Multivariate data-driven decision guidance for clinical scientists
- Burstein, Frada, De Silva, Daswin, Jelinek, Herbert, Stranieri, Andrew
- Authors: Burstein, Frada , De Silva, Daswin , Jelinek, Herbert , Stranieri, Andrew
- Date: 2013
- Type: Text , Conference paper
- Relation: 29th International Conference on Data Engineering Workshops, ICDEW 2013; Proceedings - International Conference on Data Engineering p. 193-199
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- Description: Clinical decision-support is gaining widespread attention as medical institutions and governing bodies turn towards utilising better information management for effective and efficient healthcare delivery and quality assured outcomes. Amass of data across all stages, from disease diagnosis to palliative care, is further indication of the opportunities and challenges created for effective data management, analysis, prediction and optimization techniques as parts of knowledge management in clinical environments. A Data-driven Decision Guidance Management System (DD-DGMS) architecture can encompass solutions into a single closed-loop integrated platform to empower clinical scientists to seamlessly explore a multivariate data space in search of novel patterns and correlations to inform their research and practice. The paper describes the components of such an architecture, which includes a robust data warehouse as an infrastructure for comprehensive clinical knowledge management. The proposed DD-DGMS architecture incorporates the dynamic dimensional data model as its elemental core. Given the heterogeneous nature of clinical contexts and corresponding data, the dimensional data model presents itself as an adaptive model that facilitates knowledge discovery, distribution and application, which is essential for clinical decision support. The paper reports on a trial of the DD-DGMS system prototype conducted on diabetes screening data which further establishes the relevance of the proposed architecture to a clinical context.
- Description: E1
- Authors: Burstein, Frada , De Silva, Daswin , Jelinek, Herbert , Stranieri, Andrew
- Date: 2013
- Type: Text , Conference paper
- Relation: 29th International Conference on Data Engineering Workshops, ICDEW 2013; Proceedings - International Conference on Data Engineering p. 193-199
- Full Text:
- Reviewed:
- Description: Clinical decision-support is gaining widespread attention as medical institutions and governing bodies turn towards utilising better information management for effective and efficient healthcare delivery and quality assured outcomes. Amass of data across all stages, from disease diagnosis to palliative care, is further indication of the opportunities and challenges created for effective data management, analysis, prediction and optimization techniques as parts of knowledge management in clinical environments. A Data-driven Decision Guidance Management System (DD-DGMS) architecture can encompass solutions into a single closed-loop integrated platform to empower clinical scientists to seamlessly explore a multivariate data space in search of novel patterns and correlations to inform their research and practice. The paper describes the components of such an architecture, which includes a robust data warehouse as an infrastructure for comprehensive clinical knowledge management. The proposed DD-DGMS architecture incorporates the dynamic dimensional data model as its elemental core. Given the heterogeneous nature of clinical contexts and corresponding data, the dimensional data model presents itself as an adaptive model that facilitates knowledge discovery, distribution and application, which is essential for clinical decision support. The paper reports on a trial of the DD-DGMS system prototype conducted on diabetes screening data which further establishes the relevance of the proposed architecture to a clinical context.
- Description: E1
Predicting cardiac autonomic neuropathy category for diabetic data with missing values
- Abawajy, Jemal, Kelarev, Andrei, Chowdhury, Morshed, Stranieri, Andrew, Jelinek, Herbert
- Authors: Abawajy, Jemal , Kelarev, Andrei , Chowdhury, Morshed , Stranieri, Andrew , Jelinek, Herbert
- Date: 2013
- Type: Text , Journal article
- Relation: Computers in Biology and Medicine Vol. 43, no. 10 (2013), p. 1328-1333
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- Description: Cardiovascular autonomic neuropathy (CAN) is a serious and well known complication of diabetes. Previous articles circumvented the problem of missing values in CAN data by deleting all records and fields with missing values and applying classifiers trained on different sets of features that were complete. Most of them also added alternative features to compensate for the deleted ones. Here we introduce and investigate a new method for classifying CAN data with missing values. In contrast to all previous papers, our new method does not delete attributes with missing values, does not use classifiers, and does not add features. Instead it is based on regression and meta-regression combined with the Ewing formula for identifying the classes of CAN. This is the first article using the Ewing formula and regression to classify CAN. We carried out extensive experiments to determine the best combination of regression and meta-regression techniques for classifying CAN data with missing values. The best outcomes have been obtained by the additive regression meta-learner based on M5Rules and combined with the Ewing formula. It has achieved the best accuracy of 99.78% for two classes of CAN, and 98.98% for three classes of CAN. These outcomes are substantially better than previous results obtained in the literature by deleting all missing attributes and applying traditional classifiers to different sets of features without regression. Another advantage of our method is that it does not require practitioners to perform more tests collecting additional alternative features. © 2013 Elsevier Ltd.
- Description: C1
- Authors: Abawajy, Jemal , Kelarev, Andrei , Chowdhury, Morshed , Stranieri, Andrew , Jelinek, Herbert
- Date: 2013
- Type: Text , Journal article
- Relation: Computers in Biology and Medicine Vol. 43, no. 10 (2013), p. 1328-1333
- Full Text:
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- Description: Cardiovascular autonomic neuropathy (CAN) is a serious and well known complication of diabetes. Previous articles circumvented the problem of missing values in CAN data by deleting all records and fields with missing values and applying classifiers trained on different sets of features that were complete. Most of them also added alternative features to compensate for the deleted ones. Here we introduce and investigate a new method for classifying CAN data with missing values. In contrast to all previous papers, our new method does not delete attributes with missing values, does not use classifiers, and does not add features. Instead it is based on regression and meta-regression combined with the Ewing formula for identifying the classes of CAN. This is the first article using the Ewing formula and regression to classify CAN. We carried out extensive experiments to determine the best combination of regression and meta-regression techniques for classifying CAN data with missing values. The best outcomes have been obtained by the additive regression meta-learner based on M5Rules and combined with the Ewing formula. It has achieved the best accuracy of 99.78% for two classes of CAN, and 98.98% for three classes of CAN. These outcomes are substantially better than previous results obtained in the literature by deleting all missing attributes and applying traditional classifiers to different sets of features without regression. Another advantage of our method is that it does not require practitioners to perform more tests collecting additional alternative features. © 2013 Elsevier Ltd.
