DMD-associated dilated cardiomyopathy : genotypes, phenotypes, and phenocopies
- Johnson, Renee, Otway, Robyn, Chin, Ephrem, Horvat, Claire, Ohanian, Monique, Wilcox, Jon, Su, Zheng, Prestes, Priscilla, Smolnikov, Andrei, Soka, Magdalena, Guo, Guanglan, Rath, Emma, Chakravorty, Samya, Chrzanowski, Lukasz, Hayward, Christopher, Keogh, Anne, MacDonald, Peter, Giannoulatou, Eleni, Chang, Alex, Oates, Emily, Charchar, Fadi, Seidman, Jonathan, Seidman, Christine, Hegde, Madhuri, Fatkin, Diane
- Authors: Johnson, Renee , Otway, Robyn , Chin, Ephrem , Horvat, Claire , Ohanian, Monique , Wilcox, Jon , Su, Zheng , Prestes, Priscilla , Smolnikov, Andrei , Soka, Magdalena , Guo, Guanglan , Rath, Emma , Chakravorty, Samya , Chrzanowski, Lukasz , Hayward, Christopher , Keogh, Anne , MacDonald, Peter , Giannoulatou, Eleni , Chang, Alex , Oates, Emily , Charchar, Fadi , Seidman, Jonathan , Seidman, Christine , Hegde, Madhuri , Fatkin, Diane
- Date: 2023
- Type: Text , Journal article
- Relation: Circulation: Genomic and Precision Medicine Vol. 16, no. 5 (2023), p. 421-430
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- Description: Background: Variants in the DMD gene, that encodes the cytoskeletal protein, dystrophin, cause a severe form of dilated cardiomyopathy (DCM) associated with high rates of heart failure, heart transplantation, and ventricular arrhythmias. Improved early detection of individuals at risk is needed. Methods: Genetic testing of 40 male probands with a potential X-linked genetic cause of primary DCM was undertaken using multi-gene panel sequencing, multiplex polymerase chain reaction, and array comparative genomic hybridization. Variant location was assessed with respect to dystrophin isoform patterns and exon usage. Telomere length was evaluated as a marker of myocardial dysfunction in left ventricular tissue and blood. Results: Four pathogenic/likely pathogenic DMD variants were found in 5 probands (5/40: 12.5%). Only one rare variant was identified by gene panel testing with 3 additional multi-exon deletion/duplications found following targeted assays for structural variants. All of the pathogenic/likely pathogenic DMD variants involved dystrophin exons that had percent spliced-in scores >90, indicating high levels of constitutive expression in the human adult heart. Fifteen DMD variant-negative probands (15/40: 37.5%) had variants in autosomal genes including TTN, BAG3, LMNA, and RBM20. Myocardial telomere length was reduced in patients with DCM irrespective of genotype. No differences in blood telomere length were observed between genotype-positive family members with/without DCM and controls. Conclusions: Primary genetic testing using multi-gene panels has a low yield and specific assays for structural variants are required if DMD-associated cardiomyopathy is suspected. Distinguishing X-linked causes of DCM from autosomal genes that show sex differences in clinical presentation is crucial for informed family management. © 2023 American Heart Association, Inc.
- Authors: Johnson, Renee , Otway, Robyn , Chin, Ephrem , Horvat, Claire , Ohanian, Monique , Wilcox, Jon , Su, Zheng , Prestes, Priscilla , Smolnikov, Andrei , Soka, Magdalena , Guo, Guanglan , Rath, Emma , Chakravorty, Samya , Chrzanowski, Lukasz , Hayward, Christopher , Keogh, Anne , MacDonald, Peter , Giannoulatou, Eleni , Chang, Alex , Oates, Emily , Charchar, Fadi , Seidman, Jonathan , Seidman, Christine , Hegde, Madhuri , Fatkin, Diane
- Date: 2023
- Type: Text , Journal article
- Relation: Circulation: Genomic and Precision Medicine Vol. 16, no. 5 (2023), p. 421-430
- Full Text:
- Reviewed:
- Description: Background: Variants in the DMD gene, that encodes the cytoskeletal protein, dystrophin, cause a severe form of dilated cardiomyopathy (DCM) associated with high rates of heart failure, heart transplantation, and ventricular arrhythmias. Improved early detection of individuals at risk is needed. Methods: Genetic testing of 40 male probands with a potential X-linked genetic cause of primary DCM was undertaken using multi-gene panel sequencing, multiplex polymerase chain reaction, and array comparative genomic hybridization. Variant location was assessed with respect to dystrophin isoform patterns and exon usage. Telomere length was evaluated as a marker of myocardial dysfunction in left ventricular tissue and blood. Results: Four pathogenic/likely pathogenic DMD variants were found in 5 probands (5/40: 12.5%). Only one rare variant was identified by gene panel testing with 3 additional multi-exon deletion/duplications found following targeted assays for structural variants. All of the pathogenic/likely pathogenic DMD variants involved dystrophin exons that had percent spliced-in scores >90, indicating high levels of constitutive expression in the human adult heart. Fifteen DMD variant-negative probands (15/40: 37.5%) had variants in autosomal genes including TTN, BAG3, LMNA, and RBM20. Myocardial telomere length was reduced in patients with DCM irrespective of genotype. No differences in blood telomere length were observed between genotype-positive family members with/without DCM and controls. Conclusions: Primary genetic testing using multi-gene panels has a low yield and specific assays for structural variants are required if DMD-associated cardiomyopathy is suspected. Distinguishing X-linked causes of DCM from autosomal genes that show sex differences in clinical presentation is crucial for informed family management. © 2023 American Heart Association, Inc.
Do health service waiting areas contribute to the health literacy of consumers? A scoping review
- McDonald, Cassie, Voutier, Catherine, Govil, Dhruv, D'Souza, Aruska, Truong, Dominic, Abo, Shaza, Remedios, Louisa, Granger, Catherine
- Authors: McDonald, Cassie , Voutier, Catherine , Govil, Dhruv , D'Souza, Aruska , Truong, Dominic , Abo, Shaza , Remedios, Louisa , Granger, Catherine
- Date: 2023
- Type: Text , Journal article , Review
- Relation: Health Promotion International Vol. 38, no. 4 (2023), p.
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- Description: Health service waiting areas commonly provide health information, resources and supports for consumers; however, the effect on health literacy and related outcomes remains unclear. This scoping review of the literature aimed to explore the use of waiting areas as a place to contribute to the health literacy and related outcomes of consumers attending health appointments. Articles were included if they focussed on health literacy or health literacy responsiveness (concept) in outpatient or primary care health service waiting areas (context) for adult consumers (population) and were published after 2010. Ten bibliographic databases, one full-text archive, dissertation repositories and web sources were searched. The search yielded 5095 records. After duplicate removal, 3942 title/abstract records were screened and 360 full-text records assessed. Data were charted into a standardized data extraction tool. A total of 116 unique articles (published empirical and grey literature) were included. Most articles were set in primary and community care (49%) waiting areas. A diverse range of health topics and resource types were available, but results demonstrated they were not always used by consumers. Outcomes measured in intervention studies were health knowledge, intentions and other psychological factors, self-reported and observed behaviours, clinical outcomes and health service utilization. Intervention studies overall demonstrated positive trends in health literacy-related outcomes, although the benefit declined after 3-6 months. Research on using waiting areas for health literacy purposes is increasing globally. Future research investigating the needs of consumers to inform optimal intervention design is needed. © 2023 The Author(s). Published by Oxford University Press.
- Authors: McDonald, Cassie , Voutier, Catherine , Govil, Dhruv , D'Souza, Aruska , Truong, Dominic , Abo, Shaza , Remedios, Louisa , Granger, Catherine
- Date: 2023
- Type: Text , Journal article , Review
- Relation: Health Promotion International Vol. 38, no. 4 (2023), p.
