Can genetic polymorphisms predict response variability to anodal transcranial direct current stimulation of the primary motor cortex?
- Pellegrini, Michael, Zoghi, Maryam, Jaberzadeh, Shapour
- Authors: Pellegrini, Michael , Zoghi, Maryam , Jaberzadeh, Shapour
- Date: 2021
- Type: Text , Journal article
- Relation: European Journal of Neuroscience Vol. 53, no. 5 (2021), p. 1569-1591
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- Description: Genetic mediation of cortical plasticity and the role genetic variants play in previously observed response variability to transcranial direct current stimulation (tDCS) have become important issues in the tDCS literature in recent years. This study investigated whether inter-individual variability to tDCS was in-part genetically mediated. In 61 healthy males, anodal-tDCS (a-tDCS) and sham-tDCS were administered to the primary motor cortex at 1 mA for 10-min via 6 × 4 cm active and 7 × 5 cm return electrodes. Twenty-five single-pulse transcranial magnetic stimulation (TMS) motor evoked potentials (MEP) were recorded to represent corticospinal excitability (CSE). Twenty-five paired-pulse MEPs were recorded with 3 ms inter-stimulus interval (ISI) to assess intracortical inhibition (ICI) via short-interval intracranial inhibition (SICI) and 10 ms ISI for intracortical facilitation (ICF). Saliva samples were tested for specific genetic polymorphisms in genes encoding for excitatory and inhibitory neuroreceptors. Individuals were sub-grouped based on a pre-determined threshold and via statistical cluster analysis. Two distinct subgroups were identified, increases in CSE following a-tDCS (i.e. Responders) and no increase or even reductions in CSE (i.e. Non-responders). No changes in ICI or ICF were reported. No relationships were reported between genetic polymorphisms in excitatory receptor genes and a-tDCS responders. An association was reported between a-tDCS responders and GABRA3 gene polymorphisms encoding for GABA-A receptors suggesting potential relationships between GABA-A receptor variations and capacity to undergo tDCS-induced cortical plasticity. In the largest tDCS study of its kind, this study presents an important step forward in determining the contribution genetic factors play in previously observed inter-individual variability to tDCS. © 2020 Federation of European Neuroscience Societies and John Wiley & Sons Ltd
- Authors: Pellegrini, Michael , Zoghi, Maryam , Jaberzadeh, Shapour
- Date: 2021
- Type: Text , Journal article
- Relation: European Journal of Neuroscience Vol. 53, no. 5 (2021), p. 1569-1591
- Full Text:
- Reviewed:
- Description: Genetic mediation of cortical plasticity and the role genetic variants play in previously observed response variability to transcranial direct current stimulation (tDCS) have become important issues in the tDCS literature in recent years. This study investigated whether inter-individual variability to tDCS was in-part genetically mediated. In 61 healthy males, anodal-tDCS (a-tDCS) and sham-tDCS were administered to the primary motor cortex at 1 mA for 10-min via 6 × 4 cm active and 7 × 5 cm return electrodes. Twenty-five single-pulse transcranial magnetic stimulation (TMS) motor evoked potentials (MEP) were recorded to represent corticospinal excitability (CSE). Twenty-five paired-pulse MEPs were recorded with 3 ms inter-stimulus interval (ISI) to assess intracortical inhibition (ICI) via short-interval intracranial inhibition (SICI) and 10 ms ISI for intracortical facilitation (ICF). Saliva samples were tested for specific genetic polymorphisms in genes encoding for excitatory and inhibitory neuroreceptors. Individuals were sub-grouped based on a pre-determined threshold and via statistical cluster analysis. Two distinct subgroups were identified, increases in CSE following a-tDCS (i.e. Responders) and no increase or even reductions in CSE (i.e. Non-responders). No changes in ICI or ICF were reported. No relationships were reported between genetic polymorphisms in excitatory receptor genes and a-tDCS responders. An association was reported between a-tDCS responders and GABRA3 gene polymorphisms encoding for GABA-A receptors suggesting potential relationships between GABA-A receptor variations and capacity to undergo tDCS-induced cortical plasticity. In the largest tDCS study of its kind, this study presents an important step forward in determining the contribution genetic factors play in previously observed inter-individual variability to tDCS. © 2020 Federation of European Neuroscience Societies and John Wiley & Sons Ltd
Patients with both langerhans cell histiocytosis and crohn’s disease highlight a common role of interleukin-23
- Kvedaraite, Egle, Lourda, Magda, Han, Hong, Tesi, Biance, Mitchell, Jenée
- Authors: Kvedaraite, Egle , Lourda, Magda , Han, Hong , Tesi, Biance , Mitchell, Jenée
- Date: 2021
- Type: Text , Journal article
- Relation: Acta Paediatrica, International Journal of Paediatrics Vol. 110, no. 4 (2021), p. 1315-1321
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- Description: Aim: To present the first case series of patients with Langerhans cell histiocytosis (LCH) also affected by Crohn's disease (CD), both of which are granulomatous diseases, and in LCH investigate the role of interleukin (IL)-23, which is a well-described disease mediator in CD. Methods: A case series of three patients with LCH and CD were described; a cohort of LCH patients (n = 55) as well as controls (n = 55) were analysed for circulating IL-23 levels; and the relation between the percentage of LCH cells in lesions and circulating IL-23 levels was analysed in seven LCH patients. Results: Differential diagnostic challenges for these two granulomatous diseases were highlighted in the case series, and it took up to 3 years to diagnose CD. Elevated IL-23 levels were found in LCH patients. The amount of lesional LCH cells correlated with the levels of circulating IL-23. Conclusion: Both CD and LCH should be considered in patients with inflammatory gastrointestinal involvement. The IL-23 pathway is a common immunological trait between these two granulomatous diseases. ©2020 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica. ***Please note that there are multiple authors for this article therefore only the name of the first 5 including Federation University Australia affiliate “Jenée Mitchell” is provided in this record***
- Authors: Kvedaraite, Egle , Lourda, Magda , Han, Hong , Tesi, Biance , Mitchell, Jenée
- Date: 2021
- Type: Text , Journal article
- Relation: Acta Paediatrica, International Journal of Paediatrics Vol. 110, no. 4 (2021), p. 1315-1321
- Full Text:
- Reviewed:
- Description: Aim: To present the first case series of patients with Langerhans cell histiocytosis (LCH) also affected by Crohn's disease (CD), both of which are granulomatous diseases, and in LCH investigate the role of interleukin (IL)-23, which is a well-described disease mediator in CD. Methods: A case series of three patients with LCH and CD were described; a cohort of LCH patients (n = 55) as well as controls (n = 55) were analysed for circulating IL-23 levels; and the relation between the percentage of LCH cells in lesions and circulating IL-23 levels was analysed in seven LCH patients. Results: Differential diagnostic challenges for these two granulomatous diseases were highlighted in the case series, and it took up to 3 years to diagnose CD. Elevated IL-23 levels were found in LCH patients. The amount of lesional LCH cells correlated with the levels of circulating IL-23. Conclusion: Both CD and LCH should be considered in patients with inflammatory gastrointestinal involvement. The IL-23 pathway is a common immunological trait between these two granulomatous diseases. ©2020 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica. ***Please note that there are multiple authors for this article therefore only the name of the first 5 including Federation University Australia affiliate “Jenée Mitchell” is provided in this record***
Accounting for cryptic population substructure enhances detection of inbreeding depression with genomic inbreeding coefficients: an example from a critically endangered marsupial
- Zilko, Joseph, Harley, Dan, Hansen, Birgita, Pavlova, Alexandra, Sunnucks, Paul
- Authors: Zilko, Joseph , Harley, Dan , Hansen, Birgita , Pavlova, Alexandra , Sunnucks, Paul
- Date: 2020
- Type: Text , Journal article
- Relation: Molecular Ecology Vol. 29, no. 16 (2020), p. 2978-2993
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- Description: Characterizing inbreeding depression in wildlife populations can be critical to their conservation. Coefficients of individual inbreeding can be estimated from genome-wide marker data. The degree to which sensitivity of inbreeding coefficients to population genetic substructure alters estimates of inbreeding depression in wild populations is not well understood. Using generalized linear models, we tested the power of two frequently used inbreeding coefficients that are calculated from genome-wide SNP markers, FH and F^III, to predict four fitness traits estimated over two decades in an isolated population of the critically endangered Leadbeater's possum. FH estimates inbreeding as excess observed homozygotes relative to equilibrium expectations, whereas F^III quantifies allelic similarity between the gametes that formed an individual, and upweights rare homozygotes. We estimated FH and F^III from 1,575 genome-wide SNP loci in individuals with fitness trait data (N = 179–237 per trait), and computed revised coefficients, FHby group and F^IIIby group, adjusted for population genetic substructure by calculating them separately within two different genetic groups of individuals identified in the population. Using FH or F^III in the models, inbreeding depression was detected for survival to sexual maturity, longevity and whether individuals bred during their lifetime. F^IIIby group (but not FHby group) additionally revealed significant inbreeding depression for lifetime reproductive output (total offspring assigned to each individual). Estimates of numbers of lethal equivalents indicated substantial inbreeding load, but differing between inbreeding estimators. Inbreeding depression, declining population size, and low and declining genetic diversity suggest that genetic rescue may assist in preventing extinction of this unique Leadbeater's possum population. © 2020 John Wiley & Sons Ltd
