain, is shorter in duration but higher in intensity, and involves wearing ballistic vest, helmet, and webbing. In order to enhance safety by decreasing the risk of heat injury associated with completing these three tasks, Tc is being monitored using telemetric pills. A subject who reaches a Tc of 39.5oC will be withdrawn from the task. Preliminary testing in reasonably mild environmental conditions (15-20oC WBGTO), resulted in steady increases in Tc throughout each task, though no subject's core temperature reached 39.5 in any of the tasks.
- Description: 2003005936
- Payne, Warren, Knez, Wade, Harvey, Jack, Sinclair, Wade, Elias, G., Ham, Daniel
- Authors: Payne, Warren , Knez, Wade , Harvey, Jack , Sinclair, Wade , Elias, G. , Ham, Daniel
- Date: 2005
- Type: Text , Conference paper
- Relation: Journal of Science and Medicine in Sport Vol. 8, no. 4 Supplement (2005), p. 190
- Full Text: false
- Reviewed:
- Description: The Australian Defence Force (ADF) has resolved to establish a series of physical employment standards for Infantry soldiers and Airfield Defence Guards. A key stage in establishing these standards is to analyse the physical requirements of the two jobs. The purpose of this study was to analyse the physical requirements of the key physical tasks required within the two jobs. The jobs were divided into over 100 component tasks. Some tasks were common to the two jobs while others were specific to the respective jobs. ADF subject matter experts identified 36 tasks that were considered to be the most physically demanding. These tasks were observed to determine the movement patterns (actions) and muscle groups involved, the duration, velocity and estimated of exercise intensity. An estimate was also made of the involvement of each of seven activity types (endurance, strength-endurance etc) in each task and the exercise volume contained within each task. The tasks were ranked based upon the volume of work involved within each classification of activity type and movement action. Based upon these analyses, a series of tasks were chosen as those which best reflected the range of physical requirements of an Infantry soldier and an Airfield Defence Guard. These tasks were: marching while carrying support weapons, carrying ammunition boxes, assaulting, wall climbing, sandbagging, jumping from a height, pursuiting, rope climbing, patrolling in an urban environment, population protection, patrolling in marching order, building forced entry and stair climbing, casualty evacuation, loading stores and digging.
- Description: 2003005933
Remediation of monoethanolamine after exposure to brown coal flue gases
- Lim, Jinah, Aguiar, Alita, Reynolds, Alicia, Pearson, Pauline, Kentish, Sandra, Meuleman, Erik
- Authors: Lim, Jinah , Aguiar, Alita , Reynolds, Alicia , Pearson, Pauline , Kentish, Sandra , Meuleman, Erik
- Date: 2015
- Type: Text , Journal article
- Relation: International Journal of Greenhouse Gas Control Vol. 42, no. (2015), p. 545-553
- Full Text: false
- Reviewed:
- Description: Monoethanolamine (MEA) is the solvent most commonly considered for post-combustion capture. However, the solvent will accumulate a range of contaminants during use, notably heat stable salts, that reduce its performance. This work considers the removal of these contaminants from MEA solutions that had been exposed to over 50 and 1800h of post combustion capture of flue gases from a brown coal-fired power station. Analysis indicated that these MEA solutions contained significant quantities of heat stable salts including iron, potassium, sulphate, nitrate and organic anions, particularly in the older sample. Both solutions were initially neutralised to free the protonated amine, which led to precipitation of some impurities within the older solvent. Nanofiltration was considered as an approach to further concentrate impurities, but was ineffective due to low permeation rates and low rejection of monovalent salts, at less than 20%. It was effective in concentrating metal contaminants and may be useful into the future for this reason. Conversely, electrodialysis was effective in removing up to 91% of the ionic content of the solutions, although the current efficiency fell at low feed conductivities. Monovalent salts such as sodium, potassium and nitrate were removed more readily than multivalent salts such as iron and sulphate. MEA loss was consistent with our prior work at around 0.15g/m2s and was predominantly as the free amine rather than the carbamate salt.
Oxidative degradation of amine absorbents in carbon capture systems – A dynamic modelling approach
- Dickinson, Jillian, Percy, Andrew, Puxty, Graeme, Verheyen, Vincent
- Authors: Dickinson, Jillian , Percy, Andrew , Puxty, Graeme , Verheyen, Vincent
- Date: 2016
- Type: Text , Journal article
- Relation: International Journal of Greenhouse Gas Control Vol. 53, no. (2016), p. 391-400
- Full Text: false
- Reviewed:
- Description: Fossil fuels are used widely for energy production and are likely to continue to play a major role world wide for many years to come. Much work has been done on the technology for capturing CO2 from gaseous industrial effluent. For large-scale applications like coal or natural gas-fired power plants, using amine solvents to capture post-combustion CO2 is the most mature CO2 capture technology. This technique can be used to retrofit existing plants by treating the flue gas after combustion. This paper details a dynamic mathematical model for the absorber column constructed from first principles. The loss of MEA through oxidative degradation has been quantified here for the first time and this is currently not possible using commercial packages. Reaction rate kinetics have been employed to predict the accumulation of oxidation products which is limited by the incomplete knowledge of the dominant reactions between O2 and MEA. When research has produced more detailed information about the products formed during this oxidation, it can be inserted easily into the model. Validation has been performed using data from the CSIRO PCC pilot plant at AGL Loy Yang. A limited parametric study of the impact of operating conditions on oxidation was performed.
