Interleukin-11/IL-11 receptor promotes glioblastoma cell proliferation, epithelial–mesenchymal transition, and invasion
- Authors: Stuart, Sarah , Curpen, Peter , Gomes, Adele , Lan, Michelle , Nie, Shuai , Williamson, Nicholas , Kannourakis, George , Morokoff, Andrew , Achuthan, Adrian , Luwor, Rodney
- Date: 2024
- Type: Text , Journal article
- Relation: Brain Sciences Vol. 14, no. 1 (2024), p.
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- Description: Glioblastoma is highly proliferative and invasive. However, the regulatory cytokine networks that promote glioblastoma cell proliferation and invasion into other areas of the brain are not fully defined. In the present study, we define a critical role for the IL-11/IL-11R
The Interleukin-11/IL-11 receptor promotes glioblastoma survival and invasion under glucose-starved conditions through enhanced glutaminolysis
- Authors: Stuart, Sarah , Bezawork-Geleta, Ayenachew , Areeb, Zammam , Gomez, Juliana , Tsui, Vanessa , Zulkifli, Ahmad , Paradiso, Lucia , Jones, Jordan , Nguyen, Hong , Putoczki, Tracy , Licciardi, Paul , Kannourakis, George , Morokoff, Andrew , Achuthan, Adrian , Luwor, Rodney
- Date: 2023
- Type: Text , Journal article
- Relation: International Journal of Molecular Sciences Vol. 24, no. 4 (2023), p.
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- Description: Glioblastoma cells adapt to changes in glucose availability through metabolic plasticity allowing for cell survival and continued progression in low-glucose concentrations. However, the regulatory cytokine networks that govern the ability to survive in glucose-starved conditions are not fully defined. In the present study, we define a critical role for the IL-11/IL-11R