The IOC Centres of Excellence bring prevention to Sports Medicine
- Authors: Engebretsen, Lars , Bahr, Roald , Cook, Jill , Derman, Wayne , Emery, Carolyn , Finch, Caroline , Meeuwisse, Willem , Schwellnus, Martin , Steffen, Kathrin
- Date: 2014
- Type: Text , Journal article
- Relation: British Journal of Sports Medicine Vol. 48, no. 17 (2014), p. 1270-1275
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- Description: The protection of an athlete's health and preventing injuries and illnesses in sport are top priorities for the IOC and its Medical Commission. The IOC therefore partners with selected research centres around the world and supports research in the field of sports medicine. This has enabled the IOC to develop an international network of expert scientists and clinicians in sports injury and disease prevention research. The IOC wants to promote injury and disease prevention and the improvement of physical health of the athlete by: (1) establishing long-term research programmes on injury and disease prevention (including studies on basic epidemiology, risk factors, injury mechanisms and intervention), (2) fostering collaborative relationships with individuals, institutions and organisations to improve athletes' health, (3) implementing and collaborating with applied, ongoing and novel research and development within the framework and long-term strategy of the IOC and (4) setting up knowledge translation mechanisms to share scientific research results with the field throughout the Olympic Movement and sports community and converting these results into concrete actions to protect the health of the athletes. In 2009, the IOC also identified four research centres that had an established track record in research, educational and clinical activities to achieve these ambitions: (1) the Australian Centre for Research into Injury in Sport and its Prevention (ACRISP), Australia; (2) the Sport Injury Prevention Research Centre (SIPRC), Canada; (3) the Clinical Sport and Exercise Medicine Research (CSEM), South Africa and (4) the Oslo Sports Trauma Research Center (OSTRC), Norway. This paper highlights the work carried out by these four IOC Centres of Excellence over the past 6 years and their contribution to the world of sports medicine.
The three must-do's of intervention reporting : Enhancing sports injury prevention research
- Authors: O'Brien, James , Donaldson, Alex , Barbery, Gaery , Finch, Caroline
- Date: 2014
- Type: Text , Journal article
- Relation: British Journal of Sports Medicine Vol. 48, no. 17 (2014), p. 1267-1269
- Relation: http://purl.org/au-research/grants/nhmrc/565900
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- Description: Injuries in team ball sports (eg, soccer, handball, volleyball and basketball) are common, accounting for 44% of all nonfatal sports injuries in the 27 EU Nations.1 Combined with high participation rates, this gives team ball sports the potential to pose significant health burdens, and highlights the importance of preventing injuries in this context.
What do community football players think about different exercise-training programmes? Implications for the delivery of lower limb injury prevention programmes
- Authors: Finch, Caroline , Doyle, Tim , Dempsey, Alasdair , Elliott, Bruce , Twomey, Dara , White, Peta , Diamantopoulou, Kathy , Young, Warren , Lloyd, David
- Date: 2014
- Type: Text , Journal article
- Relation: British Journal of Sports Medicine Vol. 48, no. 8 (2014), p.702-707
- Relation: http://purl.org/au-research/grants/nhmrc/565900
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- Description: Background: Players are the targeted end-users and beneficiaries of exercise-training programmes implemented during coach-led training sessions, and the success of programmes depends upon their active participation. Two variants of an exercise-training programme were incorporated into the regular training schedules of 40 community Australian Football teams, over two seasons. One variant replicated common training practices, while the second was an evidence-based programme to alter biomechanical and neuromuscular factors related to risk of knee injuries. This paper describes the structure of the implemented programmes and compares players’ end-of-season views about the programme variants. Methods: This study was nested within a larger group-clustered randomised controlled trial of the effectiveness of two exercise-training programmes (control and neuromuscular control (NMC)) for preventing knee injuries. A post-season self-report survey, derived from Health Belief Model constructs, included questions to obtain players’ views about the benefits and physical challenges of the programme in which they participated. Results: Compared with control players, those who participated in the NMC programme found it to be less physically challenging but more enjoyable and potentially of more benefit. Suggestions from players about potential improvements to the training programme and its future implementation included reducing duration, increasing range of drills/exercises and promoting its injury prevention and other benefits to players. Conclusions: Players provide valuable feedback about the content and focus of implemented exercise-training programmes, that will directly inform the delivery of similar, or more successful, programmes in the future.