- Full Text:
- Reviewed:
- Description: Health service waiting areas commonly provide health information, resources and supports for consumers; however, the effect on health literacy and related outcomes remains unclear. This scoping review of the literature aimed to explore the use of waiting areas as a place to contribute to the health literacy and related outcomes of consumers attending health appointments. Articles were included if they focussed on health literacy or health literacy responsiveness (concept) in outpatient or primary care health service waiting areas (context) for adult consumers (population) and were published after 2010. Ten bibliographic databases, one full-text archive, dissertation repositories and web sources were searched. The search yielded 5095 records. After duplicate removal, 3942 title/abstract records were screened and 360 full-text records assessed. Data were charted into a standardized data extraction tool. A total of 116 unique articles (published empirical and grey literature) were included. Most articles were set in primary and community care (49%) waiting areas. A diverse range of health topics and resource types were available, but results demonstrated they were not always used by consumers. Outcomes measured in intervention studies were health knowledge, intentions and other psychological factors, self-reported and observed behaviours, clinical outcomes and health service utilization. Intervention studies overall demonstrated positive trends in health literacy-related outcomes, although the benefit declined after 3-6 months. Research on using waiting areas for health literacy purposes is increasing globally. Future research investigating the needs of consumers to inform optimal intervention design is needed. © 2023 The Author(s). Published by Oxford University Press.
Do maturation, anthropometrics and leg muscle qualities influence repeated change of direction performance in adolescent boys and girls?
- Giuriato, Matteo, Pellino, Vittoria, Lovecchio, Nicola, Codella, Roberto, Vandoni, Matteo, Talpey, Scott
- Authors: Giuriato, Matteo , Pellino, Vittoria , Lovecchio, Nicola , Codella, Roberto , Vandoni, Matteo , Talpey, Scott
- Date: 2023
- Type: Text , Journal article
- Relation: Biology of Sport Vol. 40, no. 4 (2023), p. 1033-1038
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- Description: The ability to change direction rapidly is a key fitness quality especially in invasive sports where young players perform approximately 300 changes of direction in a game. There is currently limited understanding of how anthropometric characteristics and maturation status influence change of direction ability in adolescent. Therefore, the purpose of this investigation is to assess the influence of anthropometrics and maturation status on change of direction ability in young people. The study involved 706 adolescents (367 girls) aged 14-19-year-old attending the same high school in Northern Italy. Stature, body mass, seated height and leg length were measured to determine the anthropometrics and maturation status of the participants. Repeated change of direction ability (10 × 5 m shuttle run test), lower limb power and muscle strength were evaluated using field tests from the Eurofit test battery. Maturity offset was calculated separately for boys and girls, in accord with the equation proposed by Mirwald. Preliminary analysis with 10 × 5 m as a dependent variable and sex and PHV as a fixed factor, suggests a significant difference between sex (p < 0.001; d = 0.35) but not with PHV (p = 0.986; d = 0.000) and interaction PHV × sex (p = 0.836; d = 0.000). Our results suggested that repeated change of direction performance was influenced by anthropometrics, maturation and muscle qualities in adolescent boys and girls. © 2023 Institute of Sport. All rights reserved.
- Authors: Giuriato, Matteo , Pellino, Vittoria , Lovecchio, Nicola , Codella, Roberto , Vandoni, Matteo , Talpey, Scott
- Date: 2023
- Type: Text , Journal article
- Relation: Biology of Sport Vol. 40, no. 4 (2023), p. 1033-1038
- Full Text:
- Reviewed:
- Description: The ability to change direction rapidly is a key fitness quality especially in invasive sports where young players perform approximately 300 changes of direction in a game. There is currently limited understanding of how anthropometric characteristics and maturation status influence change of direction ability in adolescent. Therefore, the purpose of this investigation is to assess the influence of anthropometrics and maturation status on change of direction ability in young people. The study involved 706 adolescents (367 girls) aged 14-19-year-old attending the same high school in Northern Italy. Stature, body mass, seated height and leg length were measured to determine the anthropometrics and maturation status of the participants. Repeated change of direction ability (10 × 5 m shuttle run test), lower limb power and muscle strength were evaluated using field tests from the Eurofit test battery. Maturity offset was calculated separately for boys and girls, in accord with the equation proposed by Mirwald. Preliminary analysis with 10 × 5 m as a dependent variable and sex and PHV as a fixed factor, suggests a significant difference between sex (p < 0.001; d = 0.35) but not with PHV (p = 0.986; d = 0.000) and interaction PHV × sex (p = 0.836; d = 0.000). Our results suggested that repeated change of direction performance was influenced by anthropometrics, maturation and muscle qualities in adolescent boys and girls. © 2023 Institute of Sport. All rights reserved.
Does multisession cathodal transcranial direct current stimulation of the left dorsolateral prefrontal cortex prime the effects of cognitive behavioral therapy on fear of pain, fear of movement, and disability in patients with nonspecific low back pain? A randomized clinical trial study
- Ehsani, Fatemeh, Hafez Yousefi, Mohaddeseh, Jafarzadeh, Abbas, Zoghi, Maryam, Jaberzadeh, Shapour
- Authors: Ehsani, Fatemeh , Hafez Yousefi, Mohaddeseh , Jafarzadeh, Abbas , Zoghi, Maryam , Jaberzadeh, Shapour
- Date: 2023
- Type: Text , Journal article
- Relation: Brain Sciences Vol. 13, no. 10 (2023), p.
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- Description: Many studies have shown that low back pain (LBP) is associated with psychosomatic symptoms which may lead to brain changes. This study aimed to investigate the effect of the concurrent application of cognitive behavioral therapy (CBT) and transcranial direct electrical stimulation (tDCS) over the left dorsolateral prefrontal cortex (DLPFC) on fear of pain, fear of movement, and disability in patients with nonspecific LBP. This study was performed on 45 LBP patients (23 women, 22 men; mean age 33.00 ± 1.77 years) in three groups: experimental (2 mA cathodal tDCS (c-tDCS)), sham (c-tDCS turned off after 30 s), and control (only received CBT). In all groups, CBT was conducted for 20 min per session, with two sessions per week for four weeks. Fear of pain, fear of movement, and disability were evaluated using questionnaires at baseline, immediately after, and one month after completion of interventions. Results indicated that all three different types of intervention could significantly reduce fear and disability immediately after intervention (p > 0.05). However, improvement in the experimental group was significantly higher than in the other groups immediately after and at the one-month follow-up after interventions (p < 0.05). DLPFC c-tDCS can prime the immediate effects of CBT and also the lasting effects on the reduction in the fear of pain, fear of movement, and disability in LBP patients. © 2023 by the authors.
- Authors: Ehsani, Fatemeh , Hafez Yousefi, Mohaddeseh , Jafarzadeh, Abbas , Zoghi, Maryam , Jaberzadeh, Shapour
- Date: 2023
- Type: Text , Journal article
- Relation: Brain Sciences Vol. 13, no. 10 (2023), p.
- Full Text:
- Reviewed:
- Description: Many studies have shown that low back pain (LBP) is associated with psychosomatic symptoms which may lead to brain changes. This study aimed to investigate the effect of the concurrent application of cognitive behavioral therapy (CBT) and transcranial direct electrical stimulation (tDCS) over the left dorsolateral prefrontal cortex (DLPFC) on fear of pain, fear of movement, and disability in patients with nonspecific LBP. This study was performed on 45 LBP patients (23 women, 22 men; mean age 33.00 ± 1.77 years) in three groups: experimental (2 mA cathodal tDCS (c-tDCS)), sham (c-tDCS turned off after 30 s), and control (only received CBT). In all groups, CBT was conducted for 20 min per session, with two sessions per week for four weeks. Fear of pain, fear of movement, and disability were evaluated using questionnaires at baseline, immediately after, and one month after completion of interventions. Results indicated that all three different types of intervention could significantly reduce fear and disability immediately after intervention (p > 0.05). However, improvement in the experimental group was significantly higher than in the other groups immediately after and at the one-month follow-up after interventions (p < 0.05). DLPFC c-tDCS can prime the immediate effects of CBT and also the lasting effects on the reduction in the fear of pain, fear of movement, and disability in LBP patients. © 2023 by the authors.
