- Title
- Sympathetic nervous system and atherosclerosis
- Creator
- Wang, Yutang; Anesi, Jack; Maier, Michelle; Myers, Mark; Oqueli, Ernesto; Sobey, Christopher; Drummond, Grant; Denton, Kate
- Date
- 2023
- Type
- Text; Journal article; Review
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/197640
- Identifier
- vital:18928
- Identifier
-
https://doi.org/10.3390/ijms241713132
- Identifier
- ISSN:1661-6596 (ISSN)
- Abstract
- Atherosclerosis is characterized by the narrowing of the arterial lumen due to subendothelial lipid accumulation, with hypercholesterolemia being a major risk factor. Despite the recent advances in effective lipid-lowering therapies, atherosclerosis remains the leading cause of mortality globally, highlighting the need for additional therapeutic strategies. Accumulating evidence suggests that the sympathetic nervous system plays an important role in atherosclerosis. In this article, we reviewed the sympathetic innervation in the vasculature, norepinephrine synthesis and metabolism, sympathetic activity measurement, and common signaling pathways of sympathetic activation. The focus of this paper was to review the effectiveness of pharmacological antagonists or agonists of adrenoceptors (
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Relation
- International Journal of Molecular Sciences Vol. 24, no. 17 (2023), p.; https://purl.org/au-research/grants/nhmrc/1062671
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- https://creativecommons.org/licenses/by/4.0/
- Rights
- Copyright © 2023 by the authors
- Rights
- Open Access
- Subject
- 3101 Biochemistry and cell biology; 3107 Microbiology; 3404 Medicinal and biomolecular chemistry; Alpha blocker; Atherosclerosis; Beta blocker; Blood vessel; Renal denervation; Sympathetic activity
- Full Text
- Reviewed
- Funder
- This research was funded by the National Health and Medical Research Council of Australia, grant number 1062671.
- Hits: 738
- Visitors: 868
- Downloads: 136
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Published version | 3 MB | Adobe Acrobat PDF | View Details Download |