- Authors: Zilko, Joseph , Harley, Dan , Hansen, Birgita , Pavlova, Alexandra , Sunnucks, Paul
- Date: 2020
- Type: Text , Journal article
- Relation: Molecular Ecology Vol. 29, no. 16 (2020), p. 2978-2993
- Full Text:
- Reviewed:
- Description: Characterizing inbreeding depression in wildlife populations can be critical to their conservation. Coefficients of individual inbreeding can be estimated from genome-wide marker data. The degree to which sensitivity of inbreeding coefficients to population genetic substructure alters estimates of inbreeding depression in wild populations is not well understood. Using generalized linear models, we tested the power of two frequently used inbreeding coefficients that are calculated from genome-wide SNP markers, FH and F^III, to predict four fitness traits estimated over two decades in an isolated population of the critically endangered Leadbeater's possum. FH estimates inbreeding as excess observed homozygotes relative to equilibrium expectations, whereas F^III quantifies allelic similarity between the gametes that formed an individual, and upweights rare homozygotes. We estimated FH and F^III from 1,575 genome-wide SNP loci in individuals with fitness trait data (N = 179–237 per trait), and computed revised coefficients, FHby group and F^IIIby group, adjusted for population genetic substructure by calculating them separately within two different genetic groups of individuals identified in the population. Using FH or F^III in the models, inbreeding depression was detected for survival to sexual maturity, longevity and whether individuals bred during their lifetime. F^IIIby group (but not FHby group) additionally revealed significant inbreeding depression for lifetime reproductive output (total offspring assigned to each individual). Estimates of numbers of lethal equivalents indicated substantial inbreeding load, but differing between inbreeding estimators. Inbreeding depression, declining population size, and low and declining genetic diversity suggest that genetic rescue may assist in preventing extinction of this unique Leadbeater's possum population. © 2020 John Wiley & Sons Ltd
Communities of practice : a systematic review and meta-synthesis of what it means and how it really works among nursing students and novices
- Terry, Daniel, Nguyen, Hoang, Peck, Blake, Smith, Andrew, Phan, Hoang
- Authors: Terry, Daniel , Nguyen, Hoang , Peck, Blake , Smith, Andrew , Phan, Hoang
- Date: 2020
- Type: Text , Journal article , Review
- Relation: Journal of Clinical Nursing Vol. 29, no. 3-4 (2020), p. 370-380
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- Description: Aims and objectives: To evaluate the enablers, barriers and impact that communities of practice have on novice nurses and students learning to become registered nurses. Background: Communities of practice have formed the basis for conceptualising the process of learning that occurs among groups of people within a place of work—a mainstay of healthcare practice. There is a dearth of literature that focuses specifically on the outcomes from student and novice engagement with existing communities of practice. Design: Systematic review and Meta-synthesis. Methods: MEDLINE, PubMed, EMBASE, CINAHL, ProQuest, Scopus and PsycINFO databases were accessed between 1997–2019. The screening and selection of studies were based on eligibility criteria and methodological quality assessment using the Critical Appraisal Skills Programme tool for qualitative research. Meta-synthesis was grounded in the original experiences and collectively synthesised into meaningful themes. The review follows the PRISMA reporting guidelines and PRISMA checklist. Results: The findings highlight three major themes and included enablers for successful communities of practice, barriers to successful communities of practice, and success in action as described by students and novice nurses. Discussion: We suggest successful communities of practice occur when safe and supported spaces ensure students and novices feel comfortable to experiment with their learning, and we emphasise the benefits of having more novice nurses situated within close proximity and under the direct influence of the established practices of more experienced or core group of peers. Relevance to clinical practice: Communities of practice that function successfully create an environment that prioritises the embedding of novices into the broader group. In so doing, students and novice nurses feel supported, welcomed, empowered, and able to make the transition from student to colleague and novice nurse to more experienced nurse. It allows them to experiment with ever new ways of fulfilling the role, while aiding better clinical outcomes. © 2019 John Wiley & Sons Ltd
- Authors: Terry, Daniel , Nguyen, Hoang , Peck, Blake , Smith, Andrew , Phan, Hoang
- Date: 2020
- Type: Text , Journal article , Review
- Relation: Journal of Clinical Nursing Vol. 29, no. 3-4 (2020), p. 370-380
- Full Text:
- Reviewed:
- Description: Aims and objectives: To evaluate the enablers, barriers and impact that communities of practice have on novice nurses and students learning to become registered nurses. Background: Communities of practice have formed the basis for conceptualising the process of learning that occurs among groups of people within a place of work—a mainstay of healthcare practice. There is a dearth of literature that focuses specifically on the outcomes from student and novice engagement with existing communities of practice. Design: Systematic review and Meta-synthesis. Methods: MEDLINE, PubMed, EMBASE, CINAHL, ProQuest, Scopus and PsycINFO databases were accessed between 1997–2019. The screening and selection of studies were based on eligibility criteria and methodological quality assessment using the Critical Appraisal Skills Programme tool for qualitative research. Meta-synthesis was grounded in the original experiences and collectively synthesised into meaningful themes. The review follows the PRISMA reporting guidelines and PRISMA checklist. Results: The findings highlight three major themes and included enablers for successful communities of practice, barriers to successful communities of practice, and success in action as described by students and novice nurses. Discussion: We suggest successful communities of practice occur when safe and supported spaces ensure students and novices feel comfortable to experiment with their learning, and we emphasise the benefits of having more novice nurses situated within close proximity and under the direct influence of the established practices of more experienced or core group of peers. Relevance to clinical practice: Communities of practice that function successfully create an environment that prioritises the embedding of novices into the broader group. In so doing, students and novice nurses feel supported, welcomed, empowered, and able to make the transition from student to colleague and novice nurse to more experienced nurse. It allows them to experiment with ever new ways of fulfilling the role, while aiding better clinical outcomes. © 2019 John Wiley & Sons Ltd
High-intensity drinking in adult Australian twins
- Dash, Genevieve, Davis, Christal, Martin, Nicholas, Statham, Dixie, Lynskey, Michael, Slutske, Wendy
- Authors: Dash, Genevieve , Davis, Christal , Martin, Nicholas , Statham, Dixie , Lynskey, Michael , Slutske, Wendy
- Date: 2020
- Type: Text , Journal article
- Relation: Alcoholism: clinical and experimental research Vol. 44, no. 2 (2020), p. 522-531
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- Description: Background: Many adult drinkers consume far beyond the binge threshold. This “high-intensity drinking” (HID), defined as 2 (HID-2) and 3 (HID-3) times the binge threshold, is of public health interest due to its role in acute alcohol-related harms. Research on HID has mostly been limited to college-aged young adults, focused on contextual factors, and neglected the potential role of genetic influences on the propensity to engage in HID. Methods: Structured diagnostic interviews assessing past-year alcohol involvement were conducted with 3,785 individuals (1,365 men, 2,420 women; Mage = 32, range = 21 to 46), including 3,314 twins and 471 nontwin siblings from the Australian Twin Registry. Multinomial logistic regression analyses were conducted to compare HID-2 and HID-3 to binge drinking on demographic correlates, drinking characteristics, and drinking-related consequences. Biometric modeling was conducted to estimate the role of genetic, common, and individual-specific environmental factors in HID propensity. Results: Among past-year drinkers, the prevalence of HID-2 and HID-3 was both 22%, with men disproportionally represented. The frequencies of drinking, intoxication, and binge drinking significantly increased across the heavier drinking categories, which also evidenced higher average consumption quantities and higher rates of alcohol-related consequences. The propensity to engage in HID was significantly heritable (A = 37% [95% CI: 28 to 46%]), with individual-specific environmental influences accounting for the remainder of the variance. Conclusions: This study convincingly demonstrates that HID is not restricted to college-aged young adults, but also can be highly prevalent among those of working age, and that the propensity to engage in HID is partially explained by genetic influences. © 2020 by the Research Society on Alcoholism