- Description: C1
A comparison of machine learning algorithms for multilabel classification of CAN
- Kelarev, Andrei, Stranieri, Andrew, Yearwood, John, Jelinek, Herbert
- Authors: Kelarev, Andrei , Stranieri, Andrew , Yearwood, John , Jelinek, Herbert
- Date: 2012
- Type: Text , Journal article
- Relation: Advances in Computer Science and Engineering Vol. 9, no. 1 (2012), p. 1-4
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- Description: This article is devoted to the investigation and comparison of several important machine learning algorithms in their ability to obtain multilabel classifications of the stages of cardiac autonomic neuropathy (CAN). Data was collected by the Diabetes Complications Screening Research Initiative at Charles Sturt University. Our experiments have achieved better results than those published previously in the literature for similar CAN identification tasks.
- Authors: Kelarev, Andrei , Stranieri, Andrew , Yearwood, John , Jelinek, Herbert
- Date: 2012
- Type: Text , Journal article
- Relation: Advances in Computer Science and Engineering Vol. 9, no. 1 (2012), p. 1-4
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- Description: This article is devoted to the investigation and comparison of several important machine learning algorithms in their ability to obtain multilabel classifications of the stages of cardiac autonomic neuropathy (CAN). Data was collected by the Diabetes Complications Screening Research Initiative at Charles Sturt University. Our experiments have achieved better results than those published previously in the literature for similar CAN identification tasks.
Empirical investigation of multi-tier ensembles for the detection of cardiac autonomic neuropathy using subsets of the Ewing features
- Abawajy, Jemal, Kelarev, Andrei, Stranieri, Andrew, Jelinek, Herbert
- Authors: Abawajy, Jemal , Kelarev, Andrei , Stranieri, Andrew , Jelinek, Herbert
- Date: 2012
- Type: Text , Conference proceedings
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- Description: This article is devoted to an empirical investigation of performance of several new large multi-tier ensembles for the detection of cardiac autonomic neuropathy (CAN) in diabetes patients using sub-sets of the Ewing features. We used new data collected by the diabetes screening research initiative (DiScRi) project, which is more than ten times larger than the data set originally used by Ewing in the investigation of CAN. The results show that new multi-tier ensembles achieved better performance compared with the outcomes published in the literature previously. The best accuracy 97.74% of the detection of CAN has been achieved by the novel multi-tier combination of AdaBoost and Bagging, where AdaBoost is used at the top tier and Bagging is used at the middle tier, for the set consisting of the following four Ewing features: the deep breathing heart rate change, the Valsalva manoeuvre heart rate change, the hand grip blood pressure change and the lying to standing blood pressure change.
- Authors: Abawajy, Jemal , Kelarev, Andrei , Stranieri, Andrew , Jelinek, Herbert
- Date: 2012
- Type: Text , Conference proceedings
- Full Text:
- Description: This article is devoted to an empirical investigation of performance of several new large multi-tier ensembles for the detection of cardiac autonomic neuropathy (CAN) in diabetes patients using sub-sets of the Ewing features. We used new data collected by the diabetes screening research initiative (DiScRi) project, which is more than ten times larger than the data set originally used by Ewing in the investigation of CAN. The results show that new multi-tier ensembles achieved better performance compared with the outcomes published in the literature previously. The best accuracy 97.74% of the detection of CAN has been achieved by the novel multi-tier combination of AdaBoost and Bagging, where AdaBoost is used at the top tier and Bagging is used at the middle tier, for the set consisting of the following four Ewing features: the deep breathing heart rate change, the Valsalva manoeuvre heart rate change, the hand grip blood pressure change and the lying to standing blood pressure change.
High definition 3D telemedicine: The next frontier?
- Stranieri, Andrew, Collmann, Richard, Borda, Ann
- Authors: Stranieri, Andrew , Collmann, Richard , Borda, Ann
- Date: 2012
- Type: Text , Conference proceedings
- Relation: Studies in Health Technology and Informatics, 182, p.133-41.
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- Description: Evidence from the literature indicates that the degree of immersion often referred to as the "sense of being there" experienced by clinicians and patients is a factor in the success of tele-health installations. High definition and 3D telemedicine offers a compelling mechanism to achieve a sense of immersion and contribute to an enhanced quality of use. This article surveys HD3D trials in tele-health and concludes that the way HD3D is integrated into telemedicine depends on the clinical, organisational and technological context. In some settings real time HD3D is not so desirable whereas asynchronous transmission of HD3D images and videos is highly desirable. © 2012 The authors and IOS Press.
- Authors: Stranieri, Andrew , Collmann, Richard , Borda, Ann
- Date: 2012
- Type: Text , Conference proceedings
- Relation: Studies in Health Technology and Informatics, 182, p.133-41.
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- Description: Evidence from the literature indicates that the degree of immersion often referred to as the "sense of being there" experienced by clinicians and patients is a factor in the success of tele-health installations. High definition and 3D telemedicine offers a compelling mechanism to achieve a sense of immersion and contribute to an enhanced quality of use. This article surveys HD3D trials in tele-health and concludes that the way HD3D is integrated into telemedicine depends on the clinical, organisational and technological context. In some settings real time HD3D is not so desirable whereas asynchronous transmission of HD3D images and videos is highly desirable. © 2012 The authors and IOS Press.
Rule-based classifiers and meta classifiers for identification of cardiac autonomic neuropathy progression
- Jelinek, Herbert, Kelarev, Andrei, Stranieri, Andrew, Yearwood, John
- Authors: Jelinek, Herbert , Kelarev, Andrei , Stranieri, Andrew , Yearwood, John
- Date: 2012
- Type: Text , Journal article
- Relation: International Journal of Information Science and Computer Mathematics Vol. 5, no. 2 (2012), p. 49-53
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- Description: We investigate and compare several rule-based classifiers and meta classifiers in their ability to obtain multi-class classifications of cardiac autonomic neuropathy (CAN) and its progression. The best results obtained in our experiments are significantly better than the outcomes published previously in the literature for analogous CAN identification tasks or simpler binary classification tasks.