Domestic load management with coordinated photovoltaics, battery storage and electric vehicle operation
- Das, Narottam, Haque, Akramul, Zaman, Hasneen, Morsalin, Sayidul, Islam, Syed
- Authors: Das, Narottam , Haque, Akramul , Zaman, Hasneen , Morsalin, Sayidul , Islam, Syed
- Date: 2023
- Type: Text , Journal article
- Relation: IEEE Access Vol. 11, no. (2023), p. 12075-12087
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- Description: Coordinated power demand management at residential or domestic levels allows energy participants to efficiently manage load profiles, increase energy efficiency and reduce operational cost. In this paper, a hierarchical coordination framework to optimally manage domestic load using photovoltaic (PV) units, battery-energy-storage-systems (BESs) and electric vehicles (EVs) is presented. The bidirectional power flow of EV with vehicle to grid (V2G) operation manages real-time domestic load profile and takes appropriate coordinated action using its controller when necessary. The proposed system has been applied to a real power distribution network and tested with real load patterns and load dynamics. This also includes various test scenarios and prosumer's preferences e.g., with or without EVs, number of EV owners, number of households, and prosumer's daily activities. This is a combined hybrid system for hierarchical coordination that consists of PV units, BES systems and EVs. The system performance was analyzed with different commercial EV types with charging/ discharging constraints and the result shows that the domestic load demand on the distribution grid during the peak period has been reduced significantly. In the end, this proposed system's performance was compared with the prediction-based test techniques and the financial benefits were estimated. © 2013 IEEE.
- Authors: Das, Narottam , Haque, Akramul , Zaman, Hasneen , Morsalin, Sayidul , Islam, Syed
- Date: 2023
- Type: Text , Journal article
- Relation: IEEE Access Vol. 11, no. (2023), p. 12075-12087
- Full Text:
- Reviewed:
- Description: Coordinated power demand management at residential or domestic levels allows energy participants to efficiently manage load profiles, increase energy efficiency and reduce operational cost. In this paper, a hierarchical coordination framework to optimally manage domestic load using photovoltaic (PV) units, battery-energy-storage-systems (BESs) and electric vehicles (EVs) is presented. The bidirectional power flow of EV with vehicle to grid (V2G) operation manages real-time domestic load profile and takes appropriate coordinated action using its controller when necessary. The proposed system has been applied to a real power distribution network and tested with real load patterns and load dynamics. This also includes various test scenarios and prosumer's preferences e.g., with or without EVs, number of EV owners, number of households, and prosumer's daily activities. This is a combined hybrid system for hierarchical coordination that consists of PV units, BES systems and EVs. The system performance was analyzed with different commercial EV types with charging/ discharging constraints and the result shows that the domestic load demand on the distribution grid during the peak period has been reduced significantly. In the end, this proposed system's performance was compared with the prediction-based test techniques and the financial benefits were estimated. © 2013 IEEE.
DQN-based resource allocation for NOMA-MEC-aided multi-source data stream
- Ling, Jing, Xia, Junjuan, Zhu, Fusheng, Gao, Chongzhi, Lai, Shiwei, Balasubramanian, Venki
- Authors: Ling, Jing , Xia, Junjuan , Zhu, Fusheng , Gao, Chongzhi , Lai, Shiwei , Balasubramanian, Venki
- Date: 2023
- Type: Text , Journal article
- Relation: Eurasip Journal on Advances in Signal Processing Vol. 2023, no. 1 (2023), p.
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- Description: This paper investigates a non-orthogonal multiple access (NOMA)-aided mobile edge computing (MEC) network with multiple sources and one computing access point (CAP), in which NOMA technology is applied to transmit multi-source data streams to CAP for computing. To measure the performance of the considered NOMA-aided MEC network, we first design the system cost as a linear weighting function of energy consumption and delay under the NOMA-aided MEC network. Moreover, we propose a deep Q network (DQN)-based offloading strategy to minimize the system cost by jointly optimizing the offloading ratio and transmission power allocation. Finally, we design experiments to demonstrate the effectiveness of the proposed strategy. Specifically, the designed strategy can decrease the system cost by about 15% compared with local computing when the number of sources is 5. © 2023, The Author(s).
- Authors: Ling, Jing , Xia, Junjuan , Zhu, Fusheng , Gao, Chongzhi , Lai, Shiwei , Balasubramanian, Venki
- Date: 2023
- Type: Text , Journal article
- Relation: Eurasip Journal on Advances in Signal Processing Vol. 2023, no. 1 (2023), p.
- Full Text:
- Reviewed:
- Description: This paper investigates a non-orthogonal multiple access (NOMA)-aided mobile edge computing (MEC) network with multiple sources and one computing access point (CAP), in which NOMA technology is applied to transmit multi-source data streams to CAP for computing. To measure the performance of the considered NOMA-aided MEC network, we first design the system cost as a linear weighting function of energy consumption and delay under the NOMA-aided MEC network. Moreover, we propose a deep Q network (DQN)-based offloading strategy to minimize the system cost by jointly optimizing the offloading ratio and transmission power allocation. Finally, we design experiments to demonstrate the effectiveness of the proposed strategy. Specifically, the designed strategy can decrease the system cost by about 15% compared with local computing when the number of sources is 5. © 2023, The Author(s).
E-cigarette use among male smokers in Al-Ahsa, Kingdom of Saudi Arabia : a cross-sectional study
- Al Rajeh, Ahmed, Mahmud, Ilias, Al Imam, Mahmudul, Rahman, Muhammad Aziz, Al Shehri, Fariss, Alomayrin, Salman, Alfazae, Nawaf, Elmosaad, Yousif, Alasqah, Ibrahim
- Authors: Al Rajeh, Ahmed , Mahmud, Ilias , Al Imam, Mahmudul , Rahman, Muhammad Aziz , Al Shehri, Fariss , Alomayrin, Salman , Alfazae, Nawaf , Elmosaad, Yousif , Alasqah, Ibrahim
- Date: 2023
- Type: Text , Journal article
- Relation: International Journal of Environmental Research and Public Health Vol. 20, no. 1 (2023), p.
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- Description: E-cigarette use is increasing globally. Recent evidence suggests that e-cigarettes contain harmful substances that could cause adverse health outcomes. This study investigated the prevalence and associated factors of e-cigarette use among male current smokers in Saudi Arabia. We conducted a cross-sectional survey of adult male current smokers in the Al-Ahsa province of Saudi Arabia. Data were collected using a structured questionnaire. We performed logistic regression analyses to investigate the factors associated with e-cigarette use among adult male current smokers. 325 current smokers participated in the study. A third of them (33.5%) were e-cigarette users. Almost all the study participants (97.0%) had heard about e-cigarettes. Participants who were occasional smokers (Odds Ratio (OR): 2.28; 95% Confidence Interval (CI): 1.17–4.41) and had good knowledge perception of e-cigarettes (OR 3.49; 95% CI: 2.07–5.90) had higher odds of using e-cigarettes when compared to regular smokers of conventional cigarettes and current smokers with poor knowledge perception of e-cigarettes, respectively. In contrast, private employees (OR: 0.25, 95% CI: 0.07–0.85), and business owners (OR: 0.09, 95% CI: 0.01–0.63) had lower odds of using e-cigarettes compared to unemployed individuals. Compared with non-e-cigarette users, the rate of conventional cigarette smoking per day was significantly lower among e-cigarette users. Use of e-cigarette (OR: 3.57, 95% CI: 2.14–5.98), believing that e-cigarette quitting is hard (OR: 2.02, 95% CI: 1.17–3.49) and trying to quit e-cigarettes (OR: 2.17, 95% CI: 1.1–4.25) were found to be significant predictors of good knowledge perception of e-cigarettes among the current smokers. The use and knowledge perception of e-cigarettes were higher among occasional conventional male cigarette smokers than regular male smokers in Al-Ahsa province. The use of e-cigarettes as smoking cessation aids should be examined further in the Saudi Arabian setting. © 2022 by the authors.
- Authors: Al Rajeh, Ahmed , Mahmud, Ilias , Al Imam, Mahmudul , Rahman, Muhammad Aziz , Al Shehri, Fariss , Alomayrin, Salman , Alfazae, Nawaf , Elmosaad, Yousif , Alasqah, Ibrahim
- Date: 2023
- Type: Text , Journal article
- Relation: International Journal of Environmental Research and Public Health Vol. 20, no. 1 (2023), p.
