Description:
The interrelationship between the public and private sectors, and formal and informal healthcare sectors effects market-level service quality, pricing behaviour and referral networks. However, health utilisation analysis of national survey data from many low and middle income countries is constrained by the lack of disaggregated health provider data. This study is concerned with the pattern of repeat outpatient consultations for a single episode of fever from public and private qualified providers and private unqualified providers. Cross-sectional survey data from 1173 adult respondents sampled from three districts within India's most populous state-Uttar Pradesh is analysed. Data was collected during the monsoon season-September to October-in 2012. Regression analysis focuses on the pattern of repeats visits for a single episode of mild-sever fever as the dependent variable. Results show that Women and Muslims in rural north India are more likely to not access healthcare, and if they do, consult with low quality unqualified outpatient healthcare providers. For fever durations of four or more days, men are more likely to access unqualified providers compared to women. Results of the current study supports the literature that women's utilisation of outpatient healthcare for communicable illnesses in LMICs is often less than men. A relative lack of access to household resources explains why fever duration parameter estimates for women and men differ.
Description:
Concrete is arguably one of the most important and widely used materials in the world, responsible for the majority of the industrial revolution due to its unique properties. However, it is susceptible to cracking under internal and external stresses. The generated cracks result in a significant reduction in the concrete lifespan and an increase in maintenance and repair costs. In recent years, the implementation of bacterial-based healing agent in the concrete matrix has emerged as one of the most promising approaches to address the concrete cracking issue. However, the bacterial cells need to be protected from the high pH content of concrete as well as the exerted shear forces during preparation and hardening stages. To address these issues, we propose the magnetic immobilization of bacteria with iron oxide nanoparticles (IONs). In the present study, the effect of the designed bio-agent on mechanical properties of concrete (compressive strength and drying shrinkage) is investigated. The results indicate that the addition of immobilized Bacillus species with IONs in concrete matrix contributes to increasing the compressive strength. Moreover, the precipitates in the bio-concrete specimen were characterized using scanning electron microscope (SEM), X-ray diffraction (XRD), and energy-dispersive X-ray spectroscopy (EDS). The characterization studies confirm that the precipitated crystals in bio-concrete specimen were CaCO3, while no precipitation was observed in the control sample.
Description:
Genome-wide association studies (GWAS) have identified >100 loci of chronic kidney disease-defining traits (CKD-dt). Molecular mechanisms underlying these associations remain elusive. Using 280 kidney transcriptomes and 9958 gene expression profiles from 44 non-renal tissues we uncover gene expression partners (eGenes) for 88.9% of CKD-dt GWAS loci. Through epigenomic chromatin segmentation analysis and variant effect prediction we annotate functional consequences to 74% of these loci. Our colocalisation analysis and Mendelian randomisation in >130,000 subjects demonstrate causal effects of three eGenes (NAT8B, CASP9 and MUC1) on estimated glomerular filtration rate. We identify a common alternative splice variant in MUC1 (a gene responsible for rare Mendelian form of kidney disease) and observe increased renal expression of a specific MUC1 mRNA isoform as a plausible molecular mechanism of the GWAS association signal. These data highlight the variants and genes underpinning the associations uncovered in GWAS of CKD-dt.
Description:
Genome-wide association studies (GWAS) have identified >100 loci of chronic kidney disease-defining traits (CKD-dt). Molecular mechanisms underlying these associations remain elusive. Using 280 kidney transcriptomes and 9958 gene expression profiles from 44 non-renal tissues we uncover gene expression partners (eGenes) for 88.9% of CKD-dt GWAS loci. Through epigenomic chromatin segmentation analysis and variant effect prediction we annotate functional consequences to 74% of these loci. Our colocalisation analysis and Mendelian randomisation in >130,000 subjects demonstrate causal effects of three eGenes (NAT8B, CASP9 and MUC1) on estimated glomerular filtration rate. We identify a common alternative splice variant in MUC1 (a gene responsible for rare Mendelian form of kidney disease) and observe increased renal expression of a specific MUC1 mRNA isoform as a plausible molecular mechanism of the GWAS association signal. These data highlight the variants and genes underpinning the associations uncovered in GWAS of CKD-dt.