- Authors: Jelinek, Herbert , Kelarev, Andrei , Stranieri, Andrew , Yearwood, John
- Date: 2012
- Type: Text , Journal article
- Relation: International Journal of Information Science and Computer Mathematics Vol. 5, no. 2 (2012), p. 49-53
- Full Text:
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- Description: We investigate and compare several rule-based classifiers and meta classifiers in their ability to obtain multi-class classifications of cardiac autonomic neuropathy (CAN) and its progression. The best results obtained in our experiments are significantly better than the outcomes published previously in the literature for analogous CAN identification tasks or simpler binary classification tasks.
Fault-tolerant data aggregation scheme for monitoring of critical events in grid based healthcare sensor networks
- Saeed, Ather, Stranieri, Andrew, Dazeley, Richard
- Authors: Saeed, Ather , Stranieri, Andrew , Dazeley, Richard
- Date: 2011
- Type: Text , Conference paper
- Relation: Paper presented at 19th High Peformance Computing Symposium (HPC 2011) part of SCS Spring Simulation Multiconference (SpringSim'11)
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- Description: Wireless sensor devices are used for monitoring patients with serious medical conditions. Communication of content-sensitive and context sensitive datasets is crucial for the survival of patients so that informed decisions can be made. The main limitation of sensor devices is that they work on a fixed threshold to notify the relevant Healthcare Professional (HP) about the seriousness of a patient’s current state. Further, these sensor devices have limited processor, memory capabilities and battery. A new grid-based information monitoring architecture is proposed to address the issues of data loss and timely dissemination of critical information to the relevant HP. The proposed approach provides an opportunity to efficiently aggregate datasets of interest by reducing network overhead and minimizing data latency. To narrow down the problem domain, in-network processing of datasets with Grid monitoring capabilities is proposed for the efficient execution of the computational, resource and data intensive tasks. Interactive wireless sensor networks do not guarantee that data gathered from the heterogeneous sources will always arrive at the sink (base) node, but the proposed aggregation technique will provide a fault tolerant solution to the timely notification of a patient’s critical state. Experimental results received are encouraging and clearly show a reduction in the network latency rate.
- Authors: Saeed, Ather , Stranieri, Andrew , Dazeley, Richard
- Date: 2011
- Type: Text , Conference paper
- Relation: Paper presented at 19th High Peformance Computing Symposium (HPC 2011) part of SCS Spring Simulation Multiconference (SpringSim'11)
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- Description: Wireless sensor devices are used for monitoring patients with serious medical conditions. Communication of content-sensitive and context sensitive datasets is crucial for the survival of patients so that informed decisions can be made. The main limitation of sensor devices is that they work on a fixed threshold to notify the relevant Healthcare Professional (HP) about the seriousness of a patient’s current state. Further, these sensor devices have limited processor, memory capabilities and battery. A new grid-based information monitoring architecture is proposed to address the issues of data loss and timely dissemination of critical information to the relevant HP. The proposed approach provides an opportunity to efficiently aggregate datasets of interest by reducing network overhead and minimizing data latency. To narrow down the problem domain, in-network processing of datasets with Grid monitoring capabilities is proposed for the efficient execution of the computational, resource and data intensive tasks. Interactive wireless sensor networks do not guarantee that data gathered from the heterogeneous sources will always arrive at the sink (base) node, but the proposed aggregation technique will provide a fault tolerant solution to the timely notification of a patient’s critical state. Experimental results received are encouraging and clearly show a reduction in the network latency rate.
Feature selection using misclassification counts
- Bagirov, Adil, Yatsko, Andrew, Stranieri, Andrew
- Authors: Bagirov, Adil , Yatsko, Andrew , Stranieri, Andrew
- Date: 2011
- Type: Conference proceedings , Unpublished work
- Relation: Proceedings of the 9th Australasian Data Mining Conference (AusDM 2011), 51-62. Conferences in Research and Practice in Information Technology (CRPIT), Vol. 121.
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- Description: Dimensionality reduction of the problem space through detection and removal of variables, contributing little or not at all to classification, is able to relieve the computational load and instance acquisition effort, considering all the data attributes accessed each time around. The approach to feature selection in this paper is based on the concept of coherent accumulation of data about class centers with respect to coordinates of informative features. Ranking is done on the degree to which different variables exhibit random characteristics. The results are being verified using the Nearest Neighbor classifier. This also helps to address the feature irrelevance and redundancy, what ranking does not immediately decide. Additionally, feature ranking methods from different independent sources are called in for the direct comparison.
- Description: Dimensionality reduction of the problem space through detection and removal of variables, contributing little or not at all to classification, is able to relieve the computational load and the data acquisition effort, considering all data components being accessed each time around. The approach to feature selection in this paper is based on the concept of coherent accumulation of data about class centers with respect to coordinates of informative features. Ranking is done on the degree, to which different variables exhibit random characteristics. The results are being verified using the Nearest Neighbor classifier. This also helps to address the feature irrelevance, what ranking does not immediately decide. Additionally, feature ranking methods available from different independent sources are called in for direct comparison.
- Authors: Bagirov, Adil , Yatsko, Andrew , Stranieri, Andrew
- Date: 2011
- Type: Conference proceedings , Unpublished work
- Relation: Proceedings of the 9th Australasian Data Mining Conference (AusDM 2011), 51-62. Conferences in Research and Practice in Information Technology (CRPIT), Vol. 121.
- Full Text:
- Description: Dimensionality reduction of the problem space through detection and removal of variables, contributing little or not at all to classification, is able to relieve the computational load and instance acquisition effort, considering all the data attributes accessed each time around. The approach to feature selection in this paper is based on the concept of coherent accumulation of data about class centers with respect to coordinates of informative features. Ranking is done on the degree to which different variables exhibit random characteristics. The results are being verified using the Nearest Neighbor classifier. This also helps to address the feature irrelevance and redundancy, what ranking does not immediately decide. Additionally, feature ranking methods from different independent sources are called in for the direct comparison.