- Full Text:
- Reviewed:
- Description: E-cigarette use is increasing globally. Recent evidence suggests that e-cigarettes contain harmful substances that could cause adverse health outcomes. This study investigated the prevalence and associated factors of e-cigarette use among male current smokers in Saudi Arabia. We conducted a cross-sectional survey of adult male current smokers in the Al-Ahsa province of Saudi Arabia. Data were collected using a structured questionnaire. We performed logistic regression analyses to investigate the factors associated with e-cigarette use among adult male current smokers. 325 current smokers participated in the study. A third of them (33.5%) were e-cigarette users. Almost all the study participants (97.0%) had heard about e-cigarettes. Participants who were occasional smokers (Odds Ratio (OR): 2.28; 95% Confidence Interval (CI): 1.17–4.41) and had good knowledge perception of e-cigarettes (OR 3.49; 95% CI: 2.07–5.90) had higher odds of using e-cigarettes when compared to regular smokers of conventional cigarettes and current smokers with poor knowledge perception of e-cigarettes, respectively. In contrast, private employees (OR: 0.25, 95% CI: 0.07–0.85), and business owners (OR: 0.09, 95% CI: 0.01–0.63) had lower odds of using e-cigarettes compared to unemployed individuals. Compared with non-e-cigarette users, the rate of conventional cigarette smoking per day was significantly lower among e-cigarette users. Use of e-cigarette (OR: 3.57, 95% CI: 2.14–5.98), believing that e-cigarette quitting is hard (OR: 2.02, 95% CI: 1.17–3.49) and trying to quit e-cigarettes (OR: 2.17, 95% CI: 1.1–4.25) were found to be significant predictors of good knowledge perception of e-cigarettes among the current smokers. The use and knowledge perception of e-cigarettes were higher among occasional conventional male cigarette smokers than regular male smokers in Al-Ahsa province. The use of e-cigarettes as smoking cessation aids should be examined further in the Saudi Arabian setting. © 2022 by the authors.
Educational leaders’ perceptions of STEM education revealed by their drawings and texts
- Hatisaru, Vesife, Falloon, Garry, Seen, Andrew, Fraser, Sharon, Powling, Markus, Beswick, Kim
- Authors: Hatisaru, Vesife , Falloon, Garry , Seen, Andrew , Fraser, Sharon , Powling, Markus , Beswick, Kim
- Date: 2023
- Type: Text , Journal article
- Relation: International Journal of Mathematical Education in Science and Technology Vol. 54, no. 8 (2023), p. 1437-1457
- Full Text:
- Reviewed:
- Description: This study explored school principals' and teacher educators' perceptions of STEM education based on how they described STEM as a discipline, their understanding of the nature of teaching and learning of STEM, and the capabilities of a STEM-educated person. Data were generated through the Draw a STEM Learning Environment (D-STEM) instrument comprising drawn and written descriptions where participants drew a picture of a STEM learning environment and completed five prompt statements about what STEM is and how an individual develops personal STEM capability. The Legitimation Code Theory (LCT) specialization codes were used for data analysis (198 individual response items in total) to understand how the participants perceive STEM education. Almost half the participant responses indicated knowledge-code perceptions with a smaller but significant number (approximately a third of responses) indicating knower-code perceptions. The remaining responses showed élite-code perceptions, indicating a small proportion of participants valued the development of both disciplinary knowledge/practices and generic skills/attributes in STEM education. We posit that curriculum structure and reporting requirements influence these perceptions. Further research in relation to the influence of such understandings on enacted curriculum is warranted. © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
- Authors: Hatisaru, Vesife , Falloon, Garry , Seen, Andrew , Fraser, Sharon , Powling, Markus , Beswick, Kim
- Date: 2023
- Type: Text , Journal article
- Relation: International Journal of Mathematical Education in Science and Technology Vol. 54, no. 8 (2023), p. 1437-1457
- Full Text:
- Reviewed:
- Description: This study explored school principals' and teacher educators' perceptions of STEM education based on how they described STEM as a discipline, their understanding of the nature of teaching and learning of STEM, and the capabilities of a STEM-educated person. Data were generated through the Draw a STEM Learning Environment (D-STEM) instrument comprising drawn and written descriptions where participants drew a picture of a STEM learning environment and completed five prompt statements about what STEM is and how an individual develops personal STEM capability. The Legitimation Code Theory (LCT) specialization codes were used for data analysis (198 individual response items in total) to understand how the participants perceive STEM education. Almost half the participant responses indicated knowledge-code perceptions with a smaller but significant number (approximately a third of responses) indicating knower-code perceptions. The remaining responses showed élite-code perceptions, indicating a small proportion of participants valued the development of both disciplinary knowledge/practices and generic skills/attributes in STEM education. We posit that curriculum structure and reporting requirements influence these perceptions. Further research in relation to the influence of such understandings on enacted curriculum is warranted. © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Effect of corrosion on the bond behavior of steel-reinforced, alkali-activated slag concrete
- Cui, Yifei, Qu, Shihao, Gao, Kaikai, Tekle, Biruk, Bao, Jiuwen, Zhang, Peng
- Authors: Cui, Yifei , Qu, Shihao , Gao, Kaikai , Tekle, Biruk , Bao, Jiuwen , Zhang, Peng
- Date: 2023
- Type: Text , Journal article
- Relation: Materials Vol. 16, no. 6 (2023), p.
- Full Text:
- Reviewed:
- Description: Alkali-activated slag concrete (ASC) is regarded as one of the most promising sustainable construction materials for replacing ordinary Portland cement concrete (OPC) due to its comparable strength and outstanding durability in challenging environments. In this study, the corrosion of steel bars embedded in ASC and OPC was studied by means of an electrically accelerated corrosion test of steel bars in concrete. Meanwhile, the bond performance of the corroded steel bars embedded in ASC was tested and compared with corresponding OPC groups. The results showed that ASC and OPC behaved differently in terms of bond deterioration. The high chemical resistance of ASC decreased the corrosion of steel bars and, thus, increased the residue bond strength and the bond stiffness. © 2023 by the authors.
- Authors: Cui, Yifei , Qu, Shihao , Gao, Kaikai , Tekle, Biruk , Bao, Jiuwen , Zhang, Peng
- Date: 2023
- Type: Text , Journal article
- Relation: Materials Vol. 16, no. 6 (2023), p.
- Full Text:
- Reviewed:
- Description: Alkali-activated slag concrete (ASC) is regarded as one of the most promising sustainable construction materials for replacing ordinary Portland cement concrete (OPC) due to its comparable strength and outstanding durability in challenging environments. In this study, the corrosion of steel bars embedded in ASC and OPC was studied by means of an electrically accelerated corrosion test of steel bars in concrete. Meanwhile, the bond performance of the corroded steel bars embedded in ASC was tested and compared with corresponding OPC groups. The results showed that ASC and OPC behaved differently in terms of bond deterioration. The high chemical resistance of ASC decreased the corrosion of steel bars and, thus, increased the residue bond strength and the bond stiffness. © 2023 by the authors.
Effect of hydralazine on angiotensin II-induced abdominal aortic aneurysm in apolipoprotein e-deficient mice
- Wang, Yutang, Sargisson, Owen, Nguyen, Dinh, Parker, Ketura, Pyke, Stephan, Alramahi, Ahmed, Thihlum, Liam, Fang, Yan, Wallace, Morgan, Berzins, Stuart, Oqueli, Ernesto, Magliano, Dianna, Golledge, Jonathan
- Authors: Wang, Yutang , Sargisson, Owen , Nguyen, Dinh , Parker, Ketura , Pyke, Stephan , Alramahi, Ahmed , Thihlum, Liam , Fang, Yan , Wallace, Morgan , Berzins, Stuart , Oqueli, Ernesto , Magliano, Dianna , Golledge, Jonathan
- Date: 2023
- Type: Text , Journal article
- Relation: International Journal of Molecular Sciences Vol. 24, no. 21 (2023), p.
- Relation: https://purl.org/au-research/grants/nhmrc/1062671
- Full Text:
- Reviewed:
- Description: The rupture of an abdominal aortic aneurysm (AAA) causes about 200,000 deaths worldwide each year. However, there are currently no effective drug therapies to prevent AAA formation or, when present, to decrease progression and rupture, highlighting an urgent need for more research in this field. Increased vascular inflammation and enhanced apoptosis of vascular smooth muscle cells (VSMCs) are implicated in AAA formation. Here, we investigated whether hydralazine, which has anti-inflammatory and anti-apoptotic properties, inhibited AAA formation and pathological hallmarks. In cultured VSMCs, hydralazine (100
- Authors: Wang, Yutang , Sargisson, Owen , Nguyen, Dinh , Parker, Ketura , Pyke, Stephan , Alramahi, Ahmed , Thihlum, Liam , Fang, Yan , Wallace, Morgan , Berzins, Stuart , Oqueli, Ernesto , Magliano, Dianna , Golledge, Jonathan
- Date: 2023
- Type: Text , Journal article
- Relation: International Journal of Molecular Sciences Vol. 24, no. 21 (2023), p.
