- Title
- The hybrid idea of (energy minimization) optimization methods applied to study prion protein structions focusing on the beta2-alpha2 loop
- Creator
- Zhang, Jiapu
- Date
- 2015
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/169320
- Identifier
- vital:14003
- Identifier
-
https://doi.org/10.4172/2167-0501.1000175
- Identifier
- ISBN:2167-0501
- Abstract
- In molecular mechanics, current generation potential energy functions provide a reasonably good compromise between accuracy and effectiveness. This paper firstly reviewed several most commonly used classical potential energy functions and their optimization methods used for energy minimization. To minimize a potential energy function, about 95% efforts are spent on the Lennard-Jones potential of van der Waals interactions; we also give a detailed review on some effective computational optimization methods in the Cambridge Cluster Database to solve the problem of Lennard- Jones clusters. From the reviews, we found the hybrid idea of optimization methods is effective, necessary and efficient for solving the potential energy minimization problem and the Lennard-Jones clusters problem. An application to prion protein structures is then done by the hybrid idea. We focus on the
- Publisher
- OMICS International for Nigerian Society of Biochemistry and Molecular Biology
- Relation
- Biochemistry & Pharmacology Vol. 4, no. 4 (2015), p. 1-12
- Rights
- http://creativecommons.org/licenses/by/4.0/
- Rights
- Copyright © 2015 Zhang J. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Rights
- Open Access
- Rights
- This metadata is freely available under a CCO license
- Subject
- Hybrid idea; Computational optimization methods; Energy minimization; Potential energy; Lennard-Jones clusters; Application to protein structures; Prion proteins; β2-α2 loop
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