What fooled us in the knee may trip us up in the hip: Lessons from arthroscopy
- Authors: Kemp, Joanne , Crossley, Kay , Roos, Ewa , Ratzlaff, Charles
- Date: 2014
- Type: Text , Journal article
- Relation: British Journal of Sports Medicine Vol. 48, no. 16 (2014), p. 1200-1201
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- Description: Editorial
- Description: C1
Women's access needs in maternity care in rural Tasmania, Australia : a mixed methods study
- Authors: Hoang, Ha , Le, Quynh , Terry, Daniel
- Date: 2014
- Type: Text , Journal article
- Relation: Women and Birth Vol. 27, no. 1 (2014), p. 9-14
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- Description: Objectives: This study investigates (i) maternity care access issues in rural Tasmania, (ii) rural women's challenges in accessing maternity services and (iii) rural women's access needs in maternity services. Methods: A mixed-method approach using a survey and semi-structured interviews was conducted. The survey explored women's views of rural maternity services from antenatal to postnatal care, while interviews reinforced the survey results and provided insights into the access issues and needs of women in maternity care. Findings: The survey was completed by n=210 women, with a response rate of 35%, with n=22 follow-up interviews being conducted. The survey indicated the majority of rural women believed antenatal education and check-ups and postnatal check-ups should be provided locally. The majority of women surveyed also believed in the importance of having a maternity unit in the local hospital, which was further iterated and clarified within the interviews. Three main themes emerged from the interview data, namely (i) lack of access to maternity services, (ii) difficulties in accessing maternity services, and (iii) rural women's access needs. Conclusion: The study suggested that women's access needs are not fully met in some rural areas of Tasmania. Rural women face many challenges when accessing maternity services, including financial burden and risk of labouring en route. The study supports the claim that the closure of rural maternity units shifts cost and risk from the health care system to rural women and their families. © 2013 Australian College of Midwives.
A preliminary video analysis of concussion in the National Rugby League
- Authors: Gardner, Andrew , Iverson, Grant , Quinn, Tanya , Makdissi, Michael , Levi, Christopher , Shultz, Sandy , Wright, David , Stanwell, Peter
- Date: 2015
- Type: Text , Journal article
- Relation: Brain Injury Vol. 29, no. 10 (2015), p. 1182-1185
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- Description: Primary objective: To conduct the first video analysis of concussion in the Australian National Rugby League (NRL) and describe player and injury characteristics, situational factors and time to return to play.Research design: Descriptive, observational case series.Methods and procedures: Video analysis of 20 medically diagnosed concussions for three consenting clubs during the 2013 NRL season.Main outcome and results: Most concussions (83%) occurred during a high tackle, and all injured ball carriers were hit high. Loss of consciousness was observed in 30% of cases. Common observable signs of injury included clutching of the head, balance problems or wobbly legs and a blank or vacant state. There were no post-concussive seizures. All players with loss of consciousness were removed from play. However, only half of the total sample was removed from play and one athlete who was removed returned to play in the same match. Of the players who were removed from play, the large majority returned the following week. Illegal play accounted for 25% of all concussions.Conclusions: Video analysis may be a useful method to study the incidence, mechanism and management of concussion in sports such as Rugby League. Future studies may include larger numbers to validate this preliminary data and may also investigate other levels of play and age ranges. © 2015 Taylor and Francis Group, LLC.
