- Authors: Zhao, Lei , You, Greg
- Date: 2018
- Type: Text , Book chapter
- Relation: Engineering Geology and Geological Engineering for Sustainable Use of the Earth's Resources, Urbanization and Infrastructure Protection from Geohazards, Proceedings of the 1st GeoMEast International Congress and Exhibition, Egypt 2017 on Sustainable Civil Infrastructures (Part of the Sustainable Civil Infrastuctures book series) 8 p. 115-129
- Full Text: false
- Reviewed:
- Description: Cracks manifested on the north batter at Maddingley Brown Coal Open Pit Mine, Victoria, Australia in November 2013. The crack opened varies from trace to approximately 150 mm wide was located at about 20 m back from the coal face and extended for approximately 50 m on the eastern side and terminated 10 m away from the access road. Site investigations and remedy measures were implemented immediately after the cracking. This study involves in a three dimensional modeling on the cracking mechanism using finite element method (FEM) encoded in Plaxis 3D software program. From the study, it was found that the initial model based on north batter being stable for many decades tended to lead a circular critical path while the model after overburden removal showed a trend of block sliding. The safety factor of initial north batter was 1.38 through safety analysis while it was decreased to 1.17 for the coal batter after overburden removal. But the simulated shear and tensile strains indicated that the coal batter after overburden removal in fact experienced block failure. Furthermore, the simulated location of cracking was in good agreement with the actual location, and the simulated heave of the coal seam was in good agreement with the experience in Victoria brown coal open pit mining The observed vertical crack would be a combined action of the overburden removal and the groundwater flow in the unconfined aquifer.
Stability study on the northern batter of MBC Open Pit using Plaxis 3D
- Authors: Zhao, Lei , You, Greg
- Date: 2018
- Type: Text , Journal article
- Relation: Arabian Journal of Geosciences Vol. 11, no. 6 (2018), p. 1-11
- Full Text:
- Reviewed:
- Description: Cracks appeared on the northern batter at Maddingley Brown Coal Open Pit Mine, Victoria, Australia, on 8 November 2013 and a 2-day rainfall event happened 5 days later. This study models the stability of the northern batter considering the effect of the rainfall event and an emergency buttress using finite element method (FEM) encoded in Plaxis 3D. It is found that the batter tended to lead to block sliding after overburden removal. The observed vertical crack would be a combined action of the overburden removal and groundwater flow. The simulated location of cracks agrees well with the actual location, and the simulated heave of the coal seam is in good agreement with the experience in Victoria brown coal open pit mining. The rainfall accelerated the development of the cracks. With the construction of the emergency buttress, the batter became stable that is in good agreement with the monitored data.
- Authors: Zhao, Lei , You, Greg
- Date: 2018
- Type: Text , Journal article
- Relation: Arabian Journal of Geosciences Vol. 11, no. 6 (2018), p. 1-11
- Full Text:
- Reviewed:
- Description: Cracks appeared on the northern batter at Maddingley Brown Coal Open Pit Mine, Victoria, Australia, on 8 November 2013 and a 2-day rainfall event happened 5 days later. This study models the stability of the northern batter considering the effect of the rainfall event and an emergency buttress using finite element method (FEM) encoded in Plaxis 3D. It is found that the batter tended to lead to block sliding after overburden removal. The observed vertical crack would be a combined action of the overburden removal and groundwater flow. The simulated location of cracks agrees well with the actual location, and the simulated heave of the coal seam is in good agreement with the experience in Victoria brown coal open pit mining. The rainfall accelerated the development of the cracks. With the construction of the emergency buttress, the batter became stable that is in good agreement with the monitored data.
A new loss function for robust classification
- Zhao, Lei, Mammadov, Musa, Yearwood, John
- Authors: Zhao, Lei , Mammadov, Musa , Yearwood, John
- Date: 2014
- Type: Text , Journal article
- Relation: Intelligent Data Analysis Vol. 18, no. 4 (2014), p. 697-715
- Full Text: false
- Reviewed:
- Description: Loss function plays an important role in data classification. Manyloss functions have been proposed and applied to differentclassification problems. This paper proposes a new so called thesmoothed 0-1 loss function, that could be considered as anapproximation of the classical 0-1 loss function. Due to thenon-convexity property of the proposed loss function, globaloptimization methods are required to solve the correspondingoptimization problems. Together with the proposed loss function, wecompare the performance of several existing loss functions in theclassification of noisy data sets. In this comparison, differentoptimization problems are considered in regards to the convexity andsmoothness of different loss functions. The experimental resultsshow that the proposed smoothed 0-1 loss function works better ondata sets with noisy labels, noisy features, and outliers. © 2014 - IOS Press and the authors. All rights reserved.
Three-dimensional numerical study on the batter instability mechanism of Maddingley Brown Coal Open Pit, Victoria, Australia using PLAXIS 3D
- Authors: Zhao, Lei
- Date: 2019
- Type: Text , Thesis , PhD
- Full Text:
- Description: With the increased size of excavation due to long-term open cut mining, batter instability has become a major geo-hazard in Victorian Brown Coal Open Pits where facilitate some largest brown coal mining operations in the world. Block failure is a unique failure mode in Victorian brown coal mines, which is often associated with cracks and rainfall. Maddingley Brown Coal Mine (MBC) is located in Bacchus Marsh, Victoria, Australia. Slope instability has also been a major geo-problem since the open pit mining commenced in MBC in 1940s. Making clear the cracking mechanism and the correlations between rainfall and batter instability have important implications in better understanding and predicting batter failures in Victorian brown coal mines. In this research, three-dimensional geologic models were developed to investigate the mechanism of brown coal batter instability. The finite element program encoded in Plaxis 3D was employed to conduct the complex two-phase (fluid-solid) coupled numerical simulations. The results revealed the cracking mechanism of coal batter and the effects of rainfall on batter stability. It was found that the brown coal batter with overburden tends to lead a circular critical path while the batter after overburden removal shows a trend of block sliding as interpreted by the shear and tensile strains simulated. The existence of joints and the hydrostatic water pressure in the joints could adversely affect the stability of brown coal batter towards block failure. Precipitation can increase the deformation, excess pore pressure, total pore pressure, active pressure and decrease the matric suction, and thereby decrease the shear strength, effective stress, and batter stability. The results from the three-dimensional hydro-mechanically coupled finite element study were well agreed with the field monitored data, theoretical calculations, and Victorian brown coal mining experience.
- Description: Doctor of Philosophy
- Authors: Zhao, Lei
- Date: 2019
- Type: Text , Thesis , PhD
- Full Text:
- Description: With the increased size of excavation due to long-term open cut mining, batter instability has become a major geo-hazard in Victorian Brown Coal Open Pits where facilitate some largest brown coal mining operations in the world. Block failure is a unique failure mode in Victorian brown coal mines, which is often associated with cracks and rainfall. Maddingley Brown Coal Mine (MBC) is located in Bacchus Marsh, Victoria, Australia. Slope instability has also been a major geo-problem since the open pit mining commenced in MBC in 1940s. Making clear the cracking mechanism and the correlations between rainfall and batter instability have important implications in better understanding and predicting batter failures in Victorian brown coal mines. In this research, three-dimensional geologic models were developed to investigate the mechanism of brown coal batter instability. The finite element program encoded in Plaxis 3D was employed to conduct the complex two-phase (fluid-solid) coupled numerical simulations. The results revealed the cracking mechanism of coal batter and the effects of rainfall on batter stability. It was found that the brown coal batter with overburden tends to lead a circular critical path while the batter after overburden removal shows a trend of block sliding as interpreted by the shear and tensile strains simulated. The existence of joints and the hydrostatic water pressure in the joints could adversely affect the stability of brown coal batter towards block failure. Precipitation can increase the deformation, excess pore pressure, total pore pressure, active pressure and decrease the matric suction, and thereby decrease the shear strength, effective stress, and batter stability. The results from the three-dimensional hydro-mechanically coupled finite element study were well agreed with the field monitored data, theoretical calculations, and Victorian brown coal mining experience.