- Relation: https://purl.org/au-research/grants/nhmrc/1062671
- Full Text:
- Reviewed:
- Description: The rupture of an abdominal aortic aneurysm (AAA) causes about 200,000 deaths worldwide each year. However, there are currently no effective drug therapies to prevent AAA formation or, when present, to decrease progression and rupture, highlighting an urgent need for more research in this field. Increased vascular inflammation and enhanced apoptosis of vascular smooth muscle cells (VSMCs) are implicated in AAA formation. Here, we investigated whether hydralazine, which has anti-inflammatory and anti-apoptotic properties, inhibited AAA formation and pathological hallmarks. In cultured VSMCs, hydralazine (100
Effect of selected environmental factors on the seed germination of the invasive species Polygala myrtifolia (Polygalaceae) in Australia
- Roberts, Natalie, Moloney, Katrina, Monie, Kristin, Florentine, Singarayer
- Authors: Roberts, Natalie , Moloney, Katrina , Monie, Kristin , Florentine, Singarayer
- Date: 2023
- Type: Text , Journal article
- Relation: Australian Journal of Botany Vol. 71, no. 6 (2023), p. 286-295
- Full Text:
- Reviewed:
- Description: Context. Polygala myrtifolia L. has become a significant environmental weed in Australia, where it has invaded coastal ecosystems in temperate regions and there is a high risk of extensive further spread. Knowledge of seed-germination behaviour is essential to understand the potential future impact of this species. Aims. We investigated the effects of selected environmental factors and dormancy on P. myrtifolia seed germination and emergence to improve management strategies. Methods. Seeds were exposed to light, temperature, pH, salinity, osmotic potential and burial depth treatments to assess germination responses, dormancy and viability. Key results. Non-dormant seeds readily germinated to high percentages (93.0–95.0%) under specific day–night temperatures of 25°C–15°C regardless of light conditions and across all soil pH (75.0–100.0%). Salinities were tolerated up to 100 mM NaCl (70.0% germination) before sharply declining. Germination reduced from 98.3% to 40.0% at osmotic potentials of
- Authors: Roberts, Natalie , Moloney, Katrina , Monie, Kristin , Florentine, Singarayer
- Date: 2023
- Type: Text , Journal article
- Relation: Australian Journal of Botany Vol. 71, no. 6 (2023), p. 286-295
- Full Text:
- Reviewed:
- Description: Context. Polygala myrtifolia L. has become a significant environmental weed in Australia, where it has invaded coastal ecosystems in temperate regions and there is a high risk of extensive further spread. Knowledge of seed-germination behaviour is essential to understand the potential future impact of this species. Aims. We investigated the effects of selected environmental factors and dormancy on P. myrtifolia seed germination and emergence to improve management strategies. Methods. Seeds were exposed to light, temperature, pH, salinity, osmotic potential and burial depth treatments to assess germination responses, dormancy and viability. Key results. Non-dormant seeds readily germinated to high percentages (93.0–95.0%) under specific day–night temperatures of 25°C–15°C regardless of light conditions and across all soil pH (75.0–100.0%). Salinities were tolerated up to 100 mM NaCl (70.0% germination) before sharply declining. Germination reduced from 98.3% to 40.0% at osmotic potentials of
Effect of traumatic upper-limb injury on cognitive functions : a cross-sectional observational study
- Zhang, Xue, Tse, Tamara, Chen, Shao-Zhen, Qiu, Kai-Yi, Li, Xia, Zoghi, Maryam
- Authors: Zhang, Xue , Tse, Tamara , Chen, Shao-Zhen , Qiu, Kai-Yi , Li, Xia , Zoghi, Maryam
- Date: 2023
- Type: Text , Journal article
- Relation: Hand Surgery and Rehabilitation Vol. 42, no. 5 (2023), p. 413-418
- Full Text:
- Reviewed:
- Description: Objectives: There is growing evidence of cognitive impairment after traumatic peripheral lesions. The purpose of this study was to explore the association between cognitive function and traumatic upper-limb injury. We assessed difference in cognitive function between participants with and without upper-limb injury, and explored the association between cognitive function and certain variables in injured individuals: gender, age, body mass index (BMI), educational level, and occupation. We sought to identify the factors associated with cognitive function in injured subjects: time since injury, injury side, nerve injury, hand function, pain, and finger sensation. Material and methods: A cross-sectional observational study was conducted, with 2 groups: observational group (with traumatic upper-limb injury) and control group (uninjured). The 2 groups were matched for age, gender, BMI, educational level and occupation. Short-term memory and executive functions were assessed using the Rey Auditory and Verbal Learning Test (RAVLT) and Stroop Color and Word Test (SCWT), respectively. Results: 104 participants with traumatic upper-limb injury and 104 uninjured control subjects were included. There was a significant inter-group difference only in RAVLT (p < 0.01; Cohen d, of 0.38). Regression analysis demonstrated an association of pain on VAS (beta =
Effect of traumatic upper-limb injury on cognitive functions : a cross-sectional observational study
- Authors: Zhang, Xue , Tse, Tamara , Chen, Shao-Zhen , Qiu, Kai-Yi , Li, Xia , Zoghi, Maryam
- Date: 2023
- Type: Text , Journal article
- Relation: Hand Surgery and Rehabilitation Vol. 42, no. 5 (2023), p. 413-418
- Full Text:
- Reviewed:
- Description: Objectives: There is growing evidence of cognitive impairment after traumatic peripheral lesions. The purpose of this study was to explore the association between cognitive function and traumatic upper-limb injury. We assessed difference in cognitive function between participants with and without upper-limb injury, and explored the association between cognitive function and certain variables in injured individuals: gender, age, body mass index (BMI), educational level, and occupation. We sought to identify the factors associated with cognitive function in injured subjects: time since injury, injury side, nerve injury, hand function, pain, and finger sensation. Material and methods: A cross-sectional observational study was conducted, with 2 groups: observational group (with traumatic upper-limb injury) and control group (uninjured). The 2 groups were matched for age, gender, BMI, educational level and occupation. Short-term memory and executive functions were assessed using the Rey Auditory and Verbal Learning Test (RAVLT) and Stroop Color and Word Test (SCWT), respectively. Results: 104 participants with traumatic upper-limb injury and 104 uninjured control subjects were included. There was a significant inter-group difference only in RAVLT (p < 0.01; Cohen d, of 0.38). Regression analysis demonstrated an association of pain on VAS (beta =
Effects of a structured reflective interview on parental reflective functioning : a pilot randomised controlled trial
- Low, Yu, Lewis, Andrew, Serfaty, Irene
- Authors: Low, Yu , Lewis, Andrew , Serfaty, Irene
- Date: 2023
- Type: Text , Journal article
- Relation: Journal of Child and Family Studies Vol. 32, no. 2 (2023), p. 516-529
- Full Text:
- Reviewed:
- Description: The Parental Reflective Interview Procedure was developed as part of an initial assessment interview for an attachment-based intervention for child mental health conditions. This study was a pilot randomised controlled trial that utilised a parallel, single-blind trial design to evaluate the differences in the effects of the Parental Reflective Interview Procedure compared to a diagnostic interview on parental reflective functioning. The control group was administered a structured diagnostic interview (Mini International Neuropsychiatric Interview for Children and Adolescents—Parent Version) and matched for time with clinician. The study sample were 25 parents of clinic-referred children who scored above the clinical cut-off score on the Child Behaviour Checklist. Parental reflective functioning was measured with the Parental Reflective Functioning Questionnaire at baseline and repeated post-intervention, and then again at a two-week follow up. Results showed that the Parental Reflective Interview Procedure produced moderate improvements in parents’ understanding of their children’s mental states and maintenance in their reflections on intergenerational parent-child relationship patterns. The diagnostic interview showed decreases in both these dimensions. The findings suggest that the Parental Reflective Interview Procedure is a promising format for initial assessment when referral indicates difficulty in the parent-child relationship. The interview acts as a good orientation for parents to an intervention focused on parent-child relationship dynamics. Further work refining this interview, its coding and integration into a tailored feedback session is required. © 2023, The Author(s).
