- Title
- Optimization of novel 1-Methyl-1H-Pyrazole-5-carboxamides leads to high potency larval development inhibitors of the Barber's pole worm
- Creator
- Le, Thuy; Kunda, Abhijit; Ghoshal, Atanu; Preston, Sarah; Jiao, Yaqing; Ruan, Banfeng; Xue, Lian; Huang, Fei; Keiser, Jennifer; Hofmann, Andreas; Chang, Bill; Garcia-Bustos, Jose; Jabbar, Abdul; Wells, Timothy; Palmer, Michael; Gasser, Robin; Baell, Jonathan
- Date
- 2018
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/167686
- Identifier
- vital:13694
- Identifier
-
https://doi.org/10.1021/acs.jmedchem.8b01544
- Identifier
- ISBN:0022-2623
- Abstract
- A phenotypic screen of a diverse library of small molecules for inhibition of the development of larvae of the parasitic nematode Haemonchus contortus led to the identification of a 1-methyl-1H-pyrazole-5-carboxamide derivative with an IC
- Publisher
- American Chemical Society
- Relation
- Journal of Medicinal Chemistry Vol. 61, no. 23 (2018), p. 10875-10894
- Rights
- Copyright © 2018 American Chemical Society
- Rights
- This metadata is freely available under a CCO license
- Subject
- 0304 Medicinal and Biomolecular Chemistry; 0305 Organic Chemistry; 1115 Pharmacology and Pharmaceutical Sciences; Anthelmintics; Sheep; Anthelmintic drugs
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