Acute whole body UVA irradiation combined with nitrate ingestion enhances time trial performance in trained cyclists
- Authors: Muggeridge, David , Sculthorpe, Nicholas , Grace, Fergal , Willis, Gareth , Thornhill, Laurence , Weller, Richard , James, Philip , Easton, Chris
- Date: 2015
- Type: Text , Journal article
- Relation: Nitric Oxide : Biology and Chemistry Vol. 48, no. (2015), p. 3-9
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- Description: Dietary nitrate supplementation has been shown to increase nitric oxide (NO) metabolites, reduce blood pressure (BP) and enhance exercise performance. Acute exposure to ultraviolet (UV)-A light also increases NO bioavailability and reduces BP. We conducted a randomized, counterbalanced placebo-controlled trial to determine the effects of UV-A light alone and in combination with nitrate on the responses to sub-maximal steady-state exercise and time trial (TT) performance. Nine cyclists (VO2max 53.1 +/- 4.4 ml/kg/min) completed five performance trials comprising 10 min submaximal steady-state cycling followed by a 16.1 km TT. Following a familiarization the final four trials were preceded, in random order, by either (1) Nitrate gels (NIT) + UV-A, (2) Placebo (PLA) + UV-A, (3) NIT + Sham light (SHAM) and (4) PLA + SHAM (control). The NIT gels (2 x 60 ml gels, ~8.1 mmol nitrate) or a low-nitrate PLA were ingested 2.5 h prior to the trial. The light exposure consisted of 20 J/cm(2) whole body irradiation with either UV-A or SHAM light. Plasma nitrite was measured pre- and post-irradiation and VO2 was measured continuously during steady-state exercise. Plasma nitrite was higher for NIT + SHAM (geometric mean (95% CI), 332 (292-377) nM; P = 0.029) and NIT + UV-A (456 (312-666) nM; P = 0.014) compared to PLA + SHAM (215 (167-277) nM). Differences between PLA + SHAM and PLA + UV-A (282 (248-356) nM) were small and non-significant. During steady-state exercise VO2 was reduced following NIT + UVA (P = 0.034) and tended to be lower in NIT + SHAM (P = 0.086) but not PLA + UV-A (P = 0.381) compared to PLA + SHAM. Performance in the TT was significantly faster following NIT + UV-A (mean +/- SD 1447 +/- 41 s P = 0.005; d = 0.47), but not PLA + UV-A (1450 +/- 40 s; d = 0.41) or NIT + SHAM (1455 +/- 47 s; d = 0.28) compared to PLA + SHAM (1469 +/- 52 s). These findings demonstrate that exposure to UV-A light alone does not alter the physiological responses to exercise or improve performance in a laboratory setting. A combination of UV-A and NIT, however, does improve cycling TT performance in this environment, which may be due to a larger increase in NO availability.
Agility and change-of-direction speed are independent skills: Implications for training for agility in invasion sports
- Authors: Young, Warren , Dawson, Brian , Henry, Greg
- Date: 2015
- Type: Text , Journal article
- Relation: International Journal of Sports Science & Coaching Vol. 10, no. 1 (2015), p. 159-169
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- Description: This review explores the differences between agility in invasion sports (defined as including reactive decision-making) and change-of-direction speed (CODS), and highlights the implications for training. Correlations between agility tests and CODS tests indicate that they represent independent skills. Agility tests discriminate higher-from lower-standard athletes better than CODS tests, indicating that the cognitive element of agility is important to performance. Training studies have shown that the development of strength qualities can transfer to gains in CODS, but this has never been shown for agility. There is some evidence that the importance of physical qualities is greater for CODS than for agility. It was concluded that the reactive element should be included in agility training, testing and research. While there appears to be no research evidence for the benefits of strength and power training, there is some support for the use of small-sided games for improving agility.
Attitudes towards vital signs monitoring in the detection of clinical deterioration: scale development and survey of ward nurses.
