Description:
The rupture of an abdominal aortic aneurysm (AAA) causes about 200,000 deaths worldwide each year. However, there are currently no effective drug therapies to prevent AAA formation or, when present, to decrease progression and rupture, highlighting an urgent need for more research in this field. Increased vascular inflammation and enhanced apoptosis of vascular smooth muscle cells (VSMCs) are implicated in AAA formation. Here, we investigated whether hydralazine, which has anti-inflammatory and anti-apoptotic properties, inhibited AAA formation and pathological hallmarks. In cultured VSMCs, hydralazine (100
Description:
The rupture of an abdominal aortic aneurysm (AAA) causes about 200,000 deaths worldwide each year. However, there are currently no effective drug therapies to prevent AAA formation or, when present, to decrease progression and rupture, highlighting an urgent need for more research in this field. Increased vascular inflammation and enhanced apoptosis of vascular smooth muscle cells (VSMCs) are implicated in AAA formation. Here, we investigated whether hydralazine, which has anti-inflammatory and anti-apoptotic properties, inhibited AAA formation and pathological hallmarks. In cultured VSMCs, hydralazine (100
Description:
Context. Polygala myrtifolia L. has become a significant environmental weed in Australia, where it has invaded coastal ecosystems in temperate regions and there is a high risk of extensive further spread. Knowledge of seed-germination behaviour is essential to understand the potential future impact of this species. Aims. We investigated the effects of selected environmental factors and dormancy on P. myrtifolia seed germination and emergence to improve management strategies. Methods. Seeds were exposed to light, temperature, pH, salinity, osmotic potential and burial depth treatments to assess germination responses, dormancy and viability. Key results. Non-dormant seeds readily germinated to high percentages (93.0–95.0%) under specific day–night temperatures of 25°C–15°C regardless of light conditions and across all soil pH (75.0–100.0%). Salinities were tolerated up to 100 mM NaCl (70.0% germination) before sharply declining. Germination reduced from 98.3% to 40.0% at osmotic potentials of
Description:
Context. Polygala myrtifolia L. has become a significant environmental weed in Australia, where it has invaded coastal ecosystems in temperate regions and there is a high risk of extensive further spread. Knowledge of seed-germination behaviour is essential to understand the potential future impact of this species. Aims. We investigated the effects of selected environmental factors and dormancy on P. myrtifolia seed germination and emergence to improve management strategies. Methods. Seeds were exposed to light, temperature, pH, salinity, osmotic potential and burial depth treatments to assess germination responses, dormancy and viability. Key results. Non-dormant seeds readily germinated to high percentages (93.0–95.0%) under specific day–night temperatures of 25°C–15°C regardless of light conditions and across all soil pH (75.0–100.0%). Salinities were tolerated up to 100 mM NaCl (70.0% germination) before sharply declining. Germination reduced from 98.3% to 40.0% at osmotic potentials of
Description:
Objectives: There is growing evidence of cognitive impairment after traumatic peripheral lesions. The purpose of this study was to explore the association between cognitive function and traumatic upper-limb injury. We assessed difference in cognitive function between participants with and without upper-limb injury, and explored the association between cognitive function and certain variables in injured individuals: gender, age, body mass index (BMI), educational level, and occupation. We sought to identify the factors associated with cognitive function in injured subjects: time since injury, injury side, nerve injury, hand function, pain, and finger sensation. Material and methods: A cross-sectional observational study was conducted, with 2 groups: observational group (with traumatic upper-limb injury) and control group (uninjured). The 2 groups were matched for age, gender, BMI, educational level and occupation. Short-term memory and executive functions were assessed using the Rey Auditory and Verbal Learning Test (RAVLT) and Stroop Color and Word Test (SCWT), respectively. Results: 104 participants with traumatic upper-limb injury and 104 uninjured control subjects were included. There was a significant inter-group difference only in RAVLT (p < 0.01; Cohen d, of 0.38). Regression analysis demonstrated an association of pain on VAS (beta =
Description:
Objectives: There is growing evidence of cognitive impairment after traumatic peripheral lesions. The purpose of this study was to explore the association between cognitive function and traumatic upper-limb injury. We assessed difference in cognitive function between participants with and without upper-limb injury, and explored the association between cognitive function and certain variables in injured individuals: gender, age, body mass index (BMI), educational level, and occupation. We sought to identify the factors associated with cognitive function in injured subjects: time since injury, injury side, nerve injury, hand function, pain, and finger sensation. Material and methods: A cross-sectional observational study was conducted, with 2 groups: observational group (with traumatic upper-limb injury) and control group (uninjured). The 2 groups were matched for age, gender, BMI, educational level and occupation. Short-term memory and executive functions were assessed using the Rey Auditory and Verbal Learning Test (RAVLT) and Stroop Color and Word Test (SCWT), respectively. Results: 104 participants with traumatic upper-limb injury and 104 uninjured control subjects were included. There was a significant inter-group difference only in RAVLT (p < 0.01; Cohen d, of 0.38). Regression analysis demonstrated an association of pain on VAS (beta =