The failure behaviour of poorly cemented sands at a borehole wall using laboratory tests
- Hashemi, Sam, Melkoumian, Nouné, Taheri, Abbas, Jaksa, Mark
- Authors: Hashemi, Sam , Melkoumian, Nouné , Taheri, Abbas , Jaksa, Mark
- Date: 2015
- Type: Text , Journal article , Technical Note
- Relation: International Journal of Rock Mechanics and Mining Sciences Vol. 77, no. (2015/07/01/ 2015), p. 348-357
- Full Text: false
- Reviewed:
- Description: Borehole stability analysis is an important challenge for researchers in the field of geotechnical, mining and petroleum engineering. Several borehole instability problems during or after the completion of drilling, have been reported by a number of exploration companies in Australia. Many of these problems are reported in drilling projects in poorly cemented sand formations at depths of up to 200 m beneath the ground. The sand production problem, as it is known, has also been observed in weakly bonded sandstones where the debonding of sand grains can be triggered by fluid pressure and induced stresses leading to the failure of the sandstone at the borehole wall. The strength of a granular material formation is generated mainly by a natural cementing agent that bonds sand grains together.
- Description: Borehole stability analysis is an important challenge for researchers in the field of geotechnical, mining and petroleum engineering. Several borehole instability problems during or after the completion of drilling, have been reported by a number of exploration companies in Australia. Many of these problems are reported in drilling projects in poorly cemented sand formations at depths of up to 200 m beneath the ground. The sand production problem, as it is known, has also been observed in weakly bonded sandstones where the debonding of sand grains can be triggered by fluid pressure and induced stresses leading to the failure of the sandstone at the borehole wall [1], [2]. The strength of a granular material formation is generated mainly by a natural cementing agent that bonds sand grains together [3].
Wifi-based localisation datasets for No-GPS open areas using smart bins
- Nassar, Mohamed, Hasan, Mahmud, Khan, Md, Sultana, Mirza, Hasan, Md, Luxford, Len, Cole, Peter, Oatley, Giles, Koutsakis, Polychronis
- Authors: Nassar, Mohamed , Hasan, Mahmud , Khan, Md , Sultana, Mirza , Hasan, Md , Luxford, Len , Cole, Peter , Oatley, Giles , Koutsakis, Polychronis
- Date: 2020
- Type: Text , Journal article , Data article
- Relation: Computer Networks Vol. 180, no. (2020), p. 1-5
- Full Text: false
- Reviewed:
- Description: In recent years, Wifi-based localisation systems have gained significant interest because of the lack of Global Positioning System (GPS) signal in indoor and certain open areas. Over the past decade, many datasets have been introduced to enable researchers to compare different localisation techniques. Existing datasets, however, have failed to cover open areas such as parks in cases where GPS is still unavailable, and there is a lack of Wifi access points. Also, the existing datasets only focus on getting Wifi fingerprint collected and labelled by users. To the best of our knowledge, no dataset provides Received Signal Strengths (RSS) collected by Wireless Access Points (APs). In this work, we offer two datasets publicly. The first is the Fingerprint dataset in which four users generated 16,032 accurate and consistently labelled WiFi fingerprints for all available Reference Points (RPs) in a central and busy area of Murdoch University, known as Bush Court. The second is the APs dataset that includes 2,450,865 auto-generated records received from 1000 users' devices, including the four users, associated with Wifi signal strengths. To overcome the Wifi coverage problem for the Bush Court, we attached our previously designed Wireless Sensor Nodes (WSNs) to existing garbage bins, enabling them to provide real-time environmental sensing and act as soft APs that sense MAC addresses and Wifi signals from surrounding devices.
Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990-2019 : A systematic analysis for the Global Burden of Disease Study 2019
- Authors: Rahman, Muhammad Aziz
- Date: 2020
- Type: Text , Journal article
- Relation: Lancet Vol. 396, no. 10258 (2020), p. 1250-1284
- Full Text:
- Reviewed:
- Description: Background Achieving universal health coverage (UHC) involves all people receiving the health services they need, of high quality, without experiencing financial hardship. Making progress towards UHC is a policy priority for both countries and global institutions, as highlighted by the agenda of the UN Sustainable Development Goals (SDGs) and WHO's Thirteenth General Programme of Work (GPW13). Measuring effective coverage at the health-system level is important for understanding whether health services are aligned with countries' health profiles and are of sufficient quality to produce health gains for populations of all ages. Methods Based on the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we assessed UHC effective coverage for 204 countries and territories from 1990 to 2019. Drawing from a measurement framework developed through WHO's GPW13 consultation, we mapped 23 effective coverage indicators to a matrix representing health service types (eg, promotion, prevention, and treatment) and five population-age groups spanning from reproductive and newborn to older adults (>= 65 years). Effective coverage indicators were based on intervention coverage or outcome-based measures such as mortality-to-incidence ratios to approximate access to quality care; outcome-based measures were transformed to values on a scale of 0-100 based on the 2.5th and 97.5th percentile of location-year values. We constructed the UHC effective coverage index by weighting each effective coverage indicator relative to its associated potential health gains, as measured by disability-adjusted life-years for each location-year and population-age group. For three tests of validity (content, known-groups, and convergent), UHC effective coverage index performance was generally better than that of other UHC service coverage indices from WHO (ie, the current metric for SDG indicator 3.8.1 on UHC service coverage), the World Bank, and GBD 2017. We quantified frontiers of UHC effective coverage performance on the basis of pooled health spending per capita, representing UHC effective coverage index levels achieved in 2019 relative to country-level government health spending, prepaid private expenditures, and development assistance for health. To assess current trajectories towards the GPW13 UHC billion target-1 billion more people benefiting from UHC by 2023-we estimated additional population equivalents with UHC effective coverage from 2018 to 2023. Findings Globally, performance on the UHC effective coverage index improved from 45.8 (95% uncertainty interval 44.2-47.5) in 1990 to 60.3 (58.7-61.9) in 2019, yet country-level UHC effective coverage in 2019 still spanned from 95 or higher in Japan and Iceland to lower than 25 in Somalia and the Central African Republic. Since 2010, sub-Saharan Africa showed accelerated gains on the UHC effective coverage index (at an average increase of 2.6% [1.9-3.3] per year up to 2019); by contrast, most other GBD super-regions had slowed rates of progress in 2010-2019 relative to 1990-2010. Many countries showed lagging performance on effective coverage indicators for non-communicable diseases relative to those for communicable diseases and maternal and child health, despite non-communicable diseases accounting for a greater proportion of potential health gains in 2019, suggesting that many health systems are not keeping pace with the rising non-communicable disease burden and associated population health needs. In 2019, the UHC effective coverage index was associated with pooled health spending per capita (r=0.79), although countries across the development spectrum had much lower UHC effective coverage than is potentially achievable relative to their health spending. Under maximum efficiency of translating health spending into UHC effective coverage performance, countries would need to reach $1398 pooled health spending per capita (US$ adjusted for purchasing power parity) in order to achieve 80 on the UHC effective coverage index. From 2018 to 2023, an estimated 388.9 million (358.6-421.3) more population equivalents would have UHC effective coverage, falling well short of the GPW13 target of 1 billion more people benefiting from UHC during this time. Current projections point to an estimated 3.1 billion (3.0-3.2) population equivalents still lacking UHC effective coverage in 2023, with nearly a third (968.1 million [903.5-1040.3]) residing in south Asia. Interpretation The present study demonstrates the utility of measuring effective coverage and its role in supporting improved health outcomes for all people-the ultimate goal of UHC and its achievement. Global ambitions to accelerate progress on UHC service coverage are increasingly unlikely unless concerted action on non-communicable diseases occurs and countries can better translate health spending into improved performance. Focusing on effective coverage and accounting for the world's evolving health needs lays the groundwork for better understanding how close-or how far-all populations are in benefiting from UHC. Copyright (C) 2020 The Author(s). Published by Elsevier Ltd. **Please note that there are multiple authors for this article therefore only the name of the Federation University Australia affiliate is provided in this record**