- Description: Doctor of Philosophy
Rainfall-induced deformation behavior of cracks on brown coal open pit batter in Australia
- Authors: Zhao, Lei , You, Greg
- Date: 2019
- Type: Text , Conference paper
- Relation: 9th International Conference on Geotechnique, Construction Materials and Environment, 20-22 November 2019, Tokyo Japan p. 458-463
- Full Text: false
- Reviewed:
- Description: After a 26mm rainfall in 24 hours, noticeable ground movements were observed on the north batter at Maddingley Brown Coal Open Pit Mine, Victoria, Australia in February 2014. The batter is brown coal sandwiched by confining beds. Cracks manifested on the north batter months before the rainfall event, and then an emergency buttress was immediately constructed to maintain the batter stability. A three-dimensional geologic model is developed to study the rainfall-induced ground movement in this paper. The finite element program encoded in Plaxis 3D is employed to conduct the complex two-phase (fluid-solid) coupled numerical simulation. It is found that the simulated deformation is well agreed with the observed data from field survey markers. There are ground movements along the length of cracks on both sides with larger movement towards the pit bottom. These movements are the results of the combined reactions of surface run-off and sudden increased underground water level. The 26mm rainfall event did not cause instability of the batter.
Study on the stability of brown coal batter with opened cracks on Maddingley brown coal mine
- Authors: Zhao, Lei , You, Greg
- Date: 2020
- Type: Text , Journal article
- Relation: Sn Applied Sciences Vol. 2, no. 6 (Jun 2020), p. 14
- Full Text:
- Reviewed:
- Description: After a 26-mm precipitation in February 2014, noticeable ground movements were recorded on the north batter of Maddingley brown coal open pit, Victoria. To investigate the rainfall effect on the stability of the brown coal batter with opened cracks, a three-dimensional geologic model was developed, and the finite element program encoded in Plaxis 3D was employed to conduct a complex two-phase (fluid-solid) coupled numerical simulation. It was found that the simulated deformations were well agreed with the field survey data. There were ground movements along the length of cracks on both sides of the crack with larger movement towards the pit bottom. The coupled effect of hydrostatic forces from the crack in the rear of the batter and from the clay layer underlain the batter caused the block to slide, or batter failure. From the results, it revealed that both short-term high rainfall intensity precipitation and long enduring low rainfall intensity precipitation could cause the brown coal batter with opened cracks instable.
- Description: Australian Research Training Program (RTP) Scholarship Federation University Australia George Collins Memorial Scholarship.
- Authors: Zhao, Lei , You, Greg
- Date: 2020
- Type: Text , Journal article
- Relation: Sn Applied Sciences Vol. 2, no. 6 (Jun 2020), p. 14
- Full Text:
- Reviewed:
- Description: After a 26-mm precipitation in February 2014, noticeable ground movements were recorded on the north batter of Maddingley brown coal open pit, Victoria. To investigate the rainfall effect on the stability of the brown coal batter with opened cracks, a three-dimensional geologic model was developed, and the finite element program encoded in Plaxis 3D was employed to conduct a complex two-phase (fluid-solid) coupled numerical simulation. It was found that the simulated deformations were well agreed with the field survey data. There were ground movements along the length of cracks on both sides of the crack with larger movement towards the pit bottom. The coupled effect of hydrostatic forces from the crack in the rear of the batter and from the clay layer underlain the batter caused the block to slide, or batter failure. From the results, it revealed that both short-term high rainfall intensity precipitation and long enduring low rainfall intensity precipitation could cause the brown coal batter with opened cracks instable.
- Description: Australian Research Training Program (RTP) Scholarship Federation University Australia George Collins Memorial Scholarship.
Rainfall affected stability analysis of Maddingley brown coal eastern batter using plaxis 3D
- Authors: Zhao, Lei , You, Greg
- Date: 2020
- Type: Text , Journal article
- Relation: Arabian Journal of Geosciences Vol. 13, no. 20 (2020), p.
- Full Text:
- Reviewed:
- Description: Rainfall is a common factor that triggers the instability of Victorian Brown Coal (VBC) open pits which facilitate some of the largest brown coal mining operations. There has been no relevant study on rainfall-induced slope instability of VBC open pits in literature. In this paper, a three-dimensional (3D) two-phase (fluid-solid) coupled finite element method (FEM) was employed to investigate the stability of Maddingley Brown Coal (MBC) eastern batter under different rainfall conditions. It was found that the batter tends to lead a circular failure path during large rainfall. With the increase in either precipitation period or rainfall intensity, the deformation, excess pore pressure and active pressure increased, while the matric suction decreased. The hydrostatic force in the confined aquifer underlying the brown coal seam increased during rainfall; meanwhile, the resisting force decreased. As a result, the shear strength decreased and thereby the stability of the batter decreased. The safety factor and the critical failure path of the eastern batter simulated in this study were consistent with the previous study on the Northern batter. This study is a strong supplement to the literature on rainfall-induced instability of VBC batters. In the meantime, it is significant to provide a reference to the application of sophisticated 3D numerical modelling for studying slope instability of brown coal and similar mineral deposits. © 2020, Saudi Society for Geosciences.
- Description: The study is supported by the Australian Research Training Program (RTP) Scholarship and Federation University Australia George Collins Memorial Scholarship
- Authors: Zhao, Lei , You, Greg
- Date: 2020
- Type: Text , Journal article
- Relation: Arabian Journal of Geosciences Vol. 13, no. 20 (2020), p.
- Full Text:
- Reviewed:
- Description: Rainfall is a common factor that triggers the instability of Victorian Brown Coal (VBC) open pits which facilitate some of the largest brown coal mining operations. There has been no relevant study on rainfall-induced slope instability of VBC open pits in literature. In this paper, a three-dimensional (3D) two-phase (fluid-solid) coupled finite element method (FEM) was employed to investigate the stability of Maddingley Brown Coal (MBC) eastern batter under different rainfall conditions. It was found that the batter tends to lead a circular failure path during large rainfall. With the increase in either precipitation period or rainfall intensity, the deformation, excess pore pressure and active pressure increased, while the matric suction decreased. The hydrostatic force in the confined aquifer underlying the brown coal seam increased during rainfall; meanwhile, the resisting force decreased. As a result, the shear strength decreased and thereby the stability of the batter decreased. The safety factor and the critical failure path of the eastern batter simulated in this study were consistent with the previous study on the Northern batter. This study is a strong supplement to the literature on rainfall-induced instability of VBC batters. In the meantime, it is significant to provide a reference to the application of sophisticated 3D numerical modelling for studying slope instability of brown coal and similar mineral deposits. © 2020, Saudi Society for Geosciences.
- Description: The study is supported by the Australian Research Training Program (RTP) Scholarship and Federation University Australia George Collins Memorial Scholarship
Deep learning for combo object detection
- Zhao, Jing, Ardekani, Iman Tabatabaei, Pang, Shaoning
- Authors: Zhao, Jing , Ardekani, Iman Tabatabaei , Pang, Shaoning
- Date: 2019
- Type: Text , Book chapter
- Relation: Chapter 11 p. 125-137
- Full Text: false
- Reviewed:
- Description: Convolutional neural networks (CNNs) have become the most vigorous technique for a variety of different tasks in computer vision, due to their proficiency in automatically learning high-level visual representations for images. In this paper, we investigate the effect of deep neural networks on the accuracy in combo object detection setting. The insufficiency of labeled data, coupled with the uncertainty of spacial distribution and dynamic changes in luminance, creates situations where combo object detection is far more challenging. Using transfer learning, we present a system for combo object detection based on a deep CNN called ComboNN. The proposed ComboNN is pre-trained on a huge auxiliary dataset ImageNet and fine-tuned on our small dataset. The use of data augmentation and regularization technique significantly reduces overfitting and improves the robustness of the ComboNN. Experimental results demonstrate that our system is capable of making reliable prediction on combo object detection in the real-world images, and achieves much better accuracy than the state-of-the-art CNNs.
Identifying complementary and alternative medicine recommendations for insomnia treatment and care : a systematic review and critical assessment of comprehensive clinical practice guidelines
- Zhao, Fei-Yi. Y., Xu, Peijie, Kennedy, Gerard, Conduit, Russell, Zhang, Wen-Jing, Wang, Yan-Mei, Fu, Qiang-Qiang, Zheng, Zhen
- Authors: Zhao, Fei-Yi. Y. , Xu, Peijie , Kennedy, Gerard , Conduit, Russell , Zhang, Wen-Jing , Wang, Yan-Mei , Fu, Qiang-Qiang , Zheng, Zhen
- Date: 2023
- Type: Text , Journal article , Review
- Relation: Frontiers in Public Health Vol. 11, no. (2023), p.