- Description: Dimensionality reduction of the problem space through detection and removal of variables, contributing little or not at all to classification, is able to relieve the computational load and the data acquisition effort, considering all data components being accessed each time around. The approach to feature selection in this paper is based on the concept of coherent accumulation of data about class centers with respect to coordinates of informative features. Ranking is done on the degree, to which different variables exhibit random characteristics. The results are being verified using the Nearest Neighbor classifier. This also helps to address the feature irrelevance, what ranking does not immediately decide. Additionally, feature ranking methods available from different independent sources are called in for direct comparison.
Automatic sleep stage identification: difficulties and possible solutions
- Sukhorukova, Nadezda, Stranieri, Andrew, Ofoghi, Bahadorreza, Vamplew, Peter, Saleem, Muhammad Saad, Ma, Liping, Ugon, Adrien, Ugon, Julien, Muecke, Nial, Amiel, Hélène, Philippe, Carole, Bani-Mustafa, Ahmed, Huda, Shamsul, Bertoli, Marcello, Levy, P, Ganascia, J.G
- Authors: Sukhorukova, Nadezda , Stranieri, Andrew , Ofoghi, Bahadorreza , Vamplew, Peter , Saleem, Muhammad Saad , Ma, Liping , Ugon, Adrien , Ugon, Julien , Muecke, Nial , Amiel, Hélène , Philippe, Carole , Bani-Mustafa, Ahmed , Huda, Shamsul , Bertoli, Marcello , Levy, P , Ganascia, J.G
- Date: 2010
- Type: Text , Conference proceedings
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- Description: The diagnosis of many sleep disorders is a labour intensive task that involves the specialised interpretation of numerous signals including brain wave, breath and heart rate captured in overnight polysomnogram sessions. The automation of diagnoses is challenging for data mining algorithms because the data sets are extremely large and noisy, the signals are complex and specialist's analyses vary. This work reports on the adaptation of approaches from four fields; neural networks, mathematical optimisation, financial forecasting and frequency domain analysis to the problem of automatically determing a patient's stage of sleep. Results, though preliminary, are promising and indicate that combined approaches may prove more fruitful than the reliance on a approach.
- Authors: Sukhorukova, Nadezda , Stranieri, Andrew , Ofoghi, Bahadorreza , Vamplew, Peter , Saleem, Muhammad Saad , Ma, Liping , Ugon, Adrien , Ugon, Julien , Muecke, Nial , Amiel, Hélène , Philippe, Carole , Bani-Mustafa, Ahmed , Huda, Shamsul , Bertoli, Marcello , Levy, P , Ganascia, J.G
- Date: 2010
- Type: Text , Conference proceedings
- Full Text:
- Description: The diagnosis of many sleep disorders is a labour intensive task that involves the specialised interpretation of numerous signals including brain wave, breath and heart rate captured in overnight polysomnogram sessions. The automation of diagnoses is challenging for data mining algorithms because the data sets are extremely large and noisy, the signals are complex and specialist's analyses vary. This work reports on the adaptation of approaches from four fields; neural networks, mathematical optimisation, financial forecasting and frequency domain analysis to the problem of automatically determing a patient's stage of sleep. Results, though preliminary, are promising and indicate that combined approaches may prove more fruitful than the reliance on a approach.
Coalescing medical systems: A challenge for health informatics
- Stranieri, Andrew, Vaughan, Stephen
- Authors: Stranieri, Andrew , Vaughan, Stephen
- Date: 2010
- Type: Text , Conference paper
- Relation: Global Telehealth - Selected Papers from Global Telehealth 2010 (GT2010) – 15th International Conference of the International Society for Telemedicine and eHealth and 1st National Conference of the Australasian Telehealth Society
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- Description: Patients in many nations increasingly access diverse medical systems including Western medicine, Traditional Chinese Medicine, Homeopathy and Ayervedic medicine as globalisation advances. The trend toward co-existence of medical systems presents challenges for health informatics including the need to develop standards that can encompass the diversity required, the need to develop software applications that effectively inter-operate across diverse systems and the need to support patients when evaluating competing systems. This article advances the notion that the challenges can most effectively be met with the development of informatics approaches that do not assume the superiority of one medical system over another. Argument visualization to support patient decision making in selecting an appropriate medical system is presented as an application that exemplifies this stance
- Authors: Stranieri, Andrew , Vaughan, Stephen
- Date: 2010
- Type: Text , Conference paper
- Relation: Global Telehealth - Selected Papers from Global Telehealth 2010 (GT2010) – 15th International Conference of the International Society for Telemedicine and eHealth and 1st National Conference of the Australasian Telehealth Society
- Full Text:
- Reviewed:
- Description: Patients in many nations increasingly access diverse medical systems including Western medicine, Traditional Chinese Medicine, Homeopathy and Ayervedic medicine as globalisation advances. The trend toward co-existence of medical systems presents challenges for health informatics including the need to develop standards that can encompass the diversity required, the need to develop software applications that effectively inter-operate across diverse systems and the need to support patients when evaluating competing systems. This article advances the notion that the challenges can most effectively be met with the development of informatics approaches that do not assume the superiority of one medical system over another. Argument visualization to support patient decision making in selecting an appropriate medical system is presented as an application that exemplifies this stance
Exploring novel features and decision rules to identify cardiovascular autonomic neuropathy using a hybrid of wrapper-filter based feature selection
- Huda, Shamsul, Jelinek, Herbert, Ray, Biplob, Stranieri, Andrew, Yearwood, John
- Authors: Huda, Shamsul , Jelinek, Herbert , Ray, Biplob , Stranieri, Andrew , Yearwood, John
- Date: 2010
- Type: Text , Conference paper
- Relation: Paper presented at the 2010 6th International Conference on Intelligent Sensors, Sensor Networks and Information Processing, ISSNIP 2010 p. 297-302
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- Description: Cardiovascular autonomic neuropathy (CAN) is one of the important causes of mortality among diabetes patients. Statistics shows that more than 22% of people with type 2 diabetes mellitus suffer from CAN and which in turn leads to cardiovascular disease (heart attack, stroke). Therefore early detection of CAN could reduce the mortality. Traditional method for detection of CAN uses Ewing's algorithm where five noninvasive cardiovascular tests are used. Often for clinician, it is difficult to collect data from for the Ewing Battery patients due to onerous test conditions. In this paper, we propose a hybrid of wrapper-filter approach to find novel features from patients' ECG records and then generate decision rules for the new features for easier detection of CAN. In the proposed feature selection, a hybrid of filter (Maximum Relevance, MR) and wrapper (Artificial Neural Net Input Gain Measurement Approximation ANNIGMA) approaches (MR-ANNIGMA) would be used. The combined heuristics in the hybrid MRANNIGMA takes the advantages of the complementary properties of the both filter and wrapper heuristics and can find significant features. The selected features set are used to generate a new set of rules for detection of CAN. Experiments on real patient records shows that proposed method finds a smaller set of features for detection of CAN than traditional method which are clinically significant and could lead to an easier way to diagnose CAN. © 2010 IEEE.