Description:
Background: One of the most sought-after skills for performance in team sports is change of direction. Training the physical qualities of strength, speed, and power has been used to improve change of direction. These qualities of change of direction have been studied extensively for the last 20 years, and their influence is still questioned. Additionally, it is currently unknown how moderating training variables affect COD performance. Objective: This study examines the impact of strength, power, and speed training on change of direction performance. Method: Following the PRISMA guidelines, a meta-analysis was conducted. Electronic databases were searched for studies conducted from 1991 to April 2021. All studies identified for inclusion were peer-reviewed and published in English and Spanish and used an athlete population as participants. For all analyses, a significance level is set at p < 0.05. Results: Sixty-six articles were included in this meta-analysis. Two hundred fifty-one effect sizes were calculated, representing 2056 participants aged between 12 and 25 years. The global effect size (ES) for each quality is reported and Cochran's Q test: Strength (N = 48) ES: 0.844 Q = 77.63 (95%CI: 0.65;1.07); Speed (N = 17) ES: 0.70 Q = 5.69 (CI95% = 0.35;1.05); Power (N = 49) ES: 0.85 Q = 47.58 (CI95% = 0.64;1.06); Agility (N = 57) ES: 1.05 Q = 79.63 (CI95% = 0.86;1.24); Combined training (N = 13) ES: 0.51 Q = 13.79 (CI95% = 0.14;0.93), and the Control Group (N = 67) ES: 0.53 Q = 47.40 (IC95% =
Description:
Purpose: The neurotransmitter serotonin has a strong effect on behaviour and motor control. Regarding motor control, serotonin contributes to the development of fatigue and is also involved in the ability of motor neurones to operate across a large range of forces (gain control). The consumption of tryptophan-rich supplements (such as
Description:
Purpose: The neurotransmitter serotonin has a strong effect on behaviour and motor control. Regarding motor control, serotonin contributes to the development of fatigue and is also involved in the ability of motor neurones to operate across a large range of forces (gain control). The consumption of tryptophan-rich supplements (such as
Efficacy of a digital mental health biopsychosocial transdiagnostic intervention with or without therapist assistance for adults with anxiety and depression : adaptive randomized controlled trial
Description:
Introducing novel functionalities to state-of-the-art batteries has the potential to immensely enrich energy conversion chemistry. Here, we show a Zn-air battery concept wherein pollutant degradation is paired with electric power production facilitated by the in situ transformation of hydrogen peroxide (H2O2) produced on battery discharge to extremely reactive hydroxyl (˙OH) radical via Fenton's reaction. The battery delivered an open circuit voltage of nearly 1.3 V, a peak power density of nearly 55 mW cm
Description:
This study examines the potential of the soft computing technique, namely, multiple linear regression (MLR), genetic programming (GP), classification and regression trees (CART) and GA-ENN (genetic algorithm-emotional neuron network), to predict the ultimate bearing capacity (UBC) of cohesionless soils beneath shallow foundations. For the first time, two grey-box AI models, GP and CART, and one hybrid AI model, GA-ENN, were used in the literature to predict UBC. The inputs of the model are the width of footing (B), depth of footing (D), footing geometry (ratio of length to width, L/B), unit weight of sand (
Description:
This study examines the potential of the soft computing technique, namely, multiple linear regression (MLR), genetic programming (GP), classification and regression trees (CART) and GA-ENN (genetic algorithm-emotional neuron network), to predict the ultimate bearing capacity (UBC) of cohesionless soils beneath shallow foundations. For the first time, two grey-box AI models, GP and CART, and one hybrid AI model, GA-ENN, were used in the literature to predict UBC. The inputs of the model are the width of footing (B), depth of footing (D), footing geometry (ratio of length to width, L/B), unit weight of sand (
Description:
Learning about Indigenous research paradigms and methodologies offers insights and reflexive opportunities for those who seek to improve their research practice. This paper explores how research at the "interface" can enrich scholarly inquiry across the academy. Whilst a single paper cannot do justice to the sophistication and nuance of Indigenous methodologies, as an authorship team of one Indigenous and two non-Indigenous academics and through our established relationship and subsequent conversations, we present in this paper seven distilled methodological learnings that can enrich standard qualitative research practice. We predominantly explored the work of Indigenous scholars worldwide and, where relevant, have drawn on non-Indigenous scholars when there may be "interface" compatibilities. We also build off some of our previous work, such as Andrews (2020a, 2020b, 2021) and Bolton and Andrews.
Description:
Learning about Indigenous research paradigms and methodologies offers insights and reflexive opportunities for those who seek to improve their research practice. This paper explores how research at the "interface" can enrich scholarly inquiry across the academy. Whilst a single paper cannot do justice to the sophistication and nuance of Indigenous methodologies, as an authorship team of one Indigenous and two non-Indigenous academics and through our established relationship and subsequent conversations, we present in this paper seven distilled methodological learnings that can enrich standard qualitative research practice. We predominantly explored the work of Indigenous scholars worldwide and, where relevant, have drawn on non-Indigenous scholars when there may be "interface" compatibilities. We also build off some of our previous work, such as Andrews (2020a, 2020b, 2021) and Bolton and Andrews.