- Full Text:
- Reviewed:
- Description: Background: There is a need for evidence-informed guidance on the use of complementary and alternative medicine (CAM) for insomnia because of its widespread utilization and a lack of guidance on the balance of benefits and harms. This systematic review aimed to identify and summarize the CAM recommendations associated with insomnia treatment and care from existing comprehensive clinical practice guidelines (CPGs). The quality of the eligible guidelines was appraised to assess the credibility of these recommendations. Methods: Formally published CPGs incorporating CAM recommendations for insomnia management were searched for in seven databases from their inception to January 2023. The NCCIH website and six websites of international guideline developing institutions were also retrieved. The methodological and reporting quality of each included guideline was appraised using the AGREE II instrument and RIGHT statement, respectively. Results: Seventeen eligible GCPs were included, and 14 were judged to be of moderate to high methodological and reporting quality. The reporting rate of eligible CPGs ranged from 42.9 to 97.1%. Twenty-two CAM modalities were implicated, involving nutritional or natural products, physical CAM, psychological CAM, homeopathy, aromatherapy, and mindful movements. Recommendations for these modalities were mostly unclear, unambiguous, uncertain, or conflicting. Logically explained graded recommendations supporting the CAM use in the treatment and/or care of insomnia were scarce, with bibliotherapy, Tai Chi, Yoga, and auriculotherapy positively recommended based on little and weak evidence. The only consensus was that four phytotherapeutics including valerian, chamomile, kava, and aromatherapy were not recommended for insomnia management because of risk profile and/or limited benefits. Conclusions: Existing guidelines are generally limited in providing clear, evidence-informed recommendations for the use of CAM therapies for insomnia management due to a lack of high-quality evidence and multidisciplinary consultation in CPG development. More well-designed studies to provide reliable clinical evidence are therefore urgently needed. Allowing the engagement of a range of interdisciplinary stakeholders in future updates of CPGs is also warranted. Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=369155, identifier: CRD42022369155. Copyright © 2023 Zhao, Xu, Kennedy, Conduit, Zhang, Wang, Fu and Zheng.
- Authors: Zhao, Fei-Yi. Y. , Xu, Peijie , Kennedy, Gerard , Conduit, Russell , Zhang, Wen-Jing , Wang, Yan-Mei , Fu, Qiang-Qiang , Zheng, Zhen
- Date: 2023
- Type: Text , Journal article , Review
- Relation: Frontiers in Public Health Vol. 11, no. (2023), p.
- Full Text:
- Reviewed:
- Description: Background: There is a need for evidence-informed guidance on the use of complementary and alternative medicine (CAM) for insomnia because of its widespread utilization and a lack of guidance on the balance of benefits and harms. This systematic review aimed to identify and summarize the CAM recommendations associated with insomnia treatment and care from existing comprehensive clinical practice guidelines (CPGs). The quality of the eligible guidelines was appraised to assess the credibility of these recommendations. Methods: Formally published CPGs incorporating CAM recommendations for insomnia management were searched for in seven databases from their inception to January 2023. The NCCIH website and six websites of international guideline developing institutions were also retrieved. The methodological and reporting quality of each included guideline was appraised using the AGREE II instrument and RIGHT statement, respectively. Results: Seventeen eligible GCPs were included, and 14 were judged to be of moderate to high methodological and reporting quality. The reporting rate of eligible CPGs ranged from 42.9 to 97.1%. Twenty-two CAM modalities were implicated, involving nutritional or natural products, physical CAM, psychological CAM, homeopathy, aromatherapy, and mindful movements. Recommendations for these modalities were mostly unclear, unambiguous, uncertain, or conflicting. Logically explained graded recommendations supporting the CAM use in the treatment and/or care of insomnia were scarce, with bibliotherapy, Tai Chi, Yoga, and auriculotherapy positively recommended based on little and weak evidence. The only consensus was that four phytotherapeutics including valerian, chamomile, kava, and aromatherapy were not recommended for insomnia management because of risk profile and/or limited benefits. Conclusions: Existing guidelines are generally limited in providing clear, evidence-informed recommendations for the use of CAM therapies for insomnia management due to a lack of high-quality evidence and multidisciplinary consultation in CPG development. More well-designed studies to provide reliable clinical evidence are therefore urgently needed. Allowing the engagement of a range of interdisciplinary stakeholders in future updates of CPGs is also warranted. Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=369155, identifier: CRD42022369155. Copyright © 2023 Zhao, Xu, Kennedy, Conduit, Zhang, Wang, Fu and Zheng.
The role of acupuncture in treating perimenopausal insomnia : an overview and quality assessment of systematic reviews and meta-analyses
- Zhao, Fei-Yi, Zhang, Wen-Jing, Kennedy, Gerard, Conduit, Russell, Zheng, Zhen, Fu, Qiang-Qiang
- Authors: Zhao, Fei-Yi , Zhang, Wen-Jing , Kennedy, Gerard , Conduit, Russell , Zheng, Zhen , Fu, Qiang-Qiang
- Date: 2021
- Type: Text , Journal article
- Relation: Neuropsychiatric Disease and Treatment Vol. 17, no. (2021), p. 3325-3343
- Full Text:
- Reviewed:
- Description: Objective: To summarize and critically assess the reliability of the methodological quality and outcome measures from systematic reviews (SRs)/meta-analyses (MAs) and provide an overall verdict about the therapeutic value of acupuncture for perimenopausal insomnia (PMI). Methods: We conducted a comprehensive literature search for SRs/MAs of seven major data-bases (English and Chinese). For each included review, the methodological quality was appraised according to the Assessing the Methodological Quality of Systematic Reviews 2 (AMSTAR-2), the evidence quality was classified on the basis of the Grading of Recommendations, Assessment, Development and Evaluation (GRADE), and reporting quality was evaluated complying with Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2009 (PRISMA-2009). Veritas plots were used to quantify the quality of included SRs/MAs. Results: Nine SRs/MAs were deemed eligible for the present overview. Considering the assessment of results from the AMSTAR-2 checklist, the methodological quality of one SR/ MA was considered low, and the remaining eight were critically low. Major methodological deficiencies were concentrated on item 2 (the lack of protocol and/or registration informa-tion), item 7 (the lack of a list of excluded studies), and item 10 (the lack of reports on funding sources for individual studies included in the SRs/MAs). For the GRADE system, of the 25 outcomes, only three (12%) were rated as moderate-quality, while the remaining 22 were rated between low-and very low-quality. The PRISMA-2009 statement indicated three major reporting quality limitations in most SRs/MAs, namely: 1) only search terms without specific retrieval strategy; 2) incomplete descriptions for study characteristics, particularly the specific dosage and frequency of interventions in treatment/control groups; and 3) inadequate investigation and explanation of the source of high heterogeneity among original randomized control trials included. According to Veritas plots, quality rank scores of included SRs/MAs ranged from 3.3 to 8.3, with an average score of 6.4 ± 1.7. Conclusion: Acupuncture appears to be beneficial for PMI management, but the quality of evidence is weakened by the unsatisfactory quality of both SRs/MAs and original trials included. © 2021 Zhao et al.
