Contrasting colonial collectors: an examination of nineteenth-century collectors of Victorian Indigenous cultural artefacts, violence and antiquarianism
- Authors: Donovan, Paul
- Date: 2023
- Type: Text , Thesis , PhD
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- Description: The motivations and methodologies for collecting Indigenous Australian cultural material from colonial Victoria from 1802–1900 have varied widely. Some collectors enacted frontier war to disarm a colonised people and dispossess them of their land. Others sought to salvage a material scientific record of the culture of a race they believed was doomed to imminent extinction or build museum collections for public education. Some sought souvenirs or gifts to document tourism experiences, and some acquired exotic material for commercial enterprise. This dissertation offers a historical overview of political and scientific paradigms underpinning the collection of Indigenous Australian cultural material from nineteenth-century Victoria and characterises the resulting collecting practices. The nature of the collection methods and the content of the collections were examined. The dynamics of relationships between nineteenth-century collectors, Indigenous Australian communities, the source of collections, and collecting institutions were analysed following on from Nicholas Thomas’s entangled objects framework and using the methodologies of Geertz’s thick description, McBryde’s ethnohistory, Denzin’s interpretive biography and Thomas, Znaniecki and Shaw’s biographical analysis. By examining evidence in the primary sources of Indigenous Australian value for colonial material and colonial value of Indigenous material, this dissertation deconstructed the nature of the relationships between agents. It explored the nexus between objects, institutions and individuals. The case studies add depth to the understanding of the collections of Victorian cultural material still held in museums.
- Description: Doctor of Philosophy
Converting optimum compaction properties of fine-grained soils between rational energy levels
- Authors: Soltani, Amin , Azimi, Mahdieh , O'Kelly, Brendan , Horpibulsuk, Suksun
- Date: 2023
- Type: Text , Journal article
- Relation: Transportation Geotechnics Vol. 42, no. (2023), p.
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- Description: This study introduces a practical energy conversion (EC)-type modeling framework capable of converting the optimum compaction properties of fine-grained soils between any two rational compaction energy levels (CELs). Model development/calibration was carried out using a database of 242 compaction test results — the largest and most diverse database of its kind, to date, entailing 76 fine-grained soils (covering liquid limits of 16–256%), with each soil tested for at least three different CELs. On establishing the framework, an independent database of 91 compaction test results (consisting of 34 fine-grained soils tested for varying CELs) was employed for its validation. The proposed EC-based models employ measured optimum water content (OWC) and maximum dry unit weight (MDUW) values obtained for a rational CEL (preferably standard Proctor) to predict the same for higher and/or lower compactive efforts (covering 214–5416 kJ/m3). The 95% lower and upper statistical agreement limits between the predicted/converted and measured OWCs were obtained as
Coping strategies to overcome psychological distress and fear during COVID-19 pandemic in Kuwait
- Authors: Elaidy, Asmaa , Hammoud, Majeda , N. Albatineh, Ahmed , Ridha, Fatma , Hammoud, Sabri , Elsadek, Hala , Rahman, Muhammad Aziz
- Date: 2023
- Type: Text , Journal article
- Relation: Middle East Current Psychiatry Vol. 30, no. 1 (2023), p.
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- Description: Background: The COVID-19 pandemic has detrimental effects on both physical and psychological well-being of community people worldwide. The purpose of this research was to determine coping strategies and the factors associated with psychological distress and fear among adults in Kuwait during the COVID-19 pandemic. Results: Participants with good-excellent mental health perception had significantly lower prevalence of reporting high psychological distress, while those identified as patients as used health services in the past 4 weeks had significantly higher prevalence of reporting high psychological distress. On the other hand, individuals born in the same country of residence, whose financial situation was impacted by COVID-19 had significantly lower prevalence of reporting high levels of fear from COVID-19. Those with an income source, with co-morbidities, tested negative to COVID-19, being frontline or essential worker, reported medium to high psychological distress and had significantly higher prevalence of high levels of fear of COVID-19. Conclusions: Mental health services should be provided in addition to the existing services in primary healthcare settings, so that the impact of ongoing pandemic on psychological wellbeing of people in Kuwait can be addressed. © 2023, The Author(s).