- Description: Lucas Guimaraes Abreu acknowledges support from Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -Brasil (Capes) -Finance Code 001, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) and Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG). Olatunji O Adetokunboh acknowledges South African Department of Science & Innovation, and National Research Foundation. Anurag Agrawal acknowledges support from the Wellcome Trust DBT India Alliance Senior Fellowship IA/CPHS/14/1/501489. Rufus Olusola Akinyemi acknowledges Grant U01HG010273 from the National Institutes of Health (NIH) as part of the H3Africa Consortium. Rufus Olusola Akinyemi is further supported by the FLAIR fellowship funded by the UK Royal Society and the African Academy of Sciences. Syed Mohamed Aljunid acknowledges the Department of Health Policy and Management, Faculty of Public Health, Kuwait University and International Centre for Casemix and Clinical Coding, Faculty of Medicine, National University of Malaysia for the approval and support to participate in this research project. Marcel Ausloos, Claudiu Herteliu, and Adrian Pana acknowledge partial support by a grant of the Romanian National Authority for Scientific Research and Innovation, CNDSUEFISCDI, project number PN-III-P4-ID-PCCF-2016-0084. Till Winfried Barnighausen acknowledges support from the Alexander von Humboldt Foundation through the Alexander von Humboldt Professor award, funded by the German Federal Ministry of Education and Research. Juan J Carrero was supported by the Swedish Research Council (2019-01059). Felix Carvalho acknowledges UID/MULTI/04378/2019 and UID/QUI/50006/2019 support with funding from FCT/MCTES through national funds. Vera Marisa Costa acknowledges support from grant (SFRH/BHD/110001/2015), received by Portuguese national funds through Fundacao para a Ciencia e a Tecnologia (FCT), IP, under the Norma TransitA3ria DL57/2016/CP1334/CT0006. Jan-Walter De Neve acknowledges support from the Alexander von Humboldt Foundation. Kebede Deribe acknowledges support by Wellcome Trust grant number 201900/Z/16/Z as part of his International Intermediate Fellowship. Claudiu Herteliu acknowledges partial support by a grant co-funded by European Fund for Regional Development through Operational Program for Competitiveness, Project ID P_40_382. Praveen Hoogar acknowledges the Centre for Bio Cultural Studies (CBiCS), Manipal Academy of Higher Education(MAHE), Manipal and Centre for Holistic Development and Research (CHDR), Kalghatgi. Bing-Fang Hwang acknowledges support from China Medical University (CMU108-MF-95), Taichung, Taiwan. Mihajlo Jakovljevic acknowledges the Serbian part of this GBD contribution was co-funded through the Grant OI175014 of the Ministry of Education Science and Technological Development of the Republic of Serbia. Aruna M Kamath acknowledges funding from the National Institutes of Health T32 grant (T32GM086270). Srinivasa Vittal Katikireddi acknowledges funding from the Medical Research Council (MC_UU_12017/13 & MC_UU_12017/15), Scottish Government Chief Scientist Office (SPHSU13 & SPHSU15) and an NRS Senior Clinical Fellowship (SCAF/15/02). Yun Jin Kim acknowledges support from the Research Management Centre, Xiamen University Malaysia (XMUMRF/2018-C2/ITCM/0001). Kewal Krishan acknowledges support from the DST PURSE grant and UGC Center of Advanced Study (CAS II) awarded to the Department of Anthropology, Panjab University, Chandigarh, India. Manasi Kumar acknowledges support from K43 TW010716 Fogarty International Center/NIMH. Ben Lacey acknowledges support from the NIHR Oxford Biomedical Research Centre and the BHF Centre of Research Excellence, Oxford. Ivan Landires is a member of the Sistema Nacional de InvestigaciA3n (SNI), which is supported by the Secretaria Nacional de Ciencia Tecnologia e Innovacion (SENACYT), Panama. Jeffrey V Lazarus acknowledges support by a Spanish Ministry of Science, Innovation and Universities Miguel Servet grant (Instituto de Salud Carlos III/ESF, European Union [CP18/00074]). Peter T N Memiah acknowledges CODESRIA; HISTP. Subas Neupane acknowledges partial support from the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital. Shuhei Nomura acknowledges support from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (18K10082). Alberto Ortiz acknowledges support by ISCIII PI19/00815, DTS18/00032, ISCIII-RETIC REDinREN RD016/0009 Fondos FEDER, FRIAT, Comunidad de Madrid B2017/BMD-3686 CIFRA2-CM. These funding sources had no role in the writing of the manuscript or the decision to submit it for publication. George C Patton acknowledges support from a National Health & Medical Research Council Fellowship. Marina Pinheiro acknowledges support from FCT for funding through program DL 57/2016 -Norma transitA3ria. Alberto Raggi, David Sattin, and Silvia Schiavolin acknowledge support by a grant from the Italian Ministry of Health (Ricerca Corrente, Fondazione Istituto Neurologico C Besta, Linea 4 -Outcome Research: dagli Indicatori alle Raccomandazioni Cliniche). Daniel Cury Ribeiro acknowledges support from the Sir Charles Hercus Health Research Fellowship -Health Research Council of New Zealand (18/111). Perminder S Sachdev acknowledges funding from the NHMRC Australia. Abdallah M Samy acknowledges support from a fellowship from the Egyptian Fulbright Mission Program. Milena M Santric-Milicevic acknowledges support from the Ministry of Education, Science and Technological Development of the Republic of Serbia (Contract No. 175087). Rodrigo Sarmiento-Suarez acknowledges institutional support from University of Applied and Environmental Sciences in Bogota, Colombia, and Carlos III Institute of Health in Madrid, Spain. Maria Ines Schmidt acknowledges grants from the Foundation for the Support of Research of the State of Rio Grande do Sul (IATS and PrInt) and the Brazilian Ministry of Health. Sheikh Mohammed Shariful Islam acknowledges a fellowship from the National Heart Foundation of Australia and Deakin University. Aziz Sheikh acknowledges support from Health Data Research UK. Kenji Shibuya acknowledges Japan Ministry of Education, Culture, Sports, Science and Technology. Joan B Soriano acknowledges support by Centro de Investigacion en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Rafael Tabares-Seisdedos acknowledges partial support from grant PI17/00719 from ISCIII-FEDER. Santosh Kumar Tadakamadla acknowledges support from the National Health and Medical Research Council Early Career Fellowship, Australia. Marcello Tonelli acknowledges the David Freeze Chair in Health Services Research at the University of Calgary, AB, Canada.