- Authors: Zhao, Fei-Yi , Zhang, Wen-Jing , Kennedy, Gerard , Conduit, Russell , Zheng, Zhen , Fu, Qiang-Qiang
- Date: 2021
- Type: Text , Journal article
- Relation: Neuropsychiatric Disease and Treatment Vol. 17, no. (2021), p. 3325-3343
- Full Text:
- Reviewed:
- Description: Objective: To summarize and critically assess the reliability of the methodological quality and outcome measures from systematic reviews (SRs)/meta-analyses (MAs) and provide an overall verdict about the therapeutic value of acupuncture for perimenopausal insomnia (PMI). Methods: We conducted a comprehensive literature search for SRs/MAs of seven major data-bases (English and Chinese). For each included review, the methodological quality was appraised according to the Assessing the Methodological Quality of Systematic Reviews 2 (AMSTAR-2), the evidence quality was classified on the basis of the Grading of Recommendations, Assessment, Development and Evaluation (GRADE), and reporting quality was evaluated complying with Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2009 (PRISMA-2009). Veritas plots were used to quantify the quality of included SRs/MAs. Results: Nine SRs/MAs were deemed eligible for the present overview. Considering the assessment of results from the AMSTAR-2 checklist, the methodological quality of one SR/ MA was considered low, and the remaining eight were critically low. Major methodological deficiencies were concentrated on item 2 (the lack of protocol and/or registration informa-tion), item 7 (the lack of a list of excluded studies), and item 10 (the lack of reports on funding sources for individual studies included in the SRs/MAs). For the GRADE system, of the 25 outcomes, only three (12%) were rated as moderate-quality, while the remaining 22 were rated between low-and very low-quality. The PRISMA-2009 statement indicated three major reporting quality limitations in most SRs/MAs, namely: 1) only search terms without specific retrieval strategy; 2) incomplete descriptions for study characteristics, particularly the specific dosage and frequency of interventions in treatment/control groups; and 3) inadequate investigation and explanation of the source of high heterogeneity among original randomized control trials included. According to Veritas plots, quality rank scores of included SRs/MAs ranged from 3.3 to 8.3, with an average score of 6.4 ± 1.7. Conclusion: Acupuncture appears to be beneficial for PMI management, but the quality of evidence is weakened by the unsatisfactory quality of both SRs/MAs and original trials included. © 2021 Zhao et al.
The role of acupuncture in the management of insomnia as a major or residual symptom among patients with active or previous depression : a systematic review and meta-analysis
- Zhao, Fei-Yi, Kennedy, Gerard, Spencer, Sarah, Conduit, Russell, Zhang, Wen-Jing, Fu, Qiang-Qiang, Zheng, Zhen
- Authors: Zhao, Fei-Yi , Kennedy, Gerard , Spencer, Sarah , Conduit, Russell , Zhang, Wen-Jing , Fu, Qiang-Qiang , Zheng, Zhen
- Date: 2022
- Type: Text , Journal article , Review
- Relation: Frontiers in Psychiatry Vol. 13, no. (2022), p.
- Full Text:
- Reviewed:
- Description: Background: Due to concerns about risks associated with antidepressants and/or hypnotics, complementary therapies such as acupuncture have been sought by patients with active or previous depression to manage insomnia. This systematic review aimed to clarify if acupuncture is effective and safe enough to be recommended as an alternative or adjuvant therapy to standard care in ameliorating concomitant or residual insomnia, two types of insomnia associated with depression. Methods: Randomized controlled trials (RCTs) of depression-related insomnia (DI) treatment via acupuncture vs. waitlist-control or placebo-/sham-acupuncture and RCTs of DI treatment via acupuncture alone or combined with standard care [Western pharmacotherapy and/or cognitive-behavioral therapy (CBT)] vs. standard care alone were searched for from seven databases from inception to December 2021. Cochrane criteria were followed. Results: Twenty-one studies involving 1,571 participants were analyzed. For insomnia as a major symptom of active depression, meta-analyses suggested that acupuncture significantly reduced the global scores of both the Pittsburg Sleep Quality Index (PSQI) [MD = −3.12, 95% CI (−5.16, −1.08), p < 0.01] and Hamilton Depression Scale (HAMD) [SMD = −2.67, 95% CI (−3.51, −1.84), p < 0.01], in comparison with placebo-acupuncture. When compared with conventional pharmacotherapy (antidepressants and/or hypnotics), the results favored acupuncture in decreasing PSQI [MD = −1.17, 95% CI (−2.26, −0.08), p = 0.03] and HAMD [SMD = −0.47, 95% CI (−0.91, −0.02), p = 0.04]. Acupuncture was comparable to conventional pharmacotherapy in reducing scores of each domain of PSQI. For insomnia as a residual symptom of previous or partially remitted depression, acupuncture conferred a very limited, non-significant therapeutic advantage against sham-/placebo-acupuncture. Whether acupuncture has an add-on effect to conventional pharmacotherapy in this type of insomnia has not been investigated. Also, no study was available to address the efficacy differences between acupuncture and CBT or the synergistic effect of these two therapies. Conclusions: There is a low to moderate level of evidence supporting acupuncture as a safe and effective remedy alternative to or adjuvant to conventional pharmacotherapy (antidepressant and/or hypnotic) in improving insomnia and other depression symptoms among patients with active depression. Furthermore, the patients' complaint of disrupted sleep continuity is most likely to benefit from acupuncture. The benefit of acupuncture on residual insomnia associated with previous or partially remitted depression is limited. Future acupuncture studies need to consider applying optimal dosage and addressing deficiencies in trial quality. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021269880, PROSPERO, identifier: CRD42021269880. Copyright © 2022 Zhao, Kennedy, Spencer, Conduit, Zhang, Fu and Zheng.
- Authors: Zhao, Fei-Yi , Kennedy, Gerard , Spencer, Sarah , Conduit, Russell , Zhang, Wen-Jing , Fu, Qiang-Qiang , Zheng, Zhen
- Date: 2022
- Type: Text , Journal article , Review
- Relation: Frontiers in Psychiatry Vol. 13, no. (2022), p.
- Full Text:
- Reviewed:
- Description: Background: Due to concerns about risks associated with antidepressants and/or hypnotics, complementary therapies such as acupuncture have been sought by patients with active or previous depression to manage insomnia. This systematic review aimed to clarify if acupuncture is effective and safe enough to be recommended as an alternative or adjuvant therapy to standard care in ameliorating concomitant or residual insomnia, two types of insomnia associated with depression. Methods: Randomized controlled trials (RCTs) of depression-related insomnia (DI) treatment via acupuncture vs. waitlist-control or placebo-/sham-acupuncture and RCTs of DI treatment via acupuncture alone or combined with standard care [Western pharmacotherapy and/or cognitive-behavioral therapy (CBT)] vs. standard care alone were searched for from seven databases from inception to December 2021. Cochrane criteria were followed. Results: Twenty-one studies involving 1,571 participants were analyzed. For insomnia as a major symptom of active depression, meta-analyses suggested that acupuncture significantly reduced the global scores of both the Pittsburg Sleep Quality Index (PSQI) [MD = −3.12, 95% CI (−5.16, −1.08), p < 0.01] and Hamilton Depression Scale (HAMD) [SMD = −2.67, 95% CI (−3.51, −1.84), p < 0.01], in comparison with placebo-acupuncture. When compared with conventional pharmacotherapy (antidepressants and/or hypnotics), the results favored acupuncture in decreasing PSQI [MD = −1.17, 95% CI (−2.26, −0.08), p = 0.03] and HAMD [SMD = −0.47, 95% CI (−0.91, −0.02), p = 0.04]. Acupuncture was comparable to conventional pharmacotherapy in reducing scores of each domain of PSQI. For insomnia as a residual symptom of previous or partially remitted depression, acupuncture conferred a very limited, non-significant therapeutic advantage against sham-/placebo-acupuncture. Whether acupuncture has an add-on effect to conventional pharmacotherapy in this type of insomnia has not been investigated. Also, no study was available to address the efficacy differences between acupuncture and CBT or the synergistic effect of these two therapies. Conclusions: There is a low to moderate level of evidence supporting acupuncture as a safe and effective remedy alternative to or adjuvant to conventional pharmacotherapy (antidepressant and/or hypnotic) in improving insomnia and other depression symptoms among patients with active depression. Furthermore, the patients' complaint of disrupted sleep continuity is most likely to benefit from acupuncture. The benefit of acupuncture on residual insomnia associated with previous or partially remitted depression is limited. Future acupuncture studies need to consider applying optimal dosage and addressing deficiencies in trial quality. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021269880, PROSPERO, identifier: CRD42021269880. Copyright © 2022 Zhao, Kennedy, Spencer, Conduit, Zhang, Fu and Zheng.
Knowledge about, attitude toward, and practice of complementary and alternative medicine among nursing students : a systematic review of cross-sectional studies
- Zhao, Fei-Yi, Kennedy, Gerard, Cleary, Sonja, Conduit, Russell, Zhang, Wen-Jing, Fu, Qiang-Qiang, Zheng, Zhen
- Authors: Zhao, Fei-Yi , Kennedy, Gerard , Cleary, Sonja , Conduit, Russell , Zhang, Wen-Jing , Fu, Qiang-Qiang , Zheng, Zhen
- Date: 2022
- Type: Text , Journal article , Review
- Relation: Frontiers in Public Health Vol. 10, no. (2022), p.