- Authors: Low, Yu , Lewis, Andrew , Serfaty, Irene
- Date: 2023
- Type: Text , Journal article
- Relation: Journal of Child and Family Studies Vol. 32, no. 2 (2023), p. 516-529
- Full Text:
- Reviewed:
- Description: The Parental Reflective Interview Procedure was developed as part of an initial assessment interview for an attachment-based intervention for child mental health conditions. This study was a pilot randomised controlled trial that utilised a parallel, single-blind trial design to evaluate the differences in the effects of the Parental Reflective Interview Procedure compared to a diagnostic interview on parental reflective functioning. The control group was administered a structured diagnostic interview (Mini International Neuropsychiatric Interview for Children and Adolescents—Parent Version) and matched for time with clinician. The study sample were 25 parents of clinic-referred children who scored above the clinical cut-off score on the Child Behaviour Checklist. Parental reflective functioning was measured with the Parental Reflective Functioning Questionnaire at baseline and repeated post-intervention, and then again at a two-week follow up. Results showed that the Parental Reflective Interview Procedure produced moderate improvements in parents’ understanding of their children’s mental states and maintenance in their reflections on intergenerational parent-child relationship patterns. The diagnostic interview showed decreases in both these dimensions. The findings suggest that the Parental Reflective Interview Procedure is a promising format for initial assessment when referral indicates difficulty in the parent-child relationship. The interview acts as a good orientation for parents to an intervention focused on parent-child relationship dynamics. Further work refining this interview, its coding and integration into a tailored feedback session is required. © 2023, The Author(s).
Effects of α-lactalbumin on strength, fatigue and psychological parameters: a randomised double-blind cross-over study
- Mackay-Phillips, Karen, Orssatto, Lucas, Polman, Remco, Van der Pols, Jolieke, Trajano, Gabriel
- Authors: Mackay-Phillips, Karen , Orssatto, Lucas , Polman, Remco , Van der Pols, Jolieke , Trajano, Gabriel
- Date: 2023
- Type: Text , Journal article
- Relation: European Journal of Applied Physiology Vol. 123, no. 2 (2023), p. 381-393
- Full Text:
- Reviewed:
- Description: Purpose: The neurotransmitter serotonin has a strong effect on behaviour and motor control. Regarding motor control, serotonin contributes to the development of fatigue and is also involved in the ability of motor neurones to operate across a large range of forces (gain control). The consumption of tryptophan-rich supplements (such as
- Description: Purpose: The neurotransmitter serotonin has a strong effect on behaviour and motor control. Regarding motor control, serotonin contributes to the development of fatigue and is also involved in the ability of motor neurones to operate across a large range of forces (gain control). The consumption of tryptophan-rich supplements (such as α-lactalbumin) is of interest because this amino acid is the only precursor for brain serotonin synthesis. Therefore, the purpose of this study was to determine the effects of α-lactalbumin supplementation on neuromuscular performance. Methods: Using a randomised double-blind cross-over design, 16 healthy participants performed plantar flexor and handgrip maximal voluntary contractions, a 30-s submaximal handgrip contraction, and a plantar flexor fatigue protocol before and 90 min after consuming either 40 g of α-lactalbumin, an isonitrogenous beverage (Zein) or an isocaloric beverage (corn-starch). Sleepiness, mood, and cognition were assessed to evaluate any psychological effects. Results: α-Lactalbumin decreased force steadiness by 25% during the sustained submaximal handgrip contraction (p < 0.01) and induced greater fatigue (15% reduction in total torque–time integral, p = 0.01) during the fatigue protocol. These effects were not observed for the other control beverages. No effects were found for maximal or explosive strength, or psychological measurements. Conclusions: 40 g of α-lactalbumin increased handgrip force variability and reduced performance during fatiguing muscle contractions but did not influence brief maximal contractions or psychological parameters in healthy individuals. These findings support the hypothesis that the consumption of α-lactalbumin can increase motor neurone input–output gain and exacerbate central fatigue during sustained maximal exercise. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
- Authors: Mackay-Phillips, Karen , Orssatto, Lucas , Polman, Remco , Van der Pols, Jolieke , Trajano, Gabriel
- Date: 2023
- Type: Text , Journal article
- Relation: European Journal of Applied Physiology Vol. 123, no. 2 (2023), p. 381-393
- Full Text:
- Reviewed:
- Description: Purpose: The neurotransmitter serotonin has a strong effect on behaviour and motor control. Regarding motor control, serotonin contributes to the development of fatigue and is also involved in the ability of motor neurones to operate across a large range of forces (gain control). The consumption of tryptophan-rich supplements (such as
- Description: Purpose: The neurotransmitter serotonin has a strong effect on behaviour and motor control. Regarding motor control, serotonin contributes to the development of fatigue and is also involved in the ability of motor neurones to operate across a large range of forces (gain control). The consumption of tryptophan-rich supplements (such as α-lactalbumin) is of interest because this amino acid is the only precursor for brain serotonin synthesis. Therefore, the purpose of this study was to determine the effects of α-lactalbumin supplementation on neuromuscular performance. Methods: Using a randomised double-blind cross-over design, 16 healthy participants performed plantar flexor and handgrip maximal voluntary contractions, a 30-s submaximal handgrip contraction, and a plantar flexor fatigue protocol before and 90 min after consuming either 40 g of α-lactalbumin, an isonitrogenous beverage (Zein) or an isocaloric beverage (corn-starch). Sleepiness, mood, and cognition were assessed to evaluate any psychological effects. Results: α-Lactalbumin decreased force steadiness by 25% during the sustained submaximal handgrip contraction (p < 0.01) and induced greater fatigue (15% reduction in total torque–time integral, p = 0.01) during the fatigue protocol. These effects were not observed for the other control beverages. No effects were found for maximal or explosive strength, or psychological measurements. Conclusions: 40 g of α-lactalbumin increased handgrip force variability and reduced performance during fatiguing muscle contractions but did not influence brief maximal contractions or psychological parameters in healthy individuals. These findings support the hypothesis that the consumption of α-lactalbumin can increase motor neurone input–output gain and exacerbate central fatigue during sustained maximal exercise. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Efficacy of a digital mental health biopsychosocial transdiagnostic intervention with or without therapist assistance for adults with anxiety and depression : adaptive randomized controlled trial
- Andrews, Brooke, Klein, Britt, Nguyen, Huy, Corboy, Denise, McLaren, Suzanne, Watson, Shaun
- Authors: Andrews, Brooke , Klein, Britt , Nguyen, Huy , Corboy, Denise , McLaren, Suzanne , Watson, Shaun
- Date: 2023
- Type: Text , Journal article
- Relation: Journal of Medical Internet Research Vol. 25, no. (2023), p.
- Full Text:
- Reviewed:
- Description: Background: Digital mental health (DMH) interventions incorporating elements that adapt to the evolving needs of consumers have the potential to further our understanding of the optimal intensity of therapist assistance and inform stepped-care models. Objective: The primary objective was to compare the efficacy of a transdiagnostic biopsychosocial DMH program, with or without therapist assistance for adults with subthreshold symptoms or a diagnosis of anxiety or depression. Methods: In a randomized adaptive clinical trial design, all participants had access to the DMH program, with eligibility to have their program augmented with therapist assistance determined by program engagement or symptom severity. Participants who met stepped-care criteria were randomized to have their treatment program augmented with either low-intensity (10 min/week of video chat support for 7 weeks) or high-intensity (50 min/week of video chat support for 7 weeks) therapist assistance. A total of 103 participants (mean age 34.17, SD 10.50 years) were assessed before (week 0), during (weeks 3 and 6), and after the intervention (week 9) and at the 3-month follow-up (week 21). The effects of 3 treatment conditions (DMH program only, DMH program+low-intensity therapist assistance, and DMH program+high-intensity therapist assistance) on changes in the 2 primary outcomes of anxiety (7-item Generalized Anxiety Disorder Scale [GAD-7]) and depression (9-item Patient Health Questionnaire [PHQ-9]) were assessed using the Cohen d, reliable change index, and mixed-effects linear regression analyses. Results: There were no substantial differences in the outcome measures among intervention conditions. However, there were significant time effect changes in most outcomes over time. All 3 intervention conditions demonstrated strong and significant treatment effect changes in GAD-7 and PHQ-9 scores, with absolute Cohen d values ranging from 0.82 to 1.79 (all P<.05). The mixed-effects models revealed that, in the Life Flex program–only condition at week 3, mean GAD-7 and PHQ-9 scores significantly decreased from baseline by 3.54 and 4.38 (all P<.001), respectively. At weeks 6, 9, and 21, GAD-7 and PHQ-9 scores significantly decreased from baseline by at least 6 and 7 points (all P<.001), respectively. Nonresponders at week 3 who were stepped up to therapist assistance increased program engagement and treatment response. At the postintervention time point and 3-month follow-up, 67% (44/65) and 69% (34/49) of the participants, respectively, no longer met diagnostic criteria for anxiety or depression. Conclusions: The findings highlight that early detection of low engagement and non–treatment response presents an opportunity to effectively intervene by incorporating an adaptive design. Although the study findings indicate that therapist assistance was no more effective than the DMH intervention program alone for reducing symptoms of anxiety or depression, the data highlight the potential influence of participant selection bias and participant preferences within stepped-care treatment models. ©Brooke Andrews, Britt Klein, Huy Van Nguyen, Denise Corboy, Suzanne McLaren, Shaun Watson.