- Authors: Rahman, Muhammad Aziz
- Date: 2020
- Type: Text , Journal article
- Relation: Lancet Vol. 396, no. 10258 (2020), p. 1250-1284
- Full Text:
- Reviewed:
- Description: Background Achieving universal health coverage (UHC) involves all people receiving the health services they need, of high quality, without experiencing financial hardship. Making progress towards UHC is a policy priority for both countries and global institutions, as highlighted by the agenda of the UN Sustainable Development Goals (SDGs) and WHO's Thirteenth General Programme of Work (GPW13). Measuring effective coverage at the health-system level is important for understanding whether health services are aligned with countries' health profiles and are of sufficient quality to produce health gains for populations of all ages. Methods Based on the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we assessed UHC effective coverage for 204 countries and territories from 1990 to 2019. Drawing from a measurement framework developed through WHO's GPW13 consultation, we mapped 23 effective coverage indicators to a matrix representing health service types (eg, promotion, prevention, and treatment) and five population-age groups spanning from reproductive and newborn to older adults (>= 65 years). Effective coverage indicators were based on intervention coverage or outcome-based measures such as mortality-to-incidence ratios to approximate access to quality care; outcome-based measures were transformed to values on a scale of 0-100 based on the 2.5th and 97.5th percentile of location-year values. We constructed the UHC effective coverage index by weighting each effective coverage indicator relative to its associated potential health gains, as measured by disability-adjusted life-years for each location-year and population-age group. For three tests of validity (content, known-groups, and convergent), UHC effective coverage index performance was generally better than that of other UHC service coverage indices from WHO (ie, the current metric for SDG indicator 3.8.1 on UHC service coverage), the World Bank, and GBD 2017. We quantified frontiers of UHC effective coverage performance on the basis of pooled health spending per capita, representing UHC effective coverage index levels achieved in 2019 relative to country-level government health spending, prepaid private expenditures, and development assistance for health. To assess current trajectories towards the GPW13 UHC billion target-1 billion more people benefiting from UHC by 2023-we estimated additional population equivalents with UHC effective coverage from 2018 to 2023. Findings Globally, performance on the UHC effective coverage index improved from 45.8 (95% uncertainty interval 44.2-47.5) in 1990 to 60.3 (58.7-61.9) in 2019, yet country-level UHC effective coverage in 2019 still spanned from 95 or higher in Japan and Iceland to lower than 25 in Somalia and the Central African Republic. Since 2010, sub-Saharan Africa showed accelerated gains on the UHC effective coverage index (at an average increase of 2.6% [1.9-3.3] per year up to 2019); by contrast, most other GBD super-regions had slowed rates of progress in 2010-2019 relative to 1990-2010. Many countries showed lagging performance on effective coverage indicators for non-communicable diseases relative to those for communicable diseases and maternal and child health, despite non-communicable diseases accounting for a greater proportion of potential health gains in 2019, suggesting that many health systems are not keeping pace with the rising non-communicable disease burden and associated population health needs. In 2019, the UHC effective coverage index was associated with pooled health spending per capita (r=0.79), although countries across the development spectrum had much lower UHC effective coverage than is potentially achievable relative to their health spending. Under maximum efficiency of translating health spending into UHC effective coverage performance, countries would need to reach $1398 pooled health spending per capita (US$ adjusted for purchasing power parity) in order to achieve 80 on the UHC effective coverage index. From 2018 to 2023, an estimated 388.9 million (358.6-421.3) more population equivalents would have UHC effective coverage, falling well short of the GPW13 target of 1 billion more people benefiting from UHC during this time. Current projections point to an estimated 3.1 billion (3.0-3.2) population equivalents still lacking UHC effective coverage in 2023, with nearly a third (968.1 million [903.5-1040.3]) residing in south Asia. Interpretation The present study demonstrates the utility of measuring effective coverage and its role in supporting improved health outcomes for all people-the ultimate goal of UHC and its achievement. Global ambitions to accelerate progress on UHC service coverage are increasingly unlikely unless concerted action on non-communicable diseases occurs and countries can better translate health spending into improved performance. Focusing on effective coverage and accounting for the world's evolving health needs lays the groundwork for better understanding how close-or how far-all populations are in benefiting from UHC. Copyright (C) 2020 The Author(s). Published by Elsevier Ltd. **Please note that there are multiple authors for this article therefore only the name of the Federation University Australia affiliate is provided in this record**