- Authors: Mok, Wenqi , Wang, Wenru , Cooper, Simon J. , Ang, Emily , Liaw, Sok
- Date: 2015
- Type: Text , Journal article
- Relation: International Journal for Quality in Health Care Vol. 27, no. 3 (2015), p. 207-213
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- Description: Objective To develop and determine the psychometrics properties of an instrument (V-scale) and to explore nurses' attitudes towards vital signs monitoring in the detection of clinical deterioration in general wards. Design Scale development with psychometric testing and a descriptive quantitative survey. Setting Tertiary acute care hospital. Participants A total of 614 general ward nurses. Findings Principal component analysis revealed a 16-item instrument in a five-factor solution (key indicators, knowledge, communication, workload and technology) that explained 56.27% of the variance. The internal consistency was sufficient with Cronbach's alpha of 0.71 and strong item subscale correlations (0.56–0.89). The test–retest reliability was adequate with an Intraclass Correlation Coefficient (ICC) of 0.85. Many nurses (56.9%) erroneously perceived blood pressure changes as the first indicator of deterioration, and 46% agreed that an altered respiratory rate was the least important indicator. Most nurses (59.8%) also reported relying on oxygen saturation to evaluate respiratory dysfunction, and 27.4% indicated that they make quick estimates of the respiratory rate. Current practices for vital signs monitoring were considered to be time consuming (21.0%) and overwhelming (35.3%). Nurses' attitudes were most significantly influenced by whether they had a degree qualification followed by whether they worked in a general ward with a specialty and had >5 years of experience. Conclusions This exploratory study provides evidence for the psychometric properties of the V-scale. It reveals a need for continuous professional development to improve ward nurses' attitudes towards vital signs monitoring. Vital signs monitoring needs to be prioritized in workload planning.
Boxing headguard performance in punch machine tests
- Authors: McIntosh, Andrew , Patton, Declan
- Date: 2015
- Type: Text , Journal article
- Relation: British Journal of Sports Medicine Vol. 49, no. 17 (2015), p. 1108-1112
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- Description: Background: The paper presents a novel laboratory method for assessing boxing headguard impact performance. The method is applied to examine the effects of headguards on head impact dynamics and injury risk. Methods: A linear impactor was developed, and a range of impacts was delivered to an instrumented Hybrid III head and neck system both with and without an AIBA (Association Internationale de Boxe Amateur)- approved headguard. Impacts at selected speeds between 4.1 and 8.3 m/s were undertaken. The impactor mass was approximately 4 kg and an interface comprising a semirigid 'fist' with a glove was used. Results: The peak contact forces were in the range 1.9-5.9 kN. Differences in head impact responses between the Top Ten AIBA-approved headguard and bare headform in the lateral and forehead tests were large and/or significant. In the 8.3 m/s fist-glove impacts, the mean peak resultant headform accelerations for bare headform tests was approximately 130 g compared with approximately 85 g in the forehead impacts. In the 6.85 m/s bare headform impacts, mean peak resultant angular head accelerations were in the range of 5200-5600 rad/s
Caution this drug may cause serious harm! why we must report adverse effects of physical activity promotion
- Authors: Verhagen, Evert , Bolling, Caroline , Finch, Caroline
- Date: 2015
- Type: Text , Journal article
- Relation: British Journal of Sports Medicine Vol. 49, no. 1 (January 2015), p. 1-2
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Changes in the leukocyte methylome and its effect on cardiovascular-related genes after exercise
- Authors: Denham, Joshua , O'Brien, Brendan , Marques, Francine , Charchar, Fadi
- Date: 2015
- Type: Text , Journal article
- Relation: Journal of Applied Physiology Vol. 118, no. 4 (2015), p. 475-488
- Relation: http://purl.org/au-research/grants/nhmrc/1009490
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- Description: Physical exercise has proven cardiovascular benefits, yet there is no clear understanding of the related molecular mechanisms leading to this. Here we determined the beneficial epigenetic effects of exercise after sprint interval training, a form of exercise known to improve cardiometabolic health. We quantified genome-wide leukocyte DNA methylation of 12 healthy young (18-24 yr) men before and after 4 wk (thrice weekly) of sprint interval training using the 450K BeadChip (Illumina) and validated gene expression changes in an extra seven subjects. Exercise increased subjects' cardiorespiratory fitness and maximal running performance, and decreased low-density lipoprotein cholesterol concentration in conjunction with genome-wide DNA methylation changes. Notably, many CpG island and gene promoter regions were demethylated after exercise, indicating increased genome-wide transcriptional changes. Among genes with DNA methylation changes, epidermal growth factor (EGF), a ligand of the epidermal growth factor receptor known to be involved in cardiovascular disease, was demethylated and showed decreased mRNA expression. Additionally, we found that in microRNAs miR-21 and miR-210, gene DNA methylation was altered by exercise causing a cascade effect on the expression of the mature microRNA involved in cardiovascular function. Our findings demonstrate that exercise alters DNA methylation in circulating blood cells in microRNA and protein-coding genes associated with cardiovascular physiology. Copyright © 2015 the American Physiological Society