- Authors: Andrews, Brooke , Klein, Britt , Nguyen, Huy , Corboy, Denise , McLaren, Suzanne , Watson, Shaun
- Date: 2023
- Type: Text , Journal article
- Relation: Journal of Medical Internet Research Vol. 25, no. (2023), p.
- Full Text:
- Reviewed:
- Description: Background: Digital mental health (DMH) interventions incorporating elements that adapt to the evolving needs of consumers have the potential to further our understanding of the optimal intensity of therapist assistance and inform stepped-care models. Objective: The primary objective was to compare the efficacy of a transdiagnostic biopsychosocial DMH program, with or without therapist assistance for adults with subthreshold symptoms or a diagnosis of anxiety or depression. Methods: In a randomized adaptive clinical trial design, all participants had access to the DMH program, with eligibility to have their program augmented with therapist assistance determined by program engagement or symptom severity. Participants who met stepped-care criteria were randomized to have their treatment program augmented with either low-intensity (10 min/week of video chat support for 7 weeks) or high-intensity (50 min/week of video chat support for 7 weeks) therapist assistance. A total of 103 participants (mean age 34.17, SD 10.50 years) were assessed before (week 0), during (weeks 3 and 6), and after the intervention (week 9) and at the 3-month follow-up (week 21). The effects of 3 treatment conditions (DMH program only, DMH program+low-intensity therapist assistance, and DMH program+high-intensity therapist assistance) on changes in the 2 primary outcomes of anxiety (7-item Generalized Anxiety Disorder Scale [GAD-7]) and depression (9-item Patient Health Questionnaire [PHQ-9]) were assessed using the Cohen d, reliable change index, and mixed-effects linear regression analyses. Results: There were no substantial differences in the outcome measures among intervention conditions. However, there were significant time effect changes in most outcomes over time. All 3 intervention conditions demonstrated strong and significant treatment effect changes in GAD-7 and PHQ-9 scores, with absolute Cohen d values ranging from 0.82 to 1.79 (all P<.05). The mixed-effects models revealed that, in the Life Flex program–only condition at week 3, mean GAD-7 and PHQ-9 scores significantly decreased from baseline by 3.54 and 4.38 (all P<.001), respectively. At weeks 6, 9, and 21, GAD-7 and PHQ-9 scores significantly decreased from baseline by at least 6 and 7 points (all P<.001), respectively. Nonresponders at week 3 who were stepped up to therapist assistance increased program engagement and treatment response. At the postintervention time point and 3-month follow-up, 67% (44/65) and 69% (34/49) of the participants, respectively, no longer met diagnostic criteria for anxiety or depression. Conclusions: The findings highlight that early detection of low engagement and non–treatment response presents an opportunity to effectively intervene by incorporating an adaptive design. Although the study findings indicate that therapist assistance was no more effective than the DMH intervention program alone for reducing symptoms of anxiety or depression, the data highlight the potential influence of participant selection bias and participant preferences within stepped-care treatment models. ©Brooke Andrews, Britt Klein, Huy Van Nguyen, Denise Corboy, Suzanne McLaren, Shaun Watson.
Efficient future waste management : a learning-based approach with deep neural networks for smart system (LADS)
- Chauhan, Ritu, Shighra, Sahil, Madkhali, Hatim, Nguyen, Linh, Prasad, Mukesh
- Authors: Chauhan, Ritu , Shighra, Sahil , Madkhali, Hatim , Nguyen, Linh , Prasad, Mukesh
- Date: 2023
- Type: Text , Journal article
- Relation: Applied Sciences (Switzerland) Vol. 13, no. 7 (2023), p.
- Full Text:
- Reviewed:
- Description: Waste segregation, management, transportation, and disposal must be carefully managed to reduce the danger to patients, the public, and risks to the environment’s health and safety. The previous method of monitoring trash in strategically placed garbage bins is a time-consuming and inefficient method that wastes time, human effort, and money, and is also incompatible with smart city needs. So, the goal is to reduce individual decision-making and increase the productivity of the waste categorization process. Using a convolutional neural network (CNN), the study sought to create an image classifier that recognizes items and classifies trash material. This paper provides an overview of trash monitoring methods, garbage disposal strategies, and the technology used in establishing a waste management system. Finally, an efficient system and waste disposal approach is provided that may be employed in the future to improve performance and cost effectiveness. One of the most significant barriers to efficient waste management can now be overcome with the aid of a deep learning technique. The proposed method outperformed the alternative AlexNet, VGG16, and ResNet34 methods. © 2023 by the authors.
- Authors: Chauhan, Ritu , Shighra, Sahil , Madkhali, Hatim , Nguyen, Linh , Prasad, Mukesh
- Date: 2023
- Type: Text , Journal article
- Relation: Applied Sciences (Switzerland) Vol. 13, no. 7 (2023), p.
- Full Text:
- Reviewed:
- Description: Waste segregation, management, transportation, and disposal must be carefully managed to reduce the danger to patients, the public, and risks to the environment’s health and safety. The previous method of monitoring trash in strategically placed garbage bins is a time-consuming and inefficient method that wastes time, human effort, and money, and is also incompatible with smart city needs. So, the goal is to reduce individual decision-making and increase the productivity of the waste categorization process. Using a convolutional neural network (CNN), the study sought to create an image classifier that recognizes items and classifies trash material. This paper provides an overview of trash monitoring methods, garbage disposal strategies, and the technology used in establishing a waste management system. Finally, an efficient system and waste disposal approach is provided that may be employed in the future to improve performance and cost effectiveness. One of the most significant barriers to efficient waste management can now be overcome with the aid of a deep learning technique. The proposed method outperformed the alternative AlexNet, VGG16, and ResNet34 methods. © 2023 by the authors.
Electricity theft detection for energy optimization using deep learning models
- Pamir, Javaid, Nadeem, Javed, Muhammad, Houran, Mohamad, Almasoud, Abdullah, Imran, Muhammad
- Authors: Pamir , Javaid, Nadeem , Javed, Muhammad , Houran, Mohamad , Almasoud, Abdullah , Imran, Muhammad
- Date: 2023
- Type: Text , Journal article
- Relation: Energy Science and Engineering Vol. 11, no. 10 (2023), p. 3575-3596
- Full Text:
- Reviewed:
- Description: The rapid increase in nontechnical loss (NTL) has become a principal concern for distribution system operators (DSOs) over the years. Electricity theft makes up a major part of NTL. It causes losses for the DSOs and also deteriorates the quality of electricity. The introduction of advanced metering infrastructure along with the upgradation of the traditional grids to the smart grids (SGs) has helped the electric utilities to collect the electricity consumption (EC) readings of consumers, which further empowers the machine learning (ML) algorithms to be exploited for efficient electricity theft detection (ETD). However, there are still some shortcomings, such as class imbalance, curse of dimensionality, and bypassing the automated tuning of hyperparameters in the existing ML-based theft classification schemes that limit their performances. Therefore, it is essential to develop a novel approach to deal with these problems and efficiently detect electricity theft in SGs. Using the salp swarm algorithm (SSA), gate convolutional autoencoder (GCAE), and cost-sensitive learning and long short-term memory (CSLSTM), an effective ETD model named SSA–GCAE–CSLSTM is proposed in this work. Furthermore, a hybrid GCAE model is developed via the combination of gated recurrent unit and convolutional autoencoder. The proposed model comprises five submodules: (1) data preparation, (2) data balancing, (3) dimensionality reduction, (4) hyperparameters' optimization, and (5) electricity theft classification. The real-time EC data provided by the state grid corporation of China are used for performance evaluations via extensive simulations. The proposed model is compared with two basic models, CSLSTM and GCAE–CSLSTM, along with seven benchmarks, support vector machine, decision tree, extra trees, random forest, adaptive boosting, extreme gradient boosting, and convolutional neural network. The results exhibit that SSA–GCAE–CSLSTM yields 99.45% precision, 95.93% F1 score, 92.25% accuracy, and 71.13% area under the receiver operating characteristic curve score, and surpasses the other models in terms of ETD. © 2023 The Authors. Energy Science & Engineering published by Society of Chemical Industry and John Wiley & Sons Ltd.