Description:
Insecurity is no longer a condition that is specific to a set class of workers it has become a global issue. It can affect workers of any age, gender or ethnicity, across industrial or service sectors, and even our universities are no longer safe from casualisation, underemployment and outsourcing. To be sure, employment has always had elements of precariousness associated with it, particularly in the primary sectors. However, the steady intensification of capitalism around the world, and its intrusion into almost every facet of human endeavour, has meant that precarious work, as Arne Kalleberg writes, 'has become much more pervasive and generalized: [even] professional and managerial jobs are also precarious these days'. The telltale signs of precarity, such as insecurity, uncertainty and atomisation/individualisation, are frequently associated with the neoliberalisation of global societies. The twin mantras of flexibility and mobility across the economic market are further evidence of neoliberal principles, as an increasingly casualised work force allows employers the flexibility to shed and acquire labourers in accordance with the demands of capital rather than any humanitarian concern.
Description:
The decision of the Gillard government to establish a royal commission in 2012 was acclaimed by care leavers. However, they were soon disillusioned: it was not the royal commission for which they had long struggled. Its terms of reference were too broad, encompassing a range of institutions never before the subject of official inquiries, yet also too narrowly focused on sexual abuse. Care leavers who suffered other forms of abuse were excluded. This paper argues that, while care leaver advocacy contributed to the decision to establish a royal commission, the agenda was a product of other pressures fuelled by state-based inquiries about cover-ups of sexual abuse of children, particularly by clergy. Sexual abuse could no longer be regarded as a sin to be handled in-house by institutions but a crime for which the state carried superordinate responsibility. The government had to intervene to address society’s “ultimate collective shame”. The Royal Commission into Institutional Responses to Child Sexual Abuse has made a massive contribution to our understanding of child sexual abuse and to reforms in child protection policy and practice. But its mandate created unintended consequences, and questions remain about the unmet needs of care leavers who suffered other forms of abuse.
Description:
The decision of the Gillard government to establish a royal commission in 2012 was acclaimed by care leavers. However, they were soon disillusioned: it was not the royal commission for which they had long struggled. Its terms of reference were too broad, encompassing a range of institutions never before the subject of official inquiries, yet also too narrowly focused on sexual abuse. Care leavers who suffered other forms of abuse were excluded. This paper argues that, while care leaver advocacy contributed to the decision to establish a royal commission, the agenda was a product of other pressures fuelled by state-based inquiries about cover-ups of sexual abuse of children, particularly by clergy. Sexual abuse could no longer be regarded as a sin to be handled in-house by institutions but a crime for which the state carried superordinate responsibility. The government had to intervene to address society’s “ultimate collective shame”. The Royal Commission into Institutional Responses to Child Sexual Abuse has made a massive contribution to our understanding of child sexual abuse and to reforms in child protection policy and practice. But its mandate created unintended consequences, and questions remain about the unmet needs of care leavers who suffered other forms of abuse.
Description:
Poor soil physical conditions such as low hydraulic conductivity can limit salt depletion from surface soil. Altering the pore system by addition of organic and inorganic amendments may improve salt leaching as a reclamation strategy. Column studies were conducted to investigate salt leaching in amended and non-amended soil profiles. A one-dimensional water and solute transport model (HYDRUS-1D) was also assessed for its applicability to simulate salt leaching for amendment strategy. Columns of length 300 mm were filled with saline-sodic soil at the lower end (100-300 mm) and then covered with soil amended with 40% (wt/wt) fine sand and 20% (wt/wt) wood chips, separately. A control column was filled with saline-sodic soil only. One rainfall scenario typical for a location in south-west Queensland (Australia) was applied to the columns. Water potentials were monitored using tensiometers installed at three depths: 35, 120 and 250 mm. The concentrations of individual cations (Na
Description:
Poor soil physical conditions such as low hydraulic conductivity can limit salt depletion from surface soil. Altering the pore system by addition of organic and inorganic amendments may improve salt leaching as a reclamation strategy. Column studies were conducted to investigate salt leaching in amended and non-amended soil profiles. A one-dimensional water and solute transport model (HYDRUS-1D) was also assessed for its applicability to simulate salt leaching for amendment strategy. Columns of length 300 mm were filled with saline-sodic soil at the lower end (100-300 mm) and then covered with soil amended with 40% (wt/wt) fine sand and 20% (wt/wt) wood chips, separately. A control column was filled with saline-sodic soil only. One rainfall scenario typical for a location in south-west Queensland (Australia) was applied to the columns. Water potentials were monitored using tensiometers installed at three depths: 35, 120 and 250 mm. The concentrations of individual cations (Na
Description:
The principal aim of this study was to provide a close examination of nineteenth-century archival records that relate to Victorian Aboriginal people’s associations with koalas, in order to gain a greater understanding of the utilitarian and symbolic significance of koalas for Aboriginal communities, as recorded by colonists during the early period of colonization. The etymology of “koala” is discussed, before an examination is made of the animal’s spiritual importance, associated cultural traditions, and simultaneous utilitarian role. At the time of European colonization in 1788, koalas were probably found in coastal and lowland forests and woodlands across southern, central and north-eastern Victoria.