- Authors: Dash, Genevieve , Davis, Christal , Martin, Nicholas , Statham, Dixie , Lynskey, Michael , Slutske, Wendy
- Date: 2020
- Type: Text , Journal article
- Relation: Alcoholism: clinical and experimental research Vol. 44, no. 2 (2020), p. 522-531
- Full Text:
- Reviewed:
- Description: Background: Many adult drinkers consume far beyond the binge threshold. This “high-intensity drinking” (HID), defined as 2 (HID-2) and 3 (HID-3) times the binge threshold, is of public health interest due to its role in acute alcohol-related harms. Research on HID has mostly been limited to college-aged young adults, focused on contextual factors, and neglected the potential role of genetic influences on the propensity to engage in HID. Methods: Structured diagnostic interviews assessing past-year alcohol involvement were conducted with 3,785 individuals (1,365 men, 2,420 women; Mage = 32, range = 21 to 46), including 3,314 twins and 471 nontwin siblings from the Australian Twin Registry. Multinomial logistic regression analyses were conducted to compare HID-2 and HID-3 to binge drinking on demographic correlates, drinking characteristics, and drinking-related consequences. Biometric modeling was conducted to estimate the role of genetic, common, and individual-specific environmental factors in HID propensity. Results: Among past-year drinkers, the prevalence of HID-2 and HID-3 was both 22%, with men disproportionally represented. The frequencies of drinking, intoxication, and binge drinking significantly increased across the heavier drinking categories, which also evidenced higher average consumption quantities and higher rates of alcohol-related consequences. The propensity to engage in HID was significantly heritable (A = 37% [95% CI: 28 to 46%]), with individual-specific environmental influences accounting for the remainder of the variance. Conclusions: This study convincingly demonstrates that HID is not restricted to college-aged young adults, but also can be highly prevalent among those of working age, and that the propensity to engage in HID is partially explained by genetic influences. © 2020 by the Research Society on Alcoholism
Impacts of land management practices on blue carbon stocks and greenhouse gas fluxes in coastal ecosystems—a meta-analysis
- O’Connor, Jack, Fest, Benedikt, Sievers, Michael, Swearer, Stephen
- Authors: O’Connor, Jack , Fest, Benedikt , Sievers, Michael , Swearer, Stephen
- Date: 2020
- Type: Text , Journal article
- Relation: Global Change Biology Vol. 26, no. 3 (2020), p. 1354-1366
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- Description: Global recognition of climate change and its predicted consequences has created the need for practical management strategies for increasing the ability of natural ecosystems to capture and store atmospheric carbon. Mangrove forests, saltmarshes and seagrass meadows, referred to as blue carbon ecosystems (BCEs), are hotspots of atmospheric CO2 storage due to their capacity to sequester carbon at a far higher rate than terrestrial forests. Despite increased effort to understand the mechanisms underpinning blue carbon fluxes, there has been little synthesis of how management activities influence carbon stocks and greenhouse gas (GHG) fluxes in BCEs. Here, we present a global meta-analysis of 111 studies that measured how carbon stocks and GHG fluxes in BCEs respond to various coastal management strategies. Research effort has focused mainly on restoration approaches, which resulted in significant increases in blue carbon after 4 years compared to degraded sites, and the potential to reach parity with natural sites after 7–17 years. Lesser studied management alternatives, such as sediment manipulation and altered hydrology, showed only increases in biomass and weaker responses for soil carbon stocks and sequestration. The response of GHG emissions to management was complex, with managed sites emitting less than natural reference sites but emitting more compared to degraded sites. Individual GHGs also differed in their responses to management. To date, blue carbon management studies are underrepresented in the southern hemisphere and are usually limited in duration (61% of studies <3 years duration). Our meta-analysis describes the current state of blue carbon management from the available data and highlights recommendations for prioritizing conservation management, extending monitoring time frames of BCE carbon stocks, improving our understanding of GHG fluxes in open coastal systems and redistributing management and research effort into understudied, high-risk areas. © 2019 John Wiley & Sons Ltd
- Authors: O’Connor, Jack , Fest, Benedikt , Sievers, Michael , Swearer, Stephen
- Date: 2020
- Type: Text , Journal article
- Relation: Global Change Biology Vol. 26, no. 3 (2020), p. 1354-1366
- Full Text:
- Reviewed:
- Description: Global recognition of climate change and its predicted consequences has created the need for practical management strategies for increasing the ability of natural ecosystems to capture and store atmospheric carbon. Mangrove forests, saltmarshes and seagrass meadows, referred to as blue carbon ecosystems (BCEs), are hotspots of atmospheric CO2 storage due to their capacity to sequester carbon at a far higher rate than terrestrial forests. Despite increased effort to understand the mechanisms underpinning blue carbon fluxes, there has been little synthesis of how management activities influence carbon stocks and greenhouse gas (GHG) fluxes in BCEs. Here, we present a global meta-analysis of 111 studies that measured how carbon stocks and GHG fluxes in BCEs respond to various coastal management strategies. Research effort has focused mainly on restoration approaches, which resulted in significant increases in blue carbon after 4 years compared to degraded sites, and the potential to reach parity with natural sites after 7–17 years. Lesser studied management alternatives, such as sediment manipulation and altered hydrology, showed only increases in biomass and weaker responses for soil carbon stocks and sequestration. The response of GHG emissions to management was complex, with managed sites emitting less than natural reference sites but emitting more compared to degraded sites. Individual GHGs also differed in their responses to management. To date, blue carbon management studies are underrepresented in the southern hemisphere and are usually limited in duration (61% of studies <3 years duration). Our meta-analysis describes the current state of blue carbon management from the available data and highlights recommendations for prioritizing conservation management, extending monitoring time frames of BCE carbon stocks, improving our understanding of GHG fluxes in open coastal systems and redistributing management and research effort into understudied, high-risk areas. © 2019 John Wiley & Sons Ltd
Increased susceptibility to Haemonchus contortus infection by interleukin-5 modulation of eosinophil responses in sheep
- Hernández, Julia, Meeusen, Els, Rodríguez, Francisco, Piedrafita, David, González, Jorge
- Authors: Hernández, Julia , Meeusen, Els , Rodríguez, Francisco , Piedrafita, David , González, Jorge
- Date: 2020
- Type: Text , Journal article
- Relation: Parasite Immunology Vol. 42, no. 1 (2020), p.
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- Description: Eosinophils are prominent effector cells in immune responses against gastrointestinal nematode infections in ruminants, but their in vivo role has been hard to establish in large animals. Interleukin-5 is a key cytokine in the induction and stimulation of anti-parasitic eosinophil responses. This study attempted to modulate the eosinophil response in sheep through vaccination with recombinant interleukin-5 (rIL-5) and determine the effect on subsequent Haemonchus contortus infection. Nematode-resistant Canaria Hair Breed (CHB) sheep vaccinated with rIL-5 in Quil-A adjuvant, had lower blood eosinophil counts and higher mean worm burdens than control sheep vaccinated with Quil-A adjuvant alone. In addition, adult worms in IL-5-vaccinated sheep were significantly longer with higher eggs in utero in female worms, supporting an active role of eosinophils against adult parasites in CHB sheep. These results confirm that eosinophils can play a direct role in effective control of H contortus infection in sheep and offer a new approach to study immune responses in ruminants. © 2019 John Wiley & Sons Ltd
- Authors: Hernández, Julia , Meeusen, Els , Rodríguez, Francisco , Piedrafita, David , González, Jorge
- Date: 2020
- Type: Text , Journal article
- Relation: Parasite Immunology Vol. 42, no. 1 (2020), p.