Competing with injuries : Injuries prior to and during the 15th FINA World Championships 2013 (aquatics)
- Authors: Mountjoy, Margo , Junge, Astrid , Benjamen, Sarah , Boyd, Kevin , Diop, Mohamed , Gerrard, David , van den Hoogenband, Cees-Rein , Marks, Saul , Martinez-Ruiz, Enrique , Miller, Jim , Nanousis, Kyriakos , Shahpar, Farhad , Veloso, Jose , van Mechelen, Willem , Verhagen, Evert
- Date: 2015
- Type: Text , Journal article
- Relation: British Journal of Sports Medicine Vol. 49, no. 1 (2015), p. 37-43
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- Description: Background: Injury and illness surveillance is the foundation for the development of prevention strategies. Objective: To examine injuries among the aquatic disciplines in the 4 weeks prior to and during the 2013 FINA World Championships. Methods: The study was comprised of two components: (1) a retrospective athlete survey recording injuries in the 4 weeks prior to the Championships and (2) a prospective recording of injuries and illnesses by the medical teams of the participating countries and the local host medical team. Results: One-third of the 1116 responding athletes reported an injury/physical complaint in the 4 weeks prior to the Championships. Significantly more women (36.7%) than men (28.6%) reported injuries. Divers reported the highest rate of injury/physical complaints (55.7%). At the start of the Championships, 70% of injured respondents (n=258) were still symptomatic; however, full participation was expected by 76%. During the Championships, 186 new injuries were reported (8.3/100 registered athletes) with the highest injury incidence rate in water polo (15.3/100 registered athletes). The most common injured body part was the shoulder (21%). A total of 199 illnesses were reported during the Championships (9.0/100 registered athletes) with the most common diagnosis of illness being gastrointestinal infection. Environmental exposure (allergy, otitis and jellyfish stings) was responsible for 27% of all illnesses in open water swimming. Conclusions: Injuries pose a significant health risk for elite aquatic athletes. A prospective study would improve understanding of out-of-competition injuries. Future injury and illness surveillance at FINA World Championships is required to direct and measure the impact of prevention strategies.
Distinctive phenotype identification for breast cancer genotypes among hereditary breast cancer mutated genes
- Authors: Hassan, Md Rafiul , ul Haq, Imran , Ramadan, Emad , Kamruzzaman, Joarder , Ahmed, Adel
- Date: 2015
- Type: Text , Journal article
- Relation: Current Bioinformatics Vol. 10, no. 1 (2015), p. 5-15
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- Description: It is well known that the mutations in BRCA1 or BRCA2 gene can cause the hereditary breast cancer. However, it is a tedious and expensive task to identify the mutant genes that impact breast cancer due to the large number of genes and very small number of samples. Furthermore, the expressive energy of the subset of genes in comparison to that of one individual gene at a time is considered to have a profound influence in case of breast cancer. In this paper 7 tumors with BRCA1 mutation and 8 tumors with BRCA2 mutation have been used to identify the subset of discriminative genes. A combination of a non-parametric supervised and an unsupervised statistical method is introduced to analyze the gene expressions and the distinctive genes among the highly expressed genes are identified. The most important genes are filtered using the area under the curve (AUC) measure. These filtered genes are then used to build a hidden Markov model (HMM) to analyse their inter-relationship and identify the best subset among them. In addition, Protein-Protein interaction network is generated to analyse the pathways of the identified genes and their link with BRCA1 or BRCA2. Transcription Factors are identified and Gene Set Enrichment Analysis (GSEA) is calculated for the identified genes subset and the results are compared with the results mentioned in other cancer literature. Experimental results suggest that only 8 genes have been identified out of 3226 genes by the proposed hybrid method. Out of the 8 identified genes, 5 have been linked with breast cancer by other studies. Moreover, 7 genes have been associated with numerous diseases that may result in breast cancer. Furthermore, 8 transcription factors were identified that cover the identified genes and BRCA1 and BRCA2. Lastly, GSEA enrichment score of 0.52 is calculated for the identified genes and it is comparatively better considering the small subset of identified genes.