Corporate social responsibility and performance measurement systems in Iran : a levers of control perspective
- Authors: Asiaei, Kaveh , O'Connor, Neale , Moghaddam, Majid , Bontis, Nick , Sidhu, Jasvinder
- Date: 2023
- Type: Text , Journal article
- Relation: Corporate Social Responsibility and Environmental Management Vol. 30, no. 2 (2023), p. 574-588
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- Description: This study draws on Simons' levers of control model to explore how companies rely on the balanced use of diagnostic and interactive performance measurement systems (PMS) to translate corporate social responsibility (CSR) into superior performance. Data were collected based on a survey data set from 98 CFOs of public listed companies in Iran. The theoretical model was tested using partial least squares structural equation modeling (PLS-SEM, SmartPLS 3.0), which enjoys minimum demands concerning normality assumptions and sample size. The findings show that CSR is positively associated with PMS and organizational performance. Moreover, CSR is indirectly related to organizational performance through the mediating effect of PMS. This study extends the previous literature by simultaneously incorporating resource orchestration theory in the management accounting and CSR settings. The findings provide further insights into the issue of how adopting proper management control mechanisms (e.g., balanced use of PMS) can support organizations in orchestrating the social, environmental, and economic impacts more effectively. © 2022 The Authors. Corporate Social Responsibility and Environmental Management published by ERP Environment and John Wiley & Sons Ltd.
Corrosion and coating defect assessment of Coal Handling and Preparation Plants (CHPP) using an ensemble of deep convolutional neural networks and decision-level data fusion
- Authors: Yu, Yang , Hoshyar, Azadeh , Samali, Bijan , Zhang, Guang , Rashidi, Maria , Mohammadi, Masoud
- Date: 2023
- Type: Text , Journal article
- Relation: Neural Computing and Applications Vol. 35, no. 25 (2023), p. 18697-18718
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- Description: In view of the problems of ineffective feature extraction and low detection accuracy in existing detection system, this study presents a novel machine vision-based approach composed of an ensemble of deep convolutional neural networks (CNNs) and improved Dempster-Shafer (D-S) theory-based data fusion to evaluate corrosion and coating defect of coal handling and preparation plants. To start with, the structural surface image is sent to each transferred CNN for initial defect identification. Then, an improved D-S fusion algorithm is proposed to combine the identification results from different CNNs, which are vectors consisting of statistical indicators of all the potential damage severity categories. The decision-level fusion of different CNNs can effectively improve image classification. To validate the performance of the proposed method, a dataset made of 3593 surface images with different defect severities captured from mining infrastructure in field is established together with data augmentation. The validation result demonstrates that the proposed method is able to effectively improve the recognition accuracy of defect severity and reduce the wrong recognition rate. Finally, the robustness of the proposed approach is also appraised by polluting the images with different types and intensities of noise, with satisfactory results. © 2023, The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.
COVID-19 : factors associated with the psychological distress, fear and resilient coping strategies among community members in Saudi Arabia
- Authors: Alharbi, Talal , Alqurashi, Alaa , Mahmud, Ilias , Alharbi, Rayan , Islam, Sheikh , Almustanyir, Sami , Maklad, Ahmed , AlSarraj, Ahmad , Mughaiss, Lujain , Al-Tawfiq, Jaffar , Ahmed, Ahmed , Barry, Mazin , Ghozy, Sherief , Alabdan, Lulwah , Alif, Sheikh , Sultana, Farhana , Salehin, Masudus , Banik, Biswajit , Cross, Wendy , Rahman, Muhammad Aziz
- Date: 2023
- Type: Text , Journal article
- Relation: Healthcare (Switzerland) Vol. 11, no. 8 (2023), p.