- Full Text:
- Reviewed:
- Description: Eosinophils are prominent effector cells in immune responses against gastrointestinal nematode infections in ruminants, but their in vivo role has been hard to establish in large animals. Interleukin-5 is a key cytokine in the induction and stimulation of anti-parasitic eosinophil responses. This study attempted to modulate the eosinophil response in sheep through vaccination with recombinant interleukin-5 (rIL-5) and determine the effect on subsequent Haemonchus contortus infection. Nematode-resistant Canaria Hair Breed (CHB) sheep vaccinated with rIL-5 in Quil-A adjuvant, had lower blood eosinophil counts and higher mean worm burdens than control sheep vaccinated with Quil-A adjuvant alone. In addition, adult worms in IL-5-vaccinated sheep were significantly longer with higher eggs in utero in female worms, supporting an active role of eosinophils against adult parasites in CHB sheep. These results confirm that eosinophils can play a direct role in effective control of H contortus infection in sheep and offer a new approach to study immune responses in ruminants. © 2019 John Wiley & Sons Ltd
Occupational stress facing nurse academics—A mixed-methods systematic review
- Singh, Charanjit, Cross, Wendy, Munro, Ian, Jackson, Debra
- Authors: Singh, Charanjit , Cross, Wendy , Munro, Ian , Jackson, Debra
- Date: 2020
- Type: Text , Journal article , Review
- Relation: Journal of Clinical Nursing Vol. 29, no. 5-6 (2020), p. 720-735
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- Description: Aim: To better understand occupational stress faced by nurse academics. Methods: A mixed-methods systematic review, following the Joanna Briggs Institute [JBI], (Joanna Briggs Institute Reviewers’ Manual: 2014 edition, 2014) process. Studies were assessed for quality and risk of bias by using standardised critical appraisal instruments from the Joanna Briggs Institute. In addition, processes and reporting were checked against the Equator guidelines. See Appendix S1. Results: The review revealed that nursing academics do experience occupational stress, including burnout. Occupational stress for academic nurses is associated with various factors including work–life balance, workload issues, resources and support, and adapting to change. However, much of the literature focuses on nurses during the initial transition from clinical to academic environment, with rather less focus on established mid-to-late career nurse academics. Discussion: Occupational stress and burnout are evident in the university academic workforce, adversely affecting the well-being of academic nurses, and the long-term sustainability of the academic nursing workforce. While there is considerable literature focusing on the novice academic nurse, particularly during the transition period, rather less is known about occupational stress among academic nurses across the career trajectory. Various strategies to deal with the negative consequences of occupational stress are identified, including (a) quality mentors for novice and younger nursing academics; (b) training in resilience building for novice academics; (c) supporting collegial relationships and reducing bullying; (d) assistance for professional development and research; (e) better support and resources to overcome increasing workloads; and (f) greater work-related empowerment to enhance job satisfaction. Conclusion: There is a need for a broader whole-of-career research focus to more fully identify, explore and mitigate the occupational stressors that negatively affect the academic nurse workforce. Relevance to clinical practice: A strong and resilient academic nurse workforce is essential for the sustainability of the profession. Organisations should review their work practices and provide greater work-related empowerment to reduce occupational stressors among nursing academics. © 2019 John Wiley & Sons Ltd
- Authors: Singh, Charanjit , Cross, Wendy , Munro, Ian , Jackson, Debra
- Date: 2020
- Type: Text , Journal article , Review
- Relation: Journal of Clinical Nursing Vol. 29, no. 5-6 (2020), p. 720-735
- Full Text:
- Reviewed:
- Description: Aim: To better understand occupational stress faced by nurse academics. Methods: A mixed-methods systematic review, following the Joanna Briggs Institute [JBI], (Joanna Briggs Institute Reviewers’ Manual: 2014 edition, 2014) process. Studies were assessed for quality and risk of bias by using standardised critical appraisal instruments from the Joanna Briggs Institute. In addition, processes and reporting were checked against the Equator guidelines. See Appendix S1. Results: The review revealed that nursing academics do experience occupational stress, including burnout. Occupational stress for academic nurses is associated with various factors including work–life balance, workload issues, resources and support, and adapting to change. However, much of the literature focuses on nurses during the initial transition from clinical to academic environment, with rather less focus on established mid-to-late career nurse academics. Discussion: Occupational stress and burnout are evident in the university academic workforce, adversely affecting the well-being of academic nurses, and the long-term sustainability of the academic nursing workforce. While there is considerable literature focusing on the novice academic nurse, particularly during the transition period, rather less is known about occupational stress among academic nurses across the career trajectory. Various strategies to deal with the negative consequences of occupational stress are identified, including (a) quality mentors for novice and younger nursing academics; (b) training in resilience building for novice academics; (c) supporting collegial relationships and reducing bullying; (d) assistance for professional development and research; (e) better support and resources to overcome increasing workloads; and (f) greater work-related empowerment to enhance job satisfaction. Conclusion: There is a need for a broader whole-of-career research focus to more fully identify, explore and mitigate the occupational stressors that negatively affect the academic nurse workforce. Relevance to clinical practice: A strong and resilient academic nurse workforce is essential for the sustainability of the profession. Organisations should review their work practices and provide greater work-related empowerment to reduce occupational stressors among nursing academics. © 2019 John Wiley & Sons Ltd
Traits reveal ecological strategies driving carrion insect community assembly
- Evans, Maldwyn, Wallman, James, Barton, Philip
- Authors: Evans, Maldwyn , Wallman, James , Barton, Philip
- Date: 2020
- Type: Text , Journal article
- Relation: Ecological Entomology Vol. 45, no. 5 (2020), p. 966-977
- Full Text:
- Reviewed:
- Description: 1. The succession of carrion-associated (necrophilous) insects on decomposing carrion is well documented. To exploit the changing nutritious and dynamic resources available throughout the carrion decomposition process, different species colonise and consume carrion in a predictable temporal sequence. The traits of these necrophilous insects should reflect their ecological strategies. Morphological traits of these insects, such as body size and wing size, however, have not previously been examined during active and advanced decomposition. 2. We used fourth-corner multivariate generalised linear models to identify insect community morphological trait patterns and to quantify their change through time on decomposing rabbit carcasses in grassland and woodland environments. 3. We found that larger-bodied species of flies and carrion-specialist beetles were associated with the early stages of decomposition. The morphological traits of ants, in contrast, showed no changes at carcasses through time and instead showed body size differences between grassland and woodland environments. 4. Our findings indicate that specialist flies and beetles that arrive early in the decomposition process possess traits that enable rapid discovery of carrion at a large scale. Generalist beetles and ants do not share this same trait and are instead adapted to locate and consume a wider variety of resources in their preferred habitat type at their local scale. 5. Our results provide insights into the morphological adaptations linked to the ecological strategies of distinct components of carrion insect communities. Further, our results offer insights into the community assembly dynamics that structure the communities of necrophilous insect species. © 2020 The Royal Entomological Society
- Authors: Evans, Maldwyn , Wallman, James , Barton, Philip
- Date: 2020
- Type: Text , Journal article
- Relation: Ecological Entomology Vol. 45, no. 5 (2020), p. 966-977
- Full Text:
- Reviewed:
- Description: 1. The succession of carrion-associated (necrophilous) insects on decomposing carrion is well documented. To exploit the changing nutritious and dynamic resources available throughout the carrion decomposition process, different species colonise and consume carrion in a predictable temporal sequence. The traits of these necrophilous insects should reflect their ecological strategies. Morphological traits of these insects, such as body size and wing size, however, have not previously been examined during active and advanced decomposition. 2. We used fourth-corner multivariate generalised linear models to identify insect community morphological trait patterns and to quantify their change through time on decomposing rabbit carcasses in grassland and woodland environments. 3. We found that larger-bodied species of flies and carrion-specialist beetles were associated with the early stages of decomposition. The morphological traits of ants, in contrast, showed no changes at carcasses through time and instead showed body size differences between grassland and woodland environments. 4. Our findings indicate that specialist flies and beetles that arrive early in the decomposition process possess traits that enable rapid discovery of carrion at a large scale. Generalist beetles and ants do not share this same trait and are instead adapted to locate and consume a wider variety of resources in their preferred habitat type at their local scale. 5. Our results provide insights into the morphological adaptations linked to the ecological strategies of distinct components of carrion insect communities. Further, our results offer insights into the community assembly dynamics that structure the communities of necrophilous insect species. © 2020 The Royal Entomological Society
Apprenticeships and ‘future work’ : are we ready?
- Authors: Smith, Erica
- Date: 2019
- Type: Text , Journal article
- Relation: International Journal of Training and Development Vol. 23, no. 1 (2019), p. 69-88
- Full Text:
- Reviewed:
- Description: The paper evaluates the readiness of apprenticeship systems to cope with five major developments affecting the future of work. The institution of apprenticeship has evolved over time in all countries, gradually adapting to changes in industrial processes, the economy, the labour market and education systems. This paper suggests, however, that recent changes in the economy and the labour market, and their concomitant effects on the likely future of work, have the potential to disrupt apprenticeship systems quite radically worldwide, and/or to make them less relevant in the 21st century. The paper draws on data from recent Australian and international research projects undertaken by the author, as well as the author’s engagement in Australian government exercises to discuss the future of apprenticeships. The research found that adaptations of systems and processes were being undertaken at company level and by stakeholders such as trade union or employer peak bodies. They were less frequently apparent, however, in government policy. The paper analyses the data to produce a framework of readiness for ‘future work’, but also queries whether adaptation of apprenticeship systems is necessarily desirable in all instances. Although the presence of multiple stakeholders in the system has previously been viewed as a strength of the system, it can also make even minor changes difficult to implement. This could prove to be a major impediment to apprenticeship’s future or could be a means of preserving its essential features. © 2019 Brian Towers (BRITOW) and John Wiley & Sons Ltd.
- Description: International Labour Organization, ILO with the assistance of the JP Morgan Chase Foundation.
- Authors: Smith, Erica
- Date: 2019
- Type: Text , Journal article
- Relation: International Journal of Training and Development Vol. 23, no. 1 (2019), p. 69-88
- Full Text:
- Reviewed:
- Description: The paper evaluates the readiness of apprenticeship systems to cope with five major developments affecting the future of work. The institution of apprenticeship has evolved over time in all countries, gradually adapting to changes in industrial processes, the economy, the labour market and education systems. This paper suggests, however, that recent changes in the economy and the labour market, and their concomitant effects on the likely future of work, have the potential to disrupt apprenticeship systems quite radically worldwide, and/or to make them less relevant in the 21st century. The paper draws on data from recent Australian and international research projects undertaken by the author, as well as the author’s engagement in Australian government exercises to discuss the future of apprenticeships. The research found that adaptations of systems and processes were being undertaken at company level and by stakeholders such as trade union or employer peak bodies. They were less frequently apparent, however, in government policy. The paper analyses the data to produce a framework of readiness for ‘future work’, but also queries whether adaptation of apprenticeship systems is necessarily desirable in all instances. Although the presence of multiple stakeholders in the system has previously been viewed as a strength of the system, it can also make even minor changes difficult to implement. This could prove to be a major impediment to apprenticeship’s future or could be a means of preserving its essential features. © 2019 Brian Towers (BRITOW) and John Wiley & Sons Ltd.