Examining the accuracy and in-game performance effects between pre- and post-performance routines : A mixed methods study
- Authors: Mesagno, Christopher , Hill, Denise , Larkin, Paul
- Date: 2015
- Type: Text , Journal article
- Relation: Psychology of Sport and Exercise Vol. 19, no. (2015), p. 85-94
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- Description: Objectives: Researchers have identified that pre-performance routines improve performance under pressure, yet have not investigated the effects of post-performance routines. Thus, the purpose of the current study was to examine whether the type of performance routine training could improve tenpin bowling accuracy and in-game performance. Design: A mixed-method design was adopted, whereby the impact of a performance routine intervention on performance accuracy and in-game performance was examined. This was followed by participants completing semi-structured interviews which explored the perceived effect of those routines. Method: Thirty-six experienced tenpin bowlers completed 30 accuracy shots pre- and post-intervention training, with league scores obtained for in-game performance comparison. Four groups (i.e., pre-performance routine [PPR], post-performance routine [POST], combined pre-post routine, and a control group) practiced 12 games across four weeks while listening to the group specific routine instruction on an IPod. Results: It was noted that accuracy improved (albeit non-significantly) for the PPR and combined pre-post routine group, but not the other groups. Critically, all intervention groups (PPR, POST & COMBO) improved in-game performance. The qualitative data indicated that both the PPR and POST was perceived to influence positively performance, attentional and emotional control, self-awareness, self-confidence, motivation. The PPR was also considered to enhance a state of readiness, and perceived control. Conclusions: Results indicate that the PPR training enhanced accuracy and in-game performance, with the POST training acting as a supportive role for in-game performance as evidenced by the qualitative and quantitative data. Future research should continue to investigate the effects of POSTs. (C) 2015 Elsevier Ltd. All rights reserved.
Feelings of the future
- Authors: Miloyan, Beyon , Suddendorf, Thomas
- Date: 2015
- Type: Text , Journal article
- Relation: Trends in Cognitive Sciences Vol. 19, no. 4 (2015), p. 196-200
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- Description: Affective forecasting refers to the capacity to predict future feelings. Humans have been found to exhibit systematic affective forecasting biases that involve overestimation of the intensity and duration of future feelings. Although recent research has elucidated the proximate mechanisms underlying our ability to predict future feelings, explanations concerning the potential adaptive significance of these biases have attracted little attention. Here we consider the function of affective forecasts as signals of biological value, drivers of goal pursuit, and tools for eliciting collaboration. Although affective forecasting biases can have significant costs, for instance in terms of one's pursuit of happiness, they may ultimately serve adaptive functions.