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- Description: (1) Background: COVID-19 caused the worst international public health crisis, accompanied by major global economic downturns and mass-scale job losses, which impacted the psychosocial wellbeing of the worldwide population, including Saudi Arabia. Evidence of the high-risk groups impacted by the pandemic has been non-existent in Saudi Arabia. Therefore, this study examined factors associated with psychosocial distress, fear of COVID-19 and coping strategies among the general population in Saudi Arabia. (2) Methods: A cross-sectional study was conducted in healthcare and community settings in the Saudi Arabia using an anonymous online questionnaire. The Kessler Psychological Distress Scale (K-10), Fear of COVID-19 Scale (FCV-19S) and Brief Resilient Coping Scale (BRCS) were used to assess psychological distress, fear and coping strategies, respectively. Multivariate logistic regressions were used, and an Adjusted Odds Ratio (AOR) with 95% Confidence Intervals (CIs) was reported. (3) Results: Among 803 participants, 70% (n = 556) were females, and the median age was 27 years; 35% (n = 278) were frontline or essential service workers; and 24% (n = 195) reported comorbid conditions including mental health illness. Of the respondents, 175 (21.8%) and 207 (25.8%) reported high and very high psychological distress, respectively. Factors associated with moderate to high levels of psychological distress were: youth, females, non-Saudi nationals, those experiencing a change in employment or a negative financial impact, having comorbidities, and current smoking. A high level of fear was reported by 89 participants (11.1%), and this was associated with being ex-smokers (3.72, 1.14–12.14, 0.029) and changes in employment (3.42, 1.91–6.11, 0.000). A high resilience was reported by 115 participants (14.3%), and 333 participants (41.5%) had medium resilience. Financial impact and contact with known/suspected cases (1.63, 1.12–2.38, 0.011) were associated with low, medium, to high resilient coping. (4) Conclusions: People in Saudi Arabia were at a higher risk of psychosocial distress along with medium-high resilience during the COVID-19 pandemic, warranting urgent attention from healthcare providers and policymakers to provide specific mental health support strategies for their current wellbeing and to avoid a post-pandemic mental health crisis. © 2023 by the authors.
COVID-19 : psychological distress, fear, and coping strategies among community members across the United Arab Emirates
- Authors: Al Dweik, Rania , Rahman, Muhammad Aziz , Ahamed, Fathima , Ramada, Heba , Al Sheble, Yousef , ElTaher, Sondos , Cross, Wendy , Elsori, Deena
- Date: 2023
- Type: Text , Journal article
- Relation: PLoS ONE Vol. 18, no. 3 March (2023), p.
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- Description: Background The COVID-19 pandemic impacted the psychosocial well-being of the United Arab Emirates [UAE] population like other communities internationally. Objectives We aimed to identify the factors associated with psychological distress, fear, and coping amongst community members across the UAE. Methods We conducted a cross-sectional online survey across the UAE during November 2020. Adults aged
COVID-19 and the welfare state : social work’s practice and policy
- Authors: Noble, Carolyn , Ottmann, Goetz
- Date: 2023
- Type: Text , Book chapter
- Relation: Post-Pandemic Welfare and Social Work: Re-imagining the New Normal Chapter 19 p. 220-227
- Full Text: false
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- Description: This chapter attempts to situate social work within the wider social and political context of the post-pandemic
COVID-19 effects on public finance and SDG priorities in developing countries : comparative evidence from Bangladesh and Sri Lanka
- Authors: Colombage, Sisira , Barua, Suborna , Nanayakkara, Madurika , Colombage, Udari
- Date: 2023
- Type: Text , Journal article
- Relation: European Journal of Development Research Vol. 35, no. 1 (2023), p. 85-111
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- Description: The COVID-19 pandemic, an unprecedented global health crisis, rapidly transferred into a global economic and social crisis. The pandemic has threatened the world’s commitment to achieve Sustainable Development Goals (SDGs) by 2030 as governments in developing countries have shifted their priorities from attaining SDGs, to providing urgent financial needs to save lives and prevent recession in hopes for a rapid economic recovery. The rerouting of public funding priorities has undermined the progress and achievement of SDGs. We employed a mixed-method and carried out a comparative study using pre- and post-public financial data of two developing countries in South Asia; Bangladesh and Sri Lanka. A threefold analysis was conducted to investigate the evolution of the COVID-19 pandemic in two countries, the impact of the pandemic on external and internal public finance and the effect of the pandemic in shifting the policy priorities from SDGs to economic survival. This study found that both countries are highly vulnerable to the COVID-19 pandemic and are suffering from the lack of financing from external sources through the private sector as well as an increasing foreign debt. There is mounting pressure on the fiscal balance in both countries. © 2022, The Author(s).