- Full Text:
- Reviewed:
- Description: Background: The globally growing demand for complementary and alternative medicine (CAM) has attracted educators' attention to integrate CAM into conventional nursing programs. This systematic review aimed to understand the status quo of nursing students (NSs)' overall rated knowledge of, attitude/belief toward, and practice/previous use or experience (KAP) of CAM in surveys, given these factors may influence NSs' receptivity to CAM curricula, and may be of value in guiding the development of effective teaching strategies. Methods: Formally published cross-sectional quantitative studies investigating the primary outcome of KAP toward CAM by NSs were searched for from eight databases from their inception through to 28 April 2022. PRISMA 2020 guidelines were followed. Results: Twenty-six studies were included for analysis, 25 of which were judged to be of moderate to high quality. Despite limited and poorly informed knowledge of CAM therapies, the majority of NSs generally viewed them in a positive light. Furthermore, NSs usually reported an interest in further learning, and supported and welcomed the integration of CAM curricula, at least as elective modules, into existing nursing programs. Lack of evidence was perceived as a major barrier to the use or integration of CAM. Mass media and the internet were the main sources via which NSs access CAM information. Measurement of KAP in all included studies was via self-designed questionnaires/scales or adapted from previously developed questionnaires/scales. Conclusions: The need for integrating and strengthening CAM curricula into current nursing education is identified. Besides theoretical knowledge and matched clinical placement, skills training in literature searching and evidence-based practice are advised to be included in the curricula design. The experiential learning mode is strongly recommended for delivering specific CAM modalities. In addition, a standard instrumentation for determining NSs' KAP toward CAM should be designed and examined for use in different cultural settings. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=300602, identifier: PROSPERO CRD42022300602. Copyright © 2022 Zhao, Kennedy, Cleary, Conduit, Zhang, Fu and Zheng.
- Authors: Zhao, Fei-Yi , Kennedy, Gerard , Cleary, Sonja , Conduit, Russell , Zhang, Wen-Jing , Fu, Qiang-Qiang , Zheng, Zhen
- Date: 2022
- Type: Text , Journal article , Review
- Relation: Frontiers in Public Health Vol. 10, no. (2022), p.
- Full Text:
- Reviewed:
- Description: Background: The globally growing demand for complementary and alternative medicine (CAM) has attracted educators' attention to integrate CAM into conventional nursing programs. This systematic review aimed to understand the status quo of nursing students (NSs)' overall rated knowledge of, attitude/belief toward, and practice/previous use or experience (KAP) of CAM in surveys, given these factors may influence NSs' receptivity to CAM curricula, and may be of value in guiding the development of effective teaching strategies. Methods: Formally published cross-sectional quantitative studies investigating the primary outcome of KAP toward CAM by NSs were searched for from eight databases from their inception through to 28 April 2022. PRISMA 2020 guidelines were followed. Results: Twenty-six studies were included for analysis, 25 of which were judged to be of moderate to high quality. Despite limited and poorly informed knowledge of CAM therapies, the majority of NSs generally viewed them in a positive light. Furthermore, NSs usually reported an interest in further learning, and supported and welcomed the integration of CAM curricula, at least as elective modules, into existing nursing programs. Lack of evidence was perceived as a major barrier to the use or integration of CAM. Mass media and the internet were the main sources via which NSs access CAM information. Measurement of KAP in all included studies was via self-designed questionnaires/scales or adapted from previously developed questionnaires/scales. Conclusions: The need for integrating and strengthening CAM curricula into current nursing education is identified. Besides theoretical knowledge and matched clinical placement, skills training in literature searching and evidence-based practice are advised to be included in the curricula design. The experiential learning mode is strongly recommended for delivering specific CAM modalities. In addition, a standard instrumentation for determining NSs' KAP toward CAM should be designed and examined for use in different cultural settings. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=300602, identifier: PROSPERO CRD42022300602. Copyright © 2022 Zhao, Kennedy, Cleary, Conduit, Zhang, Fu and Zheng.
Identifying complementary and alternative medicine recommendations for anxiety treatment and care : a systematic review and critical assessment of comprehensive clinical practice guidelines
- Zhao, Fei-Yi, Kennedy, Gerard, Xu, Peijie, Conduit, Russell, Wang, Yan-Mei, Zhang, Wen-Jing, Wang, Hui-Ru, Yue, Li-Ping, Huang, Yu-Ling, Wang, Yin, Xu, Yan, Fu, Qiang-Qiang, Zheng, Zhen
- Authors: Zhao, Fei-Yi , Kennedy, Gerard , Xu, Peijie , Conduit, Russell , Wang, Yan-Mei , Zhang, Wen-Jing , Wang, Hui-Ru , Yue, Li-Ping , Huang, Yu-Ling , Wang, Yin , Xu, Yan , Fu, Qiang-Qiang , Zheng, Zhen
- Date: 2023
- Type: Text , Journal article , Review
- Relation: Frontiers in Psychiatry Vol. 14, no. (2023), p.
- Full Text:
- Reviewed:
- Description: Background: Clinical practice guidelines (CPGs) are used to guide decision-making, especially regarding complementary and alternative medicine (CAM) therapies that are unfamiliar to orthodox healthcare providers. This systematic review aimed to critically review and summarise CAM recommendations associated with anxiety management included in the existing CPGs. Methods: Seven databases, websites of six international guidelines developing institutions, and the National Centre for Complementary and Integrative Health website were systematically searched. Their reporting and methodological quality were evaluated using the Reporting Items for practice Guidelines in Healthcare checklist and the Appraisal of Guidelines for Research and Evaluation (2nd version) instrument, respectively. Results: Ten CPGs were included, with reporting rates between 51.4 and 88.6%. Seven of these were of moderate to high methodological quality. Seventeen CAM modalities were implicated, involving phytotherapeutics, mind–body practice, art therapy, and homeopathy. Applied relaxation was included in 70% CPGs, which varied in degree of support for its use in the treatment of generalised anxiety disorder. There were few recommendations for other therapies/products. Light therapy was not recommended for use in generalised anxiety disorder, and St John’s wort and mindfulness were not recommended for use in social anxiety disorder in individual guidelines. Recommendations for the applicability of other therapies/products for treating a specific anxiety disorder were commonly graded as “unclear, unambiguous, or uncertain”. No CAM recommendations were provided for separation anxiety disorder, specific phobia or selective mutism. Conclusion: Available guidelines are limited in providing logically explained graded CAM recommendations for anxiety treatment and care. A lack of high-quality evidence and multidisciplinary consultation during the guideline development are two major reasons. High quality and reliable clinical evidence and the engagement of a range of interdisciplinary stakeholders are needed for future CPG development and updating. Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022373694, identifier CRD42022373694. Copyright © 2023 Zhao, Kennedy, Xu, Conduit, Wang, Zhang, Wang, Yue, Huang, Wang, Xu, Fu and Zheng.
- Authors: Zhao, Fei-Yi , Kennedy, Gerard , Xu, Peijie , Conduit, Russell , Wang, Yan-Mei , Zhang, Wen-Jing , Wang, Hui-Ru , Yue, Li-Ping , Huang, Yu-Ling , Wang, Yin , Xu, Yan , Fu, Qiang-Qiang , Zheng, Zhen
- Date: 2023
- Type: Text , Journal article , Review
- Relation: Frontiers in Psychiatry Vol. 14, no. (2023), p.