- Authors: Huda, Shamsul , Jelinek, Herbert , Ray, Biplob , Stranieri, Andrew , Yearwood, John
- Date: 2010
- Type: Text , Conference paper
- Relation: Paper presented at the 2010 6th International Conference on Intelligent Sensors, Sensor Networks and Information Processing, ISSNIP 2010 p. 297-302
- Full Text:
- Reviewed:
- Description: Cardiovascular autonomic neuropathy (CAN) is one of the important causes of mortality among diabetes patients. Statistics shows that more than 22% of people with type 2 diabetes mellitus suffer from CAN and which in turn leads to cardiovascular disease (heart attack, stroke). Therefore early detection of CAN could reduce the mortality. Traditional method for detection of CAN uses Ewing's algorithm where five noninvasive cardiovascular tests are used. Often for clinician, it is difficult to collect data from for the Ewing Battery patients due to onerous test conditions. In this paper, we propose a hybrid of wrapper-filter approach to find novel features from patients' ECG records and then generate decision rules for the new features for easier detection of CAN. In the proposed feature selection, a hybrid of filter (Maximum Relevance, MR) and wrapper (Artificial Neural Net Input Gain Measurement Approximation ANNIGMA) approaches (MR-ANNIGMA) would be used. The combined heuristics in the hybrid MRANNIGMA takes the advantages of the complementary properties of the both filter and wrapper heuristics and can find significant features. The selected features set are used to generate a new set of rules for detection of CAN. Experiments on real patient records shows that proposed method finds a smaller set of features for detection of CAN than traditional method which are clinically significant and could lead to an easier way to diagnose CAN. © 2010 IEEE.
Hybrid wrapper-filter approaches for input feature selection using maximum relevance and Artificial Neural Network Input Gain Measurement Approximation (ANNIGMA)
- Huda, Shamsul, Yearwood, John, Stranieri, Andrew
- Authors: Huda, Shamsul , Yearwood, John , Stranieri, Andrew
- Date: 2010
- Type: Text , Conference proceedings
- Full Text:
- Description: Feature selection is an important research problem in machine learning and data mining applications. This paper proposes a hybrid wrapper and filter feature selection algorithm by introducing the filter's feature ranking score in the wrapper stage to speed up the search process for wrapper and thereby finding a more compact feature subset. The approach hybridizes a Mutual Information (MI) based Maximum Relevance (MR) filter ranking heuristic with an Artificial Neural Network (ANN) based wrapper approach where Artificial Neural Network Input Gain Measurement Approximation (ANNIGMA) has been combined with MR (MR-ANNIGMA) to guide the search process in the wrapper. The novelty of our approach is that we use hybrid of wrapper and filter methods that combines filter's ranking score with the wrapper-heuristic's score to take advantages of both filter and wrapper heuristics. Performance of the proposed MRANNIGMA has been verified using bench mark data sets and compared to both independent filter and wrapper based approaches. Experimental results show that MR-ANNIGMA achieves more compact feature sets and higher accuracies than both filter and wrapper approaches alone. © 2010 IEEE.
- Authors: Huda, Shamsul , Yearwood, John , Stranieri, Andrew
- Date: 2010
- Type: Text , Conference proceedings
- Full Text:
- Description: Feature selection is an important research problem in machine learning and data mining applications. This paper proposes a hybrid wrapper and filter feature selection algorithm by introducing the filter's feature ranking score in the wrapper stage to speed up the search process for wrapper and thereby finding a more compact feature subset. The approach hybridizes a Mutual Information (MI) based Maximum Relevance (MR) filter ranking heuristic with an Artificial Neural Network (ANN) based wrapper approach where Artificial Neural Network Input Gain Measurement Approximation (ANNIGMA) has been combined with MR (MR-ANNIGMA) to guide the search process in the wrapper. The novelty of our approach is that we use hybrid of wrapper and filter methods that combines filter's ranking score with the wrapper-heuristic's score to take advantages of both filter and wrapper heuristics. Performance of the proposed MRANNIGMA has been verified using bench mark data sets and compared to both independent filter and wrapper based approaches. Experimental results show that MR-ANNIGMA achieves more compact feature sets and higher accuracies than both filter and wrapper approaches alone. © 2010 IEEE.