Generation of a Novel Bacteriophage Library displaying scFv antibody fragments from the natural Buffalo host to identify antigens from adult Schistosoma japonicum for diagnostic development
- Authors: Hosking, Christopher , McWilliam, Hamish , Driguez, Patrick , Piedrafita, David , Li, Yuesheng , McManus, Donald , Ilag, Leodevico , Meeusen, Els , De Veer, Michael
- Date: 2015
- Type: Text , Journal article
- Relation: PLoS Neglected Tropical Diseases Vol. 9, no. 12 (2015), p. 1-20
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- Description: The development of effective diagnostic tools will be essential in the continuing fight to reduce schistosome infection; however, the diagnostic tests available to date are generally laborious and difficult to implement in current parasite control strategies. We generated a series of single-chain antibody Fv domain (scFv) phage display libraries from the portal lymph node of field exposed water buffaloes, Bubalus bubalis, 11–12 days post challenge with Schistosoma japonicum cercariae. The selected scFv-phages showed clear enrichment towards adult schistosomes and excretory-secretory (ES) proteins by immunofluorescence, ELISA and western blot analysis. The enriched libraries were used to probe a schistosome specific protein microarray resulting in the recognition of a number of proteins, five of which were specific to schistosomes, with RNA expression predominantly in the adult life-stage based on interrogation of schistosome expressed sequence tags (EST). As the libraries were enriched by panning against ES products, these antigens may be excreted or secreted into the host vasculature and hence may make good targets for a diagnostic assay. Further selection of the scFv library against infected mouse sera identified five soluble scFv clones that could selectively recognise soluble whole adult preparations (SWAP) relative to an irrelevant protein control (ovalbumin). Furthermore, two of the identified scFv clones also selectively recognised SWAP proteins when spiked into naïve mouse sera. These host B-cell derived scFvs that specifically bind to schistosome protein preparations will be valuable reagents for further development of a cost effective point-of-care diagnostic test. © 2015 Hosking et al.
Impact of intermittent preventive treatment in pregnancy with azithromycin-containing regimens on maternal nasopharyngeal carriage and antibiotic sensitivity of Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus : A cross-sectional survey at delivery
- Authors: Unger, Holger , Aho, Celestine , Ome-Kaius, Maria , Wangnapi, Regina , Umbers, Alexandra , Jack, Wanda , Lafana, Alice , Michael, Audrey , Hanieh, Sarah , Siba, Peter , Mueller, Ivo , Greenhill, Andrew , Rogerson, Stephen
- Date: 2015
- Type: Text , Journal article
- Relation: Journal of Clinical Microbiology Vol. 53, no. 4 (2015), p. 1317-1323
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- Description: Sulfadoxine-pyrimethamine (SP) plus azithromycin (AZ) (SPAZ) has the potential for intermittent preventive treatment of malaria in pregnancy (IPTp), but its use could increase circulation of antibiotic-resistant bacteria associated with severe pediatric infections. We evaluated the effect of monthly SPAZ-IPTp compared to a single course of SP plus chloroquine (SPCQ) on maternal nasopharyngeal carriage and antibiotic susceptibility of Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus at delivery among 854 women participating in a randomized controlled trial in Papua New Guinea. Serotyping was performed, and antibiotic susceptibility was evaluated by disk diffusion and Etest. Potential risk factors for carriage were examined. Nasopharyngeal carriage at delivery of S. pneumoniae (SPAZ, 7.2% [30/418], versus SPCQ, 19.3% [84/436]; P < 0.001) and H. influenzae (2.9% [12/418] versus 6.0% [26/436], P = 0.028), but not S. aureus, was significantly reduced among women who had received SPAZ-IPTp. The number of macrolide-resistant pneumococcal isolates was small but increased in the SPAZ group (13.3% [4/30], versus SPCQ, 2.2% [2/91]; P = 0.033). The proportions of isolates with serotypes covered by the 13-valent pneumococcal conjugate vaccine were similar (SPAZ, 10.3% [3/29], versus SPCQ, 17.6% [16/91]; P = 0.352). Although macrolide-resistant isolates were rare, they were more commonly detected in women who had received SPAZ-IPTp, despite the significant reduction of maternal carriage of S. pneumoniae and H. influenzae observed in this group. Future studies on SPAZ-IPTp should evaluate carriage and persistence of macrolide-resistant S. pneumoniae and other pathogenic bacteria in both mothers and infants and assess the clinical significance of their circulation.