Creative arts intervention in support of women experiencing a high-risk pregnancy : a qualitative descriptive thematic analysis
- Authors: Anolak, Helena , Lau, Farrah , Davis, Deborah , Browne, Jenny , Watt, Bec
- Date: 2023
- Type: Text , Journal article
- Relation: Sexual and Reproductive Healthcare Vol. 36, no. (2023), p.
- Full Text: false
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- Description: Background: Mental illness can have negative effects on both the pregnant woman and her unborn child. Studies that use the creative arts as interventions have proven to be beneficial to women's antenatal mental health and wellbeing, however, these studies are limited and emergent. Music, drawing and narrative (MDN) is an established music therapy intervention, stemming from guided imagery and music (GIM), that has the potential to support positive mental health and wellbeing. Yet, to date, there have been limited studies on the use of this form of therapy with inpatient antenatal women. Aim: To describe antenatal inpatient women's experiences of participating in a MDN session. Methods: Qualitative data were collected from a sample of 12 inpatient pregnant women who participated in MDN group sessions of drawing to music. Post intervention interviews explored the mental and emotional health of participants. A thematic analysis of the transcribed interview data was performed. Findings: Through reflection women were supported to acknowledge both the positives and difficulties of pregnancy as well as establish meaningful connections through shared experience. These thematic findings highlighted that MDN enabled this group of pregnant women to better communicate their feelings, validate emotions, engage in positive distractions, develop greater connections, improve optimism, experience calmness, and learn from others. Conclusion: This project demonstrates that MDN may offer a viable method for supporting women experiencing high risk pregnancies. © 2023 Elsevier B.V.
Critical data detection for dynamically adjustable product quality in IIoT-enabled manufacturing
- Authors: Sen, Sachin , Karmakar, Gour , Pang, Shaoning
- Date: 2023
- Type: Text , Journal article
- Relation: IEEE Access Vol. 11, no. (2023), p. 49464-49480
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- Description: The IIoT technologies, due to the widespread use of sensors, generate massive data that are key in providing innovative and efficient industrial management, operation, and product quality control processes. The significance of data has prompted relevant research communities and application developers how to harness the values of these data in secure manufacturing. Critical data analysis, identification of critical factors to improve the manufacturing process and critical data associated with product quality have been investigated in the current literature. However, the current works on product quality control are mainly based on static data analysis, where data may change, but there is no way to adjust them dynamically. Thus, they are not applicable for product quality control, at which point their adjustment is instantly required. However, many manufacturing systems exist, like beverages and food, where ingredients must be adjusted instantaneously to maintain product quality. To address this research gap, we introduce a method that identifies the critical data based on their ranking by exploiting three criticality assessment criteria that capture the instantaneous product quality change during manufacturing. These three criteria are - (1) correlation, (2) percentage quality change and (3) sensitivity for the assessment of data criticality. The product quality is estimated using polynomial regression (POLY), SVM, and DNN. The proposed method is validated using wine manufacturing data. Our proposed method accurately identifies critical data, where SVM produces the lowest average production quality prediction error (10.40%) compared with that of POLY (11%) and DNN (14.40%). © 2013 IEEE.