A classification algorithm that derives weighted sum scores for insight into disease
- Quinn, Anthony, Stranieri, Andrew, Yearwood, John, Hafen, Gaudenz
- Authors: Quinn, Anthony , Stranieri, Andrew , Yearwood, John , Hafen, Gaudenz
- Date: 2009
- Type: Text , Conference paper
- Relation: Paper presented at Third Australasian Workshop on Health Informatics and Knowledge Management (HIKM 2009), Wellington, New Zealand : Vol. 97, p. 13-17
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- Description: Data mining is often performed with datasets associated with diseases in order to increase insights that can ultimately lead to improved prevention or treatment. Classification algorithms can achieve high levels of predictive accuracy but have limited application for facilitating the insight that leads to deeper understanding of aspects of the disease. This is because the representation of knowledge that arises from classification algorithms is too opaque, too complex or too sparse to facilitate insight. Clustering, association and visualisation approaches enable greater scope for clinicians to be engaged in a way that leads to insight, however predictive accuracy is compromised or non-existent. This research investigates the practical applications of Automated Weighted Sum, (AWSum), a classification algorithm that provides accuracy comparable to other techniques whilst providing some insight into the data. This is achieved by calculating a weight for each feature value that represents its influence on the class value. Clinicians are very familiar with weighted sum scoring scales so the internal representation is intuitive and easily understood. This paper presents results from the use of the AWSum approach with data from patients suffering from Cystic Fibrosis.
- Authors: Quinn, Anthony , Stranieri, Andrew , Yearwood, John , Hafen, Gaudenz
- Date: 2009
- Type: Text , Conference paper
- Relation: Paper presented at Third Australasian Workshop on Health Informatics and Knowledge Management (HIKM 2009), Wellington, New Zealand : Vol. 97, p. 13-17
- Full Text:
- Description: Data mining is often performed with datasets associated with diseases in order to increase insights that can ultimately lead to improved prevention or treatment. Classification algorithms can achieve high levels of predictive accuracy but have limited application for facilitating the insight that leads to deeper understanding of aspects of the disease. This is because the representation of knowledge that arises from classification algorithms is too opaque, too complex or too sparse to facilitate insight. Clustering, association and visualisation approaches enable greater scope for clinicians to be engaged in a way that leads to insight, however predictive accuracy is compromised or non-existent. This research investigates the practical applications of Automated Weighted Sum, (AWSum), a classification algorithm that provides accuracy comparable to other techniques whilst providing some insight into the data. This is achieved by calculating a weight for each feature value that represents its influence on the class value. Clinicians are very familiar with weighted sum scoring scales so the internal representation is intuitive and easily understood. This paper presents results from the use of the AWSum approach with data from patients suffering from Cystic Fibrosis.
Group structured reasoning for coalescing group decisions
- Yearwood, John, Stranieri, Andrew
- Authors: Yearwood, John , Stranieri, Andrew
- Date: 2009
- Type: Text , Journal article
- Relation: Group Decision and Negotiation Vol. , no. (2009), p. 1-29
- Full Text:
- Reviewed:
- Description: In this paper we present the notion of structured reasoning through a model, called the Generic/Actual Argument Model (GAAM). The model which has been used as a computational representation for machine modelling of reasoning and for hybrid combinations of human and machine reasoning can be used as a coalescent framework for decision making. Whilst the notion of structuring reasoning is not new, structured reasoning is advanced as a technique where group consensus on reasoning structures at various levels can be used to facilitate the comprehension of complex reasoning particularly where there are multiple perspectives. For an issue, the approach provides a scaffolding structure for cognitive co-operation and a normative reasoning structure against which group participants can identify points of difference and points in common as well as the nature of the differences and similarities. Intra-group transparency characterized by the ability to recognise points in common and understand the nature of differences is important to the process of coalescing group decisions that carry maximum group support. © 2009 Springer Science+Business Media B.V.
- Authors: Yearwood, John , Stranieri, Andrew
- Date: 2009
- Type: Text , Journal article
- Relation: Group Decision and Negotiation Vol. , no. (2009), p. 1-29
- Full Text:
- Reviewed:
- Description: In this paper we present the notion of structured reasoning through a model, called the Generic/Actual Argument Model (GAAM). The model which has been used as a computational representation for machine modelling of reasoning and for hybrid combinations of human and machine reasoning can be used as a coalescent framework for decision making. Whilst the notion of structuring reasoning is not new, structured reasoning is advanced as a technique where group consensus on reasoning structures at various levels can be used to facilitate the comprehension of complex reasoning particularly where there are multiple perspectives. For an issue, the approach provides a scaffolding structure for cognitive co-operation and a normative reasoning structure against which group participants can identify points of difference and points in common as well as the nature of the differences and similarities. Intra-group transparency characterized by the ability to recognise points in common and understand the nature of differences is important to the process of coalescing group decisions that carry maximum group support. © 2009 Springer Science+Business Media B.V.
Inference of gene expression networks using memetic gene expression programming
- Zarnegar, Armita, Vamplew, Peter, Stranieri, Andrew
- Authors: Zarnegar, Armita , Vamplew, Peter , Stranieri, Andrew
- Date: 2009
- Type: Text , Conference paper
- Relation: Paper presented at Thirty-Second Australasian Computer Science Conference (ACSC 2009), Wellington, New Zealand : Vol. 91, p. 17-23
- Full Text:
- Description: In this paper we aim to infer a model of genetic networks from time series data of gene expression profiles by using a new gene expression programming algorithm. Gene expression networks are modelled by differential equations which represent temporal gene expression relations. Gene Expression Programming is a new extension of genetic programming. Here we combine a local search method with gene expression programming to form a memetic algorithm in order to find not only the system of differential equations but also fine tune its constant parameters. The effectiveness of the proposed method is justified by comparing its performance with that of conventional genetic programming applied to this problem in previous studies.
- Authors: Zarnegar, Armita , Vamplew, Peter , Stranieri, Andrew
- Date: 2009
- Type: Text , Conference paper
- Relation: Paper presented at Thirty-Second Australasian Computer Science Conference (ACSC 2009), Wellington, New Zealand : Vol. 91, p. 17-23
- Full Text:
- Description: In this paper we aim to infer a model of genetic networks from time series data of gene expression profiles by using a new gene expression programming algorithm. Gene expression networks are modelled by differential equations which represent temporal gene expression relations. Gene Expression Programming is a new extension of genetic programming. Here we combine a local search method with gene expression programming to form a memetic algorithm in order to find not only the system of differential equations but also fine tune its constant parameters. The effectiveness of the proposed method is justified by comparing its performance with that of conventional genetic programming applied to this problem in previous studies.