Impact of low-volume, high-intensity interval training on maximal aerobic capacity, health-related quality of life and motivation to exercise in ageing men
- Authors: Knowles, Ann-Marie , Herbert, Peter , Easton, Chris , Sculthorpe, Nicholas , Grace, Fergal
- Date: 2015
- Type: Text , Journal article
- Relation: Age Vol. 37, no. 2 (2015), p. 25
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- Description: There is a demand for effective training methods that encourage exercise adherence during advancing age, particularly in sedentary populations. This study examined the effects of high-intensity interval training (HIIT) exercise on health-related quality of life (HRQL), aerobic fitness and motivation to exercise in ageing men. Participants consisted of males who were either lifelong sedentary (SED; N = 25; age 63 +/- 5 years) or lifelong exercisers (LEX; N = 19; aged 61 +/- 5 years). [Formula: see text] and HRQL were measured at three phases: baseline (Phase A), week seven (Phase B) and week 13 (Phase C). Motivation to exercise was measured at baseline and week 13. [Formula: see text] was significantly higher in LEX (39.2 +/- 5.6 ml kg min(-1)) compared to SED (27.2 +/- 5.2 ml kg min(-1)) and increased in both groups from Phase A to C (SED 4.6 +/- 3.2 ml kg min(-1), 95 % CI 3.1 - 6.0; LEX 4.9 +/- 3.4 ml kg min(-1), 95 % CI 3.1-6.6) Physical functioning (97 +/- 4 LEX; 93 +/- 7 SED) and general health (70 +/- 11 LEX; 78 +/- 11 SED) were significantly higher in LEX but increased only in the SED group from Phase A to C (physical functioning 17 +/- 18, 95 % CI 9-26, general health 14 +/- 14, 95 % CI 8-21). Exercise motives related to social recognition (2.4 +/- 1.2 LEX; 1.5 +/- 1.0 SED), affiliation (2.7 +/- 1.0 LEX; 1.6 +/- 1.2 SED) and competition (3.3 +/- 1.3 LEX; 2.2 +/- 1.1) were significantly higher in LEX yet weight management motives were significantly higher in SED (2.9 +/- 1.1 LEX; 4.3 +/- 0.5 SED). The study provides preliminary evidence that low-volume HIIT increases perceptions of HRQL, exercise motives and aerobic capacity in older adults, to varying degrees, in both SED and LEX groups.
Increased expression of telomere-regulating genes in endurance athletes with long leukocyte telomeres
- Authors: Denham, Joshua , O'Brien, Brendan , Prestes, Priscilla , Brown, Nicholas , Charchar, Fadi
- Date: 2015
- Type: Text , Journal article
- Relation: Journal of Applied Physiology Vol. 120, no. 2 (2015), p. 148-158
- Relation: http://purl.org/au-research/grants/nhmrc/1009490
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- Description: Leukocyte telomeres shorten with age, and excessive shortening is associated with age-related cardiometabolic diseases. Exercise training may prevent disease through telomere length maintenance although the optimal amount of exercise that attenuates telomere attrition is unknown. Furthermore, the underlying molecular mechanisms responsible for the enhanced telomere maintenance observed in endurance athletes is poorly understood. We quantified the leukocyte telomere length and analyzed the expression of telomere-regulating genes in endurance athletes and healthy controls (both n = 61), using quantitative PCR. We found endurance athletes have significantly longer (7.1%, 208-416 nt) leukocyte telomeres and upregulated TERT (2.0-fold) and TPP1 (1.3-fold) mRNA expression compared with controls in age-adjusted analysis. The telomere length and telomere-regulating gene expression differences were no longer statistically significant after adjustment for resting heart rate and relative (V) over dotO(2 max) (all P > 0.05). Resting heart rate emerged as an independent predictor of leukocyte telomere length and TERT and TPP1 mRNA expression in stepwise regression models. To gauge whether volume of exercise was associated with leukocyte telomere length, we divided subjects into running and cycling tertiles (distance covered per week) and found individuals in the middle and highest tertiles had longer telomeres than individuals in the lowest tertile. These data emphasize the importance of cardiorespiratory fitness and exercise training in the prevention of biological aging. They also support the concept that moderate amounts of exercise training protects against biological aging, while higher amounts may not elicit additional benefits.