- Description: Lucas Guimaraes Abreu acknowledges support from Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -Brasil (Capes) -Finance Code 001, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) and Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG). Olatunji O Adetokunboh acknowledges South African Department of Science & Innovation, and National Research Foundation. Anurag Agrawal acknowledges support from the Wellcome Trust DBT India Alliance Senior Fellowship IA/CPHS/14/1/501489. Rufus Olusola Akinyemi acknowledges Grant U01HG010273 from the National Institutes of Health (NIH) as part of the H3Africa Consortium. Rufus Olusola Akinyemi is further supported by the FLAIR fellowship funded by the UK Royal Society and the African Academy of Sciences. Syed Mohamed Aljunid acknowledges the Department of Health Policy and Management, Faculty of Public Health, Kuwait University and International Centre for Casemix and Clinical Coding, Faculty of Medicine, National University of Malaysia for the approval and support to participate in this research project. Marcel Ausloos, Claudiu Herteliu, and Adrian Pana acknowledge partial support by a grant of the Romanian National Authority for Scientific Research and Innovation, CNDSUEFISCDI, project number PN-III-P4-ID-PCCF-2016-0084. Till Winfried Barnighausen acknowledges support from the Alexander von Humboldt Foundation through the Alexander von Humboldt Professor award, funded by the German Federal Ministry of Education and Research. Juan J Carrero was supported by the Swedish Research Council (2019-01059). Felix Carvalho acknowledges UID/MULTI/04378/2019 and UID/QUI/50006/2019 support with funding from FCT/MCTES through national funds. Vera Marisa Costa acknowledges support from grant (SFRH/BHD/110001/2015), received by Portuguese national funds through Fundacao para a Ciencia e a Tecnologia (FCT), IP, under the Norma TransitA3ria DL57/2016/CP1334/CT0006. Jan-Walter De Neve acknowledges support from the Alexander von Humboldt Foundation. Kebede Deribe acknowledges support by Wellcome Trust grant number 201900/Z/16/Z as part of his International Intermediate Fellowship. Claudiu Herteliu acknowledges partial support by a grant co-funded by European Fund for Regional Development through Operational Program for Competitiveness, Project ID P_40_382. Praveen Hoogar acknowledges the Centre for Bio Cultural Studies (CBiCS), Manipal Academy of Higher Education(MAHE), Manipal and Centre for Holistic Development and Research (CHDR), Kalghatgi. Bing-Fang Hwang acknowledges support from China Medical University (CMU108-MF-95), Taichung, Taiwan. Mihajlo Jakovljevic acknowledges the Serbian part of this GBD contribution was co-funded through the Grant OI175014 of the Ministry of Education Science and Technological Development of the Republic of Serbia. Aruna M Kamath acknowledges funding from the National Institutes of Health T32 grant (T32GM086270). Srinivasa Vittal Katikireddi acknowledges funding from the Medical Research Council (MC_UU_12017/13 & MC_UU_12017/15), Scottish Government Chief Scientist Office (SPHSU13 & SPHSU15) and an NRS Senior Clinical Fellowship (SCAF/15/02). Yun Jin Kim acknowledges support from the Research Management Centre, Xiamen University Malaysia (XMUMRF/2018-C2/ITCM/0001). Kewal Krishan acknowledges support from the DST PURSE grant and UGC Center of Advanced Study (CAS II) awarded to the Department of Anthropology, Panjab University, Chandigarh, India. Manasi Kumar acknowledges support from K43 TW010716 Fogarty International Center/NIMH. Ben Lacey acknowledges support from the NIHR Oxford Biomedical Research Centre and the BHF Centre of Research Excellence, Oxford. Ivan Landires is a member of the Sistema Nacional de InvestigaciA3n (SNI), which is supported by the Secretaria Nacional de Ciencia Tecnologia e Innovacion (SENACYT), Panama. Jeffrey V Lazarus acknowledges support by a Spanish Ministry of Science, Innovation and Universities Miguel Servet grant (Instituto de Salud Carlos III/ESF, European Union [CP18/00074]). Peter T N Memiah acknowledges CODESRIA; HISTP. Subas Neupane acknowledges partial support from