Description:
Shelly deposits at Moyjil (Point Ritchie, Warrnambool), Victoria, together with ages determined from a variety of techniques, have long excited interest in the possibility of a preserved early human influence in far south-eastern Australia. This paper presents a detailed analysis of the stratigraphy of the host Bridgewater Formation (Pleistocene) at Moyjil and provides the context to the shelly deposits, evidence of fire and geochronological sampling. We have identified five superposed calcarenite–palaeosol units in the Bridgewater Formation, together with two prominent erosional surfaces that may have hosted intensive human activity. Part of the sequence is overlain by the Tower Hill Tuff, previously dated as 35 ka. Coastal marine erosion during the Last Interglacial highstand created a horizontal surface on which deposits of stones and shells subsequently accumulated. Parts of the erosional surface and some of the stones are blackened, perhaps by fire. The main shell deposit was formed by probable mass flow, and additional shelly remains are dispersed in the calcareous sand that buried the surface.
Description:
Shelly deposits at Moyjil (Point Ritchie, Warrnambool), Victoria, together with ages determined from a variety of techniques, have long excited interest in the possibility of a preserved early human influence in far south-eastern Australia. This paper presents a detailed analysis of the stratigraphy of the host Bridgewater Formation (Pleistocene) at Moyjil and provides the context to the shelly deposits, evidence of fire and geochronological sampling. We have identified five superposed calcarenite–palaeosol units in the Bridgewater Formation, together with two prominent erosional surfaces that may have hosted intensive human activity. Part of the sequence is overlain by the Tower Hill Tuff, previously dated as 35 ka. Coastal marine erosion during the Last Interglacial highstand created a horizontal surface on which deposits of stones and shells subsequently accumulated. Parts of the erosional surface and some of the stones are blackened, perhaps by fire. The main shell deposit was formed by probable mass flow, and additional shelly remains are dispersed in the calcareous sand that buried the surface.
Description:
Recently, magnetic iron oxide nanoparticles (IONs) have been used to control and modify the characteristics of concrete and mortar. Concrete is one of the most used materials in the world; however, it is susceptible to cracking. Over recent years, a sustainable biotechnological approach has emerged as an alternative approach to conventional techniques to heal the concrete cracks by the incorporation of bacterial cells and nutrients into the concrete matrix. Once cracking occurs, CaCO3 is induced and the crack is healed. Considering the positive effects of IONs on the concrete properties, the effect of these nanoparticles on bacterial growth and CaCO3 biosynthesis needs to be evaluated for their possible application in bio self-healing concrete. In the present work, IONs were successfully synthesized and characterized using various techniques. The presence of IONs showed a significant effect on both bacterial growth and CaCO3 precipitation. The highest bacterial growth was observed in the presence of 150 μg/mL IONs. The highest concentration of induced CaCO3 (34.54 g/L) was achieved when the bacterial cells were immobilized with 300 μg/mL of IONs. This study provides new data and supports the possibility of using IONs as a new tool in designing the next generation of bio self-healing concrete.
Description:
We investigated (1) the relationship between Type D personality, stress intensity appraisal of a self-selected stressor, coping, and perceived coping effectiveness and (2) the relationship between Type D personality and performance. In study one, 482 athletes completed the Type D personality questionnaire (DS14), stress thermometer and MCOPE in relation to a recently experienced sport stressor. Type D was associated with increased levels of perceived stress and selection of coping strategies (more emotion and avoidance coping) as well as perceptions of their effectiveness. In study two, 32 participants completed a rugby league circuit task and were assessed on pre-performance anxiety, post-performance affect and coping. Type D was associated with poorer performance (reduced distance more errors), decreases in pre-performance self-confidence and more use of maladaptive resignation/withdrawal coping. Findings suggest that Type D is associated with maladaptive coping and reduced performance. Type D individuals would benefit from interventions related to mood modification or enhancing interpersonal functioning.