- Description: International Labour Organization, ILO with the assistance of the JP Morgan Chase Foundation.
By design : professional learning ecologies to develop primary school teachers’ makerspaces pedagogical capabilities
- Stevenson, Michael, Bower, Matt, Falloon, Garry, Forbes, Anne, Hatzigianni, Maria
- Authors: Stevenson, Michael , Bower, Matt , Falloon, Garry , Forbes, Anne , Hatzigianni, Maria
- Date: 2019
- Type: Text , Journal article
- Relation: British Journal of Educational Technology Vol. 50, no. 3 (2019), p. 1260-1274
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- Description: Makerspaces embody a growing movement of educators promoting constructionist learning with physical materials and digital technologies such as 3D design and 3D printing. As it gains traction in K-12 settings, the maker movement represents an interesting context in which to explore how professional ecologies can equip teachers with the knowledge, skills and dispositions needed to implement twenty-first century learning in their school context. This study investigated the roles of different participants from industry, school leadership and colleagues in influencing teachers’ confidence, enthusiasm, capabilities and beliefs when teaching in makerspaces. Utilising triangulated observations of activities through online questionnaires at beginning, middle and end points, as well as postproject interviews, the study explored the participation of 27 primary school teachers in a blended professional learning programme, followed by classroom delivery of modules focusing on tablet-based 3D design applications and the use of newly instaled 3D printers. Reporting no prior knowledge or experience with makerspaces, quantitative analyses revealed significant increases in teachers’ confidence and enthusiasm. Qualitative analyses of questionnaire and interview data underscored the influence of hands-on and theoretically grounded professional learning providing practical exposure to constructionist ideas, design thinking methodologies and 3D design technologies. Findings reveal the importance of targeted professional learning coupled with a substantial collegially supported implementation phase, as well as support from school leaders and industry partners to promote meaningful pedagogical change in technology-mediated maker-based learning. © 2019 British Educational Research Association
- Authors: Stevenson, Michael , Bower, Matt , Falloon, Garry , Forbes, Anne , Hatzigianni, Maria
- Date: 2019
- Type: Text , Journal article
- Relation: British Journal of Educational Technology Vol. 50, no. 3 (2019), p. 1260-1274
- Full Text:
- Reviewed:
- Description: Makerspaces embody a growing movement of educators promoting constructionist learning with physical materials and digital technologies such as 3D design and 3D printing. As it gains traction in K-12 settings, the maker movement represents an interesting context in which to explore how professional ecologies can equip teachers with the knowledge, skills and dispositions needed to implement twenty-first century learning in their school context. This study investigated the roles of different participants from industry, school leadership and colleagues in influencing teachers’ confidence, enthusiasm, capabilities and beliefs when teaching in makerspaces. Utilising triangulated observations of activities through online questionnaires at beginning, middle and end points, as well as postproject interviews, the study explored the participation of 27 primary school teachers in a blended professional learning programme, followed by classroom delivery of modules focusing on tablet-based 3D design applications and the use of newly instaled 3D printers. Reporting no prior knowledge or experience with makerspaces, quantitative analyses revealed significant increases in teachers’ confidence and enthusiasm. Qualitative analyses of questionnaire and interview data underscored the influence of hands-on and theoretically grounded professional learning providing practical exposure to constructionist ideas, design thinking methodologies and 3D design technologies. Findings reveal the importance of targeted professional learning coupled with a substantial collegially supported implementation phase, as well as support from school leaders and industry partners to promote meaningful pedagogical change in technology-mediated maker-based learning. © 2019 British Educational Research Association
Employer training in Australia : Current practices and concerns
- Smith, Erica, Callan, Victor, Tuck, Jacquiline, Smith, Andy
- Authors: Smith, Erica , Callan, Victor , Tuck, Jacquiline , Smith, Andy
- Date: 2019
- Type: Text , Journal article
- Relation: International Journal of Training and Development Vol. 23, no. 2 (2019), p. 169-183
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- Description: This paper presents and analyses results from a research project on current trends in employer training in Australia. While the formal vocational education and training (VET) system is well-researched, the everyday training that happens in workplaces is relatively under-researched in Australia. Using some of the results of an employer survey undertaken in 2015, the paper describes and analyses employer-based training across a range of industry areas. The survey included groups of questions on a range of matters, including the reasons why employers train, and how these relate to employers' perceptions of their operating environment, and the structures they have in place to manage and organize training. Detailed data are provided about three specific forms of training: in-house training and learning; the use that employers make of external providers of training; and employers' use of nationally recognised training - training from the VET system. Finally the paper reports what managers said about the barriers to providing more training. The paper analyses the findings in relation to the literature and also identified changes over time in training practices in Australian companies. Implications for training policy and practice, as well as for future research, are identified.
- Authors: Smith, Erica , Callan, Victor , Tuck, Jacquiline , Smith, Andy
- Date: 2019
- Type: Text , Journal article
- Relation: International Journal of Training and Development Vol. 23, no. 2 (2019), p. 169-183
- Full Text:
- Reviewed:
- Description: This paper presents and analyses results from a research project on current trends in employer training in Australia. While the formal vocational education and training (VET) system is well-researched, the everyday training that happens in workplaces is relatively under-researched in Australia. Using some of the results of an employer survey undertaken in 2015, the paper describes and analyses employer-based training across a range of industry areas. The survey included groups of questions on a range of matters, including the reasons why employers train, and how these relate to employers' perceptions of their operating environment, and the structures they have in place to manage and organize training. Detailed data are provided about three specific forms of training: in-house training and learning; the use that employers make of external providers of training; and employers' use of nationally recognised training - training from the VET system. Finally the paper reports what managers said about the barriers to providing more training. The paper analyses the findings in relation to the literature and also identified changes over time in training practices in Australian companies. Implications for training policy and practice, as well as for future research, are identified.
Exposing the impact of intensive advice services on health : a realist evaluation
- Dalkin, Sonia, Forster, Natalie, Hodgson, Philip, Lhussier, Monique, Philipson, Pete, Carr, Susan
- Authors: Dalkin, Sonia , Forster, Natalie , Hodgson, Philip , Lhussier, Monique , Philipson, Pete , Carr, Susan
- Date: 2019
- Type: Text , Journal article
- Relation: Health and Social Care in the Community Vol. 27, no. 3 (2019), p. 767-776
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- Description: Attention has turned to welfare advice as a potential health and social care intervention. However, establishing direct evidence of health impact has proven difficult. This is compounded by the need to understand both the facilitative contexts and mechanisms through which this impact occurs. This study investigated if, how and in which circumstances an intensive advice service had an impact on stress and well-being (as precursors to health impacts), for clients attending a branch of Citizens Advice, located in the North East of England. A mixed methods realist evaluation of three intensive advice services offered by Citizens Advice (CA) was operationalised in five phases: (a) Building programme theories, (b) refining programme theories, (c) Development of a data recording tool, (d) Testing programme theories with empirical data, (e) Impact interviews. This paper focuses on phase 4. The Warwick Edinburgh Mental Wellbeing Scale (WEMWBS) and Perceived Stress Scale (PSS) were completed by 191 clients, with a 91% follow-up rate (data collected: February 2016 to March 2017). Twenty-two CA clients participated in interviews (data collected: October 2015 to November 2016). The PSS indicated a significant decrease in stress from initial consultation to approximately 4–6 weeks post advice from 31.4 to 10.3 (p < 0.001) and the WEMWBS indicated a significant increase in client well-being from a mean of 26.9 to 46.5 (p < 0.001). Nine refined programme theories are presented which combine the qualitative and quantitative analysis; they are underpinned by three abstract theories: Capabilities model, The Decision to Trust Model, and Third Space. An explanatory framework is presented covering the micro, meso, and macro levels of CA. Use of a stress and well-being lens has allowed insight into the precursors of health in those receiving intensive advice. Using these measures whilst explaining contextual and mechanistic properties, begins to build a complex and real picture of how advice services impact on health. © 2018 John Wiley & Sons Ltd
- Authors: Dalkin, Sonia , Forster, Natalie , Hodgson, Philip , Lhussier, Monique , Philipson, Pete , Carr, Susan
- Date: 2019
- Type: Text , Journal article
- Relation: Health and Social Care in the Community Vol. 27, no. 3 (2019), p. 767-776
- Full Text:
- Reviewed:
- Description: Attention has turned to welfare advice as a potential health and social care intervention. However, establishing direct evidence of health impact has proven difficult. This is compounded by the need to understand both the facilitative contexts and mechanisms through which this impact occurs. This study investigated if, how and in which circumstances an intensive advice service had an impact on stress and well-being (as precursors to health impacts), for clients attending a branch of Citizens Advice, located in the North East of England. A mixed methods realist evaluation of three intensive advice services offered by Citizens Advice (CA) was operationalised in five phases: (a) Building programme theories, (b) refining programme theories, (c) Development of a data recording tool, (d) Testing programme theories with empirical data, (e) Impact interviews. This paper focuses on phase 4. The Warwick Edinburgh Mental Wellbeing Scale (WEMWBS) and Perceived Stress Scale (PSS) were completed by 191 clients, with a 91% follow-up rate (data collected: February 2016 to March 2017). Twenty-two CA clients participated in interviews (data collected: October 2015 to November 2016). The PSS indicated a significant decrease in stress from initial consultation to approximately 4–6 weeks post advice from 31.4 to 10.3 (p < 0.001) and the WEMWBS indicated a significant increase in client well-being from a mean of 26.9 to 46.5 (p < 0.001). Nine refined programme theories are presented which combine the qualitative and quantitative analysis; they are underpinned by three abstract theories: Capabilities model, The Decision to Trust Model, and Third Space. An explanatory framework is presented covering the micro, meso, and macro levels of CA. Use of a stress and well-being lens has allowed insight into the precursors of health in those receiving intensive advice. Using these measures whilst explaining contextual and mechanistic properties, begins to build a complex and real picture of how advice services impact on health. © 2018 John Wiley & Sons Ltd
Factors contributing to COPD hospitalisations from 2010 to 2015 : Variation among rural and metropolitan Australians
- Terry, Daniel, Nguyen, Hoang, Kim, Jeong-Ah, Islam, Rafiqul
- Authors: Terry, Daniel , Nguyen, Hoang , Kim, Jeong-Ah , Islam, Rafiqul
- Date: 2019
- Type: Text , Journal article
- Relation: Clinical Respiratory Journal Vol. 13, no. 5 (2019), p. 306-313
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- Reviewed:
- Description: Introduction: Rural and remote populations experience the greatest burden of chronic obstructive pulmonary disease (COPD), the fifth leading cause of death in Australia. Currently there is a need to prioritise health services to improve health outcomes among those at higher risk of COPD. Objectives: To investigate the differences in COPD hospitalisation between rural and urban populations and determine predictive factors contributing to COPD hospitalisation. Methods: Statewide hospitalisation data from 2010 to 2015 were obtained through the Victorian Admitted Episodes Dataset and other key data sets. The rates of hospitalisation were analysed using hierarchical multiple regression to examine the association between COPD hospitalisations and a number of predictor variables. Results: The highest COPD incidence occurred in metropolitan males aged 85 years of age and older (35.092 hospitalisations per 1000 population). Among metropolitan residents, smoking, population density and household income had a significant association with COPD hospitalisations for both sexes. Among rural males, smoking rates, household income and rural land use (farming) were significant predictors of COPD hospitalisations. There was an overall stability in statewide COPD hospitalisation over the 5 years to 2015, P = 0.420. Conclusion: This investigation highlights many rural and regional areas have much lower COPD hospitalisation rates than metropolitan areas. Between males and females, there are heterogenetic factors that contribute to the significant variation associated with COPD hospitalisation in metropolitan and rural areas, such as rural land use among rural males. This indicates that risk factor assessments, beyond smoking alone, need to be individualised and prioritised in practice to optimise care.
- Authors: Terry, Daniel , Nguyen, Hoang , Kim, Jeong-Ah , Islam, Rafiqul
- Date: 2019
- Type: Text , Journal article
- Relation: Clinical Respiratory Journal Vol. 13, no. 5 (2019), p. 306-313
- Full Text:
- Reviewed:
- Description: Introduction: Rural and remote populations experience the greatest burden of chronic obstructive pulmonary disease (COPD), the fifth leading cause of death in Australia. Currently there is a need to prioritise health services to improve health outcomes among those at higher risk of COPD. Objectives: To investigate the differences in COPD hospitalisation between rural and urban populations and determine predictive factors contributing to COPD hospitalisation. Methods: Statewide hospitalisation data from 2010 to 2015 were obtained through the Victorian Admitted Episodes Dataset and other key data sets. The rates of hospitalisation were analysed using hierarchical multiple regression to examine the association between COPD hospitalisations and a number of predictor variables. Results: The highest COPD incidence occurred in metropolitan males aged 85 years of age and older (35.092 hospitalisations per 1000 population). Among metropolitan residents, smoking, population density and household income had a significant association with COPD hospitalisations for both sexes. Among rural males, smoking rates, household income and rural land use (farming) were significant predictors of COPD hospitalisations. There was an overall stability in statewide COPD hospitalisation over the 5 years to 2015, P = 0.420. Conclusion: This investigation highlights many rural and regional areas have much lower COPD hospitalisation rates than metropolitan areas. Between males and females, there are heterogenetic factors that contribute to the significant variation associated with COPD hospitalisation in metropolitan and rural areas, such as rural land use among rural males. This indicates that risk factor assessments, beyond smoking alone, need to be individualised and prioritised in practice to optimise care.
Locating “gold standard” evidence for simulation as a substitute for clinical practice in prelicensure health professional education : a systematic review
- Bogossian, Fiona, Cant, Robyn, Ballard, Emma, Cooper, Simon, Levett-Jones, Tracy, McKenna, Lisa, Ng, Linda, Seaton, Phillippa
- Authors: Bogossian, Fiona , Cant, Robyn , Ballard, Emma , Cooper, Simon , Levett-Jones, Tracy , McKenna, Lisa , Ng, Linda , Seaton, Phillippa
- Date: 2019
- Type: Text , Journal article , Review
- Relation: Journal of Clinical Nursing Vol. 28, no. 21-22 (2019), p. 3759-3775
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- Description: Aims and objectives: To extract, examine and report the highest available levels of evidence from healthcare disciplines in the use of simulation-based education as substitution for clinical placement in prelicensure programmes. Background: Simulation is widely employed across prelicensure health professional education to create safe, realistic clinical learning experiences for students. Whether simulation can be employed to substitute for actual clinical placement, and if so, in what proportion, replacement ratio and duration, is unclear. Methods: A systematic review and quality appraisal of primary studies related to prelicensure students in all health disciplines, guided by the PRISMA checklist. Results: Ten primary studies were included, representing 2,370 students from three health disciplines in four countries. Nine studies were experimental and quasi-experimental and methodological quality was assessed as moderate to high with good to very good inter-rater agreement. Direct substitution of simulation for clinical practice ranged from 5% to 50%. With one exception, replacement ratios were 1:1 and duration of replacement ranged from 21 hr–2 years. Levels of evaluation included measures of reaction, knowledge and behaviour transfer; no negative outcomes were reported. We appraised practicalities for design of substitution, design limitations and knowledge transfer to accreditation standards for prelicensure programmes. Conclusions: This review synthesised highest levels and quality of available evidence for substitution of simulation for clinical placement in health professional education. Included studies were heterogenous in simulation interventions (proportion, ratio and duration) and in the evaluation of outcomes. Future studies should incorporate standardised simulation curricula, widen the health professions represented and strengthen experimental designs. Relevance to clinical practice: Current evidence for clinical educational preparation does not appear to be translated into programme accreditation standards governing clinical practice experience for prelicensure programmes in relevant jurisdictions. Overall, a stronger evidence base is necessary to inform future curricula and policy development, to strengthen clinical practice in health. © 2019 John Wiley & Sons Ltd
- Authors: Bogossian, Fiona , Cant, Robyn , Ballard, Emma , Cooper, Simon , Levett-Jones, Tracy , McKenna, Lisa , Ng, Linda , Seaton, Phillippa
- Date: 2019
- Type: Text , Journal article , Review
- Relation: Journal of Clinical Nursing Vol. 28, no. 21-22 (2019), p. 3759-3775
- Full Text:
- Reviewed:
- Description: Aims and objectives: To extract, examine and report the highest available levels of evidence from healthcare disciplines in the use of simulation-based education as substitution for clinical placement in prelicensure programmes. Background: Simulation is widely employed across prelicensure health professional education to create safe, realistic clinical learning experiences for students. Whether simulation can be employed to substitute for actual clinical placement, and if so, in what proportion, replacement ratio and duration, is unclear. Methods: A systematic review and quality appraisal of primary studies related to prelicensure students in all health disciplines, guided by the PRISMA checklist. Results: Ten primary studies were included, representing 2,370 students from three health disciplines in four countries. Nine studies were experimental and quasi-experimental and methodological quality was assessed as moderate to high with good to very good inter-rater agreement. Direct substitution of simulation for clinical practice ranged from 5% to 50%. With one exception, replacement ratios were 1:1 and duration of replacement ranged from 21 hr–2 years. Levels of evaluation included measures of reaction, knowledge and behaviour transfer; no negative outcomes were reported. We appraised practicalities for design of substitution, design limitations and knowledge transfer to accreditation standards for prelicensure programmes. Conclusions: This review synthesised highest levels and quality of available evidence for substitution of simulation for clinical placement in health professional education. Included studies were heterogenous in simulation interventions (proportion, ratio and duration) and in the evaluation of outcomes. Future studies should incorporate standardised simulation curricula, widen the health professions represented and strengthen experimental designs. Relevance to clinical practice: Current evidence for clinical educational preparation does not appear to be translated into programme accreditation standards governing clinical practice experience for prelicensure programmes in relevant jurisdictions. Overall, a stronger evidence base is necessary to inform future curricula and policy development, to strengthen clinical practice in health. © 2019 John Wiley & Sons Ltd
