Description:
Unlike bacteria and viruses, which are based on DNA and RNA, prions are unique as disease-causing agents since they are misfolded proteins. Prion diseases are called "protein structural conformational diseases. This monograph is the book on molecular dynamics (MD) simulations nearly for all the known normal prion protein (PrPC) PDB entries in the Protein Data Bank (PDB) and associations. Pig is a species that is largely resistant to prions, and chicken, turtles, frogs are species resisting prion infection too firstly, this book will address all PrP strong immunity species (such as rabbits, dogs, horses, water buffaloes, pigs, chicken, turtles, frogs), compared with high susceptibility species. Other PrP models and doppel models are also MD studied in this book. Secondly, all the mutants of mouse PrP and human PrP are well studied by this book. Mouse mutations in the 2-2 loop and the C-terminal will bring clear structures with highly and clearly ordered loop structures. Human mutations will cause prion diseases such as Creutzfeldt-Jakob diseases (CJDs), Gerstmann-Sträussler-Scheinker (GSS) syndrome, fatal familial insomnia (FFI), etc. Deep MD analyses of mouse and human mutants are done in this book. Thirdly, PrP binding with antibodies/compounds etc. is well MD studied in this book. The informatics of potential antiprion drugs known will be revealed. Lastly, cross- structure PrP peptides are well studied. This book is ideal for practical computing staff in the fields of computational physics, computational biology, computational chemistry, biomedicine, bioinformatics, cheminformatics, materials, applied mathematics and theoretical physics, information technology, operations research, biostatistics, etc. As an accessible introduction to these fields, this book is also ideal as a teaching material for students.
Description:
This monograph is the first easy-to-read-and-understand book on prion proteins' molecular dynamics (MD) simulations and on prions' molecular modelling (MM) constructions. It enables researchers to see what is crucial to the conformational change from normal cellular prion protein (PrPC) to diseased infectious prions (PrPSc), using MD and MM techniques. As we all know, prion diseases, caused by the body's own proteins, are invariably fatal and highly infectious neurodegenerative diseases effecting humans and almost all animals for a major public health concern. Prion contains no nucleic acids and it is a misshapen or conformation-changed protein that acts like an infectious agent; thus prion diseases are called “protein structural conformational” diseases. PrPC is predominant in
Description:
Motor-mouth and Suck-face are two teen-age geeks in love and lust, desperate to be with one another yet continually thwarted by Motor-mouth's pre-school infatuation - Hilary - who is intent on re-claiming her boy. Then one day at school - a new kid shows up - the mysterious Blasko Tupper - who knows something that none of her classmates know - the world is going to end in three days time. There's only one thing to do - throw a party, kidnap the whole school, break the bad news as gently as possible -- then find a way to blow everyone up just before armageddon to travel safely through a cosmic worm-hole into the next dimension. Simple right? Not quite. Because Blasko's mum and dad are actually part of an international conspiracy to conceal the horrible truth from the planet until it's too late. Fortunately Blasko has drugged them and tied them up in a titanium cage. Unfortunately her parents are experts at mind control and turning teenagers into blood-thirsty zombies, so before long they're on the loose and the party becomes a fight to the death - literally - where the only people who can save everyone turn out to be: Motor-mouth and Suck-face.
Description:
The story of Mullawallah (the last King Billy of Ballarat) brings together excellent research and a sensitive and passionate approach to this early period of Ballarat's seldom-told history. It spans the life of one Wathaurung man, Mullawallah, known as King Billy. Janice Newton shows a thoughtful approach to the difficult subject of early contact and of the relations between Aboriginal leaders and Europeans. Images rarely seen before enhance the pages of this well research text. (From back cover).
Description:
Music of Place introduces the communities of three very different Australian festivals: the proudly multicultural City of Moreland in inner Melbourne; the 'Top Enders' who travel each Queen's birthday weekend for their annual gathering of Australian folk music; and Sydney's diverse Asian musical cultures. Each festival has its own underlying notions that structure the relationship between place, community and identity. These individual community festivals are used to promote each community's identity, created through certain musical styles or genres that are linked to certain identities, lifestyles and ideologies. These festivals appear to be about an ideal notion of community, and the music of these festivals inherently about how each community's 'home' is imagined. Yet, each community draws on the musical repertoire of its members, and in doing so, helps shape and give meaning to that particular community's histories, cultures and everyday spaces. This book explores these festival moments, capturing the ways in which music, geography and culture intersect and interact within specific locales, so bringing into being what may be experienced as distinct Australian communities.
Description:
This insightful study provides an overview of the changing employment context in industrialized nations, the risks associated with population ageing and how these are being tackled. Prolonging working lives is high on the agenda of policymakers in most of the world's major industrialized nations. This book explains how they are keen to tackle issues associated with the ageing of populations, namely the funding of pension systems and predictions concerning a dwindling labour supply. Yet the recent history of older workers has primarily been one of premature exit from the labour force in the form of redundancy or early retirement. Add to this a previously plentiful supply of younger labour and it is clear that much of industry will be inprepared for the challenges of ageing workforces.
Description:
Report prepared by the Australian Institute of Family Studies for the Australian Government Department of Health and Ageing Australian Institute.
Description:
Report prepared by the Australian Institute of Family Studies for the Australian Government Department of Health and Ageing Australian Institute.