Poor levels of agreement between serum and saliva testosterone measurement following exercise training in aging men
- Authors: Hayes, Lawrence , Sculthorpe, Nicholas , Herbert, Peter , Baker, Julien , Hullin, David , Kilduff, Liam , Grace, Fergal
- Date: 2015
- Type: Text , Journal article
- Relation: Aging Male Vol. 18, no. 2 (2015), p. 67-70
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- Description: Testosterone (T) is a biologically important androgen that demonstrates a widely-known natural decline with advancing age. The use of salivary T (sal-T), as a determinant of systemic T, has shown promising results in recent years. However, the strength of the salivary-serum T relationship may be affected by measurement method and binding capacity with salivary proteins. The potential influence exercise may impact on this relationship is unstudied in aging men. Therefore, the aim of the present investigation was to examine the relationship of the delta change (Delta) in sal-T with Deltaserum T following six weeks exercise training. Fifteen sedentary (SED) males (aged 60.4 +/- 5.0 years of age) and 20 lifelong exercising (LE) males (60.4 +/- 4.7 years of age) were participated. Pearson's correlation coefficient revealed sal-T did not correlate with total testosterone (TT), sex hormone binding globulin (SHBG), bioactive T (bio-T), or free T (free-T) at week 0 or week 6. Deltasal-T did not correlate with DeltaTT, DeltaSHBG, Deltabio-T or Deltafree-T (r = 0.271, p = 0.180; r = 0.197, p = 0.335; r = 0.258, p = 0.205; and r = 0.257, p = 0.205, respectively). In conclusion, poor levels of agreement existed between saliva and serum measurements of T in response to exercise amongst aging men.
Resting steroid hormone concentrations in lifetime exercisers and lifetime sedentary males
- Authors: Hayes, Lawrence , Sculthorpe, Nicholas , Herbert, Peter , Baker, Julien , Hullin, David , Kilduff, Liam , Grace, Fergal
- Date: 2015
- Type: Text , Journal article
- Relation: Aging Male Vol. 18, no. 1 (2015), p. 22-26
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- Description: INTRODUCTION: Advancing age in men is associated with a progressive decline in serum testosterone (T) and interactions between exercise, aging and androgen status are poorly understood. The primary aim of this study was to establish the influence of lifelong training history on serum T, cortisol (C) and sex hormone binding globulin (SHBG) in aging men. A secondary aim was to determine the agreement between serum and salivary measurement of steroid hormones in ageing men. METHODS: Serum and salivary steroid hormones (serum C, T and SHBG, and salivary measures of C and T) were determined and compared between two distinct groups; lifelong exercising males (LE [n = 20], 60.4 +/- 4.7 year) and age matched lifelong sedentary individuals (SED [n = 28], 62.5 +/- 5.3 years). RESULTS: T-test revealed a lack of significant differences for serum C or SHBG between LE and SED, while Mann-Whitney U revealed a lack of differences in total T (TT), bioavailable T (bio-T) or free testosterone (free-T). Further, salivary T (sal-T) did not correlate with serum markers of T in LE, SED, or when pooled (r = 0.040; p > 0.05). CONCLUSIONS: Findings from this investigation suggested that resting levels of serum T and calculated free-T was unable to distinguish between diverse lifelong training histories in aging men. Further, sal-T was not an appropriate indicator of serum T and calculated free-T values in older males and considerable caution should be exercised when interpreting sal-T measurements in aging males.
Does chronic exercise attenuate age-related physiological decline in males?
- Authors: Hayes, Lawrence , Grace, Fergal , Sculthorpe, Nicholas , Herbert, Peter , Kilduff, Liam , Baker, Julien
- Date: 2013
- Type: Text , Journal article
- Relation: Research in Sports Medicine Vol. 21, no. 4 (2013), p. 343-354
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- Description: Alteration in body composition, physical function, and substrate metabolism occur with advancing age. These changes can be attenuated by exercise. This study evaluated whether master athletes (MA [n = 20]) would have improved exercise capabilities, anthropometry, and hormone profiles when compared with age-matched sedentary counterparts (S [n = 28]). The MA group was predominantly aerobically trained with some resistance exercise incorporated in their routine. The VO(2max), peak power output, and salivary testosterone was significantly higher (p < 0.05) in the MA group, while diastolic blood pressure, systolic blood pressure, and body fat percentage were lower (p < 0.05). Cortisol, fat free mass, (FFM) and total body mass were not significantly different between groups. Salivary testosterone correlated positively with VO(2max) (r(2) = .320), suggesting that increased aerobic capacity is linked with higher concentrations of testosterone. These results suggest that life-long exercise is associated with favorable body composition and attenuation of the age related decline in testosterone.
The effects of a formal exercise training programme on salivary hormone concentrations and body composition in previously sedentary aging men
- Authors: Hayes, Lawrence , Grace, Fergal , Sculthorpe, Nicholas , Herbert, Peter , Ratcliffe, John , Kilduff, Liam , Baker, Julien
- Date: 2013
- Type: Text , Journal article
- Relation: SpringerPlus Vol. 2, no. 18 (2013), p. 1-5
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- Description: Alteration in body composition, physical function, and substrate metabolism occur with advancing age. These changes may be attenuated by exercise. This study examined whether twenty eight, previously sedentary males (62.5 +/- 5.3 years of age; body mass of 89.7 +/- 16.4 kg) adhering to the ACSM minimum guidelines for aerobic exercise for six weeks would improve exercise capabilities, body composition and salivary hormone profiles. After six weeks of adhering to the guidelines, salivary testosterone and vo(2max) (absolute and relative) increased (p < 0.05), whilst body fat percentage and body mass decreased (p < 0.05). Peak power output, fat free mass and cortisol values were not significantly different. Interestingly, salivary testosterone correlated inversely with body fat percentage (R(2) = .285, p = 0.011). These results suggest that despite previous inactivity, older males can achieve improvements in cardiorespiratory fitness, body composition and anabolism by adhering to simple lifestyle changes.