The use and utility of surrogates in biodiversity monitoring programmes
- Sato, Chloe, Westgate, Martin, Barton, Philip, Foster, Claire, O'Loughlin, Luke
- Authors: Sato, Chloe , Westgate, Martin , Barton, Philip , Foster, Claire , O'Loughlin, Luke
- Date: 2019
- Type: Text , Journal article
- Relation: Journal of Applied Ecology Vol. 56, no. 6 (2019), p. 1304-1310
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- Reviewed:
- Description: **Please note that there are multiple authors for this article therefore only the name of the first 5 including Federation University Australia affiliate “Philip Barton” is provided in this record**
- Authors: Sato, Chloe , Westgate, Martin , Barton, Philip , Foster, Claire , O'Loughlin, Luke
- Date: 2019
- Type: Text , Journal article
- Relation: Journal of Applied Ecology Vol. 56, no. 6 (2019), p. 1304-1310
- Full Text:
- Reviewed:
- Description: **Please note that there are multiple authors for this article therefore only the name of the first 5 including Federation University Australia affiliate “Philip Barton” is provided in this record**
A long-term habitat fragmentation experiment leads to morphological change in a species of carabid beetle
- Evans, Maldwyn, Banks, Sam, Barton, Philip, Davies, Kendi, Driscoll, Don
- Authors: Evans, Maldwyn , Banks, Sam , Barton, Philip , Davies, Kendi , Driscoll, Don
- Date: 2018
- Type: Text , Journal article
- Relation: Ecological Entomology Vol. 43, no. 3 (2018), p. 282-293
- Full Text:
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- Description: 1. Habitat fragmentation and transformation are key drivers of species declines in landscapes. Most of the current understanding of species' responses to environmental change originates from studies of populations and communities. However, phenotypic variation offers another key aspect of species responses and could provide additional insights into the functional drivers of population change. 2. The goal of this study was to address this gap by exploring the morphological changes of a species of carabid beetle (Notonomus resplendens) with a known population response to the Wog Wog Habitat Fragmentation Experiment in Australia. We measured morphological traits associated with body size, head width, and dispersal ability. We quantified patterns of morphological variation over time and between native Eucalyptus forest fragments and the surrounding pine plantation matrix and the continuous intact native Eucalyptus forest controls. 3. We found sexually dimorphic morphological changes in response to the experimental treatments. Males increased in size, had larger legs and had smaller interocular widths in the matrix in both the short and long terms. Conversely, females became comparatively smaller and had increased interocular widths in the same treatments. Effects in the fragments were similar to those in the matrix, but exhibited more uncertainty. 4. Our results demonstrate that species can show morphological change in response to environmental change over very short time periods. We demonstrate that using both population and morphological data allows stronger inferences about the mechanisms behind species responses to environmental change. © 2017 The Royal Entomological Society
- Authors: Evans, Maldwyn , Banks, Sam , Barton, Philip , Davies, Kendi , Driscoll, Don
- Date: 2018
- Type: Text , Journal article
- Relation: Ecological Entomology Vol. 43, no. 3 (2018), p. 282-293
- Full Text:
- Reviewed:
- Description: 1. Habitat fragmentation and transformation are key drivers of species declines in landscapes. Most of the current understanding of species' responses to environmental change originates from studies of populations and communities. However, phenotypic variation offers another key aspect of species responses and could provide additional insights into the functional drivers of population change. 2. The goal of this study was to address this gap by exploring the morphological changes of a species of carabid beetle (Notonomus resplendens) with a known population response to the Wog Wog Habitat Fragmentation Experiment in Australia. We measured morphological traits associated with body size, head width, and dispersal ability. We quantified patterns of morphological variation over time and between native Eucalyptus forest fragments and the surrounding pine plantation matrix and the continuous intact native Eucalyptus forest controls. 3. We found sexually dimorphic morphological changes in response to the experimental treatments. Males increased in size, had larger legs and had smaller interocular widths in the matrix in both the short and long terms. Conversely, females became comparatively smaller and had increased interocular widths in the same treatments. Effects in the fragments were similar to those in the matrix, but exhibited more uncertainty. 4. Our results demonstrate that species can show morphological change in response to environmental change over very short time periods. We demonstrate that using both population and morphological data allows stronger inferences about the mechanisms behind species responses to environmental change. © 2017 The Royal Entomological Society
Biogeochemical responses to holocene catchment-lake dynamics in the Tasmanian World Heritage Area, Australia
- Mariani, Michela, Beck, Kristen, Fletcher, Michael-Shawn, Gell, Peter, Saunders, Krystyna, Gadd, Patricia, Chisari, Robert
- Authors: Mariani, Michela , Beck, Kristen , Fletcher, Michael-Shawn , Gell, Peter , Saunders, Krystyna , Gadd, Patricia , Chisari, Robert
- Date: 2018
- Type: Text , Journal article
- Relation: Journal of Geophysical Research: Biogeosciences Vol. 123, no. 5 (2018), p. 1610-1624
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- Description: Environmental changes such as climate, land use, and fire activity affect terrestrial and aquatic ecosystems at multiple scales of space and time. Due to the nature of the interactions between terrestrial and aquatic dynamics, an integrated study using multiple proxies is critical for a better understanding of climate- and fire-driven impacts on environmental change. Here we present a synthesis of biological and geochemical data (pollen, spores, diatoms, micro X-ray fluorescence scanning, CN content, and stable isotopes) from Dove Lake, Tasmania, allowing us to disentangle long-term terrestrial-aquatic dynamics through the last 12 kyear. We found that aquatic dynamics at Dove Lake are tightly linked to vegetation shifts dictated by regional hydroclimatic variability in western Tasmania. A major shift in the diatom composition was detected at ca. 6 ka, and it was likely mediated by changes in regional terrestrial vegetation, charcoal, and iron accumulation. High rainforest abundance prior ca. 6 ka is linked to increased terrestrially derived organic matter delivery into the lake, higher dystrophy, anoxic bottom conditions, and lower light penetration depths. The shift to a landscape with a higher proportion of sclerophyll species following the intensification of El Niño-Southern Oscillation since ca. 6 ka corresponds to a decline in terrestrial organic matter input into Dove Lake, lower dystrophy levels, higher oxygen availability, and higher light availability for algae and littoral macrophytes. This record provides new insights on terrestrial-aquatic dynamics that could contribute to the conservation management plans in the Tasmanian World Heritage Area and in temperate high-altitude dystrophic systems elsewhere.
- Authors: Mariani, Michela , Beck, Kristen , Fletcher, Michael-Shawn , Gell, Peter , Saunders, Krystyna , Gadd, Patricia , Chisari, Robert
- Date: 2018
- Type: Text , Journal article
- Relation: Journal of Geophysical Research: Biogeosciences Vol. 123, no. 5 (2018), p. 1610-1624
- Full Text:
- Reviewed:
- Description: Environmental changes such as climate, land use, and fire activity affect terrestrial and aquatic ecosystems at multiple scales of space and time. Due to the nature of the interactions between terrestrial and aquatic dynamics, an integrated study using multiple proxies is critical for a better understanding of climate- and fire-driven impacts on environmental change. Here we present a synthesis of biological and geochemical data (pollen, spores, diatoms, micro X-ray fluorescence scanning, CN content, and stable isotopes) from Dove Lake, Tasmania, allowing us to disentangle long-term terrestrial-aquatic dynamics through the last 12 kyear. We found that aquatic dynamics at Dove Lake are tightly linked to vegetation shifts dictated by regional hydroclimatic variability in western Tasmania. A major shift in the diatom composition was detected at ca. 6 ka, and it was likely mediated by changes in regional terrestrial vegetation, charcoal, and iron accumulation. High rainforest abundance prior ca. 6 ka is linked to increased terrestrially derived organic matter delivery into the lake, higher dystrophy, anoxic bottom conditions, and lower light penetration depths. The shift to a landscape with a higher proportion of sclerophyll species following the intensification of El Niño-Southern Oscillation since ca. 6 ka corresponds to a decline in terrestrial organic matter input into Dove Lake, lower dystrophy levels, higher oxygen availability, and higher light availability for algae and littoral macrophytes. This record provides new insights on terrestrial-aquatic dynamics that could contribute to the conservation management plans in the Tasmanian World Heritage Area and in temperate high-altitude dystrophic systems elsewhere.