- Full Text:
- Reviewed:
- Description: Background: Clinical practice guidelines (CPGs) are used to guide decision-making, especially regarding complementary and alternative medicine (CAM) therapies that are unfamiliar to orthodox healthcare providers. This systematic review aimed to critically review and summarise CAM recommendations associated with anxiety management included in the existing CPGs. Methods: Seven databases, websites of six international guidelines developing institutions, and the National Centre for Complementary and Integrative Health website were systematically searched. Their reporting and methodological quality were evaluated using the Reporting Items for practice Guidelines in Healthcare checklist and the Appraisal of Guidelines for Research and Evaluation (2nd version) instrument, respectively. Results: Ten CPGs were included, with reporting rates between 51.4 and 88.6%. Seven of these were of moderate to high methodological quality. Seventeen CAM modalities were implicated, involving phytotherapeutics, mind–body practice, art therapy, and homeopathy. Applied relaxation was included in 70% CPGs, which varied in degree of support for its use in the treatment of generalised anxiety disorder. There were few recommendations for other therapies/products. Light therapy was not recommended for use in generalised anxiety disorder, and St John’s wort and mindfulness were not recommended for use in social anxiety disorder in individual guidelines. Recommendations for the applicability of other therapies/products for treating a specific anxiety disorder were commonly graded as “unclear, unambiguous, or uncertain”. No CAM recommendations were provided for separation anxiety disorder, specific phobia or selective mutism. Conclusion: Available guidelines are limited in providing logically explained graded CAM recommendations for anxiety treatment and care. A lack of high-quality evidence and multidisciplinary consultation during the guideline development are two major reasons. High quality and reliable clinical evidence and the engagement of a range of interdisciplinary stakeholders are needed for future CPG development and updating. Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022373694, identifier CRD42022373694. Copyright © 2023 Zhao, Kennedy, Xu, Conduit, Wang, Zhang, Wang, Yue, Huang, Wang, Xu, Fu and Zheng.
Managing depression with complementary and alternative medicine therapies: a scientometric analysis and visualization of research activities
- Zhao, Fei-Yi, Xu, Peijie, Zheng, Zhen, Conduit, Russell, Xu, Yan, Yue, Li-Ping, Wang, Hui-Ru, Wang, Yan-Mei, Li, Yuan-Xin, Li, Chun-Yan, Zhang, Wen-Jing, Fu, Qiang-Qiang, Kennedy, Gerard
- Authors: Zhao, Fei-Yi , Xu, Peijie , Zheng, Zhen , Conduit, Russell , Xu, Yan , Yue, Li-Ping , Wang, Hui-Ru , Wang, Yan-Mei , Li, Yuan-Xin , Li, Chun-Yan , Zhang, Wen-Jing , Fu, Qiang-Qiang , Kennedy, Gerard
- Date: 2023
- Type: Text , Journal article
- Relation: Frontiers in Psychiatry Vol. 14, no. (2023), p.
- Full Text:
- Reviewed:
- Description: Background: Complementary and Alternative Medicine (CAM) interventions may prove to be an attractive option for the treatment of depression. The aim of this scientometric analysis is to determine the global scientific output of research regarding managing depression with CAM and identify the hotspots and frontiers within this theme. Methods: Publications regarding the utilization of CAM for treating depression were collected from the Web of Science Core Collection from 1993 to 2022, and analyzed and visualized by Bibliometrix R-package, VOSviewer, and CiteSpace. Results: A total of 1,710 publications were acquired. The number of annual publications showed an overall rapid upward trend, with the figure peaking at 179 in 2021. The USA was the leading research center. Totally 2,323 distinct institutions involving 7,638 scholars contributed to the research theme. However, most of the cooperation was limited to within the same country, institution or research team. The Journal of Alternative and Complementary Medicine was the most productive periodical. The CAM therapies of most interest to researchers were acupuncture and body–mind techniques, such as yoga, meditation and mindfulness. Systematic review and meta-analysis are commonly used methods. “Inflammation,” “rating scale” and “psychological stress” were identified as the most studied trend topics recently. Conclusion: Managing depression with evidence-based CAM treatment is gaining attention globally. Body–mind techniques and acupuncture are growing research hotspots or emerging trending topics. Future studies are predicted to potentially investigate the possible mechanisms of action underlying CAM treatments in reducing depression in terms of modulation of psychological stress and inflammation levels. Cross-countries/institutes/team research collaborations should be encouraged and further enhanced. Copyright © 2023 Zhao, Xu, Zheng, Conduit, Xu, Yue, Wang, Wang, Li, Li, Zhang, Fu and Kennedy.
- Authors: Zhao, Fei-Yi , Xu, Peijie , Zheng, Zhen , Conduit, Russell , Xu, Yan , Yue, Li-Ping , Wang, Hui-Ru , Wang, Yan-Mei , Li, Yuan-Xin , Li, Chun-Yan , Zhang, Wen-Jing , Fu, Qiang-Qiang , Kennedy, Gerard
- Date: 2023
- Type: Text , Journal article
- Relation: Frontiers in Psychiatry Vol. 14, no. (2023), p.
- Full Text:
- Reviewed:
- Description: Background: Complementary and Alternative Medicine (CAM) interventions may prove to be an attractive option for the treatment of depression. The aim of this scientometric analysis is to determine the global scientific output of research regarding managing depression with CAM and identify the hotspots and frontiers within this theme. Methods: Publications regarding the utilization of CAM for treating depression were collected from the Web of Science Core Collection from 1993 to 2022, and analyzed and visualized by Bibliometrix R-package, VOSviewer, and CiteSpace. Results: A total of 1,710 publications were acquired. The number of annual publications showed an overall rapid upward trend, with the figure peaking at 179 in 2021. The USA was the leading research center. Totally 2,323 distinct institutions involving 7,638 scholars contributed to the research theme. However, most of the cooperation was limited to within the same country, institution or research team. The Journal of Alternative and Complementary Medicine was the most productive periodical. The CAM therapies of most interest to researchers were acupuncture and body–mind techniques, such as yoga, meditation and mindfulness. Systematic review and meta-analysis are commonly used methods. “Inflammation,” “rating scale” and “psychological stress” were identified as the most studied trend topics recently. Conclusion: Managing depression with evidence-based CAM treatment is gaining attention globally. Body–mind techniques and acupuncture are growing research hotspots or emerging trending topics. Future studies are predicted to potentially investigate the possible mechanisms of action underlying CAM treatments in reducing depression in terms of modulation of psychological stress and inflammation levels. Cross-countries/institutes/team research collaborations should be encouraged and further enhanced. Copyright © 2023 Zhao, Xu, Zheng, Conduit, Xu, Yue, Wang, Wang, Li, Li, Zhang, Fu and Kennedy.
Acupuncture as an independent or adjuvant management to standard care for perimenopausal depression : a systematic review and meta-analysis
- Zhao, Fei, Fu, Qiang-Qiang, Kennedy, Gerard, Conduit, Russell, Zhang, Wen-Jing, Zheng, Zhen
- Authors: Zhao, Fei , Fu, Qiang-Qiang , Kennedy, Gerard , Conduit, Russell , Zhang, Wen-Jing , Zheng, Zhen
- Date: 2021
- Type: Text , Journal article , Review
- Relation: Frontiers in Psychiatry Vol. 12, no. (2021), p.
- Full Text:
- Reviewed:
- Description: Background: Many women with perimenopausal depression (PMD) have sought alternative therapies such as acupuncture because of concerns about risks associated with antidepressant and hormone replacement therapy (HRT). This systematic review aimed to clarify if acupuncture is effective for PMD compared with waitlist control or placebo/sham acupuncture, and if acupuncture alone or combined with standard care (antidepressant and/or HRT) is more effective in ameliorating PMD in comparison with standard care alone. Methods: Randomized controlled trials (RCTs) of PMD treatment via acupuncture vs. waitlist control or placebo/sham acupuncture, and RCTs of PMD treatment via acupuncture alone or combined with Western pharmacotherapy vs. Western pharmacotherapy were searched for from seven databases from inception to December 2020. Cochrane criteria were followed. Results: Twenty-five studies involving 2,213 women were analyzed. Meta-analyses indicated that acupuncture significantly reduced the global scores of Hamilton Depression Scale (HAMD) [standardized mean difference (SMD) = −0.54, 95% CI (−0.91, −0.16), p < 0.01], compared with standard care. The therapeutic effect of acupuncture maintained at 2-, 4-, and 12-week follow-ups. Acupuncture combined with standard care was more effective than standard care alone in decreasing HAMD scores [SMD = −0.82, 95% CI (−1.07, −0.58), p < 0.01]. Too few RCTs were available to assess the clinical efficacy differences between acupuncture and placebo/sham acupuncture or HRT alone. Acupuncture also showed better effects in decreasing Kupperman index (KI) scores, whether compared with antidepressant alone [MD = −4.55, 95% CI (−8.46, −0.65), p = 0.02] or antidepressant combined with HRT [MD = −0.89, 95% CI (−1.34, −0.43), p < 0.01]. Conclusions: In comparison with standard care, acupuncture alone or combined with standard care was associated with significant improvements in PMD and reductions of other menopausal symptoms. This finding suggests that acupuncture may be a useful addition to treatment for PMD. © Copyright © 2021 Zhao, Fu, Kennedy, Conduit, Zhang and Zheng.
