- Title
- Animal models, pathogenesis, and potential treatment of thoracic aortic aneurysm
- Creator
- Wang, Yutang; Panicker, Indu; Anesi, Jack; Sargisson, Owen; Atchison, Benjamin; Habenicht, Andreas
- Date
- 2024
- Type
- Text; Journal article; Review
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/199886
- Identifier
- vital:19296
- Identifier
-
https://doi.org/10.3390/ijms25020901
- Identifier
- ISSN:1661-6596 (ISSN)
- Abstract
- Thoracic aortic aneurysm (TAA) has a prevalence of 0.16–0.34% and an incidence of 7.6 per 100,000 person-years, accounting for 1–2% of all deaths in Western countries. Currently, no effective pharmacological therapies have been identified to slow TAA development and prevent TAA rupture. Large TAAs are treated with open surgical repair and less invasive thoracic endovascular aortic repair, both of which have high perioperative mortality risk. Therefore, there is an urgent medical need to identify the cellular and molecular mechanisms underlying TAA development and rupture to develop new therapies. In this review, we summarize animal TAA models including recent developments in porcine and zebrafish models: porcine models can assess new therapeutic devices or intervention strategies in a large mammal and zebrafish models can employ large-scale small-molecule suppressor screening in microwells. The second part of the review covers current views of TAA pathogenesis, derived from recent studies using these animal models, with a focus on the roles of the transforming growth factor-beta (TGF
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Relation
- International Journal of Molecular Sciences Vol. 25, no. 2 (2024), p.; https://purl.org/au-research/grants/nhmrc/1062671
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- https://creativecommons.org/licenses/by/4.0/
- Rights
- Copyright © 2024 by the authors
- Rights
- Open Access
- Subject
- 3101 Biochemistry and cell biology; 3107 Microbiology; 3404 Medicinal and biomolecular chemistry; Angiotensin II; Calcium chloride; Elastase; Marfan syndrome; β-aminopropionitrile
- Full Text
- Reviewed
- Funder
- This research was funded by the National Health and Medical Research Council of Australia, grant number 1062671.
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