Managing consequences of climate-driven species redistribution requires integration of ecology, conservation and social science
- Bonebrake, Timothy, Brown, Christopher, Bell, Johann, Blanchard, Julia, Chauvenet, Alienor, Champion, Curtis, Chen, I-Ching, Clark, Timothy, Colwell, Robert, Danielsen, Finn, Dell, Anthony, Donelson, Jennifer, Evengård, Birgitta, Ferrier, Simon, Frusher, Stewart, Garcia, Raquel, Griffis, Roger, Hobday, Alistair, Jarzyna, Marta, Lee, Emma, Lenoir, Jonathan, Linnetved, Hlif, Martin, Victoria, McCormack, Phillipa, McDonald, Jan, McDonald-Madden, Eve, Mitchell, Nicola, Mustonen, Tero, Pandolfi, John, Pettorelli, Nathalie
- Authors: Bonebrake, Timothy , Brown, Christopher , Bell, Johann , Blanchard, Julia , Chauvenet, Alienor , Champion, Curtis , Chen, I-Ching , Clark, Timothy , Colwell, Robert , Danielsen, Finn , Dell, Anthony , Donelson, Jennifer , Evengård, Birgitta , Ferrier, Simon , Frusher, Stewart , Garcia, Raquel , Griffis, Roger , Hobday, Alistair , Jarzyna, Marta , Lee, Emma , Lenoir, Jonathan , Linnetved, Hlif , Martin, Victoria , McCormack, Phillipa , McDonald, Jan , McDonald-Madden, Eve , Mitchell, Nicola , Mustonen, Tero , Pandolfi, John , Pettorelli, Nathalie
- Date: 2018
- Type: Text , Journal article
- Relation: Biological Reviews Vol. 93, no. 1 (2018), p. 284-305
- Full Text:
- Reviewed:
- Description: Climate change is driving a pervasive global redistribution of the planet's species. Species redistribution poses new questions for the study of ecosystems, conservation science and human societies that require a coordinated and integrated approach. Here we review recent progress, key gaps and strategic directions in this nascent research area, emphasising emerging themes in species redistribution biology, the importance of understanding underlying drivers and the need to anticipate novel outcomes of changes in species ranges. We highlight that species redistribution has manifest implications across multiple temporal and spatial scales and from genes to ecosystems. Understanding range shifts from ecological, physiological, genetic and biogeographical perspectives is essential for informing changing paradigms in conservation science and for designing conservation strategies that incorporate changing population connectivity and advance adaptation to climate change. Species redistributions present challenges for human well-being, environmental management and sustainable development. By synthesising recent approaches, theories and tools, our review establishes an interdisciplinary foundation for the development of future research on species redistribution. Specifically, we demonstrate how ecological, conservation and social research on species redistribution can best be achieved by working across disciplinary boundaries to develop and implement solutions to climate change challenges. Future studies should therefore integrate existing and complementary scientific frameworks while incorporating social science and human-centred approaches. Finally, we emphasise that the best science will not be useful unless more scientists engage with managers, policy makers and the public to develop responsible and socially acceptable options for the global challenges arising from species redistributions. © 2017 Cambridge Philosophical Society **Please note that there are multiple authors for this article therefore only the name of the first 30 including the now Federation University Australia affiliate “Emma Lee” is provided in this record**
- Authors: Bonebrake, Timothy , Brown, Christopher , Bell, Johann , Blanchard, Julia , Chauvenet, Alienor , Champion, Curtis , Chen, I-Ching , Clark, Timothy , Colwell, Robert , Danielsen, Finn , Dell, Anthony , Donelson, Jennifer , Evengård, Birgitta , Ferrier, Simon , Frusher, Stewart , Garcia, Raquel , Griffis, Roger , Hobday, Alistair , Jarzyna, Marta , Lee, Emma , Lenoir, Jonathan , Linnetved, Hlif , Martin, Victoria , McCormack, Phillipa , McDonald, Jan , McDonald-Madden, Eve , Mitchell, Nicola , Mustonen, Tero , Pandolfi, John , Pettorelli, Nathalie
- Date: 2018
- Type: Text , Journal article
- Relation: Biological Reviews Vol. 93, no. 1 (2018), p. 284-305
- Full Text:
- Reviewed:
- Description: Climate change is driving a pervasive global redistribution of the planet's species. Species redistribution poses new questions for the study of ecosystems, conservation science and human societies that require a coordinated and integrated approach. Here we review recent progress, key gaps and strategic directions in this nascent research area, emphasising emerging themes in species redistribution biology, the importance of understanding underlying drivers and the need to anticipate novel outcomes of changes in species ranges. We highlight that species redistribution has manifest implications across multiple temporal and spatial scales and from genes to ecosystems. Understanding range shifts from ecological, physiological, genetic and biogeographical perspectives is essential for informing changing paradigms in conservation science and for designing conservation strategies that incorporate changing population connectivity and advance adaptation to climate change. Species redistributions present challenges for human well-being, environmental management and sustainable development. By synthesising recent approaches, theories and tools, our review establishes an interdisciplinary foundation for the development of future research on species redistribution. Specifically, we demonstrate how ecological, conservation and social research on species redistribution can best be achieved by working across disciplinary boundaries to develop and implement solutions to climate change challenges. Future studies should therefore integrate existing and complementary scientific frameworks while incorporating social science and human-centred approaches. Finally, we emphasise that the best science will not be useful unless more scientists engage with managers, policy makers and the public to develop responsible and socially acceptable options for the global challenges arising from species redistributions. © 2017 Cambridge Philosophical Society **Please note that there are multiple authors for this article therefore only the name of the first 30 including the now Federation University Australia affiliate “Emma Lee” is provided in this record**
Species co-occurrence networks show reptile community reorganization under agricultural transformation
- Kay, Geoffrey, Tulloch, Ayesha, Barton, Philip, Cunningham, Saul, Driscoll, Don, Lindenmayer, David
- Authors: Kay, Geoffrey , Tulloch, Ayesha , Barton, Philip , Cunningham, Saul , Driscoll, Don , Lindenmayer, David
- Date: 2018
- Type: Text , Journal article
- Relation: Ecography Vol. 41, no. 1 (2018), p. 113-125
- Full Text:
- Reviewed:
- Description: Agricultural transformation represents one of the greatest threats to biodiversity, causing degradation and loss of habitat, leading to changes in the richness and composition of communities. These changes in richness and composition may, in turn, lead to altered species co-occurrence, but our knowledge of this remains limited. We used a novel co-occurrence network approach to examine the impact of agricultural transformation on reptile community structure within two large (> 172 000 km2; 224 sites) agricultural regions in southeastern Australia. We contrasted assemblages from sites surrounded by intact and modified landscapes and tested four key hypotheses that agricultural transformation leads to (H1) declines in species richness, (H2) altered assemblages, (H3) declines in overall co-occurrence, and (H4) complex restructuring of pairwise associations. We found that modified landscapes differed in composition but not richness compared with intact sites. Modified landscapes were also characterized by differences in co-occurrence network structure; with species sharing fewer sites with each other (reduced co-occurrence connectance), fewer highly-connected species (truncation of the frequency distribution of co-occurrence degree) and increased modularity of co-occurrence networks. Critically, overall loss of co-occurrence was underpinned by complex changes to the number and distribution of pair-wise co-occurrence links, with 41–44% of species also gaining associations with other species. Change in co-occurrence was not correlated with changes in occupancy, nor by functional trait membership, allowing a novel classification of species susceptibility to agricultural transformation. Our study reveals the value of using co-occurrence analysis to uncover impacts of agricultural transformation that may be masked in conventional studies of species richness and community composition. © 2017 The Authors
- Authors: Kay, Geoffrey , Tulloch, Ayesha , Barton, Philip , Cunningham, Saul , Driscoll, Don , Lindenmayer, David
- Date: 2018
- Type: Text , Journal article
- Relation: Ecography Vol. 41, no. 1 (2018), p. 113-125
- Full Text:
- Reviewed:
- Description: Agricultural transformation represents one of the greatest threats to biodiversity, causing degradation and loss of habitat, leading to changes in the richness and composition of communities. These changes in richness and composition may, in turn, lead to altered species co-occurrence, but our knowledge of this remains limited. We used a novel co-occurrence network approach to examine the impact of agricultural transformation on reptile community structure within two large (> 172 000 km2; 224 sites) agricultural regions in southeastern Australia. We contrasted assemblages from sites surrounded by intact and modified landscapes and tested four key hypotheses that agricultural transformation leads to (H1) declines in species richness, (H2) altered assemblages, (H3) declines in overall co-occurrence, and (H4) complex restructuring of pairwise associations. We found that modified landscapes differed in composition but not richness compared with intact sites. Modified landscapes were also characterized by differences in co-occurrence network structure; with species sharing fewer sites with each other (reduced co-occurrence connectance), fewer highly-connected species (truncation of the frequency distribution of co-occurrence degree) and increased modularity of co-occurrence networks. Critically, overall loss of co-occurrence was underpinned by complex changes to the number and distribution of pair-wise co-occurrence links, with 41–44% of species also gaining associations with other species. Change in co-occurrence was not correlated with changes in occupancy, nor by functional trait membership, allowing a novel classification of species susceptibility to agricultural transformation. Our study reveals the value of using co-occurrence analysis to uncover impacts of agricultural transformation that may be masked in conventional studies of species richness and community composition. © 2017 The Authors