- Authors: Zhao, Fei , Fu, Qiang-Qiang , Kennedy, Gerard , Conduit, Russell , Zhang, Wen-Jing , Zheng, Zhen
- Date: 2021
- Type: Text , Journal article , Review
- Relation: Frontiers in Psychiatry Vol. 12, no. (2021), p.
- Full Text:
- Reviewed:
- Description: Background: Many women with perimenopausal depression (PMD) have sought alternative therapies such as acupuncture because of concerns about risks associated with antidepressant and hormone replacement therapy (HRT). This systematic review aimed to clarify if acupuncture is effective for PMD compared with waitlist control or placebo/sham acupuncture, and if acupuncture alone or combined with standard care (antidepressant and/or HRT) is more effective in ameliorating PMD in comparison with standard care alone. Methods: Randomized controlled trials (RCTs) of PMD treatment via acupuncture vs. waitlist control or placebo/sham acupuncture, and RCTs of PMD treatment via acupuncture alone or combined with Western pharmacotherapy vs. Western pharmacotherapy were searched for from seven databases from inception to December 2020. Cochrane criteria were followed. Results: Twenty-five studies involving 2,213 women were analyzed. Meta-analyses indicated that acupuncture significantly reduced the global scores of Hamilton Depression Scale (HAMD) [standardized mean difference (SMD) = −0.54, 95% CI (−0.91, −0.16), p < 0.01], compared with standard care. The therapeutic effect of acupuncture maintained at 2-, 4-, and 12-week follow-ups. Acupuncture combined with standard care was more effective than standard care alone in decreasing HAMD scores [SMD = −0.82, 95% CI (−1.07, −0.58), p < 0.01]. Too few RCTs were available to assess the clinical efficacy differences between acupuncture and placebo/sham acupuncture or HRT alone. Acupuncture also showed better effects in decreasing Kupperman index (KI) scores, whether compared with antidepressant alone [MD = −4.55, 95% CI (−8.46, −0.65), p = 0.02] or antidepressant combined with HRT [MD = −0.89, 95% CI (−1.34, −0.43), p < 0.01]. Conclusions: In comparison with standard care, acupuncture alone or combined with standard care was associated with significant improvements in PMD and reductions of other menopausal symptoms. This finding suggests that acupuncture may be a useful addition to treatment for PMD. © Copyright © 2021 Zhao, Fu, Kennedy, Conduit, Zhang and Zheng.
Acupuncture : a promising approach for Comorbid depression and insomnia in perimenopause
- Zhao, Fei, Fu, Qiang-Aiang, Spencer, Sarah, Kennedy, Gerard, Conduit, Russell, Zhang, Wen-Jing, Zheng, Zhen
- Authors: Zhao, Fei , Fu, Qiang-Aiang , Spencer, Sarah , Kennedy, Gerard , Conduit, Russell , Zhang, Wen-Jing , Zheng, Zhen
- Date: 2021
- Type: Text , Journal article
- Relation: Nature and Science of Sleep Vol. 13, no. (2021), p. 1823-1863
- Full Text:
- Reviewed:
- Description: Comorbid depression and insomnia are ubiquitous mental complaints among women going through the perimenopausal stage of life and can result in major decline in quality of life. Antidepressive agents combined with/without hypnotics, and/or hormone therapy are currently the most common treatment for perimenopausal depression (PMD) and insomnia (PMI). Balancing the benefits of these pharmacotherapies against the risk of adverse events (AEs) is a difficult task for both clinicians and women. There has been a growing body of research regarding the utilization of acupuncture for treatment of PMD or PMI, whereas no studies of acupuncture for comorbid PMD and PMI have appeared. In this review, we summarize the clinical and preclinical evidence of acupuncture as a treatment for PMD or PMI, and then discuss the potential mechanisms involved and the role of acupuncture in helping women during this transition. Most clinical trials indicate that acupuncture ameliorates not only PMD/PMI but also climacteric symptoms with minimal AEs. It also regulates serum hormone levels. The reliability of trials is however limited due to methodological flaws in most studies. Rodent studies suggest that acupuncture prolongs total sleep time and reduces depression-like behavior in PMI and PMD models, respectively. These effects are possibly mediated through multiple mechanisms of action, including modulating sex hormones, neurotransmitters, hypothalamic-pituitary-adrenal axis/hypothalamic-pituitary-ovary axis, oxidative stress, signaling pathways, and other cellular events. In conclusion, acupuncture is a promising therapeutic strategy for comorbid depression and insomnia during perimenopause. Neuroendocrine modulation is likely to play a major role in mediating those effects. High-quality trials are required to further validate acupuncture’s effectiveness. © 2021 Zhao et al.
- Authors: Zhao, Fei , Fu, Qiang-Aiang , Spencer, Sarah , Kennedy, Gerard , Conduit, Russell , Zhang, Wen-Jing , Zheng, Zhen
- Date: 2021
- Type: Text , Journal article
- Relation: Nature and Science of Sleep Vol. 13, no. (2021), p. 1823-1863
- Full Text:
- Reviewed:
- Description: Comorbid depression and insomnia are ubiquitous mental complaints among women going through the perimenopausal stage of life and can result in major decline in quality of life. Antidepressive agents combined with/without hypnotics, and/or hormone therapy are currently the most common treatment for perimenopausal depression (PMD) and insomnia (PMI). Balancing the benefits of these pharmacotherapies against the risk of adverse events (AEs) is a difficult task for both clinicians and women. There has been a growing body of research regarding the utilization of acupuncture for treatment of PMD or PMI, whereas no studies of acupuncture for comorbid PMD and PMI have appeared. In this review, we summarize the clinical and preclinical evidence of acupuncture as a treatment for PMD or PMI, and then discuss the potential mechanisms involved and the role of acupuncture in helping women during this transition. Most clinical trials indicate that acupuncture ameliorates not only PMD/PMI but also climacteric symptoms with minimal AEs. It also regulates serum hormone levels. The reliability of trials is however limited due to methodological flaws in most studies. Rodent studies suggest that acupuncture prolongs total sleep time and reduces depression-like behavior in PMI and PMD models, respectively. These effects are possibly mediated through multiple mechanisms of action, including modulating sex hormones, neurotransmitters, hypothalamic-pituitary-adrenal axis/hypothalamic-pituitary-ovary axis, oxidative stress, signaling pathways, and other cellular events. In conclusion, acupuncture is a promising therapeutic strategy for comorbid depression and insomnia during perimenopause. Neuroendocrine modulation is likely to play a major role in mediating those effects. High-quality trials are required to further validate acupuncture’s effectiveness. © 2021 Zhao et al.
Acupuncture for comorbid depression and insomnia in perimenopause : a feasibility patient-assessor-blinded, randomized, and sham-controlled clinical trial
- Zhao, Fei, Zheng, Zhen, Fu, Qiang-Qiang, Conduit, Russell, Xu, Hong, Wang, Hui-ru, Huang, Yu-Ling, Jiang, Ting, Zhang, Wen-Jing, Kennedy, Gerard
- Authors: Zhao, Fei , Zheng, Zhen , Fu, Qiang-Qiang , Conduit, Russell , Xu, Hong , Wang, Hui-ru , Huang, Yu-Ling , Jiang, Ting , Zhang, Wen-Jing , Kennedy, Gerard
- Date: 2023
- Type: Text , Journal article
- Relation: Frontiers in Public Health Vol. 11, no. (2023), p.