- Authors: Pamir , Javaid, Nadeem , Javed, Muhammad , Houran, Mohamad , Almasoud, Abdullah , Imran, Muhammad
- Date: 2023
- Type: Text , Journal article
- Relation: Energy Science and Engineering Vol. 11, no. 10 (2023), p. 3575-3596
- Full Text:
- Reviewed:
- Description: The rapid increase in nontechnical loss (NTL) has become a principal concern for distribution system operators (DSOs) over the years. Electricity theft makes up a major part of NTL. It causes losses for the DSOs and also deteriorates the quality of electricity. The introduction of advanced metering infrastructure along with the upgradation of the traditional grids to the smart grids (SGs) has helped the electric utilities to collect the electricity consumption (EC) readings of consumers, which further empowers the machine learning (ML) algorithms to be exploited for efficient electricity theft detection (ETD). However, there are still some shortcomings, such as class imbalance, curse of dimensionality, and bypassing the automated tuning of hyperparameters in the existing ML-based theft classification schemes that limit their performances. Therefore, it is essential to develop a novel approach to deal with these problems and efficiently detect electricity theft in SGs. Using the salp swarm algorithm (SSA), gate convolutional autoencoder (GCAE), and cost-sensitive learning and long short-term memory (CSLSTM), an effective ETD model named SSA–GCAE–CSLSTM is proposed in this work. Furthermore, a hybrid GCAE model is developed via the combination of gated recurrent unit and convolutional autoencoder. The proposed model comprises five submodules: (1) data preparation, (2) data balancing, (3) dimensionality reduction, (4) hyperparameters' optimization, and (5) electricity theft classification. The real-time EC data provided by the state grid corporation of China are used for performance evaluations via extensive simulations. The proposed model is compared with two basic models, CSLSTM and GCAE–CSLSTM, along with seven benchmarks, support vector machine, decision tree, extra trees, random forest, adaptive boosting, extreme gradient boosting, and convolutional neural network. The results exhibit that SSA–GCAE–CSLSTM yields 99.45% precision, 95.93% F1 score, 92.25% accuracy, and 71.13% area under the receiver operating characteristic curve score, and surpasses the other models in terms of ETD. © 2023 The Authors. Energy Science & Engineering published by Society of Chemical Industry and John Wiley & Sons Ltd.
Emergency care in the context of armed conflict : nurses’ perspectives of the essential core competencies
- Mani, Zakaria, Kuhn, Lisa, Plummer, Virginia
- Authors: Mani, Zakaria , Kuhn, Lisa , Plummer, Virginia
- Date: 2023
- Type: Text , Journal article
- Relation: International Nursing Review Vol. 70, no. 4 (2023), p. 510-517
- Full Text:
- Reviewed:
- Description: Aim: To identify nurses’ perspectives of their core competencies for emergency care in the context of armed conflict. Introduction: Emergency department's (ED) capacity is frequently overwhelmed by a sudden surge of patients when located near armed conflict. Although emergency nurses are key frontline responders, evidence detailing core competencies needed to work in these areas remains limited. Method: The study used a cross-sectional survey design and is reported using STROBE guidelines. A validated questionnaire was administered in hospitals near the southern Kingdom of Saudi Arabia and Yemen border, where emergency nurses regularly manage large numbers of patients from armed conflict. Result: A total of 163 questionnaires were returned (68% response rate). Most participants were female and had more than six years of ED experience. The core competencies for emergency nurses working near armed conflict were identified and highly rated by participants: the highest mean value was 9.47/10 and the lowest was 8.89/10. Analysis revealed regular education, training and drills were needed to provide quality emergency nursing care for victims of armed conflict. Conclusion and implications for nursing and health policy: This study provides new evidence regarding core competencies in emergency nursing care in the context of armed conflict. The identified competencies should be incorporated into future education, curricula, training programmes and evaluations to enable emergency nurses to function effectively in the context of armed conflict. The findings will assist decision-makers to develop plans and strategies for mitigating risk and improving the future nursing response in similar contexts. © 2023 The Authors. International Nursing Review published by John Wiley & Sons Ltd on behalf of International Council of Nurses.
- Authors: Mani, Zakaria , Kuhn, Lisa , Plummer, Virginia
- Date: 2023
- Type: Text , Journal article
- Relation: International Nursing Review Vol. 70, no. 4 (2023), p. 510-517
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- Description: Aim: To identify nurses’ perspectives of their core competencies for emergency care in the context of armed conflict. Introduction: Emergency department's (ED) capacity is frequently overwhelmed by a sudden surge of patients when located near armed conflict. Although emergency nurses are key frontline responders, evidence detailing core competencies needed to work in these areas remains limited. Method: The study used a cross-sectional survey design and is reported using STROBE guidelines. A validated questionnaire was administered in hospitals near the southern Kingdom of Saudi Arabia and Yemen border, where emergency nurses regularly manage large numbers of patients from armed conflict. Result: A total of 163 questionnaires were returned (68% response rate). Most participants were female and had more than six years of ED experience. The core competencies for emergency nurses working near armed conflict were identified and highly rated by participants: the highest mean value was 9.47/10 and the lowest was 8.89/10. Analysis revealed regular education, training and drills were needed to provide quality emergency nursing care for victims of armed conflict. Conclusion and implications for nursing and health policy: This study provides new evidence regarding core competencies in emergency nursing care in the context of armed conflict. The identified competencies should be incorporated into future education, curricula, training programmes and evaluations to enable emergency nurses to function effectively in the context of armed conflict. The findings will assist decision-makers to develop plans and strategies for mitigating risk and improving the future nursing response in similar contexts. © 2023 The Authors. International Nursing Review published by John Wiley & Sons Ltd on behalf of International Council of Nurses.
Emotional wellbeing as a matter of relationships and love : insights for social work from mental health peer mentor trainees, carers and practitioners
- Ross, Dyann, Couche, Mary, Connolly, John, Bennett, Bindi
- Authors: Ross, Dyann , Couche, Mary , Connolly, John , Bennett, Bindi
- Date: 2023
- Type: Text , Journal article
- Relation: Social Work in Mental Health Vol. 21, no. 6 (2023), p. 634-655
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- Description: The research gathered lived experience accounts of emotional wellbeing as a counter to the over-focus on illness and deficit language and approaches in mental health practice. The exploratory research study involved semi-interviews with mental health peer mentor trainees, carers and practitioners to explore their ideas about emotional wellbeing, what enabled it and what challenged their wellbeing. Emotional wellbeing was understood as a fluctuating continuum of capacities to engage in everyday activities, to self-care and to foster relationships with others. The absence of emotional wellbeing was linked to a reduced quality of relationships and ability to love. © 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.
- Authors: Ross, Dyann , Couche, Mary , Connolly, John , Bennett, Bindi
- Date: 2023
- Type: Text , Journal article
- Relation: Social Work in Mental Health Vol. 21, no. 6 (2023), p. 634-655
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- Description: The research gathered lived experience accounts of emotional wellbeing as a counter to the over-focus on illness and deficit language and approaches in mental health practice. The exploratory research study involved semi-interviews with mental health peer mentor trainees, carers and practitioners to explore their ideas about emotional wellbeing, what enabled it and what challenged their wellbeing. Emotional wellbeing was understood as a fluctuating continuum of capacities to engage in everyday activities, to self-care and to foster relationships with others. The absence of emotional wellbeing was linked to a reduced quality of relationships and ability to love. © 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.
Enacting more-than-human pedagogies in response to ecological precarity : an immanent praxiography
- Authors: Jukes, Scott
- Date: 2023
- Type: Text , Journal article
- Relation: Australian Journal of Environmental Education Vol. 39, no. 2 (2023), p. 231-233
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- Authors: Jukes, Scott
- Date: 2023
- Type: Text , Journal article
- Relation: Australian Journal of Environmental Education Vol. 39, no. 2 (2023), p. 231-233
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