A web-based Narrative construction environment
- Yearwood, John, Stranieri, Andrew, Osman, Deanna
- Authors: Yearwood, John , Stranieri, Andrew , Osman, Deanna
- Date: 2008
- Type: Text , Conference paper
- Relation: Paper presented at NILE 2008: 5th International Conference on Narrative and Interactive Learning Environments, Edinburgh, Scotland : 6th-8th August 2008 p. 78-81
- Full Text:
- Description: This paper describes a web-based environment for constructing narrative from story snippets contributed by a community of interest. The underlying model uses an argument based structure to infer the next event in the narrative sequence. The approach makes use of both events and higher level story elements derived from Polti’s dramatic situations. Dramatic situations used are consistent with a theme, and events are generally constrained by the dramatic situation. The narrative generated is a function of the event history, the dramatic situations chosen and the plausible inferences about next events that are contributed by a community of interest in the theme. At this stage, a player’s actions are simulated using a random selection from a set and the implementation of a nonsense filter. Example outputs from the system are provided and discussed.
- Description: 2003006499
- Authors: Yearwood, John , Stranieri, Andrew , Osman, Deanna
- Date: 2008
- Type: Text , Conference paper
- Relation: Paper presented at NILE 2008: 5th International Conference on Narrative and Interactive Learning Environments, Edinburgh, Scotland : 6th-8th August 2008 p. 78-81
- Full Text:
- Description: This paper describes a web-based environment for constructing narrative from story snippets contributed by a community of interest. The underlying model uses an argument based structure to infer the next event in the narrative sequence. The approach makes use of both events and higher level story elements derived from Polti’s dramatic situations. Dramatic situations used are consistent with a theme, and events are generally constrained by the dramatic situation. The narrative generated is a function of the event history, the dramatic situations chosen and the plausible inferences about next events that are contributed by a community of interest in the theme. At this stage, a player’s actions are simulated using a random selection from a set and the implementation of a nonsense filter. Example outputs from the system are provided and discussed.
- Description: 2003006499
An argument structure abstraction for Bayesian belief networks: Just outcomes in on-line dispute resolution
- Muecke, Nial, Stranieri, Andrew
- Authors: Muecke, Nial , Stranieri, Andrew
- Date: 2008
- Type: Text , Conference proceedings
- Full Text:
- Description: There are many different approaches for settling disputes on-line, such as simple email systems, fixed bid systems and intelligent systems. However, to date there have been no attempts to integrate decision support methods into the dispute resolution process for the purpose of supporting outcomes that are consistent with judicial reasoning. This paper describes how a model of judicial reasoning can be used to assist divorcees with the resolution of property issues online, in a manner that is consistent with decisions a judge would make if the matter was heard in Court. The approach uses an argument based model of the discretionary nature of decisions made by judges in Australian Family Law. This is integrated with a protocol for online dispute dialogue. Predictions of the likelihood of alternates outcomes is achieved with a series of Bayesian Belief Networks
- Authors: Muecke, Nial , Stranieri, Andrew
- Date: 2008
- Type: Text , Conference proceedings
- Full Text:
- Description: There are many different approaches for settling disputes on-line, such as simple email systems, fixed bid systems and intelligent systems. However, to date there have been no attempts to integrate decision support methods into the dispute resolution process for the purpose of supporting outcomes that are consistent with judicial reasoning. This paper describes how a model of judicial reasoning can be used to assist divorcees with the resolution of property issues online, in a manner that is consistent with decisions a judge would make if the matter was heard in Court. The approach uses an argument based model of the discretionary nature of decisions made by judges in Australian Family Law. This is integrated with a protocol for online dispute dialogue. Predictions of the likelihood of alternates outcomes is achieved with a series of Bayesian Belief Networks
An intelligent learning environment for traditional Chinese medicine practitioners and students
- Jia, Long, Stranieri, Andrew, Shen, J
- Authors: Jia, Long , Stranieri, Andrew , Shen, J
- Date: 2008
- Type: Text , Conference paper
- Relation: Paper presented at HIC 2008 Australia's Health Informatics Conference; The Person in the Centre, Brunswick East, Victoria : 31st August - 2nd September 2008
- Full Text:
- Description: Objectives: This study aims to support the training of Traditional Chinese Medicine practitioners by embedding an expert diagnostic model for arthritis into an Intelligent Interactive Learning Environment (IILE). Background: The increasing prevalence of Traditional Chinese Medicine (TCM) outside China is characterised by the emergence of university level practitioner training and stringent regulatory requirements. TCM differential diagnosis is a difficult task that was traditionally taught by exposure to large numbers of patients in a master-apprentice context. In university degree programs, students and novice diagnosticians cannot have the exposure to cases possible in the traditional context. An online system that engages students in the interactive construction of a virtual case and provides immediate feedback on the appropriateness of student actions and the accuracy of diagnostic conclusions can enhance student learning. The system, an Intelligent Interactive Learning Environment (IILE) is based on an approach that has been shown to improve learning outcomes in intensive care nurse training. Methods: An expert model of diagnostic reasoning elicited from TCM expert practitioners lies at the core of the IILE. The knowledge acquisition is performed using an argumentation tree representation that has been shown to be effective in structuring complex knowledge and facilitating engineer - expert interactions. Problems associated with keeping knowledge bases up to date are mitigated with the use of a knowledge model known as ripple down rules permits dynamic updating of knowledge so that knowledge bases evolve over time. A simple narrative model builds up the virtual case study as user interaction proceeds. Results and discussion: This article reports preliminary results in the study that includes an overview of TCM differential diagnosis, the argument tree, the ripple down rule representation and the narrative based IILE. Segments of the knowledge model based solely on TCM literature are illustrated.