the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital. Shuhei Nomura acknowledges support from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (18K10082). Alberto Ortiz acknowledges support by ISCIII PI19/00815, DTS18/00032, ISCIII-RETIC REDinREN RD016/0009 Fondos FEDER, FRIAT, Comunidad de Madrid B2017/BMD-3686 CIFRA2-CM. These funding sources had no role in the writing of the manuscript or the decision to submit it for publication. George C Patton acknowledges support from a National Health & Medical Research Council Fellowship. Marina Pinheiro acknowledges support from FCT for funding through program DL 57/2016 -Norma transitA3ria. Alberto Raggi, David Sattin, and Silvia Schiavolin acknowledge support by a grant from the Italian Ministry of Health (Ricerca Corrente, Fondazione Istituto Neurologico C Besta, Linea 4 -Outcome Research: dagli Indicatori alle Raccomandazioni Cliniche). Daniel Cury Ribeiro acknowledges support from the Sir Charles Hercus Health Research Fellowship -Health Research Council of New Zealand (18/111). Perminder S Sachdev acknowledges funding from the NHMRC Australia. Abdallah M Samy acknowledges support from a fellowship from the Egyptian Fulbright Mission Program. Milena M Santric-Milicevic acknowledges support from the Ministry of Education, Science and Technological Development of the Republic of Serbia (Contract No. 175087). Rodrigo Sarmiento-Suarez acknowledges institutional support from University of Applied and Environmental Sciences in Bogota, Colombia, and Carlos III Institute of Health in Madrid, Spain. Maria Ines Schmidt acknowledges grants from the Foundation for the Support of Research of the State of Rio Grande do Sul (IATS and PrInt) and the Brazilian Ministry of Health. Sheikh Mohammed Shariful Islam acknowledges a fellowship from the National Heart Foundation of Australia and Deakin University. Aziz Sheikh acknowledges support from Health Data Research UK. Kenji Shibuya acknowledges Japan Ministry of Education, Culture, Sports, Science and Technology. Joan B Soriano acknowledges support by Centro de Investigacion en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Rafael Tabares-Seisdedos acknowledges partial support from grant PI17/00719 from ISCIII-FEDER. Santosh Kumar Tadakamadla acknowledges support from the National Health and Medical Research Council Early Career Fellowship, Australia. Marcello Tonelli acknowledges the David Freeze Chair in Health Services Research at the University of Calgary, AB, Canada.
Assessment of clogging phenomena in granular filter media used for stormwater treatment
- Kandra, Harpreet, McCarthy, David, Fletcher, Tim, Deletic, Ana
- Authors: Kandra, Harpreet , McCarthy, David , Fletcher, Tim , Deletic, Ana
- Date: 2014
- Type: Text , Journal article
- Relation: Journal of Hydrology Vol. 512, no. (2014), p. 518-527
- Full Text:
- Reviewed:
- Description: Hydraulic performance of granular filter media and its evolution over time is a key design parameter for stormwater filtration and infiltration systems that are now widely used in management of polluted urban runoff. In fact, clogging of filter media is recognised as the main limiting factor of these stormwater treatment systems. This paper focuses on the effect of physical characteristics of filter media and flow-through rates on the clogging of stormwater filters. Five replicate experimental columns were constructed using zeolite, scoria, riversand and polymeric glass beads, and different flow-through rates were achieved using restricted outlets. The systems were dosed with semi-synthetic stormwater and the evolution of hydraulic performance and sediment removal rate was observed (for four filter media and across four flow rates) to investigate impacts of media type and flow rate. It was found that shape and smoothness of filter media grains had limited effect on clogging and sediment removal rate. All media except scoria clogged after similar volumes of stormwater but scoria-based filters were found to be highly variable in performance, most likely due to breakdown of its particles. Conversely, flow-through rate significantly affected clogging and sediment removal rate. For instance, in the case of zeolite filters, the systems with the lowest flow rate clogged after application of over 30. m of stormwater, while the unrestricted zeolite columns (with 200 times the flow rate) clogged after only 10. m of applied stormwater. At the same time, the zeolite filters with the lowest flow rate had an overall treatment efficiency of 88% compared with the unrestricted design's efficiency of 59%. Further work is needed to analyse the influence of filter bed design, stormwater inflow characteristics and drying and wetting regimes on clogging and to understand the location of the clogged material in these filters. © 2014 Elsevier B.V.
