- Title
- Fasting triglycerides are positively associated with cardiovascular mortality risk in people with diabetes
- Creator
- Wang, Yutang; Fang, Yan; Magliano, Dianna; Charchar, Fadi; Sobey, Christopher; Drummond, Grant; Golledge, Jonathan
- Date
- 2023
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/194491
- Identifier
- vital:18368
- Identifier
-
https://doi.org/10.1093/cvr/cvac124
- Identifier
- ISSN:0008-6363 (ISSN)
- Abstract
- Aims We investigated the association of fasting triglycerides with cardiovascular disease (CVD) mortality. Methods and results This cohort study included US adults from the National Health and Nutrition Examination Surveys from 1988 to 2014. CVD mortality outcomes were ascertained by linkage to the National Death Index records. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of triglycerides for CVD mortality. The cohort included 26 570 adult participants, among which 3978 had diabetes. People with higher triglycerides had a higher prevalence of diabetes at baseline. The cohort was followed up for a mean of 12.0 years with 1492 CVD deaths recorded. A 1-natural-log-unit higher triglyceride was associated with a 30% higher multivariate-adjusted risk of CVD mortality in participants with diabetes (HR, 1.30; 95% CI, 1.08–1.56) but not in those without diabetes (HR, 0.95; 95% CI, 0.83–1.07). In participants with diabetes, people with high triglycerides (200–499 mg/dL) had a 44% (HR, 1.44; 95% CI, 1.12–1.85) higher multivariate-adjusted risk of CVD mortality compared with those with normal triglycerides (<150 mg/dL). The findings remained significant when diabetes was defined by fasting glucose levels alone, or after further adjustment for the use of lipid-lowering medications, or after the exclusion of those who took lipid-lowering medications. Conclusion This study demonstrates that fasting triglycerides of
- Publisher
- Oxford University Press
- Relation
- Cardiovascular Research Vol. 119, no. 3 (2023), p. 826-834; https://purl.org/au-research/grants/nhmrc/1062671
- Rights
- All metadata describing materials held in, or linked to, the repository is freely available under a CC0 licence
- Rights
- https://creativecommons.org/licenses/by/4.0/
- Rights
- Copyright © The Author(s) 2022
- Rights
- Open Access
- Subject
- 3201 Cardiovascular medicine and haematology; CVD; Diabetes; Hypertriglyceridaemia; Mortality; Risk factor
- Full Text
- Reviewed
- Funder
- This work was supported by a grant from the National Health and Medical Research Council of Australia (grant number 1062671).
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