- Full Text:
- Reviewed:
- Description: Background and objective: Whilst acupuncture is widely used for treating psychosomatic diseases, there is little high-quality evidence supporting its application in comorbid perimenopausal depression (PMD) and insomnia (PMI) which are common complaints during climacteric. This feasibility, patient-assessor-blinded, randomized, sham-controlled clinical trial addresses this gap by investigating the efficacy and safety of acupuncture on depressed mood and poor sleep in women with comorbid PMD and PMI. Methods: Seventy eligible participants were randomly assigned to either real-acupuncture (RA) or sham-acupuncture (SA) groups. Either RA or SA treatment were delivered in 17 sessions over 8 weeks. The primary outcomes for mood and sleep were changes on 17-items Hamilton Depression Rating Scale (HAM-D17) and Pittsburgh Sleep Quality Index (PSQI) scores, from baseline to 16-week follow-up. Secondary outcome measures involved anxiety symptoms, perimenopausal symptoms, quality of life, participants' experience of and satisfaction with the acupuncture treatment. Blood samples were taken to measure reproductive hormone levels. Intention-To-Treat and Per-Protocol analyses were conducted with linear mixed-effects models. The James' and Bang's blinding indices were used to assess the adequacy of blinding. Results: Sixty-five participants completed all treatment sessions, and 54 and 41 participants completed the eight- and 16-week follow-ups, respectively. At post-treatment and 8-week follow-up, the RA group showed a significantly greater reduction in PSQI scores than the SA group did; although the reduction of HAM-D17 scores in RA group was significant, the change was not statistically different from that of SA. There were no significant mean differences between baseline and 16-week follow-up in either HAM-D17 or PSQI in either group. There were no significant between-group differences in serum reproductive hormone levels. All treatments were tolerable and no serious adverse events were reported, and the blinding was successful. Conclusion: Acupuncture is safe and can contribute to clinically relevant improvements in comorbid PMD and PMI, with satisfactory short-and medium-term effects. Whether the anti-depressive benefit of acupuncture is specific or non-specific remains to be determined. No evidence was found for any longer-term benefit of acupuncture compared to sham at 16 weeks. Further research is required to elucidate mechanisms underlying the short to medium term effects of acupuncture. Copyright © 2023 Zhao, Zheng, Fu, Conduit, Xu, Wang, Huang, Jiang, Zhang and Kennedy.
- Authors: Zhao, Fei , Zheng, Zhen , Fu, Qiang-Qiang , Conduit, Russell , Xu, Hong , Wang, Hui-ru , Huang, Yu-Ling , Jiang, Ting , Zhang, Wen-Jing , Kennedy, Gerard
- Date: 2023
- Type: Text , Journal article
- Relation: Frontiers in Public Health Vol. 11, no. (2023), p.
- Full Text:
- Reviewed:
- Description: Background and objective: Whilst acupuncture is widely used for treating psychosomatic diseases, there is little high-quality evidence supporting its application in comorbid perimenopausal depression (PMD) and insomnia (PMI) which are common complaints during climacteric. This feasibility, patient-assessor-blinded, randomized, sham-controlled clinical trial addresses this gap by investigating the efficacy and safety of acupuncture on depressed mood and poor sleep in women with comorbid PMD and PMI. Methods: Seventy eligible participants were randomly assigned to either real-acupuncture (RA) or sham-acupuncture (SA) groups. Either RA or SA treatment were delivered in 17 sessions over 8 weeks. The primary outcomes for mood and sleep were changes on 17-items Hamilton Depression Rating Scale (HAM-D17) and Pittsburgh Sleep Quality Index (PSQI) scores, from baseline to 16-week follow-up. Secondary outcome measures involved anxiety symptoms, perimenopausal symptoms, quality of life, participants' experience of and satisfaction with the acupuncture treatment. Blood samples were taken to measure reproductive hormone levels. Intention-To-Treat and Per-Protocol analyses were conducted with linear mixed-effects models. The James' and Bang's blinding indices were used to assess the adequacy of blinding. Results: Sixty-five participants completed all treatment sessions, and 54 and 41 participants completed the eight- and 16-week follow-ups, respectively. At post-treatment and 8-week follow-up, the RA group showed a significantly greater reduction in PSQI scores than the SA group did; although the reduction of HAM-D17 scores in RA group was significant, the change was not statistically different from that of SA. There were no significant mean differences between baseline and 16-week follow-up in either HAM-D17 or PSQI in either group. There were no significant between-group differences in serum reproductive hormone levels. All treatments were tolerable and no serious adverse events were reported, and the blinding was successful. Conclusion: Acupuncture is safe and can contribute to clinically relevant improvements in comorbid PMD and PMI, with satisfactory short-and medium-term effects. Whether the anti-depressive benefit of acupuncture is specific or non-specific remains to be determined. No evidence was found for any longer-term benefit of acupuncture compared to sham at 16 weeks. Further research is required to elucidate mechanisms underlying the short to medium term effects of acupuncture. Copyright © 2023 Zhao, Zheng, Fu, Conduit, Xu, Wang, Huang, Jiang, Zhang and Kennedy.
Rotational stiffness of cold-formed steel roof purlin-sheeting connections
- Zhao, Congxiao, Yang, Jian, Wang, Feiliang, Chan, Andrew
- Authors: Zhao, Congxiao , Yang, Jian , Wang, Feiliang , Chan, Andrew
- Date: 2014
- Type: Text , Journal article
- Relation: Engineering Structures Vol. 59, no. February 2014 (2014), p. 284-297
- Full Text: false
- Reviewed:
- Description: Cold-formed steel (CFS) sections are commonly used in modern roof construction. Most purlin members are of thin-walled open cross section. They are usually subjected to roof loading at the top flange in either an upward or a downward direction. The load application points, where the sheeting/purlin connections are located, are often eccentric to the shear centre, and thus inevitably generate a torsional moment that will induce twisting and/or warping deformations in addition to bending deflection. This type of complexity associated with the loading conditions will be exacerbated by the occurrence of single- or mixed-mode buckling (e.g. overall, distortional and local buckling) due to compression flanges tending to move sideways. The connections between purlin and roof sheeting provide a restraining effect on purlin members by preventing such lateral and twisting movements, and thus have a beneficial effect on their load-carrying capacity. In design practice, this effect should be taken into account from a design-efficiency perspective. To this end, a key step is to quantify the rotational restraint stiffness by using an engineering-orientated model. This paper firstly reports a series of torsional restraint tests (F-tests) for both sigma and zed sections. Two loading directions were examined by adjusting the purlin fixing direction. The rotational angles between the connected flange and sheeting were recorded at each loading step, from which the moment–rotation curves were produced and presented for each test case. A linear relationship has been observed for the moment–rotation relationship from all test specimens. Secondly, a hand calculation model for calculating the rotational stiffness at each connection was developed. In that model, the rotation was deemed to be primarily caused by the localised deformation of the roof sheeting and the distortional deformation of the purlin flange. The rotation caused by the separation of connection was found to be negligible. The model was validated by the experimental test results and an example was presented to demonstrate the application of the model proposed. The rotational stiffness calculated by this model can be used to evaluate the input parameters required for numerical modelling of purlin–sheeting interaction.
The shareholder's structure and CEO turnover in Chinese listed companies
- Zhao, Chao, Lowe, Julian, Pi, Lili
- Authors: Zhao, Chao , Lowe, Julian , Pi, Lili
- Date: 2005
- Type: Text , Journal article
- Relation: Reform Vol. 131, no. 1 (2005), p. 93-100
- Full Text: false
- Reviewed:
- Description: C1
- Description: 2003001142
- Authors: Zhao, Chao
- Date: 2009
- Type: Text , Conference paper
- Relation: Innovation and Knowledge Management in Twin Track Economies Challenges and Solutions - Proceedings of the 11th International Business Information Management Association Conference, IBIMA 2009 Vol. 1-3, p. 263-272
- Full Text: false
- Reviewed:
- Description: The aim of this research is to examine the importance of the nature and spatial dimension of knowledge sources on innovation of local firms in a cluster based on the regional innovation system approach. First, we introduce the "local buzz" and "global pipeline" argument. Second, we propose a conceptual framework incorporating two spatial dimensions of knowledge sources: local knowledge networks and global knowledge linkages, which include knowledge flows from inward foreign direct investment (FDI) to local firms as a part of global knowledge linkages. Third, we use qualitative analyses and firm survey data from a Guangzhou software cluster to show that global knowledge linkages and local knowledge networks are of similar importance to the innovation of local firms in a cluster, especially for local innovative firms. Customers, competitors, consultants and new personnel are the four most important knowledge sources to the innovation of local firms from both local knowledge networks and global knowledge linkages. The local firms with knowledge more from global knowledge linkages are more innovative. Finally, some policy implications, based on the research, are identified.