Description:
This study introduces a practical energy conversion (EC)-type modeling framework capable of converting the optimum compaction properties of fine-grained soils between any two rational compaction energy levels (CELs). Model development/calibration was carried out using a database of 242 compaction test results — the largest and most diverse database of its kind, to date, entailing 76 fine-grained soils (covering liquid limits of 16–256%), with each soil tested for at least three different CELs. On establishing the framework, an independent database of 91 compaction test results (consisting of 34 fine-grained soils tested for varying CELs) was employed for its validation. The proposed EC-based models employ measured optimum water content (OWC) and maximum dry unit weight (MDUW) values obtained for a rational CEL (preferably standard Proctor) to predict the same for higher and/or lower compactive efforts (covering 214–5416 kJ/m3). The 95% lower and upper statistical agreement limits between the predicted/converted and measured OWCs were obtained as
Description:
This study introduces a practical energy conversion (EC)-type modeling framework capable of converting the optimum compaction properties of fine-grained soils between any two rational compaction energy levels (CELs). Model development/calibration was carried out using a database of 242 compaction test results — the largest and most diverse database of its kind, to date, entailing 76 fine-grained soils (covering liquid limits of 16–256%), with each soil tested for at least three different CELs. On establishing the framework, an independent database of 91 compaction test results (consisting of 34 fine-grained soils tested for varying CELs) was employed for its validation. The proposed EC-based models employ measured optimum water content (OWC) and maximum dry unit weight (MDUW) values obtained for a rational CEL (preferably standard Proctor) to predict the same for higher and/or lower compactive efforts (covering 214–5416 kJ/m3). The 95% lower and upper statistical agreement limits between the predicted/converted and measured OWCs were obtained as
Description:
Background The COVID-19 pandemic impacted the psychosocial well-being of the United Arab Emirates [UAE] population like other communities internationally. Objectives We aimed to identify the factors associated with psychological distress, fear, and coping amongst community members across the UAE. Methods We conducted a cross-sectional online survey across the UAE during November 2020. Adults aged
Description:
Background The COVID-19 pandemic impacted the psychosocial well-being of the United Arab Emirates [UAE] population like other communities internationally. Objectives We aimed to identify the factors associated with psychological distress, fear, and coping amongst community members across the UAE. Methods We conducted a cross-sectional online survey across the UAE during November 2020. Adults aged
Description:
The Collaborative Evaluation & Research Centre (formally CERG) evaluated the crew’s experiences pre and post yacht events using a mixed methods approach. The Cyan yacht had a crew of 12 and competed in a number of events in the racing calendar leading up to the Sydney to Hobart race in January 2023. This was the first time that this boat and many of the crew competed in the Sydney to Hobart yacht race.
Description:
The Collaborative Evaluation & Research Centre (formally CERG) evaluated the crew’s experiences pre and post yacht events using a mixed methods approach. The Cyan yacht had a crew of 12 and competed in a number of events in the racing calendar leading up to the Sydney to Hobart race in January 2023. This was the first time that this boat and many of the crew competed in the Sydney to Hobart yacht race.
Description:
The plakin family of cytoskeletal proteins play an important role in cancer progression yet are under-studied in cancer, especially ovarian cancer. These large cytoskeletal proteins have primary roles in the maintenance of cytoskeletal integrity. They are also associated with scaffolds of intermediate filaments and hemidesmosomal adhesion complexes mediating signalling pathways that regulate cellular growth, migration, invasion and differentiation, as well as a stress response. Abnormalities of plakins, and the closely related spectraplakins, result in serious pathologies of skin, striated muscle and nervous tissue. Their prevalence in epithelial cells suggests that plakins may play a role in epithelial ovarian cancer progression and recurrence. This thesis sought to explore the expression of plakin proteins, particularly plectin (PLEC), desmoplakin (DSP), periplakin (PPL) and envoplakin (EVPL) in ovarian cancer progression, comparing surgical stages, historical Silverberg histological grading and current World Health Organisation (WHO) pathological classification of ovarian tumour types. The study also investigated the potential role that the plakin family of proteins may play in regulating cancer cell growth, survival, migration, invasion and drug resistance. It highlights potential relationships between plakins and epithelial-mesenchymal transition (EMT) and relates how these interactions may affect ovarian cancer progression, chemoresistance and ultimately recurrence. This study hypothesises that the molecular changes in the expression of plakins in benign ovarian tumours compared to various grades and stages of ovarian carcinomas, as well as floating cellular aggregates (spheroids) in the peritoneal ascites microenvironment, may contribute to the progression of the disease. It also attempts to understand these crucial changes in plakin expression in response to chemotherapy treatment and relate these findings in the perspective of disease recurrence.