Critical review of the models used to determine soil water content using TDR-measured apparent permittivity
- Authors: He, Hailong , Zou, Wenxiu , Jones, Scott , Robinson, David , Horton, Robert , Dyck, Miles , Filipović, Vilim , Noborio, Kosuke , Bristow, Keith , Gong, Yuan , Sheng, Wenyi , Wu, Qingbai , Feng, Hao , Liu, Yang
- Date: 2023
- Type: Text , Book chapter
- Relation: Advances in Agronomy Chapter 4 p. 169-219
- Full Text: false
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- Description: Time domain reflectometry (TDR) is the most widely used non-destructive, easily automated method to determine water content of soils and other porous media. However, it should be noted that two key steps are required for TDR applications: (1) Obtain and analyze TDR waveforms using travel-time analysis to determine apparent permittivity; (2) determine a new- or apply an existing relationship between the derived apparent permittivity and the volumetric water content of the porous medium of interest. Activities associated with the first key step were presented in a previous review of TDR applications in porous media including soils, plants, snow, food, and concrete (He et al., 2021, Advances in Agronomy, 83–155). This review focuses on the second step required by TDR applications to determine soil water content in both field and laboratory environments. Numerous mathematical models have been developed to enhance our ability to better estimate water content with TDR-measured apparent dielectric permittivity. When applied judiciously, TDR measurements can help to better understand processes such as coupled transport of water, solutes, and heat, measure the soil water balance and improve the efficiency of irrigation scheduling. However, there are important differences in the formulation, applicability, and accuracy of these models, and no systematic review has been previously undertaken. The objectives of this study are to (1) review and synthesize models relating TDR-measured apparent permittivity to water content in porous media, and (2) analyze the relationships between models. This review examines a total of 157 models that are categorized into 123 empirical models, 11 semi-empirical models, and 23 physical models, based on their development, underlying theories, phase configurations, applications to mineral or organic soils, and unfrozen or frozen conditions. Model limitations and perspectives are discussed and several unresolved questions are presented to highlight the need for further research in this rapidly expanding field. © 2023 Elsevier Inc.
Cross disciplinary teaching : a pedagogical model to support teachers in the development and implementation of outdoor learning opportunities
- Authors: Neville, Ian , Petrass, Lauren , Ben, Francis
- Date: 2023
- Type: Text , Journal article
- Relation: Journal of Outdoor and Environmental Education Vol. 26, no. 1 (2023), p. 1-21
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- Description: There is a growing body of empirical evidence documenting the positive effects associated with participation in environmental education and outdoor learning for students, teachers and the wider community. Despite this, there has been a substantial reduction in outdoor learning opportunities for school students, possibly due to the focus on evidenced-based outcomes, high-stakes standardised testing programs, and a lack of teacher knowledge, confidence and expertise in teaching and learning outdoors. Accordingly, this study presents an evidenced based model to support teaching practice. The model will assist teachers in the development and implementation of outdoor learning opportunities and offers applied examples that address curriculum outcomes. A comprehensive literature review methodology was implemented to identify peer-reviewed literature on teaching and learning outdoors and outdoor pedagogies. A thematic synthesis and constant comparative technique enabled development of themes, from which three themes emerged: the environment; the learner; and the educator, which inform the proposed model offered by the authors. The three interrelated components (the environment, the learner and the educator) require consideration for students to gain maximum benefit from outdoor learning experiences. The model, coupled with the applied examples, supports teachers to plan and facilitate immersive outdoor experiences that promote learning. © 2022, The Author(s).
Cross-sectional study of soil-transmitted helminthiases in black belt region of Alabama, USA
- Authors: Poole, Claudette , Barker, Troy , Bradbury, Richard , Capone, Drew , Chatham, Amy , Handali, Sukwan , Rodriguez, Eduardo , Qvarnstrom, Yvonne , Brown, Joe
- Date: 2023
- Type: Text , Journal article
- Relation: Emerging Infectious Diseases Vol. 29, no. 12 (2023), p. 2461-2470
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- Description: We conducted a cross-sectional study to determine the prevalence of soil-transmitted helminthiases (STH) in areas of rural Alabama, USA, that have sanitation deficits. We enrolled 777 children; 704 submitted stool specimens and 227 a dried blood spot sample. We microscopically examined stool specimens from all 704 children by using Mini-FLOTAC for helminth eggs. We tested a subset by using molecular techniques: real-time PCR analysis for 5 STH species, TaqMan Array Cards for enteric helminths, and digital PCR for Necator americanus hookworm. We analyzed dried blood spots for Strongyloides stercoralis and Toxocara spp. roundworms by using serologic testing. Despite 12% of our cohort reporting living in homes that directly discharge untreated domestic wastewater, stool testing for STH was negative; however, 5% of dried blood spots were positive for Toxocara spp. roundworms. Survey data suggests substantial numbers of children in this region may be exposed to raw sewage, which is itself a major public health concern. © 2023 Centers for Disease Control and Prevention (CDC). All rights reserved.