- Description: 2003006755
- Authors: Jia, Long , Stranieri, Andrew , Shen, J
- Date: 2008
- Type: Text , Conference paper
- Relation: Paper presented at HIC 2008 Australia's Health Informatics Conference; The Person in the Centre, Brunswick East, Victoria : 31st August - 2nd September 2008
- Full Text:
- Description: Objectives: This study aims to support the training of Traditional Chinese Medicine practitioners by embedding an expert diagnostic model for arthritis into an Intelligent Interactive Learning Environment (IILE). Background: The increasing prevalence of Traditional Chinese Medicine (TCM) outside China is characterised by the emergence of university level practitioner training and stringent regulatory requirements. TCM differential diagnosis is a difficult task that was traditionally taught by exposure to large numbers of patients in a master-apprentice context. In university degree programs, students and novice diagnosticians cannot have the exposure to cases possible in the traditional context. An online system that engages students in the interactive construction of a virtual case and provides immediate feedback on the appropriateness of student actions and the accuracy of diagnostic conclusions can enhance student learning. The system, an Intelligent Interactive Learning Environment (IILE) is based on an approach that has been shown to improve learning outcomes in intensive care nurse training. Methods: An expert model of diagnostic reasoning elicited from TCM expert practitioners lies at the core of the IILE. The knowledge acquisition is performed using an argumentation tree representation that has been shown to be effective in structuring complex knowledge and facilitating engineer - expert interactions. Problems associated with keeping knowledge bases up to date are mitigated with the use of a knowledge model known as ripple down rules permits dynamic updating of knowledge so that knowledge bases evolve over time. A simple narrative model builds up the virtual case study as user interaction proceeds. Results and discussion: This article reports preliminary results in the study that includes an overview of TCM differential diagnosis, the argument tree, the ripple down rule representation and the narrative based IILE. Segments of the knowledge model based solely on TCM literature are illustrated.
- Description: 2003006755
AWSum - applying data mining in a health care scenario
- Quinn, Anthony, Jelinek, Herbert, Stranieri, Andrew, Yearwood, John
- Authors: Quinn, Anthony , Jelinek, Herbert , Stranieri, Andrew , Yearwood, John
- Date: 2008
- Type: Text , Conference paper
- Relation: Paper presented at International Conference on Intelligent Sensors, Sensor Networks and Information Processing, ISSNIP 2008, Sydney, New South Wales : 15th-18th December 2008 p. 291-296
- Full Text:
- Description: This paper investigates the application of a new data mining algorithm called Automated Weighted Sum, (AWSum), to diabetes screening data to explore its use in providing researchers with new insight into the disease and secondarily to explore the potential the algorithm has for the generation of prognostic models for clinical use. There are many data mining classifiers that produce high levels of predictive accuracy but their application to health research and clinical applications is limited because they are complex, produce results that are difficult to interpret and are difficult to integrate with current knowledge and practises. This is because most focus on accuracy at the expense of informing the user as to the influences that lead to their classification results. By providing this information on influences a researcher can be pointed to new potentially interesting avenues for investigation. AWSum measures influence by calculating a weight for each feature value that represents its influence on a class value relative to other class values. The results produced, although on limited data, indicated the approach has potential uses for research and has some characteristics that may be useful in the future development of prognostic models.
- Description: 2003006660
- Authors: Quinn, Anthony , Jelinek, Herbert , Stranieri, Andrew , Yearwood, John
- Date: 2008
- Type: Text , Conference paper
- Relation: Paper presented at International Conference on Intelligent Sensors, Sensor Networks and Information Processing, ISSNIP 2008, Sydney, New South Wales : 15th-18th December 2008 p. 291-296
- Full Text:
- Description: This paper investigates the application of a new data mining algorithm called Automated Weighted Sum, (AWSum), to diabetes screening data to explore its use in providing researchers with new insight into the disease and secondarily to explore the potential the algorithm has for the generation of prognostic models for clinical use. There are many data mining classifiers that produce high levels of predictive accuracy but their application to health research and clinical applications is limited because they are complex, produce results that are difficult to interpret and are difficult to integrate with current knowledge and practises. This is because most focus on accuracy at the expense of informing the user as to the influences that lead to their classification results. By providing this information on influences a researcher can be pointed to new potentially interesting avenues for investigation. AWSum measures influence by calculating a weight for each feature value that represents its influence on a class value relative to other class values. The results produced, although on limited data, indicated the approach has potential uses for research and has some characteristics that may be useful in the future development of prognostic models.
- Description: 2003006660
Dramatic level analysis for interactive narrative
- Macfadyen, Alyx, Stranieri, Andrew, Yearwood, John
- Authors: Macfadyen, Alyx , Stranieri, Andrew , Yearwood, John
- Date: 2008
- Type: Text , Conference paper
- Relation: Paper presented at NILE 2008: 5th International Conference on Narrative and Interactive Learning Environments, Edinburgh, Scotland : 6th-8th August 2008 p. 17-22
- Full Text:
- Description: In interactive 3D narratives, a user’s narrative emerges through interactions with the system and embodied agencies (characters) mediated through the 3D environment. We present a methodology that identifies and measures four factors in interactive narrative where agency is present. We describe a technique for measuring drama, agency and engagement and compare the centrality of a designed interactive narrative with the emergent participatory narrative. This methodology has application as an analytic device for any interactive narrative where agency is fundamental. The adoption of the FrameNet semantic resource and the interpretation of interaction in narrative, situate this work in the domain of 3D interactive narratives, mixed and augmented realities and polymorphic narratives that cross forms of media.
- Description: 2003006540
- Authors: Macfadyen, Alyx , Stranieri, Andrew , Yearwood, John
- Date: 2008
- Type: Text , Conference paper
- Relation: Paper presented at NILE 2008: 5th International Conference on Narrative and Interactive Learning Environments, Edinburgh, Scotland : 6th-8th August 2008 p. 17-22
- Full Text:
- Description: In interactive 3D narratives, a user’s narrative emerges through interactions with the system and embodied agencies (characters) mediated through the 3D environment. We present a methodology that identifies and measures four factors in interactive narrative where agency is present. We describe a technique for measuring drama, agency and engagement and compare the centrality of a designed interactive narrative with the emergent participatory narrative. This methodology has application as an analytic device for any interactive narrative where agency is fundamental. The adoption of the FrameNet semantic resource and the interpretation of interaction in narrative, situate this work in the domain of 3D interactive narratives, mixed and augmented realities and polymorphic narratives that cross forms of media.
- Description: 2003006540