Description:
We investigated (1) the relationship between Type D personality, stress intensity appraisal of a self-selected stressor, coping, and perceived coping effectiveness and (2) the relationship between Type D personality and performance. In study one, 482 athletes completed the Type D personality questionnaire (DS14), stress thermometer and MCOPE in relation to a recently experienced sport stressor. Type D was associated with increased levels of perceived stress and selection of coping strategies (more emotion and avoidance coping) as well as perceptions of their effectiveness. In study two, 32 participants completed a rugby league circuit task and were assessed on pre-performance anxiety, post-performance affect and coping. Type D was associated with poorer performance (reduced distance more errors), decreases in pre-performance self-confidence and more use of maladaptive resignation/withdrawal coping. Findings suggest that Type D is associated with maladaptive coping and reduced performance. Type D individuals would benefit from interventions related to mood modification or enhancing interpersonal functioning.
Working towards more effective implementation, dissemination and scale-up of lower-limb injury-prevention programs : Insights from community Australian football coaches
Description:
Advances in bottom-up material design have been significantly progressed through DNA-based approaches. However, the routine integration of semiconducting properties, particularly long-range electrical conduction, into the basic topological motif of DNA remains challenging. Here, we demonstrate this with a coordination polymer derived from 6-thioguanosine (6-TG-H), a sulfur-containing analog of a natural nucleoside. The complexation reaction with Au(I) ions spontaneously assembles luminescent one-dimensional helical chains, characterized as {Au (μ-6-TG)} , extending many μm in length that are structurally analogous to natural DNA. Uniquely, for such a material, this gold-thiolate can be transformed into a wire-like conducting form by oxidative doping. We also show that this self-assembly reaction is compatible with a 6-TG-modified DNA duplex and provides a straightforward method by which to integrate semiconducting sequences, site-specifically, into the framework of DNA materials, transforming their properties in a fundamental and technologically useful manner.Integration of semiconducting properties into the basic topological motif of DNA remains challenging. Here, the authors show a coordination polymer derived from 6-thioguanosine that complexes with Au(I) ions to form a wire-like material that can also integrate semiconducting sequences into the framework of DNA materials.
Description:
There is an increasing appreciation for the role of the human Y chromosome in phenotypic differences between the sexes in health and disease. Previous studies have shown that genetic variation within the Y chromosome is associated with cholesterol levels, which is an established risk factor for atherosclerosis, the underlying cause of coronary artery disease (CAD), a major cause of morbidity and mortality worldwide. However, the exact mechanism and potential genes implicated are still unidentified. To date, Y chromosome-linked long non-coding RNAs (lncRNAs) are poorly characterized and the potential link between these new regulatory RNA molecules and hepatic function in men has not been investigated. Advanced technologies of lncRNA subcellular localization and silencing were used to identify a novel intergenic Y-linked lncRNA, named lnc-KDM5D-4, and investigate its role in fatty liver-associated atherosclerosis. We found that lnc-KDM5D-4 is retained within the nucleus in hepatocytes. Its knockdown leads to changes in genes leading to increased lipid droplets formation in hepatocytes resulting in a downstream effect contributing to the chronic inflammatory process that underpin CAD. Our findings provide the first evidence for the implication of lnc-KDM5D-4 in key processes related to fatty liver and cellular inflammation associated with atherosclerosis and CAD in men.
Description:
There is an increasing appreciation for the role of the human Y chromosome in phenotypic differences between the sexes in health and disease. Previous studies have shown that genetic variation within the Y chromosome is associated with cholesterol levels, which is an established risk factor for atherosclerosis, the underlying cause of coronary artery disease (CAD), a major cause of morbidity and mortality worldwide. However, the exact mechanism and potential genes implicated are still unidentified. To date, Y chromosome-linked long non-coding RNAs (lncRNAs) are poorly characterized and the potential link between these new regulatory RNA molecules and hepatic function in men has not been investigated. Advanced technologies of lncRNA subcellular localization and silencing were used to identify a novel intergenic Y-linked lncRNA, named lnc-KDM5D-4, and investigate its role in fatty liver-associated atherosclerosis. We found that lnc-KDM5D-4 is retained within the nucleus in hepatocytes. Its knockdown leads to changes in genes leading to increased lipid droplets formation in hepatocytes resulting in a downstream effect contributing to the chronic inflammatory process that underpin CAD. Our findings provide the first evidence for the implication of lnc-KDM5D-4 in key processes related to fatty liver and cellular inflammation associated with atherosclerosis and CAD in men.