Cultivating whole-heartedness in the academy during a time of COVID : insights from/within an inter-collegial friendship
- Authors: Green, Monica , McClam, Sherie
- Date: 2023
- Type: Text , Book chapter
- Relation: Reflections on Valuing Wellbeing in Higher Education : Reforming Our Acts of Self-care Chapter 9 p. 111-124
- Full Text: false
- Reviewed:
- Description: This chapter explores how we, Sherie (American) and Monica (Australian), two feminist teacher educators and collaborators, used reflective dialogic exchanges to examine our academic lives during the COVID-19 pandemic in 2020. The underpinning personal and emotional layers of our wholehearted conversations sit within our robust inter-collegial friendship, which offers us critical support and reminders about the importance of self-care/compassion in our navigation of academic complexities and obligations. The chapter is framed by three of Brene Brown’s ‘wholehearted’ provocations or prompts that we used to explore our respective lived COVID-19 experiences within the broader milieu of contemporary academia. The chapter concludes with insights about the ways in which collegial friendships contribute to academic wellbeing and self-care. © 2023 selection and editorial matter, Narelle Lemon.
Cultural landscapes : human impacts on wetlands
- Authors: Mills, Keely , Jones, Matthew , Hunt, Laura , Saulnier-Talbot, Emilie , Elias, Deevena , Nankabirwa, Angela , Lejju, Julius , Gell, Peter
- Date: 2023
- Type: Text , Book chapter
- Relation: Ramsar Wetlands: Values, Assessment, Management Chapter 10 p. 237-258
- Full Text: false
- Reviewed:
- Description: Wetlands provide a wealth of ecosystem services to people, including ecological, economic, and socio-cultural benefits. However, more than 30% of freshwater species are threatened with extinction, and freshwater biodiversity is declining faster than that observed in oceans or forests. When it comes to the management of wetlands, it often occurs too late and when ecosystem services to people are at risk of being lost. It is easy to observe and monitor the recent impacts of people on wetland systems, but the changes we see today are a product of hundreds, even thousands of years of direct and indirect human impact. Without a deeper understanding of the long-term context of human impacts on wetland systems, it is impossible to manage the problems they experience (such as changes in hydrology, nutrient loading, acidification, and salinisation). Despite the 20th century being the period in which humans have exerted the greatest impact on wetland systems, it was also the period in which we developed a greater appreciation of wetlands as anthropogenically altered landscapes, and, maybe paradoxically, the benefits that accrue from healthy wetlands. Palaeolimnological approaches allow an understanding of wetland system variability over millennial scales, providing background context for anthropogenically forced change. This palaeo-perspective enables a deeper understanding of the long-term context of human impacts on wetland systems and can provide a fresh perspective when managing impacted systems. © 2023 Elsevier Inc. All rights reserved.
Cyan Moon crew preparation for the Sydney To Hobart Yacht Race March 2023
- Authors: Porter, Joanne , Simic, Megan , Talpey, Scott , Fenton, Sam , Casey, Meghan , McNeal, Dominic , Statham, Dixie , Prokopiv, Valerie , Miller, Libby
- Date: 2023
- Type: Text , Technical report , Report
- Full Text:
- Description: The Collaborative Evaluation & Research Centre (formally CERG) evaluated the crew’s experiences pre and post yacht events using a mixed methods approach. The Cyan yacht had a crew of 12 and competed in a number of events in the racing calendar leading up to the Sydney to Hobart race in January 2023. This was the first time that this boat and many of the crew competed in the Sydney to Hobart yacht race.