- Authors: Kandra, Harpreet , McCarthy, David , Fletcher, Tim , Deletic, Ana
- Date: 2014
- Type: Text , Journal article
- Relation: Journal of Hydrology Vol. 512, no. (2014), p. 518-527
- Full Text:
- Reviewed:
- Description: Hydraulic performance of granular filter media and its evolution over time is a key design parameter for stormwater filtration and infiltration systems that are now widely used in management of polluted urban runoff. In fact, clogging of filter media is recognised as the main limiting factor of these stormwater treatment systems. This paper focuses on the effect of physical characteristics of filter media and flow-through rates on the clogging of stormwater filters. Five replicate experimental columns were constructed using zeolite, scoria, riversand and polymeric glass beads, and different flow-through rates were achieved using restricted outlets. The systems were dosed with semi-synthetic stormwater and the evolution of hydraulic performance and sediment removal rate was observed (for four filter media and across four flow rates) to investigate impacts of media type and flow rate. It was found that shape and smoothness of filter media grains had limited effect on clogging and sediment removal rate. All media except scoria clogged after similar volumes of stormwater but scoria-based filters were found to be highly variable in performance, most likely due to breakdown of its particles. Conversely, flow-through rate significantly affected clogging and sediment removal rate. For instance, in the case of zeolite filters, the systems with the lowest flow rate clogged after application of over 30. m of stormwater, while the unrestricted zeolite columns (with 200 times the flow rate) clogged after only 10. m of applied stormwater. At the same time, the zeolite filters with the lowest flow rate had an overall treatment efficiency of 88% compared with the unrestricted design's efficiency of 59%. Further work is needed to analyse the influence of filter bed design, stormwater inflow characteristics and drying and wetting regimes on clogging and to understand the location of the clogged material in these filters. © 2014 Elsevier B.V.
Measurement invariance of the Internet Gaming Disorder Scale Short-Form (IGDS9-SF) between the United States of America, India and the United Kingdom
- Pontes, Halley, Stavropoulos, Vasileios, Griffiths, Mark
- Authors: Pontes, Halley , Stavropoulos, Vasileios , Griffiths, Mark
- Date: 2017
- Type: Text , Journal article
- Relation: Psychiatry Research Vol. 257, no. (2017), p. 472-478
- Full Text:
- Reviewed:
- Description: The Internet Gaming Disorder Scale Short-Form (IGDS9-SF) has been extensively used worldwide to assess Internet Gaming Disorder (IGD) behaviors. Therefore, investigating cultural limitations and implications in its applicability is necessary. The cross-cultural feasibility of a test can be psychometrically evaluated with measurement invariance analyses. Thus, the present study used Multigroup Confirmatory Factor Analysis (MGCFA) to examine the IGDS9-SF measurement invariance across garners from the United States of America (USA), India, and the United Kingdom (UK). A total of 1013 garners from the USA (n = 405), India (n = 336), and the UK (n = 272) were recruited. Although the one-factor structure of the IGD construct was supported, cross-country variations were demonstrated considering the way that this was reflected on items assessing preoccupation/salience, tolerance, deception, gaming escapism/mood modification, as well as daily activities' impairment related to gaming. Furthermore, the same scores on items assessing withdrawal symptoms, tolerance, lack of control over gaming engagement, escapism/mood modification and daily activities impairment associated to gaming, have been found to reflect various levels of IGD severity across the three groups. The implications of these results are further discussed in the context of existing evidence regarding the assessment of IGD.
- Authors: Pontes, Halley , Stavropoulos, Vasileios , Griffiths, Mark
- Date: 2017
- Type: Text , Journal article
- Relation: Psychiatry Research Vol. 257, no. (2017), p. 472-478
- Full Text:
- Reviewed:
- Description: The Internet Gaming Disorder Scale Short-Form (IGDS9-SF) has been extensively used worldwide to assess Internet Gaming Disorder (IGD) behaviors. Therefore, investigating cultural limitations and implications in its applicability is necessary. The cross-cultural feasibility of a test can be psychometrically evaluated with measurement invariance analyses. Thus, the present study used Multigroup Confirmatory Factor Analysis (MGCFA) to examine the IGDS9-SF measurement invariance across garners from the United States of America (USA), India, and the United Kingdom (UK). A total of 1013 garners from the USA (n = 405), India (n = 336), and the UK (n = 272) were recruited. Although the one-factor structure of the IGD construct was supported, cross-country variations were demonstrated considering the way that this was reflected on items assessing preoccupation/salience, tolerance, deception, gaming escapism/mood modification, as well as daily activities' impairment related to gaming. Furthermore, the same scores on items assessing withdrawal symptoms, tolerance, lack of control over gaming engagement, escapism/mood modification and daily activities impairment associated to gaming, have been found to reflect various levels of IGD severity across the three groups. The implications of these results are further discussed in the context of existing evidence regarding the assessment of IGD.