Cyberbullying, mental health, and lesbian, gay, and bisexual youth with disabilities : intersectionalities and environmental risks
- Authors: Gates, Trevor , Bills, Kaycee , Bennett, Bindi , Kelly, Brian
- Date: 2023
- Type: Text , Journal article
- Relation: Journal of Child and Family Studies Vol. 32, no. 10 (2023), p. 3159-3166
- Full Text: false
- Reviewed:
- Description: Lesbian, gay, and bisexual youth with disabilities are at risk for being cyberbullied. Additionally, these risks can be compounded by other intersectional factors, such as cultural identity. Youth with multiple marginalized identities are at risk for stress, discrimination, and poor mental health outcomes as a result of bullying. However, research exploring the intersections between risk, sexual identity, and disability is sparse. In this article, we begin to address this gap in a diverse sample of lesbian, gay, and bisexual youth who have reported being cyberbullied in the Youth Risk Behavior Surveillance System. We discuss implications for child and family studies, identifying opportunities for further discussion on risk, mental health, and person-in-environment factors for lesbian, gay, and bisexual youth with disabilities. © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Cytoskeletal plakins in epithelial ovarian cancer
- Authors: Wesley, Tamsin
- Date: 2023
- Type: Text , Thesis , PhD
- Full Text: false
- Description: The plakin family of cytoskeletal proteins play an important role in cancer progression yet are under-studied in cancer, especially ovarian cancer. These large cytoskeletal proteins have primary roles in the maintenance of cytoskeletal integrity. They are also associated with scaffolds of intermediate filaments and hemidesmosomal adhesion complexes mediating signalling pathways that regulate cellular growth, migration, invasion and differentiation, as well as a stress response. Abnormalities of plakins, and the closely related spectraplakins, result in serious pathologies of skin, striated muscle and nervous tissue. Their prevalence in epithelial cells suggests that plakins may play a role in epithelial ovarian cancer progression and recurrence. This thesis sought to explore the expression of plakin proteins, particularly plectin (PLEC), desmoplakin (DSP), periplakin (PPL) and envoplakin (EVPL) in ovarian cancer progression, comparing surgical stages, historical Silverberg histological grading and current World Health Organisation (WHO) pathological classification of ovarian tumour types. The study also investigated the potential role that the plakin family of proteins may play in regulating cancer cell growth, survival, migration, invasion and drug resistance. It highlights potential relationships between plakins and epithelial-mesenchymal transition (EMT) and relates how these interactions may affect ovarian cancer progression, chemoresistance and ultimately recurrence. This study hypothesises that the molecular changes in the expression of plakins in benign ovarian tumours compared to various grades and stages of ovarian carcinomas, as well as floating cellular aggregates (spheroids) in the peritoneal ascites microenvironment, may contribute to the progression of the disease. It also attempts to understand these crucial changes in plakin expression in response to chemotherapy treatment and relate these findings in the perspective of disease recurrence.
- Description: Doctor of Philosophy
Data evolution governance for ontology-based digital twin product lifecycle management
- Authors: Ren, Zijie , Shi, Jianhua , Imran, Muhammad
- Date: 2023
- Type: Text , Journal article
- Relation: IEEE Transactions on Industrial Informatics Vol. 19, no. 2 (2023), p. 1791-1802
- Full Text: false
- Reviewed:
- Description: Product lifecycle management (PLM) is an effective method for enhancing the market competitiveness of modern manufacturing industries. The digital twin is characterized by a profound integration of physics and information systems, which provides a technical means for integrating multisource information and breaking the time and space barrier of communication at each link of the lifecycle. Currently, however, the application of this technology focuses primarily on the product itself and 'service-oriented' application results. There is a lack of focus on twin data and its internal evolutionary mechanisms separately. In the management of global data resources, the benefits of digital twin technology cannot be fully realized. This article applies ontology technology in an innovative manner to the field of the digital twin to increase the reusability of twin data. Initially, a four-layered ontology-based twin data management architecture is presented. Then, a three-dimensional and three-granularity unified evolution model of full lifecycle twin data is proposed, as well as its ontology model. Then, the service mode of data components at each stage of the lifecycle is defined, a knowledge-sharing plane is established in the digital twin, and a data governance method based on ontology reasoning using data components on the shared plane is proposed. The ICandyBox simulation platform is then used to demonstrate the concept of the proposed method, and future research directions are proposed. © 2005-2012 IEEE.